Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

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Advocacy and Support Organizations

 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 750 free, full-text research articles on human participants. First 3 results:

Na,K-ATPase β1-subunit is a target of sonic hedgehog signaling and enhances medulloblastoma tumorigenicity.
 

Author(s): Seung Joon Lee, Alisa Litan, Zhiqin Li, Bruce Graves, Stephan Lindsey, Sonali P Barwe, Sigrid A Langhans

Journal:

 

The Sonic hedgehog (Shh) signaling pathway plays an important role in cerebellar development, and mutations leading to hyperactive Shh signaling have been associated with certain forms of medulloblastoma, a common form of pediatric brain cancer. While the fundamentals of this pathway ...

Last Updated: 19 Aug 2015

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miR-367 promotes proliferation and stem-like traits in medulloblastoma cells.
 

Author(s): Carolini Kaid, Patrícia B G Silva, Beatriz A Cortez, Carolina O Rodini, Patricia Semedo-Kuriki, Oswaldo K Okamoto

Journal: Cancer Sci.. 2015 Sep;106(9):1188-95.

 

In medulloblastoma, abnormal expression of pluripotency factors such as LIN28 and OCT4 has been correlated with poor patient survival. The miR-302/367 cluster has also been shown to control self-renewal and pluripotency in human embryonic stem cells and induced pluripotent stem cells, ...

Last Updated: 23 Sep 2015

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AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma.
 

Author(s): Yen-Hsing Li, Jia Luo, Yung-Yi C Mosley, Victoria E Hedrick, Lake N Paul, Julia Chang, GuangJun Zhang, Yu-Kuo Wang, Max R Banko, Anne Brunet, Shihuan Kuang, Jen-Leih Wu, Chun-Ju Chang, Matthew P Scott, Jer-Yen Yang

Journal: Cell Rep. 2015 Jul;12(4):599-609.

 

The Hedgehog (Hh) pathway regulates cell differentiation and proliferation during development by controlling the Gli transcription factors. Cell fate decisions and progression toward organ and tissue maturity must be coordinated, and how an energy sensor regulates the Hh pathway is ...

Last Updated: 30 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 42 free, full-text review articles on human participants. First 3 results:

Medulloblastoma development: tumor biology informs treatment decisions.
 

Author(s): Vidya Gopalakrishnan, Rong-Hua Tao, Tara Dobson, William Brugmann, Soumen Khatua

Journal: CNS Oncol. 2015 ;4(2):79-89.

 

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments including surgery, craniospinal radiation and high-dose chemotherapy have led to improvement in survival. However, the risk for recurrence as well as significant long-term neurocognitive and endocrine ...

Last Updated: 15 Mar 2015

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Management of pediatric and adult patients with medulloblastoma.
 

Author(s): Allison M Martin, Eric Raabe, Charles Eberhart, Kenneth J Cohen

Journal: Curr Treat Options Oncol. 2014 Dec;15(4):581-94.

 

Approximately 70 % of newly diagnosed children with medulloblastoma (MB) will be classified as "standard risk": their tumor is localized to the posterior fossa, they undergo a near or gross total resection, the tumor does not meet the criteria for large cell/anaplastic histology, ...

Last Updated: 31 Oct 2014

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Targeted treatment for sonic hedgehog-dependent medulloblastoma.
 

Author(s): Mark W Kieran

Journal: Neuro-oncology. 2014 Aug;16(8):1037-47.

 

Novel treatment options, including targeted therapies, are needed for patients with medulloblastoma (MB), especially for those with high-risk or recurrent/relapsed disease. Four major molecular subgroups of MB have been identified, one of which is characterized by activation of the ...

Last Updated: 15 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 15 Feb 2016

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Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
 

Status: Recruiting

Condition Summary: Medulloblastoma; Neuroectodermal Tumor

 

Last Updated: 28 Apr 2016

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Last Updated: 24 Mar 2016

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