Mantle cell lymphoma

Common Name(s)

Mantle cell lymphoma

Mantle cell lymphoma (MCL) belongs to a group of diseases known as  non-HodgkinÕs lymphomas (NHL), which are cancers that affect the the lymphatic system (part of the immune system). MCL accounts for 6% of all non-Hodgkin lymphomas and is mostly found in males during their early 60s. Lymphocytes, which are white blood cells that make up the lymphatic system. There are two main types: B-lymphocytes (B-cells) and T-lymphocytes (T-cells). Mantel cell lymphoma is a B-cell lymphoma that develops from cancerous B-cells within a region of the lymph node known as the mantle zone. Although mantle cell lymphomas are slow-growing cancers, at the time of diagnosis, they are usually widespread in the lymph nodes and require intensive treatment because they can become lethal within a short period of time.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Mantle cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Mantle cell lymphoma" returned 636 free, full-text research articles on human participants. First 3 results:

From Minimal Residual Disease to Maintenance Therapy: Optimizing Tools for Treatment of Mantle Cell Lymphoma.
 

Author(s): Michael Tallarico, Sonali M Smith

Journal: Oncology (Williston Park, N.Y.). 2016 Apr;30(4):361-2.

 

Last Updated: 16 Apr 2016

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Discovery and characterization of a novel CCND1/MRCK gene fusion in mantle cell lymphoma.
 

Author(s): Chioniso Patience Masamha, Todd R Albrecht, Eric J Wagner

Journal:

 

The t(11;14) translocation resulting in constitutive cyclin D1 expression is an early event in mantle cell lymphoma (MCL) transformation. Patients with a highly proliferative phenotype produce cyclin D1 transcripts with truncated 3'UTRs that evade miRNA regulation. Here, we report ...

Last Updated: 30 Mar 2016

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Development of highly aggressive mantle cell lymphoma after sofosbuvir treatment of hepatitis C.
 

Author(s): R J Lin, T Moskovits, C S Diefenbach, K B Hymes

Journal:

 

Last Updated: 12 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Mantle cell lymphoma" returned 48 free, full-text review articles on human participants. First 3 results:

Clinical Management Updates in Mantle Cell Lymphoma.
 

Author(s): Robert Chen, James Sanchez, Steven T Rosen

Journal: Oncology (Williston Park, N.Y.). 2016 Apr;30(4):353-60.

 

Mantle cell lymphoma is an aggressive B-cell non-Hodgkin lymphoma that is often considered incurable. Different clinical and biological biomarkers can be utilized to categorize this lymphoma into various risk levels. Several randomized trials reported in 2015 shed light on the optimal ...

Last Updated: 16 Apr 2016

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Outcomes of both abbreviated hyper-CVAD induction followed by autologous hematopoietic cell transplantation and conventional chemotherapy for mantle cell lymphoma: a 10-year single-centre experience with literature review.
 

Author(s): Turki Abdulaziz Alwasaidi, Abdulaziz Hamadah, Sultan Altouri, Jason Tay, Sheryl McDiarmid, Carolyn Faught, David Allan, Lothar Huebsch, Christopher Bredeson, Isabelle Bence-Bruckler

Journal: Cancer Med. 2015 Dec;4(12):1817-27.

 

We retrospectively evaluated consecutive patients diagnosed with Mantle cell lymphoma (MCL) between 01 January 2000 and 31 December 2009. Eighty eight patients with MCL were included in the analysis of whom 46 (52%) received abbreviated Hyper-CVAD (a total of two cycles; with addition ...

Last Updated: 15 Jan 2016

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Mantle cell lymphoma: 2015 update on diagnosis, risk-stratification, and clinical management.
 

Author(s): Julie M Vose

Journal: Am. J. Hematol.. 2015 Aug;90(8):739-45.

 

Mantle cell lymphoma (MCL) is a non-Hodgkin lymphoma characterized by involvement of the lymph nodes, spleen, blood and bone marrow with a short remission duration to standard therapies and a median overall survival (OS) of 4-5 years.

Last Updated: 21 Jul 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Bortezomib (VELCADE), Cladribine and Rituximab (VCR) in Mantle Cell Lymphoma (PSHCI 10-011)
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 29 Apr 2015

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Trial of Bortezomib, Cytarabine, and Dexamethasone in Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 1 Nov 2016

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Combination of Ibrutinib and Bortezomib to Treat Patients With Mantle Cell Lymphoma
 

Status: Recruiting

Condition Summary: Mantle Cell Lymphoma

 

Last Updated: 24 Oct 2016

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