Macular Degeneration

Common Name(s)

Macular Degeneration

Age-related macular degeneration (AMD) is an eye condition characterized by progressive destruction of the macula. The macula is located in the retina in the eye and enables one to see fine details and perform tasks that require central vision, such as reading and driving. Signs and symptoms include vision loss, which usually becomes noticeable in a person's sixties or seventies and tends to worsen over time. There are 2 major types of AMD, known as the dry form and the wet form. The dry form accounts for up to 90% of cases and is characterized by slowly progressive vision loss. The wet form is associated with severe vision loss that can worsen rapidly. AMD is caused by a combination of genetic and environmental factors, some of which have been identified. Increasing age is the most important non-genetic risk factor. The condition appears to run in families in some cases. While there is currently no cure for AMD, there are therapies available to help slow the progression of the condition.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular Degeneration" for support, advocacy or research.

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Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 3 Oct 2013

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

Last Updated: 3 Jan 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular Degeneration" for support, advocacy or research.

Logo
Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 3 Oct 2013

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

http://www.mdsupport.org

Last Updated: 3 Jan 2013

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General Support Organizations

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General Resources

Resource links directories

Links to organizations, agencies, hospitals, and commercial distributors of low vision products and services.

Updated 3 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Macular Degeneration" returned 1309 free, full-text research articles on human participants. First 3 results:

Early signs of exudative age-related macular degeneration in Asians.
 

Author(s): Mariko Sasaki, Ryo Kawasaki, Atsuro Uchida, Takashi Koto, Hajime Shinoda, Kazuo Tsubota, Tien Yin Wong, Yoko Ozawa

Journal: Optom Vis Sci. 2014 Aug;91(8):849-53.

 

To investigate the relationship between the early signs of age-related macular degeneration (AMD) and the risk of developing exudative AMD (typical AMD or polypoidal choroidal vasculopathy [PCV]) in the fellow eye of Japanese patients with unilateral exudative AMD, focusing particularly ...

Last Updated: 25 Jul 2014

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Sustained visual acuity loss in the comparison of age-related macular degeneration treatments trials.
 

Author(s): Gui-shuang Ying, Benjamin J Kim, Maureen G Maguire, Jiayan Huang, Ebenezer Daniel, Glenn J Jaffe, Juan E Grunwald, Kevin J Blinder, Christina J Flaxel, Firas Rahhal, Carl Regillo, Daniel F Martin,

Journal: JAMA Ophthalmol. 2014 Aug;132(8):915-21.

 

Although anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration (AMD) results in improved vision overall, loss of substantial vision can occur. Understanding the processes that lead to loss of vision may lead to preventive strategies.

Last Updated: 15 Aug 2014

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A single-arm, investigator-initiated study of the efficacy, safety and tolerability of intravitreal aflibercept injection in subjects with exudative age-related macular degeneration, previously treated with ranibizumab or bevacizumab: 6-month interim analysis.
 

Author(s): Rishi P Singh, Sunil Srivastava, Justis P Ehlers, Rumneek Bedi, Andrew P Schachat, Peter K Kaiser

Journal: Br J Ophthalmol. 2014 Jun;98 Suppl 1():i22-27.

 

To evaluate efficacy and safety of intravitreal aflibercept injection (IAI) in subjects who were previously treated with ranibizumab and/or bevacizumab for active exudative age-related macular degeneration (AMD).

Last Updated: 19 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Macular Degeneration" returned 165 free, full-text review articles on human participants. First 3 results:

Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration.
 

Author(s): Chi-Chao Chan, Daniel Ardeljan

Journal: Adv. Exp. Med. Biol.. 2014 ;801():193-8.

 

The pathology of age-related macular degeneration (AMD) is characterized by degeneration of photoreceptors and retinal pigment epithelial cells as well as by changes of choroidal capillaries in the macula. Although AMD is not a typical uveitis, there is a consistence and an imbalance ...

Last Updated: 25 Mar 2014

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Age-related macular degeneration: beyond anti-angiogenesis.
 

Author(s): David L Kent

Journal:

 

Recently, anti-vascular endothelial growth factor therapies for neovascular age-related macular degeneration have been developed. These agents, originally developed for their anti-angiogenic mechanism of action, probably also work through an anti-permeability effect in preventing ...

Last Updated: 15 Jan 2014

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Mechanism of inflammation in age-related macular degeneration: an up-to-date on genetic landmarks.
 

Author(s): Francesco Parmeggiani, Francesco S Sorrentino, Mario R Romano, Ciro Costagliola, Francesco Semeraro, Carlo Incorvaia, Sergio D'Angelo, Paolo Perri, Katia De Nadai, Elia Bonomo Roversi, Paola Franceschelli, Adolfo Sebastiani, Michele Rubini

Journal: Mediators Inflamm.. 2013 ;2013():435607.

 

Age-related macular degeneration (AMD) is the most common cause of irreversible visual impairment among people over 50 years of age, accounting for up to 50% of all cases of legal blindness in Western countries. Although the aging represents the main determinant of AMD, it must be ...

Last Updated: 26 Dec 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
 

Status: Recruiting

Condition Summary: Age-Related Macular Degeneration; Wet Macular Degeneration; Macular Degeneration; Eye Diseases; Retinal Diseases

 

Last Updated: 24 Apr 2013

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Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt's Macular Dystrophy (SMD)
 

Status: Recruiting

Condition Summary: Stargardt's Macular Dystrophy; Fundus Flavimaculatus; Juvenile Macular Dystrophy

 

Last Updated: 19 Sep 2014

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OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
 

Status: Recruiting

Condition Summary: Wet Macular Degeneration

 

Last Updated: 6 Mar 2014

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