Malignant germ cell tumor

Common Name(s)

Malignant germ cell tumor

Malignant germ cell tumor is a rare form of cancer characterized by abnormal cell growth of immature cells that develop into male and female reproductive systems. Individuals with this disorder may grow harmful tumors in the ovaries, testes, abdomen, pelvis or lower back, which can spread to the rest of the body if not diagnosed and treated early. This form of cancer can thus cause individuals to lose reproductive ability. Common symptoms include weight loss, abdominal pain and breathing problems. An individual may also feel a mass or growth in their abdomen. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant germ cell tumor" returned 12 free, full-text research articles on human participants. First 3 results:

Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads.
 

Author(s): Icela Palma, Nayely Garibay, Rocio Pena-Yolanda, Alejandra Contreras, Atlantida Raya, Carolina Dominguez, Mirna Romero, Gerardo Aristi, Gloria Queipo

Journal: Dis. Markers. 2013 ;34(6):419-24.

 

Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor.

Last Updated: 22 May 2013

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Overexpression of karyopherin 2 in human ovarian malignant germ cell tumor correlates with poor prognosis.
 

Author(s): Li He, Hui Ding, Jian-Hua Wang, Yun Zhou, Li Li, Yan-Hong Yu, Long Huang, Wei-Hua Jia, Musheng Zeng, Jing-Ping Yun, Rong-Zhen Luo, Min Zheng

Journal: PLoS ONE. 2012 ;7(9):e42992.

 

The aim of this study was to identify a biomarker useful in the diagnosis and therapy of ovarian malignant germ cell tumor (OMGCT).

Last Updated: 10 Sep 2012

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Residual tumor after the salvage surgery is the major risk factors for primary treatment failure in malignant ovarian germ cell tumors: a retrospective study of single institution.
 

Author(s): Chung Won Lee, Min Jong Song, Sung Taek Park, Eun Young Ki, Sung Jong Lee, Keun Ho Lee, Ki Sung Ryu, Jong Sup Park, Soo Young Hur

Journal:

 

Malignant ovarian germ cell tumors are rare, and knowledge of their prognostic factors is limited, with little available randomized data. This study was conducted to evaluate the clinicopathologic characteristics of malignant ovarian germ cell tumors and to determine the association ...

Last Updated: 14 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant germ cell tumor" returned 1 free, full-text review articles on human participants. First 3 results:

False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature.
 

Author(s): Bart E P B Ballieux, Nir I Weijl, Hans Gelderblom, Johannes van Pelt, Susanne Osanto

Journal: Oncologist. 2008 Nov;13(11):1149-54.

 

A 39-year-old male patient with a favorable prognosis stage IIB metastatic malignant germ cell tumor (GCT) and elevated pre- and postorchiectomy serum human chorionic gonadotropin (hCG) was treated with three courses of combination chemotherapy resulting in a rapid normalization of ...

Last Updated: 25 Nov 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Multicenter Study to Evaluate a Risk-adapted Strategy for Treatment of Extra Cranial Non Seminomateous Malignant Germ Cell Tumour in Children and Adolescent
 

Status: Not yet recruiting

Condition Summary: Extra Cranial Non Seminomateous Malignant Germ Cell Tumour

 

Last Updated: 2 Apr 2014

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Studying Biomarkers in Samples From Younger Patients With Malignant Germ Cell Tumor Progression
 

Status: Not yet recruiting

Condition Summary: Childhood Germ Cell Tumor; Extragonadal Germ Cell Tumor; Ovarian Cancer; Testicular Germ Cell Tumor

 

Last Updated: 9 Sep 2011

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Everolimus for Patients With Relapsed/Refractory Germ Cell Cancer
 

Status: Recruiting

Condition Summary: Testicular Cancer; Germ Cell Cancer

 

Last Updated: 21 Jun 2011

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