Anemia

Common Name(s)

Anemia, Anemias

Anemia occurs when there is a decreased amount of hemoglobin, an iron-rich protein inside red blood cells, that helps carry oxygen throughout the body. Symptoms include general weakness, tiredness, difficulty concentrating, shortness of breath, confusion, dizziness, headaches, brittle nails, pale skin, and lightheadedness. Severe anemia, when it goes untreated, can cause heart and other organ failures, and in rare and extreme cases, even death. Although there are many types of anemia, anemias are categorized into three main groups: anemia caused by blood loss, anemia caused by decreased red blood cell production, and anemia caused by the destruction of red blood cells. Anemia through blood loss is usually caused from gastrointestinal bleeding such as ulcers or hemorrhoids, but can also occur from surgery or frequent blood donations. Anemia is also more commonly in females than in males due to menstruation and pregnancy. Anemia due to a lack of red blood cell production or increased red blood cell destruction can be due to abnormal red blood cells or various other conditions or factors including sickle cell anemia, iron and other vitamin deficiencies, poor dieting, bone marrow conditions, organ irregularities, infections, and toxins.

Anemia can be diagnosed through a physical examination and a simple blood test, although diagnosing the type of anemia may require more tests. Treatments vary depending on the severity and kind of the anemia including proper dieting, iron, and vitamin supplements. If the anemia is severe other treatments, including blood transfusions or medications, may be needed. If you or a family member has been diagnosed with anemia, talk to your doctor about the most current treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anemia" for support, advocacy or research.

Logo
Mucolipidosis Type IV (ML4) Foundation

The mission of the Foundation is to fund, promote and support scientific research dedicated to developing treatments and a cure for ML4 by providing critical financial support to researchers; linking individuals with ML4 to researchers for clinical studies; sponsoring symposia and other programs to encourage scientific cooperation, collaboration, and communication among researchers, the medical community, goverment organizations, and the patient community.

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anemia" for support, advocacy or research.

Logo
Mucolipidosis Type IV (ML4) Foundation

The mission of the Foundation is to fund, promote and support scientific research dedicated to developing treatments and a cure for ML4 by providing critical financial support to researchers; linking individuals with ML4 to researchers for clinical studies; sponsoring symposia and other programs to encourage scientific cooperation, collaboration, and communication among researchers, the medical community, goverment organizations, and the patient community.

http://www.ml4.org

Last Updated: 15 Mar 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anemia" returned 5183 free, full-text research articles on human participants. First 3 results:

Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia.
 

Author(s): Neal S Young, Seishi Ogawa

Journal: N. Engl. J. Med.. 2015 Oct;373(17):1675-6.

 

Last Updated: 22 Oct 2015

Go To URL
Avoidance of Blood Transfusion to Patients Suffering From Myocardial Injury and Severe Anemia Is Associated With Increased Long-Term Mortality: A Retrospective Cohort Analysis.
 

Author(s): Irina Barbarova, Robert Klempfner, Avigal Rapoport, Yishay Wasserstrum, Idan Goren, Ana Kats, Gad Segal

Journal: Medicine (Baltimore). 2015 Sep;94(38):e1635.

 

Myocardial injury and anemia are common among patients in internal medicine departments. Nevertheless, the level of anemia in which blood should be given to these patients is ill defined. We conducted a retrospective, cohort analysis. A total of 209 patients hospitalized to internal ...

Last Updated: 25 Sep 2015

Go To URL
Anemia in ST-Elevation Myocardial Infarction Patients with Markers of Inadequate Bone Marrow Response.
 

Author(s): Yaron Arbel, Assi Milwidsky, Ariel Finkelstein, Amir Halkin, Miri Revivo, Shlomo Berliner, Martin Ellis, Itzhak Herz, Gad Keren, Shmuel Banai

Journal: Isr. Med. Assoc. J.. 2015 Aug;17(8):500-4.

