Lung Cancer

Common Name(s)

Lung Cancer, Cancer, Lung

Lung cancer is a type of cancer that begins in the lung, often in the branching tube-like airways called the bronchi. The major types are small cell lung cancer and non-small cell lung cancer. Within non-small cell lung cancer, there are sub-types, including large-cell carcinoma, squamous cell carcinoma, and adenocarcinoma. Lung cancer occurs when cells in the lung develop mutations that cause the cells to divide rapidly and resist death. Tumors may result.

Signs of lung cancer include a frequent raspy cough, hacking, wheeziness, hoarseness, chest pain, shortness of breath, bloody mucus, difficulty swallowing, recurring lung infections, neck and face swelling, body pain, headaches, fever, weakness, weight loss, and loss of appetite.

Most lung cancers are caused by smoking. Other risk factors include inhaling second-hand smoke; asbestos, radon, and uranium dust exposure; a personal history of lung disease or infection; and a family history of lung cancer. There is some evidence that a diet high in fat and cholesterol may increase the risk of developing lung cancer.

Several tests are used to diagnose lung cancer. In a procedure called a bronchoscopy, a doctor places a narrow tube with a camera down the nose and air passages to view the lung. A biopsy can then collect and analyze lung tissue to check for cancer cells. Blood tests, X-ray imaging, computed tomography (CT) scans, PET scans, and magnetic resonance imaging (MRI) can also be used in diagnosis. Fluid may be removed from the lung with a needle and tested for cancer cells in a procedure called thoracentesis.

Treatment for lung cancer often involves surgical removal of parts of the lung. Chemotherapy and/or radiation therapy may also be used. Cancer pain medication can help alleviate symptoms. If you have been diagnosed with lung cancer, talk to your doctor about the most current treatment options. Support groups are available for more resources and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lung Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Free to Breathe

Free to Breathe is a partnership of lung cancer survivors, advocates, researchers, healthcare professionals and industry leaders united in the belief that every person with lung cancer deserves a cure. Free to Breathe is dedicated to doubling lung cancer survival by 2022.

Last Updated: 16 Oct 2014

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HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

Last Updated: 9 Jul 2015

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Lung Cancer Alliance

Lung Cancer Alliance is committed to ending injustice and saving lives through an alliance of advocacy, education and support.

Last Updated: 20 Feb 2013

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Lung Cancer Foundation of America

LCFA’s mission is the dramatic improvement in survivorship of lung cancer patients through the funding of transformative science, with the ultimate goal of curing the disease. To accomplish this, LCFA will work to raise both the funds and the national profile of lung cancer in order to substantially increase support of innovative and groundbreaking research efforts.

Last Updated: 28 Aug 2014

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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The bonnie j addario lung cancer foundation

Eradicating Lung Cancer with our patients, survivors, and their families through research, early detection, awareness, education, prevention, and treatment.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lung Cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Free to Breathe

Free to Breathe is a partnership of lung cancer survivors, advocates, researchers, healthcare professionals and industry leaders united in the belief that every person with lung cancer deserves a cure. Free to Breathe is dedicated to doubling lung cancer survival by 2022.

http://www.freetobreathe.org

Last Updated: 16 Oct 2014

View Details
HealthyWomen

HealthyWomen (HW) is the nation's leading independent health information source for women. Our core mission is to educate, inform and empower women to make smart health choices for themselves and their families. For more than 20 years, millions of women have been coming to HW for answers to their most pressing and personal health care questions. Through our wide array of online and print publications, HW provides health information that is original, objective, reviewed by medical experts and reflective of the advances in evidence-based health research.

http://www.healthywomen.org

Last Updated: 9 Jul 2015

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Lung Cancer Alliance

Lung Cancer Alliance is committed to ending injustice and saving lives through an alliance of advocacy, education and support.

http://www.lungcanceralliance.org

Last Updated: 20 Feb 2013

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Lung Cancer Foundation of America

LCFA’s mission is the dramatic improvement in survivorship of lung cancer patients through the funding of transformative science, with the ultimate goal of curing the disease. To accomplish this, LCFA will work to raise both the funds and the national profile of lung cancer in order to substantially increase support of innovative and groundbreaking research efforts.

http://www.LCFAmerica.org

Last Updated: 28 Aug 2014

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

View Details
Logo
The bonnie j addario lung cancer foundation

Eradicating Lung Cancer with our patients, survivors, and their families through research, early detection, awareness, education, prevention, and treatment.

http://www.lungcancerfoundation.org

Last Updated: 15 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lung Cancer" returned 16814 free, full-text research articles on human participants. First 3 results:

Multislice Analysis of Blood Flow Values in CT Perfusion Studies of Lung Cancer.
 

