Malignant hyperthermia

Common Name(s)

Malignant hyperthermia

Malignant hyperthermia is a severe reaction to particular drugs used during surgery and other invasive procedures. People at increased risk for this disorder are said to have malignant hyperthermia susceptibility. If given these drugs, these people may experience muscle rigidity, breakdown of muscle fibers, a high fever, increased acid levels in the blood and other tissues, and a rapid heart rate. Without prompt treatment, the complications of malignant hyperthermia can be life-threatening. There are at least six forms of malignant hyperthermia susceptibility, which are associated with mutations in different genes (e.g.,  CACNA1S, RYR1). The susceptibility is inherited in an autosomal dominant fashion. People with certain inherited muscle diseases (e.g., central core disease and multiminicore disease) also have malignant hyperthermia susceptibility.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

Last Updated: 6 May 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant hyperthermia" for support, advocacy or research.

Malignant Hyperthermia Association of the United States

The mission of MHAUS is to promote optimum care and scientific understanding of MH and related disorders.

http://www.mhaus.org

Last Updated: 6 May 2014

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General Resources

North American Malignant Hyperthermia Registry

The Registry's goal is to acquire, analyze, and disseminate case-specific clinical and laboratory information related to malignant hyperthermia susceptibility.

Updated 21 Dec 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant hyperthermia" returned 304 free, full-text research articles on human participants. First 3 results:

Using exome data to identify malignant hyperthermia susceptibility mutations.
 

Author(s): Stephen G Gonsalves, David Ng, Jennifer J Johnston, Jamie K Teer, Peter D Stenson, David N Cooper, James C Mullikin, Leslie G Biesecker,

Journal: Anesthesiology. 2013 Nov;119(5):1043-53.

 

Malignant hyperthermia susceptibility (MHS) is a life-threatening, inherited disorder of muscle calcium metabolism, triggered by anesthetics and depolarizing muscle relaxants. An unselected cohort was screened for MHS mutations using exome sequencing. The aim of this study was to ...

Last Updated: 7 Nov 2013

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Exome sequencing reveals novel rare variants in the ryanodine receptor and calcium channel genes in malignant hyperthermia families.
 

Author(s): Jerry H Kim, Gail P Jarvik, Brian L Browning, Ramakrishnan Rajagopalan, Adam S Gordon, Mark J Rieder, Peggy D Robertson, Deborah A Nickerson, Nickla A Fisher, Philip M Hopkins

Journal: Anesthesiology. 2013 Nov;119(5):1054-65.

 

About half of malignant hyperthermia (MH) cases are associated with skeletal muscle ryanodine receptor 1 (RYR1) and calcium channel, voltage-dependent, L type, α1S subunit (CACNA1S) gene mutations, leaving many with an unknown cause. The authors chose to apply a sequencing approach ...

Last Updated: 8 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant hyperthermia" returned 26 free, full-text review articles on human participants. First 3 results:

Exercise-induced rhabdomyolysis and stress-induced malignant hyperthermia events, association with malignant hyperthermia susceptibility, and RYR1 gene sequence variations.
 

Author(s): Antonella Carsana

Journal: ScientificWorldJournal. 2013 ;2013():531465.

 

Exertional rhabdomyolysis (ER) and stress-induced malignant hyperthermia (MH) events are syndromes that primarily afflict military recruits in basic training and athletes. Events similar to those occurring in ER and in stress-induced MH events are triggered after exposure to anesthetic ...

Last Updated: 11 Mar 2013

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Malignant hyperthermia: clinical and molecular aspects.
 

Author(s): Ana Carolina de Carvalho Correia, Polyana Cristina Barros Silva, Bagnólia Araújo da Silva

Journal: Rev Bras Anestesiol. ;62(6):820-37.

 

Malignant hyperthermia (MH) is a potentially lethal pharmacogenetic disorder that affects genetically predisposed individuals. It manifests in susceptible individuals in response to exposure to Inhalant anesthetics, depolarizing muscle relaxants or extreme physical activity in hot ...

Last Updated: 26 Nov 2012

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Malignant hyperthermia.
 

Author(s): Oliver Bandschapp, Thierry Girard

Journal:

 

Malignant hyperthermia (MH) is a subclinical myopathy, usually triggered by volatile anaesthetics and depolarising muscle relaxants. Clinical symptoms are variable, and the condition is sometimes difficult to identify. Nevertheless, rapid recognition and specific as well as symptomatic ...

Last Updated: 1 Aug 2012

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Effectiveness of Carbon Filters to Reduce the Anesthetic Gas Concentration in an Anesthetized Patient
 

Status: Not yet recruiting

Condition Summary: Malignant Hyperthermia

 

Last Updated: 19 Jun 2012

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Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies
 

Status: Recruiting

Condition Summary: Sepsis; Primary Myopathies

 

Last Updated: 28 Apr 2014

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Video-assisted Hyperthermic Pleural Chemoperfusion vs Talc Pleurodesis for Refractory Malignant Pleural Effusions.
 

Status: Recruiting

Condition Summary: Safety of Intervention; Efficacy of Intervention; Cost Effectiveness

 

Last Updated: 26 Mar 2014

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