Macular degeneration

Common Name(s)

Macular degeneration

Age-Related Macular Degeneration (AMD) is a common eye condition which causes vision loss that gets worse over time (progressive). The disorder causes damage to the macula, which is the center of the back of the eye (retina). This area helps a person see fine details and perform tasks, such as reading and driving (sharp central vision). AMD is the leading cause of vision loss in adults.

Vision loss caused by AMD usually only affects the center of the eye, allowing affected people to recognize objects on the edges of their vision (peripheral vision). Some cases of AMD cause total blindness. The progression of the disease is painless, making it difficult for affected people to notice that their vision is getting worse until the vision loss is severe. There are 2 major types of AMD: wet AMD and dry AMD. 90% of all cases of AMD are "dry," resulting in slow and gradual vision loss, while the wet form can cause severe and rapid vision loss. Additional information about each form is available in separate description entries.

The cause of AMD is still unclear. Age and genetics are the two most significant risk factors. AMD is usually found in adults over 55 and the risk increases with age. Females are more likely to develop the condition. Smoking also significantly increases the chances of developing the disorder. AMD is usually diagnosed by an eye doctor (ophthalmologist) who uses both a routine eye exam and special eye tests, such as optical coherence tomography (OCT), to look at images of the retina. There is no cure for AMD, but good nutrition and protection from UV rays can help slow or prevent symptoms. If you or a loved one has been diagnosed with AMD, talk with a doctor about current treatment options. Support groups can provide additional information and connect you with other families affected by AMD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

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Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

Last Updated: 15 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

Logo
Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

http://www.mdsupport.org

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

http://www.ropard.org

Last Updated: 15 May 2015

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General Support Organizations

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General Resources

Resource links directories

Links to organizations, agencies, hospitals, and commercial distributors of low vision products and services.

Updated 3 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Macular degeneration" returned 1393 free, full-text research articles on human participants. First 3 results:

The effect of normal aging and age-related macular degeneration on perceptual learning.
 

Author(s): Andrew T Astle, Alan J Blighe, Ben S Webb, Paul V McGraw

Journal: J Vis. 2015 ;15(10):16.

 

We investigated whether perceptual learning could be used to improve peripheral word identification speed. The relationship between the magnitude of learning and age was established in normal participants to determine whether perceptual learning effects are age invariant. We then ...

Last Updated: 26 Nov 2015

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A review of "approach of Turkish ophthalmologists to micronutrition in age-related macular degeneration".
 

Author(s): Yakup Aksoy, Mehmet Koray Sevinc

Journal: Arq Bras Oftalmol. ;78(3):202.

 

Last Updated: 30 Jul 2015

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Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.
 

Author(s): Ling Shen, Thomas J Hoffmann, Ronald B Melles, Lori C Sakoda, Mark N Kvale, Yambazi Banda, Catherine Schaefer, Neil Risch, Eric Jorgenson

Journal: Invest. Ophthalmol. Vis. Sci.. 2015 Jul;56(8):4290-9.

 

We compared across age-related macular degeneration (AMD) subtypes the effect of AMD risk variants, their predictive power, and heritability.

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Macular degeneration" returned 217 free, full-text review articles on human participants. First 3 results:

Parainflammation, chronic inflammation, and age-related macular degeneration.
 

Author(s): Mei Chen, Heping Xu

Journal: J. Leukoc. Biol.. 2015 Nov;98(5):713-25.

 

Inflammation is an adaptive response of the immune system to noxious insults to maintain homeostasis and restore functionality. The retina is considered an immune-privileged tissue as a result of its unique anatomic and physiologic properties. During aging, the retina suffers from ...

Last Updated: 3 Nov 2015

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Profile of conbercept in the treatment of neovascular age-related macular degeneration.
 

Author(s): Xinmin Lu, Xiaodong Sun

Journal:

 

In developed countries, age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over the age of 65 years. Vascular endothelial growth factor (VEGF) plays a vital role in the formation of neovascular AMD. VEGF regulates angiogenesis, enhances ...

Last Updated: 11 May 2015

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Anti-VEGF therapies in the treatment of choroidal neovascularisation secondary to non-age-related macular degeneration: a systematic review.
 

Author(s): Arabella Stuart, John A Ford, Susan Duckworth, Colin Jones, Augustine Pereira

Journal:

 

The aim of this study is to systematically review the evidence for anti-vascular endothelial growth factor (VEGF) therapy in choroidal neovascularisation secondary to conditions other than age-related macular degeneration.

Last Updated: 5 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
 

Status: Recruiting

Condition Summary: Age-Related Macular Degeneration; Wet Macular Degeneration; Macular Degeneration; Eye Diseases; Retinal Diseases

 

Last Updated: 24 Apr 2013

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OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
 

Status: Recruiting

Condition Summary: Wet Macular Degeneration

 

Last Updated: 7 Apr 2015

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Sub-tenon Triamcinolone Acetonide in Age-Related Macular Degeneration as Adjunct to Ranibizumab
 

Status: Recruiting

Condition Summary: Wet Macular Degeneration

 

Last Updated: 8 Feb 2011

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