Long QT syndrome 2

Common Name(s)

Long QT syndrome 2

Congenital long QT syndrome is electrocardiographically characterized by a prolonged QT interval and polymorphic ventricular arrhythmias (torsade de pointes). These cardiac arrhythmias may result in recurrent syncope, seizure, or sudden death ({7:Jongbloed et al., 1999}).
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Long QT syndrome 2" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Long QT syndrome 2" returned 30 free, full-text research articles on human participants. First 3 results:

Mechanistic basis for type 2 long QT syndrome caused by KCNH2 mutations that disrupt conserved arginine residues in the voltage sensor.
 

Author(s): Christie M McBride, Ashley M Smith, Jennifer L Smith, Allison R Reloj, Ellyn J Velasco, Jonathan Powell, Claude S Elayi, Daniel C Bartos, Don E Burgess, Brian P Delisle

Journal: J. Membr. Biol.. 2013 May;246(5):355-64.

 

KCNH2 encodes the Kv11.1 channel, which conducts the rapidly activating delayed rectifier K+ current (I Kr) in the heart. KCNH2 mutations cause type 2 long QT syndrome (LQT2), which increases the risk for life-threatening ventricular arrhythmias. LQT2 mutations are predicted to prolong ...

Last Updated: 15 May 2013

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Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: higher recurrence of events under metoprolol.
 

Author(s): Priya Chockalingam, Lia Crotti, Giulia Girardengo, Jonathan N Johnson, Katy M Harris, Jeroen F van der Heijden, Richard N W Hauer, Britt M Beckmann, Carla Spazzolini, Roberto Rordorf, Annika Rydberg, Sally-Ann B Clur, Markus Fischer, Freek van den Heuvel, Stefan Kääb, Nico A Blom, Michael J Ackerman, Peter J Schwartz, Arthur A M Wilde

Journal: J. Am. Coll. Cardiol.. 2012 Nov;60(20):2092-9.

 

The purpose of this study was to compare the efficacy of beta-blockers in congenital long QT syndrome (LQTS).

Last Updated: 9 Nov 2012

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Phylogenetic and physicochemical analyses enhance the classification of rare nonsynonymous single nucleotide variants in type 1 and 2 long-QT syndrome.
 

Author(s): John R Giudicessi, Jamie D Kapplinger, David J Tester, Marielle Alders, Benjamin A Salisbury, Arthur A M Wilde, Michael J Ackerman

Journal: Circ Cardiovasc Genet. 2012 Oct;5(5):519-28.

 

Hundreds of nonsynonymous single nucleotide variants (nsSNVs) have been identified in the 2 most common long-QT syndrome-susceptibility genes (KCNQ1 and KCNH2). Unfortunately, an ≈3%

Last Updated: 17 Oct 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Long QT syndrome 2" returned 0 free, full-text review articles on human participants.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Comparison Between Epinephrine and Exercise Test in QT Long Syndrome Patients
 

Status: Recruiting

Condition Summary: Long QT Syndrome Type 1 or 2

 

Last Updated: 23 May 2014

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