Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 598 free, full-text research articles on human participants. First 3 results:

Gastrointestinal involvement by mantle cell lymphoma observed by endoscopy: A case report.
 

Author(s): De-Ming Li, Yue-Ping Jiang

Journal: Medicine (Baltimore). 2017 Mar;96(11):e6321.

 

Mantle cell lymphoma (MCL) is a subtype of non-Hodgkin B-cell lymphoma, accounting for 6% of all non-Hodgkin lymphoma. The typical appearance of intestinal MCL is multiple lymphomatous polyposis, whereas presentation as protruding lesions is uncommon. We herein report the case of ...

Last Updated: 15 Mar 2017

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Decoding the DNA Methylome of Mantle Cell Lymphoma in the Light of the Entire B Cell Lineage.
 

Author(s): Ana C Queirós, Renée Beekman, Roser Vilarrasa-Blasi, Martí Duran-Ferrer, Guillem Clot, Angelika Merkel, Emanuele Raineri, Nuria Russiñol, Giancarlo Castellano, Sílvia Beà, Alba Navarro, Marta Kulis, Núria Verdaguer-Dot, Pedro Jares, Anna Enjuanes, María José Calasanz, Anke Bergmann, Inga Vater, Itziar Salaverría, Harmen J G van de Werken, Wyndham H Wilson, Avik Datta, Paul Flicek, Romina Royo, Joost Martens, Eva Giné, Armando Lopez-Guillermo, Hendrik G Stunnenberg, Wolfram Klapper, Christiane Pott, Simon Heath, Ivo G Gut, Reiner Siebert, Elías Campo, José I Martín-Subero

Journal: Cancer Cell. 2016 Nov;30(5):806-821.

 

We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas (MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We identified two MCL subgroups, respectively carrying epigenetic imprints of germinal-center-inexperienced and ...

Last Updated: 15 Nov 2016

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Negative prognostic impact of low absolute CD4(+) T cell counts in peripheral blood in mantle cell lymphoma.
 

Author(s): Xin-Yu Zhang, Ji Xu, Hua-Yuan Zhu, Yan Wang, Li Wang, Lei Fan, Yu-Jie Wu, Jian-Yong Li, Wei Xu

Journal: Cancer Sci.. 2016 Oct;107(10):1471-1476.

 

Tumor microenvironment and host immunity are closely related to outcome in patients with mantle cell lymphoma (MCL). However, few researchers have focused on the prognostic value of peripheral blood lymphocyte subsets counts. The purpose of this study was to investigate the prognostic ...

Last Updated: 15 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 46 free, full-text review articles on human participants. First 3 results:

Clinical Management Updates in Mantle Cell Lymphoma.
 

Author(s): Robert Chen, James Sanchez, Steven T Rosen

Journal: Oncology (Williston Park, N.Y.). 2016 Apr;30(4):353-60.

 

Mantle cell lymphoma is an aggressive B-cell non-Hodgkin lymphoma that is often considered incurable. Different clinical and biological biomarkers can be utilized to categorize this lymphoma into various risk levels. Several randomized trials reported in 2015 shed light on the optimal ...

Last Updated: 16 Apr 2016

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The role of targeted treatment in mantle cell lymphoma: is transplant dead or alive?
 

Author(s): Martin Dreyling, Simone Ferrero,

Journal: Haematologica. 2016 Feb;101(2):104-14.

 

Based on the profound biological insights of the last years into the molecular pathogenesis of mantle cell lymphoma and the clinical introduction of new targeted drugs, with high efficacy and a good safety profile, the therapeutic scenario for this tumor has been shown to be thoroughly ...

Last Updated: 2 Feb 2016

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Outcomes of both abbreviated hyper-CVAD induction followed by autologous hematopoietic cell transplantation and conventional chemotherapy for mantle cell lymphoma: a 10-year single-centre experience with literature review.
 

Author(s): Turki Abdulaziz Alwasaidi, Abdulaziz Hamadah, Sultan Altouri, Jason Tay, Sheryl McDiarmid, Carolyn Faught, David Allan, Lothar Huebsch, Christopher Bredeson, Isabelle Bence-Bruckler

Journal: Cancer Med. 2015 Dec;4(12):1817-27.

 

We retrospectively evaluated consecutive patients diagnosed with Mantle cell lymphoma (MCL) between 01 January 2000 and 31 December 2009. Eighty eight patients with MCL were included in the analysis of whom 46 (52%) received abbreviated Hyper-CVAD (a total of two cycles; with addition ...

Last Updated: 15 Jan 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Trial of Bortezomib, Cytarabine, and Dexamethasone in Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 1 Nov 2016

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Last Updated: 9 Jan 2017

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Last Updated: 16 Mar 2017

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