Mast cell disease

Common Name(s)

Mast cell disease, Mastocytosis

Mastocytosis is a disorder that can occur in both children and adults. It is caused by the presence of too many mast cells in the body. Mast cells contain substances such as histamine that regulate allergic reactions. Signs and symptoms of mastocytosis may include musculoskeletal pain, abdominal discomfort, nausea, vomiting, ulcers, diarrhea, and skin lesions. Treatment may include medications such as antihistamines (to prevent the effect of mast cell histamine) and anticholinergics (to relieve intestinal cramping).

There are two broad categories of mastocytosis, cutaneous and systemic. Cutaneous mastocytosis only affects the skin and is usually diagnosed in children. Systemic mastocytosis affects more than one part of the body and is usually diagnosed in adults. GARD provides additional information on cutaneous mastocytosis and systemic mastocytosis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mast cell disease" for support, advocacy or research.

The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

Last Updated: 20 Nov 2012

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mast cell disease" for support, advocacy or research.

The Mastocytosis Society, Inc

The Mastocytosis Society is a 501(c)3 nonprofit organization dedicated to supporting patients affected by Mastocytosis or Mast Cell Activation Disorders as well as their families, caregivers, and physicians through research, education, and advocacy.

http://www.TMSforacure.org

Last Updated: 20 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mast cell disease" returned 24 free, full-text research articles on human participants. First 3 results:

Familial occurrence of systemic mast cell activation disease.
 

Author(s): Gerhard J Molderings, Britta Haenisch, Manuela Bogdanow, Rolf Fimmers, Markus M Nöthen

Journal:

 

Systemic mast cell activation disease (MCAD) comprises disorders characterized by an enhanced release of mast cell mediators accompanied by accumulation of dysfunctional mast cells. Demonstration of familial clustering would be an important step towards defining the genetic contribution ...

Last Updated: 7 Oct 2013

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Complement factor C5a as mast cell activator mediates vascular remodelling in vein graft disease.
 

Author(s): Margreet R de Vries, Anouk Wezel, Abbey Schepers, Peter J van Santbrink, Trent M Woodruff, Hans W M Niessen, Jaap F Hamming, Johan Kuiper, Ilze Bot, Paul H A Quax

Journal: Cardiovasc. Res.. 2013 Feb;97(2):311-20.

 

Failure of vein graft conduits due to vein graft thickening, accelerated atherosclerosis, and subsequent plaque rupture is applicable to 50% of all vein grafts within 10 years. New potential therapeutic targets to treat vein graft disease may be found in components of the innate immune ...

Last Updated: 15 Jan 2013

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Systemic mastocytosis with an associated non mast cell lineage clonal hematological disease in a child.
 

Author(s): Sunita Sharma, Aparna Harbhajanka, Akanksha Jain, Anju Seth

Journal: Indian J Pathol Microbiol. ;54(4):854-6.

 

Last Updated: 11 Jan 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mast cell disease" returned 7 free, full-text review articles on human participants. First 3 results:

Systemic mast cell activation disease: the role of molecular genetic alterations in pathogenesis, heritability and diagnostics.
 

Author(s): Britta Haenisch, Markus M Nöthen, Gerhard J Molderings

Journal: Immunology. 2012 Nov;137(3):197-205.

 

Despite increasing understanding of its pathophysiology, the aetiology of systemic mast cell activation disease (MCAD) remains largely unknown. Research has shown that somatic mutations in kinases are necessary for the establishment of a clonal mast cell population, in particular ...

Last Updated: 2 Oct 2012

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Regulation of mast cell responses in health and disease.
 

Author(s): Alasdair M Gilfillan, Michael A Beaven

Journal: Crit. Rev. Immunol.. 2011 ;31(6):475-529.

 

Mast cells are multifunctional cells that initiate not only IgE-dependent allergic diseases but also play a fundamental role in innate and adaptive immune responses to microbial infection. They are also thought to play a role in angiogenesis, tissue remodeling, wound healing, and ...

Last Updated: 10 Feb 2012

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An emerging role for the lipid mediator sphingosine-1-phosphate in mast cell effector function and allergic disease.
 

Author(s): Ana Olivera, Juan Rivera

Journal: Adv. Exp. Med. Biol.. 2011 ;716():123-42.

 

Sphingosine-1-phosphate (S1P) plays important roles regulating functions of diverse biological systems, including the immune system. S1P affects immune cell function mostly by acting through its receptors at the cell membrane but it can also induce S1P receptor-independent responses ...

Last Updated: 29 Jun 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Phase 3 Study to Compare Efficacy and Safety of Masitinib to Placebo in the Treatment of Patients With Smouldering Systemic, Indolent Systemic or Cutaneous Mastocytosis With Handicap
 

Status: Recruiting

Condition Summary: Smouldering Systemic Mastocytosis; Indolent Systemic Mastocytosis; Cutaneous Mastocytosis With Handicap; Mastocytosis

 

Last Updated: 25 Sep 2012

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Brentuximab Vedotin in Treating Patients With Advanced Systemic Mastocytosis or Mast Cell Leukemia
 

Status: Recruiting

Condition Summary: Aggressive Systemic Mastocytosis; Mast Cell Leukemia; Systemic Mastocytosis

 

Last Updated: 17 Dec 2013

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Cladribine Plus Pegylated Interpheron Alfa-2a in Systemic Mastocytosis
 

Status: Recruiting

Condition Summary: Advanced Systemic Mastocytosis

 

Last Updated: 19 May 2012

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