Malignant germ cell tumor

Common Name(s)

Malignant germ cell tumor

Malignant germ cell tumor is a rare form of cancer characterized by abnormal cell growth of immature cells that develop into male and female reproductive systems. Individuals with this disorder may grow harmful tumors in the ovaries, testes, abdomen, pelvis or lower back, which can spread to the rest of the body if not diagnosed and treated early. This form of cancer can thus cause individuals to lose reproductive ability. Common symptoms include weight loss, abdominal pain and breathing problems. An individual may also feel a mass or growth in their abdomen. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant germ cell tumor" returned 22 free, full-text research articles on human participants. First 3 results:

Ovarian malignant mixed germ cell tumor with clear cell carcinoma in a postmenopausal woman.
 

Author(s): Xiu-Jie Yu, Lin Zhang, Zai-Ping Liu, Yi-Quan Shi, Yi-Xin Liu

Journal:

 

Malignant germ cell tumors of the ovary are very rare and account for about 2-5% of all ovarian tumors of germ origin. Most patients are adolescent and young women, approximately two-thirds of them are under 20 years of age, occasionally in postmenopausal women. But clear cell carcinoma ...

Last Updated: 12 Feb 2015

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Utility of OCT3/4, TSPY and β-catenin as biological markers for gonadoblastoma formation and malignant germ cell tumor development in dysgenetic gonads.
 

Author(s): Icela Palma, Nayely Garibay, Rocio Pena-Yolanda, Alejandra Contreras, Atlantida Raya, Carolina Dominguez, Mirna Romero, Gerardo Aristi, Gloria Queipo

Journal: Dis. Markers. 2013 ;34(6):419-24.

 

Gonadoblastoma (GB) is regarded as an in situ form of germ cell tumor in dysgenetic gonads, and 30% of patients with GB develop a dysgerminoma/seminoma tumor.

Last Updated: 22 May 2013

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Recurrent rhabdomyosarcoma after adjuvant chemotherapy for stage I non-seminomatous germ cell tumor with malignant transformation.
 

Author(s): Hiroshi Ushida, Shuichi Koizumi, Kenjiro Katoh, Hidetoshi Okabe, Yusaku Okada, Keisei Okamoto

Journal: Int. J. Urol.. 2013 May;20(5):544-6.

 

We report a rare case of stage I non-seminomatous testicular germ cell tumor with malignant transformation. The patient received two cycles of chemotherapy (cisplatin, bleomycin and etoposide) tailored to testicular germ cell tumors as an adjuvant therapy after orchiectomy. However, ...

Last Updated: 7 May 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant germ cell tumor" returned 2 free, full-text review articles on human participants. First 3 results:

Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.
 

Author(s): Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu

Journal:

 

Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest ...

Last Updated: 8 Sep 2014

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False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature.
 

Author(s): Bart E P B Ballieux, Nir I Weijl, Hans Gelderblom, Johannes van Pelt, Susanne Osanto

Journal: Oncologist. 2008 Nov;13(11):1149-54.

 

A 39-year-old male patient with a favorable prognosis stage IIB metastatic malignant germ cell tumor (GCT) and elevated pre- and postorchiectomy serum human chorionic gonadotropin (hCG) was treated with three courses of combination chemotherapy resulting in a rapid normalization of ...

Last Updated: 25 Nov 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Mar 2016

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Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Central Nervous System Germ Cell Tumor; Adult Ependymoblastoma; Adult Medulloblastoma; Adult Pineoblastoma; Adult Supratentorial Primitive Neuroectodermal Tumor; Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Ependymoblastoma; Medulloepithelioma; Ototoxicity; Recurrent Adult Brain Neoplasm; Recurrent Childhood Central Nervous System Embryonal Neoplasm; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 28 Apr 2016

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Last Updated: 11 May 2016

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