Malignant fibrous histiocytoma

Common Name(s)

Malignant fibrous histiocytoma

Malignant fibrous histiocytoma is a rare form of cancer characterized by abnormal cell growth in the fibrous support tissue or the bone. Individuals with this disorder may grow harmful tumors in the muscles and bone that can spread to the rest of the body if not diagnosed and treated early. The abnormal cell growth usually develops in the extremities (toes, fingers etc.), but can also form anywhere in the body. This form of cancer can thus cause individuals to be less capable of performing important movements, like walking and running. Some individuals may loss their ability to move certain parts of their body (paralysis). Common symptoms include weight loss, abdominal pain and breathing problems. Diagnosis may require blood tests and imaging studies such as a CT scan. A physician may also need to take a biopsy, which is where they surgically remove a small portion of the tumor to look at under a microscope. Treatment is developed on a case-by-case basis and may include a combination of chemotherapy, radiation, and surgery.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant fibrous histiocytoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malignant fibrous histiocytoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malignant fibrous histiocytoma" returned 271 free, full-text research articles on human participants. First 3 results:

Giant cell variant of malignant fibrous histiocytoma of male breast: A rare case report.
 

Author(s): Kamlesh Kumar Harsh, Ashok Kalwar, Akhil Kapoor, Shankar Lal Jakhar, Harvindra Singh Kumar

Journal: J Cancer Res Ther. ;11(3):657.

 

Malignant fibrous histiocytoma (MFH) is the most common form of soft tissue sarcoma during middle and late adulthood in the deep connective tissue of the extremities, abdominal cavity, and retroperitoneum. However, primary breast sarcoma is a rare disease entity, comprising less than ...

Last Updated: 13 Oct 2015

Go To URL
Malignant fibrous histiocytoma of visceral organs: clinicopathologic features and diagnostic value of ezrin and HMG-CoA reductase.
 

Author(s): Jinyang Gu, Shu Zhang, Xingyu Wu, Jiong Shi, Bin Zhang, Xiaoqi Zhang, Jun Yang, Halmurat Obulkasim, Fei Duan, Chao Deng, Jing He, Xiaoping Zou, Yitao Ding

Journal:

 

Malignant fibrous histiocytoma (MFH) of the breast and visceral organs is extremely rare. There is an incomplete understanding of the clinical pathology of the primary MFH originating from the breast and visceral organs, especially in comparison with other soft tissue sarcomas. As ...

Last Updated: 5 Jun 2015

Go To URL
Storiform-pleomorphic type of multifocal malignant fibrous histiocytoma of the lumbar spine.
 

Author(s): Aykut Akpinar, Cengiz Omer Ozdemir, Necati Ucler, Haci Mehmet Inan

Journal:

 

We present the extremely rare case of a 67-year-old male with malignant fibrous histiocytoma, arising in the lumbar spine, demonstrated with radiological and pathological studies.

Last Updated: 22 Dec 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malignant fibrous histiocytoma" returned 27 free, full-text review articles on human participants. First 3 results:

Unusual localization of a primary pleomorphic malignant fibrous histiocytoma on the mitral valve: a case report and review of the literature.
 

Author(s): Edvin Prifti, Fadil Ademaj, Majlinda Ikonomi, Aurel Demiraj

Journal:

 

It has been reported that cardiac malignant fibrous histiocytomas occur more frequently in the left side of the heart, especially in the left atrium, but rarely invade the mitral valve. We present a case with a giant malignant fibrous histiocytoma with an unusual localization involving ...

Last Updated: 31 Oct 2015

Go To URL
Diagnostic and therapeutic strategy and the most efficient prognostic factors of breast malignant fibrous histiocytoma.
 

Author(s): Si-Qi Qiu, Xiao-Long Wei, Wen-He Huang, Ming-Yao Wu, Yun-Sheng Qin, Yang-Kang Li, Guo-Jun Zhang

Journal: Sci Rep. 2013 ;3():2529.

 

We analyzed the clinicopathological features of 9 breast malignant fibrous histiocytoma (MFH) patients. Immunohistochemistry was used to make both diagnosis and differential diagnosis, and to identify prognostic factors. All tumors lacked epithelial markers but expressed mesenchymal ...

Last Updated: 28 Aug 2013

Go To URL
Malignant fibrous histiocytoma of right atrium.
 

Author(s): Huai-Sheng Chen, Wei Wang, Cheng-Ying Hong

Journal: Chin. Med. J.. 2013 ;126(10):1994-5.

 

Last Updated: 15 May 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Ifosfamide and Doxorubicin, Radiation Therapy, and/or Surgery in Treating Young Patients With Localized Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Childhood Malignant Fibrous Histiocytoma of Bone; Sarcoma

 

Last Updated: 9 Aug 2013

Go to URL
Radiation Therapy With or Without Combination Chemotherapy or Pazopanib Hydrochloride Before Surgery in Treating Patients With Newly Diagnosed Non-Rhabdomyosarcoma Soft Tissue Sarcomas That Can Be Removed by Surgery
 

Status: Recruiting

Condition Summary: Adult Fibrosarcoma; Alveolar Soft Part Sarcoma; Angiomatoid Fibrous Histiocytoma; Atypical Fibroxanthoma; Clear Cell Sarcoma of Soft Tissue; Epithelioid Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma; Extraskeletal Myxoid Chondrosarcoma; Extraskeletal Osteosarcoma; Fibrohistiocytic Neoplasm; Glomus Tumor of the Skin; Inflammatory Myofibroblastic Tumor; Intimal Sarcoma; Leiomyosarcoma; Liposarcoma; Low Grade Fibromyxoid Sarcoma; Low Grade Myofibroblastic Sarcoma; Malignant Cutaneous Granular Cell Tumor; Malignant Peripheral Nerve Sheath Tumor; Malignant Triton Tumor; Mesenchymal Chondrosarcoma; Myxofibrosarcoma; Myxoid Chondrosarcoma; Myxoinflammatory Fibroblastic Sarcoma; Nerve Sheath Neoplasm; PEComa; Pericytic Neoplasm; Plexiform Fibrohistiocytic Tumor; Sclerosing Epithelioid Fibrosarcoma; Stage IB Soft Tissue Sarcoma; Stage IIB Soft Tissue Sarcoma; Stage III Soft Tissue Sarcoma; Stage IV Soft Tissue Sarcoma; Synovial Sarcoma; Undifferentiated (Embryonal) Sarcoma; Undifferentiated High Grade Pleomorphic Sarcoma of Bone

 

Last Updated: 25 Aug 2016

Go to URL
Doxorubicin With Upfront Dexrazoxane for the Treatment of Advanced or Metastatic Soft Tissue Sarcoma
 

Status: Recruiting

Condition Summary: Sarcoma, Soft Tissue; Soft Tissue Sarcoma; Undifferentiated Pleomorphic Sarcoma; Leiomyosarcoma; Liposarcoma; Synovial Sarcoma; Myxofibrosarcoma; Angiosarcoma; Fibrosarcoma; Malignant Peripheral Nerve Sheath Tumor; Epithelioid Sarcoma

 

Last Updated: 11 Jul 2016

Go to URL