Author(s): Silvia Malavasi, Domenico Barone, Giampaolo Gavelli, Alessandro Bevilacqua

Journal: Biomed Res Int. 2017 ;2017():3236893.

 

Objectives. Tumour heterogeneity represents a key issue in CT perfusion (CTp), where all studies are usually based on global mean or median values of perfusion maps, often computed on whole tumour. We sought to determine whether, and to what extent, such global values can be representative ...

Last Updated: 6 Feb 2017

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Chlorella sorokiniana induces mitochondrial-mediated apoptosis in human non-small cell lung cancer cells and inhibits xenograft tumor growth in vivo.
 

Author(s): Ping-Yi Lin, Ching-Tsan Tsai, Wan-Ling Chuang, Ya-Hsuan Chao, I-Horng Pan, Yu-Kuo Chen, Chi-Chen Lin, Bing-Yen Wang

Journal:

 

Lung cancer is one of the leading causes of cancer related deaths worldwide. Marine microalgae are a source of biologically active compounds and are widely consumed as a nutritional supplement in East Asian countries. It has been reported that Chlorella or Chlorella extracts have ...

Last Updated: 1 Feb 2017

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CACNA1B (Cav2.2) Overexpression and Its Association with Clinicopathologic Characteristics and Unfavorable Prognosis in Non-Small Cell Lung Cancer.
 

Author(s): Xiaoyu Zhou, Wei Wang, Shu Zhang, Xudong Wang, Zhiyuan Tang, Jun Gu, Jun Li, Jianan Huang

Journal: Dis. Markers. 2017 ;2017():6136401.

 

CACNA1B (Cav2.2) encodes an N-type voltage-gated calcium channel (VGCC) ubiquitously expressed in brain and peripheral nervous system that is important for regulating neuropathic pain. Because intracellular calcium concentration is a key player in cell proliferation and apoptosis, ...

Last Updated: 27 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lung Cancer" returned 1919 free, full-text review articles on human participants. First 3 results:

The Hedgehog Signaling Networks in Lung Cancer: The Mechanisms and Roles in Tumor Progression and Implications for Cancer Therapy.
 

Author(s): Yoshinori Abe, Nobuyuki Tanaka

Journal: Biomed Res Int. 2016 ;2016():7969286.

 

Lung cancer is the most common cause of cancer-related death worldwide and is classified into small cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). Several gene mutations that contribute to aberrant cell proliferation have been identified in lung adenocarcinoma, a ...

Last Updated: 20 Jan 2017

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The effect of smoking on lung cancer: ethnic differences and the smoking paradox.
 

Author(s): Keum Ji Jung, Christina Jeon, Sun Ha Jee

Journal:

 

The objectives of this review were to determine whether the smoking paradox still exists and to summarize possible explanations for the smoking paradox. Based on published data, we compared the risk of cigarette smoking for lung cancer in Western and Asian countries. We extracted ...

Last Updated: 17 Jan 2017

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A meta-analysis of efficacy and safety of antibodies targeting PD-1/PD-L1 in treatment of advanced nonsmall cell lung cancer.
 

Author(s): Cuihua Wang, Xuetao Yu, Wei Wang

Journal: Medicine (Baltimore). 2016 Dec;95(52):e5539.

 

Nonsmall cell lung cancer (NSCLC)-patients treated with standard chemotherapy experienced progression rapidly. A novel therapy based on programed death 1 (PD-1)/programed death ligand 1 (PD-L1) inhibitors showed an increasing potential in several malignancies including advanced NSCLC.

Last Updated: 29 Dec 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Molecular Predictors of Cancer in Patients at High Risk of Lung Cancer
 

Status: Recruiting

Condition Summary: Lung Cancer

 

Last Updated: 12 Jul 2016

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Last Updated: 19 Jul 2016

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Last Updated: 19 Jan 2017

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