Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 762 free, full-text research articles on human participants. First 3 results:

Anomalous vascularization in a Wnt medulloblastoma: a case report.
 

Author(s): Angela Di Giannatale, Andrea Carai, Antonella Cacchione, Antonio Marrazzo, Vito Andrea Dell'Anna, Giovanna Stefania Colafati, Francesca Diomedi-Camassei, Evelina Miele, Agnese Po, Elisabetta Ferretti, Franco Locatelli, Angela Mastronuzzi

Journal:

 

Medulloblastoma is the most common malignant brain tumor in children. To date only few cases of medulloblastoma with hemorrhages have been reported in the literature. Although some studies speculate on the pathogenesis of this anomalous increased vascularization in medulloblastoma, ...

Last Updated: 15 Jul 2016

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Evasion of Cell Senescence Leads to Medulloblastoma Progression.
 

Author(s): Lukas Tamayo-Orrego, Chia-Lun Wu, Nicolas Bouchard, Ahmed Khedher, Shannon M Swikert, Marc Remke, Patryk Skowron, Michael D Taylor, Frédéric Charron

Journal: Cell Rep. 2016 Mar;14(12):2925-37.

 

How brain tumors progress from precancerous lesions to advanced cancers is not well understood. Using Ptch1(+/-) mice to study medulloblastoma progression, we found that Ptch1 loss of heterozygosity (LOH) is an early event that is associated with high levels of cell senescence in ...

Last Updated: 31 Mar 2016

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An analysis of medulloblastoma: 10 year experience of a referral institution in South India.
 

Author(s): S Gaur, S S Kumar, P Balasubramaniam

Journal: Indian J Cancer. ;52(4):575-8.

 

Medulloblastoma is an embryonal tumor with aggressive behavior and is more commonly seen in children than adults. The aim of this study was to determine the epidemiological patterns of medulloblastoma in a tertiary care center in Southern India.

Last Updated: 10 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 49 free, full-text review articles on human participants. First 3 results:

[Medulloblastoma in adults: report of 13 cases and literature review].
 

Author(s): Jamal Drissi, Mariam Affane, Abdelhamid Elomrani, Mouna Khouchani

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Last Updated: 18 Feb 2016

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Young investigator challenge: Cytomorphologic analysis of cerebrospinal fluid in 70 pediatric patients with medulloblastoma and review of the literature focusing on novel diagnostic and prognostic tests.
 

Author(s): Domenico Damiani, Voichita Suciu, Felipe Andreiuolo, Julien Calderaro, Philippe Vielh

Journal: Cancer Cytopathol. 2015 Nov;123(11):644-9.

 

Medulloblastoma (MB) is the most common malignant pediatric brain tumor and is currently treated with combined therapies. Recent advances in genetics and protein expression in this entity have led to the elaboration of a new molecular classification, and novel targeted therapies are ...

Last Updated: 15 Jan 2016

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The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma.
 

Author(s): Jerry Vriend, Saeid Ghavami, Hassan Marzban

Journal:

 

Cerebellar granule cells precursors are derived from the upper rhombic lip and migrate tangentially independent of glia along the subpial stream pathway to form the external germinal zone. Postnatally, granule cells migrate from the external germinal zone radially through the Purkinje ...

Last Updated: 17 Oct 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 10 Nov 2016

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 9 Nov 2016

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Last Updated: 28 Jul 2016

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