Mayer-Rokitansky-Kuster-Hauser Syndrome

Common Name(s)

Mayer-Rokitansky-Kuster-Hauser Syndrome

Mayer-Rokitansky-KŸster-Hauser (MRKH) syndrome is a disorder that mainly affects the female reproductive system. This condition causes the vagina and uterus to be underdeveloped or absent. Ovaries are usually present and functional. Additional features may include kidney and/or skeletal abnormalities. While the cause of MRKH syndrome is unknown, it likely results from a combination of genetic and environmental factors. Most cases occur in women with no history of the disorder in their family. Less often, the condition is passed through generations in a family. Some of these cases appear to be inherited in an autosomal dominant fashion. Although women with this condition are usually unable to carry a pregnancy, they may be able to have children through assisted reproduction.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mayer-Rokitansky-Kuster-Hauser Syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mayer-Rokitansky-Kuster-Hauser Syndrome" returned 28 free, full-text research articles on human participants. First 3 results:

Acne and PCOS are less frequent in women with Mayer-Rokitansky-Küster-Hauser syndrome despite a high rate of hyperandrogenemia: a cross-sectional study.
 

Author(s): Katharina Rall, Gabriele Conzelmann, Norbert Schäffeler, Melanie Henes, Diethelm Wallwiener, Matthias Möhrle, Sara Y Brucker

Journal:

 

Acne is a very common skin condition during adolescence and adulthood. Patients with uterovaginal agenesis (Mayer-Rokitansky-Küster-Hauser syndrome, MRKH) treated at the Tübingen University Center for Rare Female Genital Malformations, however, clinically appeared to be less frequently ...

Last Updated: 21 Mar 2014

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Multicentric paraspinal neuroglial heterotopia with Müllerian and renal agenesis: a variant of Mayer-Rokitansky-Küster-Hauser syndrome?
 

Author(s): Lu-Hau Deng, Chii-Hong Lee

Journal:

 

Neuroglial heterotopia is a rare congenital anomaly that mostly involves the head and neck region. We report a female fetus with multicentric paraspinal neuroglial heterotopia in the retropharyngeal and retroperitoneal spaces, right renal agenesis, left renal hypoplasia, and Müllerian ...

Last Updated: 15 Nov 2013

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Large leiomyoma in a woman with Mayer-Rokitansky-Kuster-Hauser syndrome.
 

Author(s): Kishan S Rawat, Tbs Buxi, Anurag Yadav, Samarjit S Ghuman, Shashi Dhawan

Journal:

 

Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a rare congenital anomaly characterized as aplasia or hypoplasia of uterus and vagina in women with normal development of secondary sex characteristics. It affects 1 in 4000-5000 female births. Women with this syndrome present with ...

Last Updated: 24 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mayer-Rokitansky-Kuster-Hauser Syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

[Atipical form of Mayer-Rokitansky-Kuster-Hauser syndrome with renal malformation and skeletal abnormalities (MURCS association)].
 

Author(s): Mariana de Almeida Pinto Borges, Maria Lucia Elias Pires, Denise Leite Maia Monteiro, Suely Rodrigues Dos Santos

Journal: Rev Bras Ginecol Obstet. 2012 Mar;34(3):133-8.

 

The atypical and more severe form of Mayer-Rokitansky-Kuster-Hauser syndrome (MRKH) or MRKH type II is also known as MURCS association, an acronym meaning aplasia/hypoplasia of Müllerian ducts (MU), congenital renal dysplasia (R) and cervico-thoracic dysplasia (CS). It affects female ...

Last Updated: 10 Apr 2012

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Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome.
 

Author(s): Karine Morcel, Laure Camborieux, , Daniel Guerrier

Journal:

 

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is characterized by congenital aplasia of the uterus and the upper part (2/3) of the vagina in women showing normal development of secondary sexual characteristics and a normal 46, XX karyotype. It affects at least 1 out of 4500 ...

Last Updated: 27 Mar 2007

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The Mayer-Rokitansky-Küster-Hauser syndrome (congenital absence of uterus and vagina)--phenotypic manifestations and genetic approaches.
 

Author(s): Daniel Guerrier, Thomas Mouchel, Laurent Pasquier, Isabelle Pellerin

Journal:

 

The Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome affects at least 1 out of 4500 women and has for a long time been considered as a sporadic anomaly. Congenital absence of upper vagina and uterus is the prime feature of the disease which, in addition, is often found associated with ...

Last Updated: 16 Feb 2006

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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