Macular degeneration

Common Name(s)

Macular degeneration

Age-Related Macular Degeneration (AMD) is a common eye condition which causes vision loss that gets worse over time (progressive). The disorder causes damage to the macula, which is the center of the back of the eye (retina). This area helps a person see fine details and perform tasks, such as reading and driving (sharp central vision). AMD is the leading cause of vision loss in adults.

Vision loss caused by AMD usually only affects the center of the eye, allowing affected people to recognize objects on the edges of their vision (peripheral vision). Some cases of AMD cause total blindness. The progression of the disease is painless, making it difficult for affected people to notice that their vision is getting worse until the vision loss is severe. There are 2 major types of AMD: wet AMD and dry AMD. 90% of all cases of AMD are "dry," resulting in slow and gradual vision loss, while the wet form can cause severe and rapid vision loss. Additional information about each form is available in separate description entries.

The cause of AMD is still unclear. Age and genetics are the two most significant risk factors. AMD is usually found in adults over 55 and the risk increases with age. Females are more likely to develop the condition. Smoking also significantly increases the chances of developing the disorder. AMD is usually diagnosed by an eye doctor (ophthalmologist) who uses both a routine eye exam and special eye tests, such as optical coherence tomography (OCT), to look at images of the retina. There is no cure for AMD, but good nutrition and protection from UV rays can help slow or prevent symptoms. If you or a loved one has been diagnosed with AMD, talk with a doctor about current treatment options. Support groups can provide additional information and connect you with other families affected by AMD.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

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Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

Last Updated: 15 May 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Macular degeneration" for support, advocacy or research.

Logo
Association for Macular Diseases, Inc.

The Association for Macular Diseases, Inc. acts as a nationwide support group for individuals and their families endeavoring to adjust to the restrictions and changes brought about by macular disease.

Last Updated: 2 Jun 2010

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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Macular Degeneration Support

The mission of MD Support is to provide information, support and advocacy for people affected by macular degeneration and similar diseases of the retina leading to central vision loss.

http://www.mdsupport.org

Last Updated: 3 Jan 2013

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Vision Research ROPARD Foundation

The Mission of the Vision Research ROPARD Foundation is to support research, programs and services designed to prevent, treat and/or provide adaptive resources to patients of all ages and their family members affected by vision threatening retinal disease. We carry out this mission through clinically relevant research, educational programs for patients, family members and general public, physician educational programs, and community support programs; such as, the Children’s Low Vision Resource Center.

http://www.ropard.org

Last Updated: 15 May 2015

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General Support Organizations

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General Resources

Resource links directories

Links to organizations, agencies, hospitals, and commercial distributors of low vision products and services.

Updated 3 Jan 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Macular degeneration" returned 1941 free, full-text research articles on human participants. First 3 results:

Quantitative proteomic analysis of aqueous humor from patients with drusen and reticular pseudodrusen in age-related macular degeneration.
 

Author(s): Je-Hyun Baek, Daehan Lim, Kyu Hyung Park, Jae-Byoung Chae, Hyoik Jang, Jonghyun Lee, Hyewon Chung

Journal:

 

To identify novel biomarkers related to the pathogenesis of dry age-related macular degeneration (AMD), we adopted a human retinal pigment epithelial (RPE) cell culture model that mimics some features of dry AMD including the accumulation of intra- and sub-RPE deposits. Then, we investigated ...

Last Updated: 31 Dec 1969

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Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis.
 

Author(s): Jun Zhang, Shuang Li, Shuqiong Hu, Jiguo Yu, Yi Xiang

Journal:

 

The purpose of this study is to discuss whether genetic variants (rs2230199, rs1047286, rs2230205, and rs2250656) in the C3 gene account for a significant risk of advanced AMD.

Last Updated: 31 Dec 1969

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Retinal pigment epithelium hyperplasia overlying pigment epithelial detachment in age-related macular degeneration can masquerade as neovascularization on optical coherence tomography angiography.
 

Author(s): Ling Chen, Xiongze Zhang, Yuhong Gan, Bing Liu, Yuxin Zhang, Feng Wen

Journal: Graefes Arch. Clin. Exp. Ophthalmol.. 2018 Dec;256(12):2283-2291.

 

To report the image artifacts due to retinal pigment epithelium (RPE) hyperplasia overlying retinal pigment epithelial detachment (PED) in age-related macular degeneration (AMD), which can masquerade as neovascularization on optical coherence tomography angiography (OCTA).

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Macular degeneration" returned 355 free, full-text review articles on human participants. First 3 results:

Conbercept for patients with age-related macular degeneration: a systematic review.
 

Author(s): Jiaxing Zhang, Yi Liang, Juan Xie, Dong Li, Qian Hu, Xiaosi Li, Wenyi Zheng, Rui He

Journal:

 

Conbercept is a novel vascular endothelial growth factor (VEGF) inhibitor for the treatment of wet age-related macular degeneration (AMD). This systematic review aims to assess the efficacy and safety of conbercept in the treatment of wet AMD.

Last Updated: 31 Dec 1969

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Therapeutic effects of various therapeutic strategies on non-exudative age-related macular degeneration: A PRISMA-compliant network meta-analysis of randomized controlled trials.
 

Author(s): Yanli Wei, Hongxia Liao, Jian Ye

Journal: Medicine (Baltimore). 2018 May;97(21):e10422.

 

Age-related macular degeneration (AMD) is a chronic progressive central retinal disease. Geographic atrophy (GA) is a late stage of dry AMD (DAMD) and is a slowly but inexorably progressive disease that causes irreversible blindness over time. We aimed to assess various therapeutic ...

Last Updated: 31 Dec 1969

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Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration.
 

Author(s): Laura Lorés-Motta, Eiko K de Jong, Anneke I den Hollander

Journal: Mol Diagn Ther. 2018 06;22(3):315-343.

 

Precision medicine aims to improve patient care by adjusting medication to each patient's individual needs. Age-related macular degeneration (AMD) is a heterogeneous eye disease in which several pathways are involved, and the risk factors driving the disease differ per patient. As ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Age-Related Macular Degeneration, Scotopic Dysfunction, and Driving Performance in a Simulator
 

Status: Recruiting

Condition Summary: Age-related Macular Degeneration

 

Last Updated: 16 Sep 2018

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Two-week Retreatment Interval Study for Treated Age-related Macular Degeneration Refractory to Monthly Aflibercept
 

Status: Not yet recruiting

Condition Summary: Neovascular Age-related Macular Degeneration

 

Last Updated: 18 Apr 2018

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