Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 654 free, full-text research articles on human participants. First 3 results:

From Minimal Residual Disease to Maintenance Therapy: Optimizing Tools for Treatment of Mantle Cell Lymphoma.
 

Author(s): Michael Tallarico, Sonali M Smith

Journal: Oncology (Williston Park, N.Y.). 2016 Apr;30(4):361-2.

 

Last Updated: 16 Apr 2016

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Lenalidomide plus Rituximab for Mantle-Cell Lymphoma.
 

Author(s): Jia Ruan, John P Leonard

Journal: N. Engl. J. Med.. 2016 Feb;374(8):793.

 

Last Updated: 3 Mar 2016

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Identification of miR-15b as a transformation-related factor in mantle cell lymphoma.
 

Author(s): Fumiko Arakawa, Yoshizo Kimura, Noriaki Yoshida, Hiroaki Miyoshi, Atushi Doi, Kaori Yasuda, Kazutaka Nakajima, Junichi Kiyasu, Daisuke Niino, Yasuo Sugita, Kosuke Tashiro, Satoru Kuhara, Masao Seto, Koichi Ohshima

Journal: Int. J. Oncol.. 2016 Feb;48(2):485-92.

 

Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma with a poor prognosis. It is characterized by the t(11;14)(q13;q32) translocation, resulting in over-expression of CCND1. Morphologically, MCL is categorised into two types: classical MCL (cMCL) and aggressive MCL (aMCL), ...

Last Updated: 28 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 46 free, full-text review articles on human participants. First 3 results:

Clinical Management Updates in Mantle Cell Lymphoma.
 

Author(s): Robert Chen, James Sanchez, Steven T Rosen

Journal: Oncology (Williston Park, N.Y.). 2016 Apr;30(4):353-60.

 

Mantle cell lymphoma is an aggressive B-cell non-Hodgkin lymphoma that is often considered incurable. Different clinical and biological biomarkers can be utilized to categorize this lymphoma into various risk levels. Several randomized trials reported in 2015 shed light on the optimal ...

Last Updated: 16 Apr 2016

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Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical management.
 

Author(s): Julie M Vose

Journal: Am. J. Hematol.. 2015 Aug;90(8):739-45.

 

Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood and bone marrow with a short remission duration to standard therapies and a median overall survival (OS) of 4-5 years.

Last Updated: 21 Jul 2015

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Refining the Mantle Cell Lymphoma Paradigm: Impact of Novel Therapies on Current Practice.
 

Author(s): Irit Avivi, Andre Goy

Journal: Clin. Cancer Res.. 2015 Sep;21(17):3853-61.

 

Although mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma, proactive research efforts fueled by challenges in the management of MCL have led to an increase in median overall survival (OS) of 2.5 years in the mid 1990s to beyond 5 years nowadays. This improvement ...

Last Updated: 2 Sep 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Enzalutamide in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Recurrent Mantle Cell Lymphoma; Refractory Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage II Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 6 Sep 2016

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Bortezomib and Rituximab in Treating Patients With Mantle Cell Lymphoma Who Have Previously Undergone Stem Cell Transplantation
 

Status: Recruiting

Condition Summary: Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 9 Jun 2016

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Ibrutinib After Intensive Induction in Treating Patients With Previously Untreated Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Contiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Stage I Mantle Cell Lymphoma; Stage III Mantle Cell Lymphoma; Stage IV Mantle Cell Lymphoma

 

Last Updated: 5 May 2016

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