Malignant hyperthermia

Common Name(s)

Malignant hyperthermia

Malignant hyperthermia is a severe reaction to particular drugs used during surgery and other invasive procedures. People at increased risk for this disorder are said to have malignant hyperthermia susceptibility. If given these drugs, these people may experience muscle rigidity, breakdown of muscle fibers, a high fever, increased acid levels in the blood and other tissues, and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening. There are at least six forms of malignant hyperthermia susceptibility, which are associated with mutations in different genes (e.g.,  CACNA1S, RYR1). The susceptibility is inherited in an autosomal dominant fashion. People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have malignant hyperthermia susceptibility.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

Last Updated: 6 May 2014

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The RYR-1 Foundation

The primary goal of the Foundation is to find a cure for RYR-1 related muscle diseases. To achieve this goal, the Foundation has several missions: 1) Support Research 2) Physician Education 3) Patient/family support and advocacy

Last Updated: 16 Mar 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

http://www.mhaus.org

Last Updated: 6 May 2014

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The RYR-1 Foundation

The primary goal of the Foundation is to find a cure for RYR-1 related muscle diseases. To achieve this goal, the Foundation has several missions: 1) Support Research 2) Physician Education 3) Patient/family support and advocacy

http://www.ryr1.org

Last Updated: 16 Mar 2015

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General Resources

North American Malignant Hyperthermia Registry

The Registry's goal is to acquire, analyze, and disseminate case-specific clinical and laboratory information related to malignant hyperthermia susceptibility.

Updated 21 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant hyperthermia" returned 194 free, full-text research articles on human participants. First 3 results:

Simple intrapleural hyperthermia at thoracoscopic exploration to treat malignant pleural effusion.
 

Author(s): Youngkyu Moon, Kyung Soo Kim, Jae Kil Park

Journal:

 

Malignant pleural effusion (MPE) occurs at a terminal stage of cancer, and related symptoms may considerably reduce a patient's respiratory function and quality of life. We assessed the benefit of simple intrapleural hyperthermia (SIH) during thoracoscopic exploration for MPE.

Last Updated: 29 Oct 2015

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Is there a link between exertional heat stroke and susceptibility to malignant hyperthermia?
 

Author(s): Emmanuel Sagui, Coline Montigon, Amandine Abriat, Arnaud Jouvion, Sandrine Duron-Martinaud, Frédéric Canini, Fabien Zagnoli, David Bendahan, Dominique Figarella-Branger, Michel Brégigeon, Christian Brosset

Journal:

 

The identification of a predisposition toward malignant hyperthermia (MH) as a risk factor for exertional heat stroke (EHS) remains a matter of debate. Such a predisposition indicates a causal role for MH susceptibility (MHS) after EHS in certain national recommendations and has led ...

Last Updated: 11 Aug 2015

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Divergent Activity Profiles of Type 1 Ryanodine Receptor Channels Carrying Malignant Hyperthermia and Central Core Disease Mutations in the Amino-Terminal Region.
 

Author(s): Takashi Murayama, Nagomi Kurebayashi, Toshiko Yamazawa, Hideto Oyamada, Junji Suzuki, Kazunori Kanemaru, Katsuji Oguchi, Masamitsu Iino, Takashi Sakurai

Journal:

 

The type 1 ryanodine receptor (RyR1) is a Ca2+ release channel in the sarcoplasmic reticulum of skeletal muscle and is mutated in several diseases, including malignant hyperthermia (MH) and central core disease (CCD). Most MH and CCD mutations cause accelerated Ca2+ release, resulting ...

Last Updated: 27 Jun 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant hyperthermia" returned 22 free, full-text review articles on human participants. First 3 results:

Malignant hyperthermia: a review.
 

Author(s): Henry Rosenberg, Neil Pollock, Anja Schiemann, Terasa Bulger, Kathryn Stowell

Journal:

 

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle that presents as a hypermetabolic response to potent volatile anesthetic gases such as halothane, sevoflurane, desflurane, isoflurane and the depolarizing muscle relaxant succinylcholine, and rarely, in humans, ...

Last Updated: 5 Aug 2015

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[Malignant hyperthermia - problem in dental surgery. An introductory report].
 

Author(s): Ewa Kamińska, Anna Janas, Piotr Osica

Journal: Dev Period Med. ;18(4):483-8.

 

Malignant hyperthermia is a genetic defect of uncontrolled hypermetabolic skeletal muscle response to anesthetic triggering drugs. Some congenital myopathies are regarded as risk increasing factors. The use of volatile anaesthetics or suxamethonium (succinylcholine) in patients who ...

Last Updated: 16 Apr 2015

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Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations.
 

Author(s): Antonella Carsana

Journal: ScientificWorldJournal. 2013 ;2013():531465.

 

Exertional rhabdomyolysis (ER) and stress-induced malignant hyperthermia (MH) events are syndromes that primarily afflict military recruits in basic training and athletes. Events similar to those occurring in ER and in stress-induced MH events are triggered after exposure to anesthetic ...

Last Updated: 11 Mar 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Case Control Study of Patients With Diagnosis of Malignant Hyperthermia
 

Status: Recruiting

Condition Summary: Malignant Hyperthermia

 

Last Updated: 25 Sep 2015

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Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
 

Status: Recruiting

Condition Summary: Sepsis; Primary Myopathies

 

Last Updated: 27 May 2016

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Adjuvant Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Gastric Cancer
 

Status: Recruiting

Condition Summary: Locally Advanced Malignant Neoplasm; Gastric Cancer

 

Last Updated: 2 Feb 2016

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