Megaloblastic anemia

Common Name(s)

Megaloblastic anemia, Imerslund-Grasbeck syndrome

Imerslund-Grasbeck syndrome (IGS) is a rare condition characterized by vitamin B12 deficiency, often causing megaloblastic anemia. IGS usually appears in childhood. Other features may include failure to thrive, infections, and neurological damage. Mild proteinuria (with no signs of kidney disease) is present in about half of affected individuals. IGS is caused by mutations in either the CUBN or AMN gene and is inherited in an autosomal recessive manner. Treatment includes life-long vitamin B12 injections, with which affected individuals can stay healthy for decades.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Megaloblastic anemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Megaloblastic anemia" returned 100 free, full-text research articles on human participants. First 3 results:

Drug-Induced Megaloblastic Anemia.
 

Author(s): Charles S Hesdorffer, Dan L Longo

Journal: N. Engl. J. Med.. 2016 Feb;374(7):696-7.

 

Last Updated: 18 Feb 2016

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Diffuse alveolar damage in a patient with Epstein Barr virus (EBV)-positive diffuse large B-cell lymphoma,severely low serum folate, and megaloblastic anemia: a case report of autopsy.
 

Author(s): Ikuo Matsuda, Noriko Kajimoto, Minao Hamada, Yoshifumi Shimizu, Satoru Kuki, Seiichi Hirota

Journal:

 

We report a case of a 49-year-old Japanese man, who was admitted to our hospital because of severe dyspnea. He was found to have severely low serum folate and megaloblastic anemia, which was at first suspected to cause his dyspnea. It was assumed that severely low serum folate might ...

Last Updated: 12 May 2014

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Prominent Howell-Jolly bodies when megaloblastic anemia develops in a hyposplenic patient.
 

Author(s): Barbara J Bain

Journal: Am. J. Hematol.. 2014 Aug;89(8):852.

 

Last Updated: 21 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Megaloblastic anemia" returned 6 free, full-text review articles on human participants. First 3 results:

Laboratory testing for cobalamin deficiency in megaloblastic anemia.
 

Author(s): Matthew J Oberley, David T Yang

Journal: Am. J. Hematol.. 2013 Jun;88(6):522-6.

 

Cobalamin (vitamin B12) deficiency is a common cause of megaloblastic anemia in Western populations. Laboratory evaluation of megaloblastic anemia frequently includes the assessment of patient cobalamin and folate status. Current total serum cobalamin measurements are performed in ...

Last Updated: 22 May 2013

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Megaloblastic anemia and other causes of macrocytosis.
 

Author(s): Florence Aslinia, Joseph J Mazza, Steven H Yale

Journal: Clin Med Res. 2006 Sep;4(3):236-41.

 

Last Updated: 21 Sep 2006

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Megaloblastic anemia associated with psoriasis: case report and review of the literature.
 

Author(s): A Iwama, A Miwa, T Suzuki, H Ema, T Suda, S Sakamoto, Y Miura

Journal: Intern. Med.. 1992 Jan;31(1):127-30.

 

A 68-yr-old male with severe psoriasis developed megaloblastic anemia due to folate deficiency 3 months after the cessation of low-dose methotrexate therapy. The mechanism of megaloblastic anemia in this case was suggested to be multifactorial. The case report and a review of megaloblastic ...

Last Updated: 28 May 1992

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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