Medulloblastoma

Common Name(s)

Medulloblastoma

Medulloblastoma is a type of cancerous brain tumor. It is the most common brain tumor in children. The tumor develops in the lower rear part of the brain called the cerebellum. The tumor is fast growing and can spread (malignant), however the cancer usually only spreads within the brain and spinal cord. Medulloblastomas are seen in children under age of 10, but the tumor can be found in adults, most often between the ages of 20-44 years. The exact cause of medulloblastoma is unknown, but mutations or changes in certain genes and chromosomes have been identified which may be involved. Although symptoms vary, common types of symptoms include headaches, vomiting, behavioral and appetite changes, and unusual eye movements. Treatment usually involves surgically removing the tumor, followed by radiation therapy. Chemotherapy may also be used in older children and adults. The prognosis (or outlook) for individuals with a medulloblasoma is looking better as treatments are improving. About 60% of the adults who underwent treatment live five years or more. Outcome for children is even better, reaching up to 80% survival after five years. However, survival rate for infants is poor, with only 50% five year survival rate. Talk with your doctors if you or your child has been diagnosed with a medulloblasoma to undrestand your options and decide on the best treatment plan. Support groups are also a good source of information and support.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Medulloblastoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Medulloblastoma" returned 782 free, full-text research articles on human participants. First 3 results:

Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.
 

Author(s): Chi-Jung Huang, Chia-Long Lee, Chih-Yi Liu, Shih-Hung Huang, Jia-Woei Hou, Yi-Hou Chen, Chih-Cheng Chien, Chih-Ming Ho, Wen-Cheng Lo, Kun-Long Hung

Journal: Int. J. Mol. Med.. 2017 May;39(5):1195-1205.

 

Medulloblastoma (MB) is the most common pediatric malignant brain tumor and patients with high-risk or recurrent MB respond poorly to current therapies, and have a higher related mortality. For this reason, potential molecules related to MB need be identified in order to develop ...

Last Updated: 24 Mar 2017

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Uniformity under in vitro conditions: Changes in the phenotype of cancer cell lines derived from different medulloblastoma subgroups.
 

Author(s): Petr Chlapek, Karel Zitterbart, Leos Kren, Lenka Filipova, Jaroslav Sterba, Renata Veselska

Journal:

 

Medulloblastoma comprises four main subgroups (WNT, SHH, Group 3 and Group 4) originally defined by transcriptional profiling. In primary medulloblastoma tissues, these groups are thought to be distinguishable using the immunohistochemical detection of β-catenin, filamin A, GAB1 ...

Last Updated: 23 Feb 2017

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Medulloblastoma and ependymoma cells display increased levels of 5-carboxylcytosine and elevated TET1 expression.
 

Author(s): Ashley Ramsawhook, Lara Lewis, Beth Coyle, Alexey Ruzov

Journal:

 

Alteration of DNA methylation (5-methylcytosine, 5mC) patterns represents one of the causes of tumorigenesis and cancer progression. Tet proteins can oxidise 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine and 5-carboxylcytosine (5caC). Although the roles of these oxidised ...

Last Updated: 23 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Medulloblastoma" returned 52 free, full-text review articles on human participants. First 3 results:

A Proteogenomic Approach to Understanding MYC Function in Metastatic Medulloblastoma Tumors.
 

Author(s): Jerome A Staal, Yanxin Pei, Brian R Rood

Journal:

 

Brain tumors are the leading cause of cancer-related deaths in children, and medulloblastoma is the most prevalent malignant childhood/pediatric brain tumor. Providing effective treatment for these cancers, with minimal damage to the still-developing brain, remains one of the greatest ...

Last Updated: 24 Oct 2016

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In vitro models of medulloblastoma: Choosing the right tool for the job.
 

Author(s): Delyan P Ivanov, Beth Coyle, David A Walker, Anna M Grabowska

Journal: J. Biotechnol.. 2016 Oct;236():10-25.

 

The recently-defined four molecular subgroups of medulloblastoma have required updating of our understanding of in vitro models to include molecular classification and risk stratification features from clinical practice. This review seeks to build a more comprehensive picture of the ...

Last Updated: 18 Sep 2016

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Evasion of cell senescence in SHH medulloblastoma.
 

Author(s): Lukas Tamayo-Orrego, Shannon M Swikert, Frédéric Charron

Journal: Cell Cycle. 2016 Aug;15(16):2102-2107.

 

The mechanisms leading to brain tumor formation are poorly understood. Using Ptch1(+/-) mice as a medulloblastoma model, sequential mutations were found to shape tumor evolution. Initially, medulloblastoma preneoplastic lesions display loss of heterozygosity of the Ptch1 wild-type ...

Last Updated: 17 Jun 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 26 Apr 2017

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A Clinical and Molecular Risk-Directed Therapy for Newly Diagnosed Medulloblastoma
 

Status: Recruiting

Condition Summary: Medulloblastoma

 

Last Updated: 30 Mar 2017

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Last Updated: 15 May 2017

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