Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 631 free, full-text research articles on human participants. First 3 results:

FNC efficiently inhibits mantle cell lymphoma growth.
 

Author(s): Yan Zhang, Rong Zhang, Xixi Ding, Bangan Peng, Ning Wang, Fang Ma, Youmei Peng, Qingduan Wang, Junbiao Chang

Journal:

 

FNC, 2'-deoxy-2'-β-fluoro-4'-azidocytidine, is a novel cytidine analogue, that has shown strong antiproliferative activity in human lymphoma, lung adenocarcinoma and acute myeloid leukemia. In this study, we investigated the effects of FNC on mantle cell lymphoma (MCL) and the underlying ...

Last Updated: 31 Dec 1969

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Gastrointestinal involvement by mantle cell lymphoma observed by endoscopy: A case report.
 

Author(s): De-Ming Li, Yue-Ping Jiang

Journal: Medicine (Baltimore). 2017 Mar;96(11):e6321.

 

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin B-cell lymphoma, accounting for 6% of all non-Hodgkin lymphoma. The typical appearance of intestinal MCL is multiple lymphomatous polyposis, whereas presentation as protruding lesions is uncommon. We herein report the case of ...

Last Updated: 31 Dec 1969

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Association between quality of response and outcomes in patients with newly diagnosed mantle cell lymphoma receiving VR-CAP versus R-CHOP in the phase 3 LYM-3002 study.
 

Author(s): Gregor Verhoef, Tadeusz Robak, Huiqiang Huang, Halyna Pylypenko, Noppadol Siritanaratkul, Juliana Pereira, Johannes Drach, Jiri Mayer, Rumiko Okamoto, Lixia Pei, Brendan Rooney, Andrew Cakana, Helgi van de Velde, Franco Cavalli

Journal: Haematologica. 2017 May;102(5):895-902.

 

In the phase 3 LYM-3002 study comparing intravenous VR-CAP with R-CHOP in patients with newly-diagnosed, measurable stage II-IV mantle cell lymphoma, not considered or ineligible for transplant, the median progression-free survival was significantly improved with VR-CAP (24.7 versus ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 51 free, full-text review articles on human participants. First 3 results:

Male breast cancer and mantle cell lymphoma in a single patient: A case report and literature review.
 

Author(s): Jun Liu, Hongquan Wei, Keqing Zhu, Liqin Lai, Xiaoyu Han, Yue Yang

Journal: Medicine (Baltimore). 2017 Dec;96(48):e8911.

 

Although still relatively rare, multiple primary malignant neoplasms (MPMNs) have been increasingly reported in recent years.

Last Updated: 31 Dec 1969

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Current Approaches to Mantle Cell Lymphoma: Diagnosis, Prognosis, and Therapies.
 

Author(s): Jonathon B Cohen, Jasmine M Zain, Brad S Kahl

Journal: Am Soc Clin Oncol Educ Book. 2017 ;37():512-525.

 

Mantle cell lymphoma (MCL) is a unique lymphoma subtype, both biologically and clinically. Virtually all cases are characterized by a common genetic lesion, t(11;14), resulting in overexpression of cyclin D1. The clinical course is moderately aggressive, and the disease is considered ...

Last Updated: 31 Dec 1969

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Mantle Cell Lymphoma: Contemporary Diagnostic and Treatment Perspectives in the Age of Personalized Medicine.
 

Author(s): Jose D Sandoval-Sus, Eduardo M Sotomayor, Bijal D Shah

Journal: Hematol Oncol Stem Cell Ther. 2017 Sep;10(3):99-115.

 

Mantle cell lymphoma is a clinically heterogeneous disease occurring within a heterogeneous patient population, highlighting a need for personalized therapy to ensure optimal outcomes. It is therefore critical to understand the benefits and risks associated with both intensive and ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial of Bortezomib, Cytarabine, and Dexamethasone in Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 31 Oct 2017

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A Study of Ixazomib and Ibrutinib in Relapsed/Refractory Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle-Cell Lymphoma

 

Last Updated: 15 Jan 2018

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Last Updated: 9 Jan 2017

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