Marchiafava Bignami disease

Common Name(s)

Marchiafava Bignami disease

Marchiafava Bignami disease is defined by characteristic demyelination of the corpus callosum (erosion of the protective covering of nerve fibers joining the 2 hemispheres of the brain). The disease seems to most often affect severe and chronic alcoholics in their middle or late adult life. Early symptoms may include depression, paranoia, psychosis, or dementia. Seizures are common, and hemiparesis, aphasia, abnormal movements, and ataxia may sometimes progress to coma and/or death. The cause of Marchiafava Bignami disease, including the potential role of nutritional deficiency, is unknown. Improvement and recovery of some individuals has been reported.  Treatment focuses on nutritional support and rehabilitation from alcoholism.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Marchiafava Bignami disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Marchiafava Bignami disease" returned 19 free, full-text research articles on human participants. First 3 results:

Marchiafava-Bignami disease mimics motor neuron disease: case report.
 

Author(s): Yasunobu Hoshino, Yuji Ueno, Hideki Shimura, Nobukazu Miyamoto, Masao Watanabe, Nobutaka Hattori, Takao Urabe

Journal:

 

Marchiafava-Bignami disease (MBD) is a rare neurologic complication of chronic alcohol consumption that is characterized by callosal lesions involving demyelination and necrosis. Various reversible neurologic symptoms are found in patients with MBD. Dysarthria and dysphagia are found ...

Last Updated: 6 Jan 2014

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Imaging for diagnosis of Marchiafava-Bignami disease.
 

Author(s): Viroj Wiwanitkit

Journal: Neurol India. ;57(6):837.

 

Last Updated: 8 Feb 2010

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Marchiafava-Bignami disease-like lesions due to central nervous system lupus.
 

Author(s): Yoichiro Kashiwagi, Takahiko Horiuchi, Chie Harashima, Fujio Matsubara, Shin-Ichi Harashima

Journal:

 

Last Updated: 16 Jul 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Marchiafava Bignami disease" returned 1 free, full-text review articles on human participants. First 3 results:

Cortical involvement in Marchiafava-Bignami disease can be a predictor of a poor prognosis: a case report and review of the literature.
 

Author(s): Michito Namekawa, Yuko Nakamura, Imaharu Nakano

Journal: Intern. Med.. 2013 ;52(7):811-3.

 

Marchiafava-Bignami disease (MBD) is a rare alcohol-associated disorder characterized by demyelination and necrosis of the corpus callosum. We herein present the case of a 56-year-old man with chronic alcoholism who was admitted to our hospital in a coma without focal or lateralizing ...

Last Updated: 2 Apr 2013

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Symptoms, Diagnosis, and Treatment

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