Lymphatic filariasis

Common Name(s)

Lymphatic filariasis

Lymphatic filariasis is a parasitic disease caused by microscopic, thread-like worms that only live in the human lymph system, which maintains the body's fluid balance and fights infections. It is spread from person to person by mosquitoes. Most infected people are asymptomatic and never develop clinical symptoms. A small percentage of people develop lymphedema, which may affect the legs, arms, breasts, and genitalia; bacterial infections that cause hardening and thickening of the skin, called elephantiasis; hydrocele (swelling of the scrotum) in men; and pulmonary tropical eosinophilia syndrome. Treatment may include a yearly dose of medicine, called diethylcarbamazine (DEC); while this drug does not kill all of the adult worms, it prevents infected people from giving the disease to someone else.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphatic filariasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphatic filariasis" returned 259 free, full-text research articles on human participants. First 3 results:

Are we nearly there yet? Coverage and compliance of mass drug administration for lymphatic filariasis elimination.
 

Author(s): Neal D E Alexander

Journal: Trans. R. Soc. Trop. Med. Hyg.. 2015 Mar;109(3):173-4.

 

Lymphatic filariasis has been targeted for elimination by 2020, and a threshold of 65% coverage of mass drug administration (MDA) has been adopted by the Global Programme to Eliminate Lymphatic Filariasis (GPELF). A recent review by Babu and Babu of 36 studies of MDA for lymphatic ...

Last Updated: 10 Feb 2015

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Factors associated with the performance and cost-effectiveness of using lymphatic filariasis transmission assessment surveys for monitoring soil-transmitted helminths: a case study in Kenya.
 

Author(s): Jennifer L Smith, Hugh J W Sturrock, Liya Assefa, Birgit Nikolay, Sammy M Njenga, Jimmy Kihara, Charles S Mwandawiro, Simon J Brooker

Journal: Am. J. Trop. Med. Hyg.. 2015 Feb;92(2):342-53.

 

Transmission assessment surveys (TAS) for lymphatic filariasis have been proposed as a platform to assess the impact of mass drug administration (MDA) on soil-transmitted helminths (STHs). This study used computer simulation and field data from pre- and post-MDA settings across Kenya ...

Last Updated: 5 Feb 2015

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Hydrocele fluid: can it be used for immunodiagnosis of lymphatic filariasis?
 

Author(s): S Mishra, K G Achary, N N Mandal, A Tripathy, S K Kar, M S Bal

Journal: J Vector Borne Dis. 2014 Sep;51(3):188-93.

 

Diagnosis of lymphatic filariasis using serum has been established but the utility of hydrocele fluid for the purpose is not exactly known. Since, hydrocele is a chronic form of the disease manifestation in a variety of situations and often poses difficulty in diagnosing its origin, ...

Last Updated: 25 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphatic filariasis" returned 23 free, full-text review articles on human participants. First 3 results:

A review of factors that influence individual compliance with mass drug administration for elimination of lymphatic filariasis.
 

Author(s): Alison Krentel, Peter U Fischer, Gary J Weil

Journal:

 

The success of programs to eliminate lymphatic filariasis (LF) depends in large part on their ability to achieve and sustain high levels of compliance with mass drug administration (MDA). This paper reports results from a comprehensive review of factors that affect compliance with MDA.

Last Updated: 26 Nov 2013

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Drug targets for lymphatic filariasis: a bioinformatics approach.
 

Author(s): Om Prakash Sharma, Yellamandaya Vadlamudi, Arun Gupta Kota, Vikrant Kumar Sinha, Muthuvel Suresh Kumar

Journal: J Vector Borne Dis. 2013 Sep;50(3):155-62.

 

This review article discusses the current scenario of the national and international burden due to lymphatic filariasis (LF) and describes the active elimination programmes for LF and their achievements to eradicate this most debilitating disease from the earth. Since, bioinformatics ...

Last Updated: 13 Nov 2013

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Insights into the pathogenesis of disease in human lymphatic filariasis.
 

Author(s): Thomas B Nutman

Journal: Lymphat Res Biol. 2013 Sep;11(3):144-8.

 

Although two thirds of the 120 million people infected with lymph-dwelling filarial parasites have subclinical infections, ∼40 million have lymphedema and/or other pathologic manifestations including hydroceles (and other forms of urogenital disease), episodic adenolymphangitis, ...

Last Updated: 18 Sep 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Mass Drug Administration for Lymphatic Filariasis and Onchocerciasis for Liberia
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 11 Aug 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Soil Transmitted Helminth Infections

 

Last Updated: 8 Dec 2014

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Optimization of Mass Drug Administration With Existing Drug Regimens for Lymphatic Filariasis and Onchocerciasis for Ivory Coast (DOLF-Ivory Coast)
 

Status: Recruiting

Condition Summary: Lymphatic Filariasis; Onchocerciasis; Soil Transmitted Helminth (STH) Infections

 

Last Updated: 8 Dec 2014

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