Malignant germ cell tumor

Common Name(s)

Malignant germ cell tumor

Malignant germ cell tumor is a rare form of cancer characterized by abnormal cell growth of immature cells that develop into male and female reproductive systems. Individuals with this disorder may grow harmful tumors in the ovaries, testes, abdomen, pelvis or lower back, which can spread to the rest of the body if not diagnosed and treated early. This form of cancer can thus cause individuals to lose reproductive ability. Common symptoms include weight loss, abdominal pain and breathing problems. An individual may also feel a mass or growth in their abdomen. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant germ cell tumor" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant germ cell tumor" returned 25 free, full-text research articles on human participants. First 3 results:

Is adjuvant chemotherapy indicated in ovarian immature teratomas? A combined data analysis from the Malignant Germ Cell Tumor International Collaborative.
 

Author(s): Farzana Pashankar, Juliet P Hale, Ha Dang, Mark Krailo, William E Brady, Carlos Rodriguez-Galindo, James C Nicholson, Matthew J Murray, Deborah F Bilmire, Sara Stoneham, G Suren Arul, Thomas A Olson, Daniel Stark, Furqan Shaikh, James F Amatruda, Allan Covens, David M Gershenson, A Lindsay Frazier

Journal: Cancer. 2016 Jan;122(2):230-7.

 

There is a debate regarding the management of ovarian immature teratomas (ITs). In adult women, postoperative chemotherapy is standard except for stage I, grade 1 disease, whereas surgery alone is standard in pediatric patients. To determine the role of chemotherapy, a pooled analysis ...

Last Updated: 11 Jan 2016

Go To URL
Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis.
 

Author(s): Jen-Yin Hou, Hsi-Che Liu, Ting-Chi Yeh, Jin-Cherng Sheu, Kuan-Hao Chen, Ching-Yi Chang, Der-Cherng Liang

Journal: Pediatr Neonatol. 2015 Oct;56(5):301-6.

 

The survival of children with malignant germ cell tumor (GCT) increased over the past 2 decades with platinum-based chemotherapy. This report has three objectives: (1) comparison of PVB (cisplatin, vinblastine, and bleomycin) with JEB (carboplatin, etoposide, and bleomycin) regimens; ...

Last Updated: 12 Oct 2015

Go To URL
Ovarian malignant mixed germ cell tumor with clear cell carcinoma in a postmenopausal woman.
 

Author(s): Xiu-Jie Yu, Lin Zhang, Zai-Ping Liu, Yi-Quan Shi, Yi-Xin Liu

Journal:

 

Malignant germ cell tumors of the ovary are very rare and account for about 2-5% of all ovarian tumors of germ origin. Most patients are adolescent and young women, approximately two-thirds of them are under 20 years of age, occasionally in postmenopausal women. But clear cell carcinoma ...

Last Updated: 12 Feb 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant germ cell tumor" returned 2 free, full-text review articles on human participants. First 3 results:

Unclassified mixed germ cell-sex cord-stromal tumor with multiple malignant cellular elements in a young woman: a case report and review of the literature.
 

Author(s): Shujie Pang, Lin Zhang, Yiquan Shi, Yixin Liu

Journal:

 

Unclassified mixed germ cell-sex cord-stromal tumor composed of germ cells and sex cord derivatives is a rare neoplasm. Approximately 10% of such tumors have malignant germ cell components. We report the case of a 28 year-old female with a right adnexal mass measuring 8 cm in greatest ...

Last Updated: 8 Sep 2014

Go To URL
False-positive serum human chorionic gonadotropin (HCG) in a male patient with a malignant germ cell tumor of the testis: a case report and review of the literature.
 

Author(s): Bart E P B Ballieux, Nir I Weijl, Hans Gelderblom, Johannes van Pelt, Susanne Osanto

Journal: Oncologist. 2008 Nov;13(11):1149-54.

 

A 39-year-old male patient with a favorable prognosis stage IIB metastatic malignant germ cell tumor (GCT) and elevated pre- and postorchiectomy serum human chorionic gonadotropin (hCG) was treated with three courses of combination chemotherapy resulting in a rapid normalization of ...

Last Updated: 25 Nov 2008

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 30 Mar 2016

Go to URL
Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Adult Central Nervous System Germ Cell Tumor; Adult Ependymoblastoma; Adult Medulloblastoma; Adult Pineoblastoma; Adult Supratentorial Primitive Neuroectodermal Tumor; Childhood Atypical Teratoid/Rhabdoid Tumor; Childhood Central Nervous System Germ Cell Tumor; Childhood Ependymoblastoma; Medulloepithelioma; Ototoxicity; Recurrent Adult Brain Neoplasm; Recurrent Childhood Central Nervous System Embryonal Neoplasm; Recurrent Childhood Malignant Germ Cell Tumor; Recurrent Childhood Medulloblastoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor

 

Last Updated: 7 Nov 2016

Go to URL
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors
 

Status: Recruiting

Condition Summary: Germ Cell Tumor; Teratoma; Choriocarcinoma; Germinoma; Mixed Germ Cell Tumor; Yolk Sac Tumor; Childhood Teratoma; Malignant Germ Cell Neoplasm; Extragonadal Seminoma; Non-seminomatous Germ Cell Tumor; Seminoma

 

Last Updated: 16 Nov 2016

Go to URL