Anemia

Common Name(s)

Anemia, Anemias

Anemia occurs when there is a decreased amount of hemoglobin, an iron-rich protein inside red blood cells, that helps carry oxygen throughout the body. Symptoms include general weakness, tiredness, difficulty concentrating, shortness of breath, confusion, dizziness, headaches, brittle nails, pale skin, and lightheadedness. Severe anemia, when it goes untreated, can cause heart and other organ failures, and in rare and extreme cases, even death. Although there are many types of anemia, anemias are categorized into three main groups: anemia caused by blood loss, anemia caused by decreased red blood cell production, and anemia caused by the destruction of red blood cells. Anemia through blood loss is usually caused from gastrointestinal bleeding such as ulcers or hemorrhoids, but can also occur from surgery or frequent blood donations. Anemia is also more commonly in females than in males due to menstruation and pregnancy. Anemia due to a lack of red blood cell production or increased red blood cell destruction can be due to abnormal red blood cells or various other conditions or factors including sickle cell anemia, iron and other vitamin deficiencies, poor dieting, bone marrow conditions, organ irregularities, infections, and toxins.

Anemia can be diagnosed through a physical examination and a simple blood test, although diagnosing the type of anemia may require more tests. Treatments vary depending on the severity and kind of the anemia including proper dieting, iron, and vitamin supplements. If the anemia is severe other treatments, including blood transfusions or medications, may be needed. If you or a family member has been diagnosed with anemia, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anemia" for support, advocacy or research.

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Mucolipidosis Type IV (ML4) Foundation

The mission of the Foundation is to fund, promote and support scientific research dedicated to developing treatments and a cure for ML4 by providing critical financial support to researchers; linking individuals with ML4 to researchers for clinical studies; sponsoring symposia and other programs to encourage scientific cooperation, collaboration, and communication among researchers, the medical community, goverment organizations, and the patient community.

Last Updated: 15 Mar 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anemia" for support, advocacy or research.

Logo
Mucolipidosis Type IV (ML4) Foundation

The mission of the Foundation is to fund, promote and support scientific research dedicated to developing treatments and a cure for ML4 by providing critical financial support to researchers; linking individuals with ML4 to researchers for clinical studies; sponsoring symposia and other programs to encourage scientific cooperation, collaboration, and communication among researchers, the medical community, goverment organizations, and the patient community.

http://www.ml4.org

Last Updated: 15 Mar 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anemia" returned 4200 free, full-text research articles on human participants. First 3 results:

Is sickle cell anemia a risk factor for severe dental malocclusion?
 

Author(s): Cyrene Piazera Silva Costa, Halinna Larissa Cruz Correa Carvalho, Soraia de Fátima Carvalho Souza, Erika Bárbara Abreu Fonseca Thomaz

Journal: Braz Oral Res. 2015 ;29(1):.

 

The aim of this study was to investigate possible associations between sickle cell anemia (SCA) and the severity of dental malocclusion (MO). This was a retrospective cohort study of 93 individuals with SCA (G1) and 186 individuals without the disease (G2). SCA patients were randomly ...

Last Updated: 28 Jan 2015

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Cerebral venous sinus thrombosis with increased factor VIII activity in an adult with iron deficiency anemia.
 

Author(s): Hiroshi Yokota, Yuki Ida, Shinya Sugiura, Ken Sasaki, Hiroo Itoh

Journal: Neurol India. ;62(6):674-5.

 

Last Updated: 16 Jan 2015

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Ubiquitin-SUMO circuitry controls activated fanconi anemia ID complex dosage in response to DNA damage.
 

Author(s): Ian Gibbs-Seymour, Yasuyoshi Oka, Eeson Rajendra, Brian T Weinert, Lori A Passmore, Ketan J Patel, Jesper V Olsen, Chunaram Choudhary, Simon Bekker-Jensen, Niels Mailand

Journal: Mol. Cell. 2015 Jan;57(1):150-64.

 

We show that central components of the Fanconi anemia (FA) DNA repair pathway, the tumor suppressor proteins FANCI and FANCD2 (the ID complex), are SUMOylated in response to replication fork stalling. The ID complex is SUMOylated in a manner that depends on the ATR kinase, the FA ...

Last Updated: 10 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anemia" returned 430 free, full-text review articles on human participants. First 3 results:

[Defectiveness of bone marrow mesenchymal stem cells in acquired aplastic anemia].
 

Author(s): Jing-Liao Zhang, Xiao-Fan Zhu

Journal: Zhongguo Dang Dai Er Ke Za Zhi. 2015 Jan;17(1):100-6.

 

The defectiveness of bone marrow mesenchymal stem cells (BM-MSCs) in acquired aplastic anemia (AA) has been a frequent research topic in recent years. This review summarizes the defectiveness of BM-MSCs which is responsible for the mechanism of acquired AA and the prospective application ...

Last Updated: 24 Jan 2015

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Aplastic anemia in adolescents and young adults.
 

Author(s): Amy E DeZern, Eva C Guinan

Journal: Acta Haematol.. 2014 ;132(3-4):331-9.

 

Adolescent and young adult patient presentations of aplastic anemia require a particular perspective on both diagnosis and treatment. This unique age group necessitates a thorough diagnostic evaluation to ensure the etiology, acquired or inherited, is sufficiently determined. The ...

Last Updated: 17 Sep 2014

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Successful treatment of severe immune hemolytic anemia after allogeneic stem cell transplantation with bortezomib: report of a case and review of literature.
 

Author(s): Sakura Hosoba, David L Jaye, Cynthia Cohen, John D Roback, Edmund K Waller

Journal: Transfusion. 2015 Feb;55(2):259-64.

 

Immune hemolytic anemia is a well-known complication after allogeneic hematopoietic stem cell transplantation (HSCT). Posttransplant hemolytic anemia results in increased red blood cell transfusions and medical sequelae including iron overload.

Last Updated: 16 Feb 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Childhood Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Fanconi Anemia; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Secondary Myelodysplastic Syndromes; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 5 May 2015

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Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
 

Status: Recruiting

Condition Summary: Congenital Hemolytic Anemia; Diamond-Blackfan Anemia

 

Last Updated: 22 Nov 2014

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Eltrombopag for Moderate Aplastic Anemia
 

Status: Recruiting

Condition Summary: Eltrombopag; Aplastic Anemia; Aplastic Anemia Treatment; Moderate Aplastic Anemia; Moderate Aplastic Anemia Treatment

 

Last Updated: 30 Apr 2015

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