Melkersson-Rosenthal syndrome

Common Name(s)

Melkersson-Rosenthal syndrome

Melkersson-Rosenthal syndrome is a rare neurological disorder characterized by recurring facial paralysis, swelling of the face and lips, and the development of folds and furrows in the tongue. Onset is in childhood or early adolescence. After recurrent attacks, swelling may persist and increase, eventually becoming permanent. The lip may become hard, cracked, and fissured with a reddish-brown discoloration. The cause of Melkersson-Rosenthal syndrome is unknown, but there may be a genetic predisposition. It can be symptomatic of Crohn's disease or sarcoidosis.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Melkersson-Rosenthal syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Melkersson-Rosenthal syndrome" returned 14 free, full-text research articles on human participants. First 3 results:

Successful treatment of Miescher's cheilitis in Melkersson-Rosenthal syndrome with betamethasone injections and doxycycline.
 

Author(s): Lamia Oudrhiri, Soumiya Chiheb, Farida Marnissi, Soumaya Zamiati, Hakima Benchikhi

Journal: Pan Afr Med J. 2012 ;13():75.

 

We report a case of a 19-year-old girl who presented with 5-year history of swelling of upper lip and fissured tongue treated with dapsone then oral steroids without any improvement. Clinical examination found peripheral facial nerve paralysis and Labial mucosa biopsy showed non-necrotizing ...

Last Updated: 11 Feb 2013

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Granulomatous cheilitis of Miescher: the diagnostic proof for a Melkersson-Rosenthal syndrome.
 

Author(s): Andreea Liana Răchişan, A Hruşcă, D Gheban, Simona Căinap, T L Pop, A Băican, L Fodor, N Miu, Mariana Andreica

Journal: Rom J Morphol Embryol. 2012 ;53(3 Suppl):851-3.

 

The Melkersson-Rosenthal syndrome (MRS) is a very rare clinical entity and its classical form is being characterized by the following triad: facial nerve palsy, swelling of the lips and fissured tongue. However, the monosymptomatic form is more common and the typical manifestation ...

Last Updated: 28 Nov 2012

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Re 'Isolated eyelid edema in Melkersson-Rosenthal syndrome: a case series'.
 

Author(s): A A McNab

Journal: Eye (Lond). 2012 Jun;26(6):893; author reply 893-4.

 

Last Updated: 14 Jun 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Melkersson-Rosenthal syndrome" returned 1 free, full-text review articles on human participants. First 3 results:

[Macrocheilitis and Melkersson-Rosenthal syndrome. Review of 19 cases].
 

Author(s): C Marques, A Machado, A P Baptista

Journal: Acta Med Port. 1994 Oct;7(10):533-40.

 

Melkersson-Rosenthal syndrome is an uncommon condition of unknown cause. The classical triad includes recurrent orofacial oedema involving predominantly the lips (macrocheilitis), intermittent peripheral facial palsy and scrotal tongue. Some authors consider Miescher's cheilitis as ...

Last Updated: 16 Mar 1995

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Symptoms, Diagnosis, and Treatment

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