Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 587 free, full-text research articles on human participants. First 3 results:

Combined MYC and P53 defects emerge at medulloblastoma relapse and define rapidly progressive, therapeutically targetable disease.
 

Author(s): Rebecca M Hill, Sanne Kuijper, Janet C Lindsey, Kevin Petrie, Ed C Schwalbe, Karen Barker, Jessica K R Boult, Daniel Williamson, Zai Ahmad, Albert Hallsworth, Sarra L Ryan, Evon Poon, Simon P Robinson, Ruth Ruddle, Florence I Raynaud, Louise Howell, Colin Kwok, Abhijit Joshi, Sarah Leigh Nicholson, Stephen Crosier, David W Ellison, Stephen B Wharton, Keith Robson, Antony Michalski, Darren Hargrave, Thomas S Jacques, Barry Pizer, Simon Bailey, Fredrik J Swartling, William A Weiss, Louis Chesler, Steven C Clifford

Journal: Cancer Cell. 2015 Jan;27(1):72-84.

 

We undertook a comprehensive clinical and biological investigation of serial medulloblastoma biopsies obtained at diagnosis and relapse. Combined MYC family amplifications and P53 pathway defects commonly emerged at relapse, and all patients in this group died of rapidly progressive ...

Last Updated: 14 Jan 2015

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SnapShot: Medulloblastoma.
 

Author(s): Jessica M Rusert, Xiaochong Wu, Charles G Eberhart, Michael D Taylor, Robert J Wechsler-Reya

Journal: Cancer Cell. 2014 Dec;26(6):940-940.e1.

 

Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification ...

Last Updated: 10 Dec 2014

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The G protein α subunit Gαs is a tumor suppressor in Sonic hedgehog-driven medulloblastoma.
 

Author(s): Xuelian He, Liguo Zhang, Ying Chen, Marc Remke, David Shih, Fanghui Lu, Haibo Wang, Yaqi Deng, Yang Yu, Yong Xia, Xiaochong Wu, Vijay Ramaswamy, Tom Hu, Fan Wang, Wenhao Zhou, Dennis K Burns, Se Hoon Kim, Marcel Kool, Stefan M Pfister, Lee S Weinstein, Scott L Pomeroy, Richard J Gilbertson, Joshua B Rubin, Yiping Hou, Robert Wechsler-Reya, Michael D Taylor, Q Richard Lu

Journal: Nat. Med.. 2014 Sep;20(9):1035-42.

 

Medulloblastoma, the most common malignant childhood brain tumor, exhibits distinct molecular subtypes and cellular origins. Genetic alterations driving medulloblastoma initiation and progression remain poorly understood. Herein, we identify GNAS, encoding the G protein Gαs, as a ...

Last Updated: 9 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 36 free, full-text review articles on human participants. First 3 results:

Secondary oligodendroglioma after postoperative irradiation for medulloblastoma: a case report and review of the literature.
 

Author(s): Hong-Lin He, Ying-En Lee, Han-Jung Chen, Chao-Tien Hsu, Yu-Yi Huang, I-Wei Chang

Journal:

 

Medulloblastoma, a malignant, invasive embryonal tumor of the cerebellum, occurs most often in children. It has high metastatic potential and is usually treated by aggressive multimodal therapy, including surgery, chemotherapy and craniospinal irradiation. Multiple secondary tumors ...

Last Updated: 12 May 2014

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RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma.
 

Author(s): Rebecca Bish, Christine Vogel

Journal: Mol. Cells. 2014 May;37(5):357-64.

 

Medulloblastoma, the most common malignant brain tumor in children, is a disease whose mechanisms are now beginning to be uncovered by high-throughput studies of somatic mutations, mRNA expression patterns, and epigenetic profiles of patient tumors. One emerging theme from studies ...

Last Updated: 11 Jun 2014

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The rationale for targeted therapies in medulloblastoma.
 

Author(s): Tobey J MacDonald, Dolly Aguilera, Robert C Castellino

Journal: Neuro-oncology. 2014 Jan;16(1):9-20.

 

Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Patients with MB who are classified as having high-risk disease or those with recurrent disease respond poorly to current therapies and have an increased risk of MB-related mortality. Preclinical studies ...

Last Updated: 24 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 6 Apr 2015

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Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
 

Status: Recruiting

Condition Summary: Medulloblastoma; Neuroectodermal Tumor

 

Last Updated: 5 Feb 2015

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Last Updated: 14 Apr 2014

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