Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is the most common brain tumor in children. It accounts for 16% of all pediatric brain tumors, and 40% of all cerebellar tumors in childhood are medulloblastoma. Medulloblastoma occurs bimodally, with peak incidences between 3 and 4 years and 8 and 9 years of age. Approximately 10 to 15% of medulloblastomas are diagnosed in infancy. Medulloblastoma accounts for less than 1% of central nervous system (CNS) tumors in adults, with highest incidence in adults 20 to 34 years of age. In 1 to 2% of patients, medulloblastoma is associated with Gorlin syndrome ({109400}), a nevoid basal carcinoma syndrome. Medulloblastoma also occurs in up to 40% of patients with Turcot syndrome ({276300}). Medulloblastoma is thought to arise from neural stem cell precursors in the granular cell layer of the cerebellum. Standard treatment includes surgery, chemotherapy, and, depending on the age of the patient, radiation therapy ({6:Crawford et al., 2007)}.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 503 free, full-text research articles on human participants. First 3 results:

A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma.
 

Author(s): Peikai Chen, Yubo Fan, Tsz-kwong Man, Y S Hung, Ching C Lau, Stephen T C Wong

Journal: BMC Bioinformatics. 2013 ;14 Suppl 18():S1.

 

Subtypes are widely found in cancer. They are characterized with different behaviors in clinical and molecular profiles, such as survival rates, gene signature and copy number aberrations (CNAs). While cancer is generally believed to have been caused by genetic aberrations, the number ...

Last Updated: 25 Feb 2014

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TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma.
 

Author(s): Marc Remke, Vijay Ramaswamy, John Peacock, David J H Shih, Christian Koelsche, Paul A Northcott, Nadia Hill, Florence M G Cavalli, Marcel Kool, Xin Wang, Stephen C Mack, Mark Barszczyk, A Sorana Morrissy, Xiaochong Wu, Sameer Agnihotri, Betty Luu, David T W Jones, Livia Garzia, Adrian M Dubuc, Nataliya Zhukova, Robert Vanner, Johan M Kros, Pim J French, Erwin G Van Meir, Rajeev Vibhakar, Karel Zitterbart, Jennifer A Chan, László Bognár, Almos Klekner, Boleslaw Lach, Shin Jung, Ali G Saad, Linda M Liau, Steffen Albrecht, Massimo Zollo, Michael K Cooper, Reid C Thompson, Oliver O Delattre, Franck Bourdeaut, François F Doz, Miklós Garami, Peter Hauser, Carlos G Carlotti, Timothy E Van Meter, Luca Massimi, Daniel Fults, Scott L Pomeroy, Toshiro Kumabe, Young Shin Ra, Jeffrey R Leonard, Samer K Elbabaa, Jaume Mora, Joshua B Rubin, Yoon-Jae Cho, Roger E McLendon, Darell D Bigner, Charles G Eberhart, Maryam Fouladi, Robert J Wechsler-Reya, Claudia C Faria, Sidney E Croul, Annie Huang, Eric Bouffet, Cynthia E Hawkins, Peter B Dirks, William A Weiss, Ulrich Schüller, Ian F Pollack, Stefan Rutkowski, David Meyronet, Anne Jouvet, Michelle Fèvre-Montange, Nada Jabado, Marta Perek-Polnik, Wieslawa A Grajkowska, Seung-Ki Kim, James T Rutka, David Malkin, Uri Tabori, Stefan M Pfister, Andrey Korshunov, Andreas von Deimling, Michael D Taylor

Journal: Acta Neuropathol.. 2013 Dec;126(6):917-29.

 

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we ...

Last Updated: 18 Nov 2013

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Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups.
 

Author(s): Laura A Genovesi, Ching Ging Ng, Melissa J Davis, Marc Remke, Michael D Taylor, David J Adams, Alistair G Rust, Jerrold M Ward, Kenneth H Ban, Nancy A Jenkins, Neal G Copeland, Brandon J Wainwright

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2013 Nov;110(46):E4325-34.

 

The Sleeping Beauty (SB) transposon mutagenesis screen is a powerful tool to facilitate the discovery of cancer genes that drive tumorigenesis in mouse models. In this study, we sought to identify genes that functionally cooperate with sonic hedgehog signaling to initiate medulloblastoma ...

Last Updated: 13 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 30 free, full-text review articles on human participants. First 3 results:

Hepatic sinusoidal obstruction syndrome during chemotherapy for childhood medulloblastoma: report of a case and review of the literature.
 

Author(s): Rishi S Kotecha, Amy Buckland, Marianne B Phillips, Catherine H Cole, Nicholas G Gottardo

Journal: J. Pediatr. Hematol. Oncol.. 2014 Jan;36(1):76-80.

 

Hepatic sinusoidal obstruction syndrome (HSOS), also known as veno-occlusive disease, is a well-recognized toxic complication after autologous and allogeneic hematopoietic stem cell transplant, during treatment of Wilms tumor and rhabdomyosarcoma associated with actinomycin-D, and ...

Last Updated: 18 Dec 2013

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Signaling pathway and molecular subgroups of medulloblastoma.
 

Author(s): Kay Ka-Wai Li, Kin-Mang Lau, Ho-Keung Ng

Journal:

 

Medulloblastoma (MB) is the most common malignant brain tumor in children. Although multimodality treatment regimens including surgery, radiotherapy and chemotherapy have greatly improved disease outcome, about one-third of MB patient remains incurable, and many long-term survivors ...

Last Updated: 4 Jul 2013

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Medulloblastoma biology in the post-genomic era.
 

Author(s): Tenley C Archer, Scott L Pomeroy

Journal: Future Oncol. 2012 Dec;8(12):1597-604.

 

Medulloblastomas, the most common malignant pediatric brain tumors, are comprised of four molecularly distinct subtypes. However, treatment has yet to exploit these molecular vulnerabilities. Three recent studies sequenced a total of 310 primary tumors and identified that two of the ...

Last Updated: 12 Dec 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 18 Jun 2014

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Last Updated: 14 Apr 2014

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