Macular Dystrophy

Common Name(s)

Macular Dystrophy

Macular dystrophy is a genetic eye disorder that causes vision loss. It causes damage to the area of the eye called the macula, which is responsible for central vision. When the macula is damaged, people have trouble seeing straight ahead. Vision becomes blurry and distorted. However, side (peripheral) vision is not affected. Vision slowly worsens over time. Unfortunately, there is no treatment available for macular dystrophy at this time. However, promising new research is currently being conducted.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular Dystrophy" for support, advocacy or research.

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular Dystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Macular Dystrophy" returned 155 free, full-text research articles on human participants. First 3 results:

Multimodal analysis of the progression of Best vitelliform macular dystrophy.
 

Author(s): Giuseppe Querques, Jennyfer Zerbib, Anouk Georges, Nathalie Massamba, Raimondo Forte, Lea Querques, Jean-Michel Rozet, Josseline Kaplan, Eric H Souied

Journal:

 

To investigate the multimodal morphological features in the different stages of Best vitelliform macular dystrophy (VMD) in subjects harboring mutations in the BEST1 gene, and their changes during the progression of the disease.

Last Updated: 5 May 2014

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Quantitative fundus autofluorescence and optical coherence tomography in best vitelliform macular dystrophy.
 

Author(s): Tobias Duncker, Jonathan P Greenberg, Rithambara Ramachandran, Donald C Hood, R Theodore Smith, Tatsuo Hirose, Russell L Woods, Stephen H Tsang, François C Delori, Janet R Sparrow

Journal:

 

Quantitative fundus autofluorescence (qAF), spectral domain optical coherence tomography (SD-OCT) segmentation, and multimodal imaging were performed to elucidate the pathogenesis of Best vitelliform macular dystrophy (BVMD) and to identify abnormalities in lesion versus nonlesion fundus areas.

Last Updated: 14 Mar 2014

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Comparison of macular choroidal thickness in adult onset foveomacular vitelliform dystrophy and age-related macular degeneration.
 

Author(s): Florence Coscas, Nathalie Puche, Gabriel Coscas, Mayer Srour, Catherine Français, Agnes Glacet-Bernard, Giuseppe Querques, Eric H Souied

Journal:

 

To compare macular choroidal thickness (MCT) in eyes with adult onset foveomacular vitelliform dystrophy (AOFVD) and eyes with AMD.

Last Updated: 6 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Macular Dystrophy" returned 2 free, full-text review articles on human participants. First 3 results:

Macular dystrophy associated with the mitochondrial DNA A3243G mutation: pericentral pigment deposits or atrophy? Report of two cases and review of the literature.
 

Author(s): Alejandra Daruich, Alexandre Matet, François-Xavier Borruat

Journal:

 

The A3243G point mutation in mitochondrial DNA (mtDNA) is associated with MELAS (mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes) and MIDD syndromes (maternally inherited diabetes and deafness). Both MELAS and MIDD patients can present with visual symptoms ...

Last Updated: 17 Jun 2014

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Macular corneal dystrophy. Studies of sulfated glycosaminoglycans in corneal explant and confluent stromal cell cultures.
 

Author(s): G K Klintworth, C F Smith

Journal: Am. J. Pathol.. 1977 Oct;89(1):167-82.

 

The inherited disorder macular corneal dystrophy (MCD), a localized corneal mucopolysaccharidosis, is currently thought to result from an inability to catabolize corneal keratan sulfate (keratan sulfate 1). As studies on isolated cells have provided insight into metabolic abnormalities ...

Last Updated: 30 Nov 1977

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)
 

Status: Recruiting

Condition Summary: Stargardt's Macular Dystrophy; Fundus Flavimaculatus; Juvenile Macular Dystrophy

 

Last Updated: 19 Sep 2014

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Sub-retinal Transplantation of hESC Derived RPE(MA09-hRPE)Cells in Patients With Stargardt's Macular Dystrophy
 

Status: Recruiting

Condition Summary: Stargardt's Macular Dystrophy

 

Last Updated: 3 Nov 2014

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Safety and Tolerability of MA09-hRPE Cells in Patients With Stargardt's Macular Dystrophy(SMD)
 

Status: Recruiting

Condition Summary: Stargardt's Macular Dystrophy

 

Last Updated: 22 Oct 2012

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