Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 566 free, full-text research articles on human participants. First 3 results:

SnapShot: Medulloblastoma.
 

Author(s): Jessica M Rusert, Xiaochong Wu, Charles G Eberhart, Michael D Taylor, Robert J Wechsler-Reya

Journal: Cancer Cell. 2014 Dec;26(6):940-940.e1.

 

Medulloblastoma (MB) is the most common malignant brain tumor in children, where one-third of patients succumb to their disease. This SnapShot describes the classification of MB subgroups, historically by histopathology and currently based on genomic information. Genomics-based classification ...

Last Updated: 10 Dec 2014

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Genetic drivers of metastatic dissemination in sonic hedgehog medulloblastoma.
 

Author(s): Noah C Jenkins, Ricky R Kalra, Adrian Dubuc, Walavan Sivakumar, Carolyn A Pedone, Xiaochong Wu, Michael D Taylor, Daniel W Fults

Journal:

 

Leptomeningeal dissemination (LMD), the metastatic spread of tumor cells via the cerebrospinal fluid to the brain and spinal cord, is an ominous prognostic sign for patients with the pediatric brain tumor medulloblastoma. The need to reduce the risk of LMD has driven the development ...

Last Updated: 22 Aug 2014

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Gender effect in experimental models of human medulloblastoma: does the estrogen receptor β signaling play a role?
 

Author(s): Alessandra Ciucci, Daniela Meco, Ilaria De Stefano, Daniele Travaglia, Gian Franco Zannoni, Giovanni Scambia, Riccardo Riccardi, Anna Saran, Mariateresa Mancuso, Daniela Gallo

Journal:

 

The male-to-female sex ratio for medulloblastoma (MB) is approximately 1.5∶1, female gender being also a favorable prognostic factor. This study aimed at evaluating the impact of gender on MB tumorigenesis.

Last Updated: 8 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 36 free, full-text review articles on human participants. First 3 results:

Secondary oligodendroglioma after postoperative irradiation for medulloblastoma: a case report and review of the literature.
 

Author(s): Hong-Lin He, Ying-En Lee, Han-Jung Chen, Chao-Tien Hsu, Yu-Yi Huang, I-Wei Chang

Journal:

 

Medulloblastoma, a malignant, invasive embryonal tumor of the cerebellum, occurs most often in children. It has high metastatic potential and is usually treated by aggressive multimodal therapy, including surgery, chemotherapy and craniospinal irradiation. Multiple secondary tumors ...

Last Updated: 12 May 2014

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RNA binding protein-mediated post-transcriptional gene regulation in medulloblastoma.
 

Author(s): Rebecca Bish, Christine Vogel

Journal: Mol. Cells. 2014 May;37(5):357-64.

 

Medulloblastoma, the most common malignant brain tumor in children, is a disease whose mechanisms are now beginning to be uncovered by high-throughput studies of somatic mutations, mRNA expression patterns, and epigenetic profiles of patient tumors. One emerging theme from studies ...

Last Updated: 11 Jun 2014

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The rationale for targeted therapies in medulloblastoma.
 

Author(s): Tobey J MacDonald, Dolly Aguilera, Robert C Castellino

Journal: Neuro-oncology. 2014 Jan;16(1):9-20.

 

Medulloblastoma (MB) is the most frequent malignant brain tumor in children. Patients with MB who are classified as having high-risk disease or those with recurrent disease respond poorly to current therapies and have an increased risk of MB-related mortality. Preclinical studies ...

Last Updated: 24 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 17 Feb 2015

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Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor
 

Status: Recruiting

Condition Summary: Medulloblastoma; Neuroectodermal Tumor

 

Last Updated: 5 Feb 2015

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Last Updated: 14 Apr 2014

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