Malignant germ cell tumor

Common Name(s)

Malignant germ cell tumor

Malignant germ cell tumor is a rare form of cancer characterized by abnormal cell growth of immature cells that develop into male and female reproductive systems. Individuals with this disorder may grow harmful tumors in the ovaries, testes, abdomen, pelvis or lower back, which can spread to the rest of the body if not diagnosed and treated early. This form of cancer can thus cause individuals to lose reproductive ability. Common symptoms include weight loss, abdominal pain and breathing problems. An individual may also feel a mass or growth in their abdomen. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant germ cell tumor" returned 23 free, full-text research articles on human participants. First 3 results:

Swyer's Syndrome with Mixed Ovarian Malignant Germ Cell Tumor and Ovarian Gonadoblastoma.
 

Author(s): Hong-Lan Zhu, Dong-Mei Bao, Yue Wang, Dan-Hua Shen, Yi Li, Heng Cui

Journal: Chin. Med. J.. 2016 Jul;129(14):1752-4.

 

Last Updated: 14 Jul 2016

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Ovarian malignant mixed germ cell tumor: A rare combination with five germ cell components.
 

Author(s): Sinai Khandeparkar Siddhi Gaurish, Joshi Avinash, Shalaka Hardas, Maithili Mandar Kulkarni, Chitrangi Prashant Barpande

Journal: Indian J Pathol Microbiol. ;59(1):122-3.

 

Last Updated: 10 Mar 2016

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Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative.
 

Author(s): Farzana Pashankar, Juliet P Hale, Ha Dang, Mark Krailo, William E Brady, Carlos Rodriguez-Galindo, James C Nicholson, Matthew J Murray, Deborah F Bilmire, Sara Stoneham, G Suren Arul, Thomas A Olson, Daniel Stark, Furqan Shaikh, James F Amatruda, Allan Covens, David M Gershenson, A Lindsay Frazier

Journal: Cancer. 2016 Jan;122(2):230-7.

 

There is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy is standard except for stage I, grade 1 disease, whereas surgery alone is standard in pediatric patients. To determine the role of chemotherapy, a pooled analysis ...

Last Updated: 11 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant germ cell tumor" returned 2 free, full-text review articles on human participants. First 3 results:

Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.
 

Author(s): Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu

Journal:

 

Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest ...

Last Updated: 8 Sep 2014

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False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature.
 

Author(s): Bart E P B Ballieux, Nir I Weijl, Hans Gelderblom, Johannes van Pelt, Susanne Osanto

Journal: Oncologist. 2008 Nov;13(11):1149-54.

 

A 39-year-old male patient with a favorable prognosis stage IIB metastatic malignant germ cell tumor (GCT) and elevated pre- and postorchiectomy serum human chorionic gonadotropin (hCG) was treated with three courses of combination chemotherapy resulting in a rapid normalization of ...

Last Updated: 25 Nov 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Mar 2016

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Active Surveillance, Bleomycin, Carboplatin, Etoposide, or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Germ Cell Tumor; Childhood Extracranial Germ Cell Tumor; Childhood Germ Cell Tumor; Extragonadal Embryonal Carcinoma; Grade 2 Immature Ovarian Teratoma; Grade 3 Immature Ovarian Teratoma; Malignant Germ Cell Tumor; Stage I Ovarian Choriocarcinoma; Stage I Ovarian Embryonal Carcinoma; Stage I Ovarian Teratoma; Stage I Ovarian Yolk Sac Tumor; Stage I Testicular Choriocarcinoma; Stage I Testicular Embryonal Carcinoma; Stage I Testicular Yolk Sac Tumor; Stage II Ovarian Choriocarcinoma; Stage II Ovarian Embryonal Carcinoma; Stage II Ovarian Yolk Sac Tumor; Stage II Testicular Choriocarcinoma; Stage II Testicular Embryonal Carcinoma; Stage II Testicular Yolk Sac Tumor; Stage III Ovarian Choriocarcinoma; Stage III Ovarian Embryonal Carcinoma; Stage III Ovarian Yolk Sac Tumor; Stage III Testicular Choriocarcinoma; Stage III Testicular Embryonal Carcinoma; Stage III Testicular Yolk Sac Tumor; Stage IV Ovarian Choriocarcinoma; Stage IV Ovarian Embryonal Carcinoma; Stage IV Ovarian Yolk Sac Tumor; Testicular Mixed Choriocarcinoma and Embryonal Carcinoma; Testicular Mixed Choriocarcinoma and Teratoma; Testicular Mixed Choriocarcinoma and Yolk Sac Tumor

 

Last Updated: 8 May 2017

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Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Central Nervous System Germ Cell Tumor; Adult Ependymoblastoma; Adult Medulloblastoma; Adult Pineoblastoma; Adult Supratentorial Primitive Neuroectodermal Tumor; Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Ependymoblastoma; Medulloepithelioma; Ototoxicity; Recurrent Adult Brain Neoplasm; Recurrent Childhood Central Nervous System Embryonal Neoplasm; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 19 Apr 2017

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