Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 756 free, full-text research articles on human participants. First 3 results:

[MRI diagnosis of spinal metastasis of medulloblastoma. A clinical case and literature review].
 

Author(s): S S Ozerov, G V Tereshchenko, A V Artemov, E V Kumirova, A E Samarin, L I Papusha, N S Grachev, O G Zheludkova

Journal: Zh Vopr Neirokhir Im N N Burdenko. 2015 ;79(5):72-6; discussion 76.

 

the study objective was to improve the quality of detection of medulloblastoma metastases.

Last Updated: 4 Nov 2015

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Exogenous HGF Bypasses the Effects of ErbB Inhibition on Tumor Cell Viability in Medulloblastoma Cell Lines.
 

Author(s): Walderik W Zomerman, Sabine L A Plasschaert, Sander H Diks, Harm-Jan Lourens, Tiny Meeuwsen-de Boer, Eelco W Hoving, Wilfred F A den Dunnen, Eveline S J M de Bont

Journal:

 

Recent clinical trials investigating receptor tyrosine kinase (RTK) inhibitors showed a limited clinical response in medulloblastoma. The present study investigated the role of micro-environmental growth factors expressed in the brain, such as HGF and EGF, in relation to the effects ...

Last Updated: 27 Oct 2015

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Ecto-5'-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model.
 

Author(s): Angélica R Cappellari, Micheli M Pillat, Hellio D N Souza, Fabrícia Dietrich, Francine H Oliveira, Fabrício Figueiró, Ana L Abujamra, Rafael Roesler, Joanna Lecka, Jean Sévigny, Ana Maria O Battastini, Henning Ulrich

Journal:

 

Ecto-5'-nucleotidase/CD73 (ecto-5'-NT) participates in extracellular ATP catabolism by converting adenosine monophosphate (AMP) into adenosine. This enzyme affects the progression and invasiveness of different tumors. Furthermore, the expression of ecto-5'-NT has also been suggested ...

Last Updated: 23 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 42 free, full-text review articles on human participants. First 3 results:

Medulloblastoma development: tumor biology informs treatment decisions.
 

Author(s): Vidya Gopalakrishnan, Rong-Hua Tao, Tara Dobson, William Brugmann, Soumen Khatua

Journal: CNS Oncol. 2015 ;4(2):79-89.

 

Medulloblastoma is the most common malignant pediatric brain tumor. Current treatments including surgery, craniospinal radiation and high-dose chemotherapy have led to improvement in survival. However, the risk for recurrence as well as significant long-term neurocognitive and endocrine ...

Last Updated: 15 Mar 2015

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Management of pediatric and adult patients with medulloblastoma.
 

Author(s): Allison M Martin, Eric Raabe, Charles Eberhart, Kenneth J Cohen

Journal: Curr Treat Options Oncol. 2014 Dec;15(4):581-94.

 

Approximately 70 % of newly diagnosed children with medulloblastoma (MB) will be classified as "standard risk": their tumor is localized to the posterior fossa, they undergo a near or gross total resection, the tumor does not meet the criteria for large cell/anaplastic histology, ...

Last Updated: 31 Oct 2014

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Targeted treatment for sonic hedgehog-dependent medulloblastoma.
 

Author(s): Mark W Kieran

Journal: Neuro-oncology. 2014 Aug;16(8):1037-47.

 

Novel treatment options, including targeted therapies, are needed for patients with medulloblastoma (MB), especially for those with high-risk or recurrent/relapsed disease. Four major molecular subgroups of MB have been identified, one of which is characterized by activation of the ...

Last Updated: 15 Jul 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 17 Jun 2016

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Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
 

Status: Recruiting

Condition Summary: Medulloblastoma; Neuroectodermal Tumor

 

Last Updated: 31 May 2016

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Last Updated: 27 Jun 2016

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