 

Anemia confers an adverse prognosis in patients with ST-elevation myocardial infarction (STEMI). Several mechanisms have been implicated in the etiology of anemia in this setting, including inflammation, blood loss, and the presence of comorbidities such as renal failure.

Last Updated: 23 Sep 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anemia" returned 474 free, full-text review articles on human participants. First 3 results:

Management of Iron-Deficiency Anemia in Inflammatory Bowel Disease: A Systematic Review.
 

Author(s): Ole Haagen Nielsen, Mark Ainsworth, Mehmet Coskun, G√ľnter Weiss

Journal: Medicine (Baltimore). 2015 Jun;94(23):e963.

 

Anemia is the most frequent complication of inflammatory bowel disease (IBD), but anemia, mostly due to iron deficiency, has long been neglected in these patients. The aim was to briefly present the pathophysiology, followed by a balanced overview of the different forms of iron replacement ...

Last Updated: 11 Jun 2015

Go To URL
Advances in mechanisms, diagnosis, and treatment of pernicious anemia.
 

Author(s): Cristhiam M Rojas Hernandez, Thein Hlaing Oo

Journal: Discov Med. 2015 Mar;19(104):159-68.

 

Pernicious anemia (PA) is an entity initially described in 1849 as a condition that consisted of pallor, weakness, and progressive health decline. Since then several advances led to the conclusion that PA is an autoimmune disease characterized by the deficient absorption of dietary ...

Last Updated: 1 Apr 2015

Go To URL
Crosstalk between translesion synthesis, Fanconi anemia network, and homologous recombination repair pathways in interstrand DNA crosslink repair and development of chemoresistance.
 

Author(s): Brittany Haynes, Nadia Saadat, Brian Myung, Malathy P V Shekhar

Journal: Mutat Res Rev Mutat Res. ;763():258-66.

 

Bifunctional alkylating and platinum based drugs are chemotherapeutic agents used to treat cancer. These agents induce DNA adducts via formation of intrastrand or interstrand (ICL) DNA crosslinks, and DNA lesions of the ICL type are particularly toxic as they block DNA replication ...

Last Updated: 21 Mar 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Identification of de Novo Fanconi Anemia in Younger Patients With Newly Diagnosed Acute Myeloid Leukemia
 

Status: Recruiting

Condition Summary: Childhood Acute Erythroleukemia (M6); Childhood Acute Megakaryocytic Leukemia (M7); Childhood Acute Minimally Differentiated Myeloid Leukemia (M0); Childhood Acute Monoblastic Leukemia (M5a); Childhood Acute Monocytic Leukemia (M5b); Childhood Acute Myeloblastic Leukemia With Maturation (M2); Childhood Acute Myeloblastic Leukemia Without Maturation (M1); Childhood Acute Myelomonocytic Leukemia (M4); Childhood Myelodysplastic Syndromes; Chronic Myelomonocytic Leukemia; de Novo Myelodysplastic Syndromes; Fanconi Anemia; Refractory Anemia; Refractory Anemia With Excess Blasts; Refractory Anemia With Excess Blasts in Transformation; Refractory Anemia With Ringed Sideroblasts; Secondary Myelodysplastic Syndromes; Untreated Childhood Acute Myeloid Leukemia and Other Myeloid Malignancies

 

Last Updated: 5 Nov 2015

Go to URL
Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
 

Status: Recruiting

Condition Summary: Congenital Hemolytic Anemia; Diamond-Blackfan Anemia

 

Last Updated: 20 Jan 2016

Go to URL
A Pilot, Phase I/II Study of the Amino Acid Leucine in the Treatment of Patients With Transfusion-Dependent Diamond Blackfan Anemia
 

Status: Recruiting

Condition Summary: Diamond Blackfan Anemia; Blackfan Diamond Syndrome; DBA; Congenital Hypoplastic Anemia; Pure Red Cell Aplasia

 

Last Updated: 19 Nov 2015

Go to URL