Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 768 free, full-text research articles on human participants. First 3 results:

Suppression of GLI sensitizes medulloblastoma cells to mitochondria-mediated apoptosis.
 

Author(s): Zhongxiao Lin, Sisi Li, Hansong Sheng, Ming Cai, Lin Yuan Si Ma, Liuxun Hu, Shangyu Xu, Li Sheng Yu, Nu Zhang

Journal: J. Cancer Res. Clin. Oncol.. 2016 Dec;142(12):2469-2478.

 

The sonic hedgehog (SHH) signalling pathway plays the important role in medulloblastoma (MB). Altered GLI expression plays a key role in these processes, and the inhibition of GLI may be a good cancer-targeted therapy. This study aimed to investigate whether GANT61, a GLI inhibitor, ...

Last Updated: 7 Sep 2016

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Update on the integrated histopathological and genetic classification of medulloblastoma - a practical diagnostic guideline.
 

Author(s): Torsten Pietsch, Christine Haberler

Journal: Clin. Neuropathol.. ;35(6):344-352.

 

The revised WHO classification of tumors of the CNS 2016 has introduced the concept of the integrated diagnosis. The definition of medulloblastoma entities now requires a combination of the traditional histological information with additional molecular/genetic features. For definition ...

Last Updated: 26 Oct 2016

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MPS1 kinase as a potential therapeutic target in medulloblastoma.
 

Author(s): Irina Alimova, June Ng, Peter Harris, Diane Birks, Andrew Donson, Michael D Taylor, Nicholas K Foreman, Sujatha Venkataraman, Rajeev Vibhakar

Journal: Oncol. Rep.. 2016 Nov;36(5):2633-2640.

 

Medulloblastoma is the most common type of malignant brain tumor that affects children. Although recent advances in chemotherapy and radiation have improved outcomes, high-risk patients perform poorly with significant morbidity. Gene expression profiling has revealed that monopolar ...

Last Updated: 16 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 52 free, full-text review articles on human participants. First 3 results:

A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors.
 

Author(s): Jerome A Staal, Yanxin Pei, Brian R Rood

Journal:

 

Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest ...

Last Updated: 24 Oct 2016

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In vitro models of medulloblastoma: Choosing the right tool for the job.
 

Author(s): Delyan P Ivanov, Beth Coyle, David A Walker, Anna M Grabowska

Journal: J. Biotechnol.. 2016 Oct;236():10-25.

 

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a more comprehensive picture of the ...

Last Updated: 18 Sep 2016

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Evasion of cell senescence in SHH medulloblastoma.
 

Author(s): Lukas Tamayo-Orrego, Shannon M Swikert, Frédéric Charron

Journal: Cell Cycle. 2016 Aug;15(16):2102-2107.

 

The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1(+/-) mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type ...

Last Updated: 17 Jun 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Apr 2017

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 30 Mar 2017

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Last Updated: 15 May 2017

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