Lymphangioma

Common Name(s)

Lymphangioma

Lymphangioma is a benign (non-cancerous) mass made of fluid-filled spaces, which is thought to occur due to abnormal development of the lymphatic system. They are always present at birth, although they may change and become more apparent over time. Lymphangiomas are most commonly found in the head and neck region, but can affect almost any part of the body (except the brain). Some may appear as a tiny blue or red spot while others are massive and affect an entire limb (arm or leg). The signs and symptoms vary depending on the size and location of the mass; however, lymphangiomas can disfigure affected areas and potentially disrupt the function of nearby organs or tissues regardless of size. The exact underlying cause is unknown. Treatment options vary based on the signs and symptoms present in each person but may include surgery.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphangioma" for support, advocacy or research.

Lymphangiomatosis & Gorham's Disease Alliance

Our mission is to improve the care of patients through our patient support programs, and by raising funds to support research that will identify effective treatments and cures. We strive to educate patients and families, and the medical and scientific communities, by providing important, relevant information, and by being the leading advocate for the worldwide member-community.

Last Updated: 5 Nov 2012

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Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

Last Updated: 14 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lymphangioma" for support, advocacy or research.

Lymphangiomatosis & Gorham's Disease Alliance

Our mission is to improve the care of patients through our patient support programs, and by raising funds to support research that will identify effective treatments and cures. We strive to educate patients and families, and the medical and scientific communities, by providing important, relevant information, and by being the leading advocate for the worldwide member-community.

http://www.lgdalliance.org/

Last Updated: 5 Nov 2012

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Lymphatic Education & Research Network

Our Mission is to fight lymphatic disease and lymphedema through education, research and advocacy. We seek to accelerate the prevention, treatment and cure of the disease while bringing patients and medical professionals together to address the unmet needs surrounding lymphatic disorders.

http://www.lymphaticnetwork.org

Last Updated: 14 May 2014

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General Support Organizations

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General Resources

Lymphatic Malformation Research

The LGDA is closely affiliated with the Lymphatic Malformation Institute (LMI). The LMI receives requests for research projects into lymphatic diseases including lymphangiomatosis and Gorham's disease.

Updated 3 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lymphangioma" returned 246 free, full-text research articles on human participants. First 3 results:

Abdominal cystic lymphangioma in a term newborn: A case report and update of new treatments.
 

Author(s): Ilaria Amodeo, Giacomo Cavallaro, Genny Raffaeli, Lorenzo Colombo, Monica Fumagalli, Riccardo Cavalli, Ernesto Leva, Fabio Mosca

Journal: Medicine (Baltimore). 2017 Feb;96(8):e5984.

 

Lymphatic malformations are benign anomalies derived from the abnormal development of lymphatic channels. Usually asymptomatic, they can cause compression on adjacent structures or present acute complications (bleeding or infection). Small asymptomatic lesions can be conservatively ...

Last Updated: 22 Feb 2017

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[Cystic lymphangioma on the floor of the oral cavity extending to the submandibular region in adult patients].
 

Author(s): Elboukhari Ali, Nador Karim, Attifi Hicham, Zalagh Mohamed

Journal:

 

Cystic lymphangiomas are congenital benign lesions occurring predominantly in the head and neck area, especially in the posterior cervical triangle. These malformations involving the lymphatic vessels are frequently diagnosed in children. We report the clinical case of a 28-year-old ...

Last Updated: 31 Oct 2016

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A 36-Year-Old Female with Recurrent Left Sided Pleural Effusion: A Rare Case of Mediastinal Lymphangioma.
 

Author(s): Rajesh N Swarnakar, Jetendra D Hazarey, Chetan Dhoble, Bhavesh Vaghani, Alaine S Ainsley, James F Khargie, Lorena Likaj

Journal:

 

BACKGROUND Lymphangioma is an atypical non-malignant, lymphatic lesion that is congenital in origin. Lymphangioma is most frequently observed in the head and neck, but can occur at any location in the body. About 65% of lymphangiomas are apparent at birth, while 80-90% are diagnosed ...

Last Updated: 28 Oct 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lymphangioma" returned 30 free, full-text review articles on human participants. First 3 results:

[Cervicothoracic cystic lymphangioma: about a case].
 

Author(s): Karim Nadour, Mountassir Moujahid

Journal:

 

Cervicothoracic cystic lymphangiomas are rare benign tumors developing from sequestration of embryonic lymph sac which is gradually filled with lymph fluid. The diagnosis is based on clinical signs (laterocervical swelling) and imaging (ultrasound and CT scan), then confirmed by histology ...

Last Updated: 15 Mar 2017

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[Retroperitoneal cystic lymphangioma: about 5 cases and review of the literature].
 

Author(s): Ahmed Saadi, Haroun Ayed, Omar Karray, Walid Kerkeni, Abderrazak Bouzouita, Mohamed Cherif, Riadh Ben Slama, Amine Derouiche, Mohamed Chebil

Journal:

 

Cystic lymphangioma is a rare, benign malformation of the lymphatic vessels which may be observed on various locations. Retroperitoneal location is less common than mesenteric location. Cystic lymphangioma has a polymorphic clinical presentation. Diagnosis is based on imaging but ...

Last Updated: 15 Mar 2017

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Laparoscopic resection of retroperitoneal lymphangioma around the pancreas: a case report and review of the literature.
 

Author(s): Takafumi Sato, Yoichi Matsuo, Kazuyoshi Shiga, Kenta Saito, Mamoru Morimoto, Hirotaka Miyai, Hiromitsu Takeyama

Journal:

 

Lymphangiomas are rare, benign tumors. An intra-abdominal location of these lesions is rarer still and there are only a few reports describing laparoscopic resection for retroperitoneal lymphangiomas, especially in tumors that mimic pancreatic tumors.

Last Updated: 15 Dec 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Sildenafil for the Treatment of Lymphatic Malformations
 

Status: Recruiting

Condition Summary: Lymphatic Malformations; Lymphatic Diseases

 

Last Updated: 9 May 2017

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Lymphatic Anomalies Registry
 

Status: Recruiting

Condition Summary: Lymphatic Malformation; Generalized Lymphatic Anomaly (GLA); Central Conducting Lymphatic Anomaly; CLOVES Syndrome; Gorham-Stout Disease ("Disappearing Bone Disease"); Blue Rubber Bleb Nevus Syndrome; Kaposiform Lymphangiomatosis; Kaposiform Hemangioendothelioma/Tufted Angioma; Klippel-Trenaunay Syndrome; Lymphangiomatosis

 

Last Updated: 26 Jul 2016

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Registry for Vascular Anomalies Associated With Coagulopathy
 

Status: Recruiting

Condition Summary: Multifocal Lymphangioendotheliomatosis With Thrombocytopenia; Cutaneovisceral Angiomatosis With Thrombocytopenia; Vascular Anomaly With Thrombocytopenia; Hemangiomas

 

Last Updated: 21 Mar 2017

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