Lymphatic filariasis

Common Name(s)

Lymphatic filariasis

Lymphatic filariasis is a parasitic disease caused by microscopic, thread-like worms that only live in the human lymph system, which maintains the body's fluid balance and fights infections. It is spread from person to person by mosquitoes. Most infected people are asymptomatic and never develop clinical symptoms. A small percentage of people develop lymphedema, which may affect the legs, arms, breasts, and genitalia; bacterial infections that cause hardening and thickening of the skin, called elephantiasis; hydrocele (swelling of the scrotum) in men; and pulmonary tropical eosinophilia syndrome. Treatment may include a yearly dose of medicine, called diethylcarbamazine (DEC); while this drug does not kill all of the adult worms, it prevents infected people from giving the disease to someone else.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphatic filariasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphatic filariasis" returned 234 free, full-text research articles on human participants. First 3 results:

Lymphatic filariasis in Luangwa District, South-East Zambia.
 

Author(s): Sheila Tamara Shawa, Enala T Mwase, Erling M Pedersen, Paul E Simonsen

Journal:

 

Past case reports and recent data from LF mapping surveys indicate that LF occurs in Zambia, but no studies have been carried out to document its epidemiology and health implications. The present study assessed infection, disease, transmission and human perception aspects of LF in ...

Last Updated: 6 Feb 2014

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Transmission assessment surveys (TAS) to define endpoints for lymphatic filariasis mass drug administration: a multicenter evaluation.
 

Author(s): Brian K Chu, Michael Deming, Nana-Kwadwo Biritwum, Windtaré R Bougma, Améyo M Dorkenoo, Maged El-Setouhy, Peter U Fischer, Katherine Gass, Manuel Gonzalez de Peña, Leda Mercado-Hernandez, Dominique Kyelem, Patrick J Lammie, Rebecca M Flueckiger, Upendo J Mwingira, Rahmah Noordin, Irene Offei Owusu, Eric A Ottesen, Alexandre Pavluck, Nils Pilotte, Ramakrishna U Rao, Dilhani Samarasekera, Mark A Schmaedick, Sunil Settinayake, Paul E Simonsen, Taniawati Supali, Fasihah Taleo, Melissa Torres, Gary J Weil, Kimberly Y Won

Journal:

 

Lymphatic filariasis (LF) is targeted for global elimination through treatment of entire at-risk populations with repeated annual mass drug administration (MDA). Essential for program success is defining and confirming the appropriate endpoint for MDA when transmission is presumed ...

Last Updated: 16 Dec 2013

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Urban lymphatic filariasis in the metropolis of Dar es Salaam, Tanzania.
 

Author(s): Mbutolwe E Mwakitalu, Mwelecele N Malecela, Erling M Pedersen, Franklin W Mosha, Paul E Simonsen

Journal:

 

The last decades have seen a considerable increase in urbanization in Sub-Saharan Africa, and it is estimated that over 50% of the population will live in urban areas by 2040. Rapid growth of cities combined with limited economic resources often result in informal settlements and ...

Last Updated: 17 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphatic filariasis" returned 22 free, full-text review articles on human participants. First 3 results:

A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis.
 

Author(s): Alison Krentel, Peter U Fischer, Gary J Weil

Journal:

 

The success of programs to eliminate lymphatic filariasis (LF) depends in large part on their ability to achieve and sustain high levels of compliance with mass drug administration (MDA). This paper reports results from a comprehensive review of factors that affect compliance with MDA.

Last Updated: 26 Nov 2013

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Insights into the pathogenesis of disease in human lymphatic filariasis.
 

Author(s): Thomas B Nutman

Journal: Lymphat Res Biol. 2013 Sep;11(3):144-8.

 

Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, ...

Last Updated: 18 Sep 2013

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Last Updated: 6 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 11 Aug 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Soil Transmitted Helminth Infections

 

Last Updated: 18 Jul 2013

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 30 Apr 2014

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