Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is the most common brain tumor in children. It accounts for 16% of all pediatric brain tumors, and 40% of all cerebellar tumors in childhood are medulloblastoma. Medulloblastoma occurs bimodally, with peak incidences between 3 and 4 years and 8 and 9 years of age. Approximately 10 to 15% of medulloblastomas are diagnosed in infancy. Medulloblastoma accounts for less than 1% of central nervous system (CNS) tumors in adults, with highest incidence in adults 20 to 34 years of age. In 1 to 2% of patients, medulloblastoma is associated with Gorlin syndrome ({109400}), a nevoid basal carcinoma syndrome. Medulloblastoma also occurs in up to 40% of patients with Turcot syndrome ({276300}). Medulloblastoma is thought to arise from neural stem cell precursors in the granular cell layer of the cerebellum. Standard treatment includes surgery, chemotherapy, and, depending on the age of the patient, radiation therapy ({6:Crawford et al., 2007)}.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 563 free, full-text research articles on human participants. First 3 results:

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma.
 

Author(s): Peikai Chen, Yubo Fan, Tsz-kwong Man, Y S Hung, Ching C Lau, Stephen T C Wong

Journal: BMC Bioinformatics. 2013 ;14 Suppl 18():S1.

 

Subtypes are widely found in cancer. They are characterized with different behaviors in clinical and molecular profiles, such as survival rates, gene signature and copy number aberrations (CNAs). While cancer is generally believed to have been caused by genetic aberrations, the number ...

Last Updated: 25 Feb 2014

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Intra-operative 5-aminolevulinic acid (ALA)-induced fluorescence of medulloblastoma: phenotypic variability and CD133(+) expression according to different fluorescence patterns.
 

Author(s): Alessandro Della Puppa, Giorgio Gioffrè, Marina Paola Gardiman, Chiara Frasson, Diego Cecchin, Renato Scienza, Luca Persano

Journal: Neurol. Sci.. 2014 Jan;35(1):99-102.

 

5-Aminolevulinic acid (5-ALA) fluorescence has been proved advantageous in glioma surgery. Conflicting results have been reported by few studies published in literature about intra-operative 5-ALA-induced fluorescence of medulloblastoma (MDB). The aim of this study is to verify if ...

Last Updated: 6 Jan 2014

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Multiplex meta-analysis of medulloblastoma expression studies with external controls.
 

Author(s): Alexander A Morgan, Achal S Achrol, Matthew D Li, Purvesh J Khatri, Samuel H Cheshier

Journal: Pac Symp Biocomput. 2014 ;():99-109.

 

We propose and discuss a method for doing gene expression meta-analysis (multiple datasets) across multiplex measurement modalities measuring the expression of many genes simultaneously (e.g. microarrays and RNAseq) using external control samples and a method of heterogeneity detection ...

Last Updated: 3 Dec 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 34 free, full-text review articles on human participants. First 3 results:

Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature.
 

Author(s): Rishi S Kotecha, Amy Buckland, Marianne B Phillips, Catherine H Cole, Nicholas G Gottardo

Journal: J. Pediatr. Hematol. Oncol.. 2014 Jan;36(1):76-80.

 

Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and ...

Last Updated: 18 Dec 2013

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Signaling pathway and molecular subgroups of medulloblastoma.
 

Author(s): Kay Ka-Wai Li, Kin-Mang Lau, Ho-Keung Ng

Journal:

 

Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors ...

Last Updated: 4 Jul 2013

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Adult medulloblastoma, from spongioblastoma cerebelli to the present day: a review of treatment and the integration of molecular markers.
 

Author(s): Nicole Shonka, Alba Brandes, John F De Groot

Journal: Oncology (Williston Park, N.Y.). 2012 Nov;26(11):1083-91.

 

Although they represent the most common malignant brain tumor in the pediatric population, medulloblastomas are rare in adults, with an incidence of 0.5 per million. With only one exception, all of the prospective clinical trials in this disease have been done in the pediatric population, ...

Last Updated: 21 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 21 Aug 2014

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Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
 

Status: Recruiting

Condition Summary: Medulloblastoma; Neuroectodermal Tumor

 

Last Updated: 15 Jul 2014

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Last Updated: 14 Apr 2014

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