Malaria

Common Name(s)

Malaria

Malaria is a serious and sometimes fatal disease caused by a parasite that commonly infects a certain type of mosquito which feeds on humans. Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death. People who get malaria are typically very sick with high fevers, shaking chills, and flu-like illness. In general, malaria is a curable disease if diagnosed and treated promptly and correctly. Treatment depends on many factors including disease severity, the species of malaria parasite causing the infection and the part of the world in which the infection was acquired.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Malaria" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Malaria" returned 8194 free, full-text research articles on human participants. First 3 results:

Human antibodies fix complement to inhibit Plasmodium falciparum invasion of erythrocytes and are associated with protection against malaria.
 

Author(s): Michelle J Boyle, Linda Reiling, Gaoqian Feng, Christine Langer, Faith H Osier, Harvey Aspeling-Jones, Yik Sheng Cheng, Janine Stubbs, Kevin K A Tetteh, David J Conway, James S McCarthy, Ivo Muller, Kevin Marsh, Robin F Anders, James G Beeson

Journal: Immunity. 2015 Mar;42(3):580-90.

 

Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate ...

Last Updated: 19 Mar 2015

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[Haemophagocytic lymphohistiocytosis syndrome - related to severe malaria: rare association].
 

Author(s): Ahlem Trifi, Abdelwaheb Terra, Sami Abdellatif, Foued Daly, Mouna Oueslati, Lamia Laamari, Kalthoum Kallel, Salah Ben Lakhal, Hanen Tiouiri, Emna Chaker

Journal: Tunis Med. 2014 Jul;92(7):515-6.

 

Last Updated: 17 Mar 2015

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Antisense long noncoding RNAs regulate var gene activation in the malaria parasite Plasmodium falciparum.
 

Author(s): Inbar Amit-Avraham, Guy Pozner, Shiri Eshar, Yair Fastman, Netanel Kolevzon, Eylon Yavin, Ron Dzikowski

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2015 Mar;112(9):E982-91.

 

The virulence of Plasmodium falciparum, the causative agent of the deadliest form of human malaria, is attributed to its ability to evade human immunity through antigenic variation. These parasites alternate between expression of variable antigens, encoded by members of a multicopy ...

Last Updated: 4 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Malaria" returned 802 free, full-text review articles on human participants. First 3 results:

Fatal cerebral malaria: a venous efflux problem.
 

Author(s): Ute Frevert, Adéla Nacer

Journal:

 

Most Plasmodium falciparum-infected children with cerebral malaria (CM) die from respiratory arrest, but the underlying pathology is unclear. Here we present a model in which the ultimate cause of death from CM is severe intracranial hypertension. Dynamic imaging of mice infected ...

Last Updated: 21 Nov 2014

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Challenges of drug-resistant malaria.
 

Author(s): Shweta Sinha, Bikash Medhi, Rakesh Sehgal

Journal: Parasite. 2014 ;21():61.

 

Over the past six decades, the drug resistance of Plasmodium falciparum has become an issue of utmost concern. Despite the remarkable progress that has been made in recent years in reducing the mortality rate to about 30% with the scaling-up of vector control, introduction of artemisinin-based ...

Last Updated: 18 Nov 2014

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The association between malaria and non-typhoid Salmonella bacteraemia in children in sub-Saharan Africa: a literature review.
 

Author(s): Ebako Ndip Takem, Anna Roca, Aubrey Cunnington

Journal:

 

Plasmodium falciparum malaria and non-typhoid Salmonella (NTS) bacteraemia are both major causes of morbidity and mortality in children in sub-Saharan Africa. Co-infections are expected to occur because of their overlapping geographical distribution, but accumulating evidence indicates ...

Last Updated: 21 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mass Drug Administration With Dihydroartemisinin + Piperaquine for Reducing Malaria in Southern Zambia
 

Status: Recruiting

Condition Summary: Malaria; Malaria, Falciparum

 

Last Updated: 30 Dec 2014

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Malaria in Early Life Study
 

Status: Recruiting

Condition Summary: Plasmodium Falciparum Malaria; Plasmodium Vivax Malaria

 

Last Updated: 31 May 2014

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Randomized Trial of Erythropoietin During Cerebral Malaria
 

Status: Recruiting

Condition Summary: Cerebral Malaria

 

Last Updated: 12 Jun 2008

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