Macular degeneration

Common Name(s)

Macular degeneration

Age-Related Macular Degeneration (AMD) is a common eye condition which causes vision loss that gets worse over time (progressive). The disorder causes damage to the macula, which is the center of the back of the eye (retina). This area helps a person see fine details and perform tasks, such as reading and driving (sharp central vision). AMD is the leading cause of vision loss in adults.

Vision loss caused by AMD usually only affects the center of the eye, allowing affected people to recognize objects on the edges of their vision (peripheral vision). Some cases of AMD cause total blindness. The progression of the disease is painless, making it difficult for affected people to notice that their vision is getting worse until the vision loss is severe. There are 2 major types of AMD: wet AMD and dry AMD. 90% of all cases of AMD are "dry," resulting in slow and gradual vision loss, while the wet form can cause severe and rapid vision loss. Additional information about each form is available in separate description entries.

The cause of AMD is still unclear. Age and genetics are the two most significant risk factors. AMD is usually found in adults over 55 and the risk increases with age. Females are more likely to develop the condition. Smoking also significantly increases the chances of developing the disorder. AMD is usually diagnosed by an eye doctor (ophthalmologist) who uses both a routine eye exam and special eye tests, such as optical coherence tomography (OCT), to look at images of the retina. There is no cure for AMD, but good nutrition and protection from UV rays can help slow or prevent symptoms. If you or a loved one has been diagnosed with AMD, talk with a doctor about current treatment options. Support groups can provide additional information and connect you with other families affected by AMD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

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Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

Last Updated: 15 May 2015

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

Logo
Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

http://www.mdsupport.org

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

http://www.ropard.org

Last Updated: 15 May 2015

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General Support Organizations

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General Resources

Resource links directories

Links to organizations, agencies, hospitals, and commercial distributors of low vision products and services.

Updated 3 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Macular degeneration" returned 1489 free, full-text research articles on human participants. First 3 results:

Lamellar Macular Holes Associated with End-Stage Exudative Age-Related Macular Degeneration.
 

Author(s): Ori Segal, Joseph R Ferencz, Michael Mimouni, Ronit Nesher, Perri Cohen, Arie Y Nemet

Journal: Isr. Med. Assoc. J.. 2015 Dec;17(12):750-4.

 

Reports of lamellar macular holes (LMHs) with underlying age-related macular degeneration (AMD) are rare, and the specific definition, pathogenesis and surgical recommendations for this macular condition remain unclear.

Last Updated: 22 Feb 2016

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[Optical coherence tomography angiography in the diagnosis of neovascular age-related macular degeneration].
 

Author(s): T B Shaimov, I E Panova, R B Shaimov, V A Shaimova, T A Shaimova, A V Fomin

Journal: Vestn Oftalmol. ;131(5):4-12.

 

to determine optical coherence tomography (OCT) angiography signs of classic and occult choroidal neovascularization (CNV) in patients with age-related macular degeneration (AMD) and evaluate their information value in monitoring the effect of anti-VEGF therapy.

Last Updated: 5 Feb 2016

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[Diagnostic approach of macular degeneration with "spectral-domain" OCT: clinical case].
 

Author(s): Aziz El Ouafi, Med El Mellaoui, Abdelkader Laktaoui

Journal:

 

Last Updated: 2 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Macular degeneration" returned 234 free, full-text review articles on human participants. First 3 results:

The Dry Form of Age-Related Macular Degeneration (AMD): The Current Concepts of Pathogenesis and Prospects for Treatment.
 

Author(s): Hanna M Zając-Pytrus, Agnieszka Pilecka, Anna Turno-Kręcicka, Joanna Adamiec-Mroczek, Marta Misiuk-Hojło

Journal: Adv Clin Exp Med. ;24(6):1099-104.

 

Age-related macular degeneration (AMD) is a disease that causes varying degrees of blindness, which afflicts millions of adults in their later years. Preliminary changes occur during normal aging, but in some individuals the pathology leads to the development of AMD. The pathology ...

Last Updated: 16 Jan 2016

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Age-Related Macular Degeneration and Incident Stroke: A Systematic Review and Meta-Analysis.
 

Author(s): Antonio B Fernandez, Gregory A Panza, Benjamin Cramer, Saurav Chatterjee, Ramya Jayaraman, Wen-Chih Wu

Journal:

 

Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness in people over 65 years old in the United States and has been associated with cardiovascular risk and decreased survival. There is conflicting data, however, regarding the contribution of AMD ...

Last Updated: 20 Nov 2015

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Treatment of Exudative Age-related Macular Degeneration: Focus on Aflibercept.
 

Author(s): Alfredo García-Layana, Marta S Figueroa, Javier Araiz, José M Ruiz-Moreno, Francisco Gómez-Ulla, Luis Arias-Barquet, Nicholas Reiter

Journal: Drugs Aging. 2015 Oct;32(10):797-807.

 

A formulation of aflibercept for intravitreal injection (Eylea) is approved for the treatment of patients with exudative age-related macular degeneration (AMD). Aflibercept has a significantly higher affinity for Vascular endothelial growth factor (VEGF)-A compared with other monoclonal ...

Last Updated: 16 Oct 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

An Open-label Study to Evaluate the Clinical and Economic Benefits of I-Ray in Patients With Choroidal Neovascularization Secondary to Age-related Macular Degeneration
 

Status: Recruiting

Condition Summary: Age-Related Macular Degeneration; Wet Macular Degeneration; Macular Degeneration; Eye Diseases; Retinal Diseases

 

Last Updated: 24 Apr 2013

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Last Updated: 20 Apr 2016

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OZURDEX in Age Related Macular Degeneration as Adjunct to Ranibizumab
 

Status: Recruiting

Condition Summary: Wet Macular Degeneration

 

Last Updated: 7 Apr 2015

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