Megacolon

Common Name(s)

Megacolon

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Megacolon" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

Last Updated: 28 Feb 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Megacolon" for support, advocacy or research.

Association of Gastrointestinal Motility Disorders, Inc. (AGMD)

AGMD is a nonprofit international organization which serves as an integral educational resource concerning digestive motility diseases and disorders. It also functions as an important information base for members of the medical and scientific communities. In addition, it provides a forum for patients suffering from digestive motility diseases and disorders as well as their families and members of the medical community.

http://www.agmd-gimotility.org

Last Updated: 28 Feb 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Megacolon" returned 104 free, full-text research articles on human participants. First 3 results:

Trypanosomiasis-induced megacolon illustrates how myenteric neurons modulate the risk for colon cancer in rats and humans.
 

Author(s): Vinicius Kannen, Enio C de Oliveira, Bruno Zene Motta, Annuar Jose Chaguri, Mariângela Ottoboni Brunaldi, Sérgio B Garcia

Journal:

 

Trypanosomiasis induces a remarkable myenteric neuronal degeneration leading to megacolon. Very little is known about the risk for colon cancer in chagasic megacolon patients. To clarify whether chagasic megacolon impacts on colon carcinogenesis, we investigated the risk for colon ...

Last Updated: 18 Apr 2015

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A case of toxic megacolon caused by clostridium difficile infection and treated with fecal microbiota transplantation.
 

Author(s): Tae Geun Gweon, Kyung Jin Lee, Dong Hoon Kang, Sung Soo Park, Kyung Hoon Kim, Hyeon Jin Seong, Tae Hyun Ban, Sung Jin Moon, Jin Su Kim, Sang Woo Kim

Journal: Gut Liver. 2015 Mar;9(2):247-50.

 

Clostridium difficile infection. The mortality rate of fulminant C. difficile infection is reported to be as high as 50%. Fecal microbiota transplantation is a highly effective treatment in patients with recurrent or refractory C. difficile infection. However, there are few published ...

Last Updated: 27 Feb 2015

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Difficulties in the diagnostics and treatment of near-total congenital megacolon.
 

Author(s): L Topor, A Ulici, D Mălureanu, I Stoica, A Moga

Journal: Chirurgia (Bucur). ;109(5):701-4.

 

Near total colonic aganglionosis is one of the rarest forms of Hirschsprung's disease and until recent years it has been considered deadly. Establishing a correct diagnosis has proven to be challenging, because while the clinical and radiological features can be useful, they are not ...

Last Updated: 7 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Megacolon" returned 8 free, full-text review articles on human participants. First 3 results:

Chagasic megacolon: enteric neurons and related structures.
 

Author(s): Samir Jabari, Enio C de Oliveira, Axel Brehmer, Alexandre B M da Silveira

Journal: Histochem. Cell Biol.. 2014 Sep;142(3):235-44.

 

Megacolon, the irreversible dilation of a colonic segment, is a structural sign associated with various gastrointestinal disorders. In its hereditary, secondary form (e.g. in Hirschsprung's disease), dilation occurs in an originally healthy colonic segment due to an anally located, ...

Last Updated: 14 Aug 2014

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Toxic megacolon associated with cytomegalovirus infection in a patient with steroid-naïve ulcerative colitis.
 

Author(s): Ken Inoue, Naoki Wakabayashi, Kohei Fukumoto, Shinya Yamada, Nobukatsu Bito, Naohisa Yoshida, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Osamu Handa, Tomohisa Takagi, Hideyuki Konishi, Nobuaki Yagi, Satoshi Kokura, Mitsuo Kishimoto, Akio Yanagisawa, Yuji Naito

Journal: Intern. Med.. 2012 ;51(19):2739-43.

 

Most cases of cytomegalovirus (CMV) colitis in patients with inflammatory bowel disease (IBD) occur in those treated with immunosuppressants and/or corticosteroids. We herein present the case of a 57-year-old man with toxic megacolon associated with CMV colitis in corticosteroid-naïve ...

Last Updated: 5 Oct 2012

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Congenital aganglionic megacolon in Nigerian adults: two case reports and review of the literature.
 

Author(s): A A Bakari, B M Gali, A G Ibrahim, H A Nggada, N Ali, D Dogo, A M Abubakar

Journal: Niger J Clin Pract. ;14(2):249-52.

 

Congenital aganglionic mega colon (Hirschsprung's disease) is a motor disorder in the gut, due to a defect in the craniocaudal migration of the neuroblast originating from the neural crest that occurs during the first twelve weeks of gestation, causing a functional intestinal obstruction, ...

Last Updated: 23 Aug 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Trial on Treatments of Hirschsprung Allied Disease
 

Status: Recruiting

Condition Summary: Complications of Treatment; Complication of Surgical Procedure; Megacolon, Not Hirschsprung

 

Last Updated: 6 Aug 2014

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Fast-track Surgery in the Treatment of Hirschsprung's Disease
 

Status: Recruiting

Condition Summary: Surgery

 

Last Updated: 24 Jan 2015

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Probiotics for Prophylaxis of Postoperative Hirschsprungs Associated Enterocolitis
 

Status: Recruiting

Condition Summary: Hirschsprung Disease

 

Last Updated: 27 Jan 2016

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