Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 525 free, full-text research articles on human participants. First 3 results:

Racial differences in mantle cell lymphoma in the United States.
 

Author(s): Yu Wang, Shuangge Ma

Journal:

 

MCL (mantle cell lymphoma) is a rare subtype of NHL (non-Hodgkin lymphoma) with mostly poor prognosis. Different races have different etiology, presentation, and progression patterns.

Last Updated: 23 Oct 2014

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Case report of a metachronous multiple tumor: mantle cell lymphoma in the orbital region associated with epithelial malignancies at other sites.
 

Author(s): Juliana S F Medrado, Mirtha Ramírez Dittrich, Jacqueline M Sousa, Luiz F Teixeira, Paulo Góis Manso

Journal: Arq Bras Oftalmol. ;77(1):54-6.

 

Here we report the case of a 73-year-old man who was diagnosed with metachronous, multiple primary tumors with non-Hodgkin B-cell mantle cell lymphoma involving the orbit on the basis of biopsy and immunohistochemistry in 2012. The patient had been diagnosed with non-Hodgkin small ...

Last Updated: 31 Jul 2014

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Follicular lymphoma with progression to diffuse large B-cell lymphoma and concurrent CD5-negative mantle cell lymphoma-3 entities in a lymph node.
 

Author(s): Janese A Trimaldi, Jeremy W Bowers, Celeste Bello, Elizabeth M Sagatys

Journal: Cancer Control. 2014 Jul;21(3):251-4.

 

A 68-year-old woman with a history of follicular lymphoma had pathological findings of grade 3B follicular lymphoma, mantle cell lymphoma (MCL), and diffuse large B-cell lymphoma (DLBCL) identified in 1 lymph node. The DLBCL appeared to be a transformation of the follicular lymphoma. ...

Last Updated: 24 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 37 free, full-text review articles on human participants. First 3 results:

Mantle cell lymphoma presented with unilateral palsy: a case report and review of literature.
 

Author(s): Ri-Han Wu, Yu-Juan Chen, Jing Huang, Xue-Yuan Liu

Journal: Neurol India. ;62(3):315-7.

 

Last Updated: 18 Jul 2014

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Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report.
 

Author(s): Stephanie L Holdener, Lacey Harrington, Johnny Nguyen, Pedro Horna, Elizabeth Sagatys, Bijal Shah, Ling Zhang

Journal:

 

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without ...

Last Updated: 12 May 2014

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Mantle cell lymphoma with in situ or mantle zone growth pattern: a study of five cases and review of literature.
 

Author(s): Peihong Hsu, Tianyu Yang, Silvat Sheikh-Fayyaz, Judith Brody, Jela Bandovic, Sarma Roy, Jordan Laser, Jonathan E Kolitz, Craig Devoe, Xinmin Zhang

Journal:

 

We present two rare cases of in situ mantle cell lymphoma ("in situ MCL") and three cases of MCL with mantle zone growth pattern (MCL-MZGP). The patients include four males and one female, with a median age of 66 years (range, 52 to 86 years). Two present with isolated lymphadenopathy ...

Last Updated: 3 Apr 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bortezomib and Rituximab in Treating Patients With Mantle Cell Lymphoma Who Have Previously Undergone Stem Cell Transplantation
 

Status: Recruiting

Condition Summary: Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 14 Jan 2015

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Ibrutinib After Intensive Induction in Treating Patients With Previously Untreated Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 14 Jan 2015

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Ofatumumab in Combination With Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine Sulfate, and Dexamethasone Alternating With Ofatumumab in Combination With Cytarabine and Methotrexate in Treating Patients With Newly Diagnosed Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 5 Mar 2015

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