Locked-in syndrome

Common Name(s)

Locked-in syndrome

Locked-in syndrome is a rare neurological disorder. Signs and symptoms include paralysis of voluntary muscles in the body, except for those that control eye movement.Individuals with locked-in syndrome are conscious and can think and reason, but are unable to speak or move.  It may be caused by brain stem stroke, traumatic brain injury, diseases of the circulatory system, diseases that destroy the myelin sheath surrounding nerve cells, or medication overdose.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Locked-in syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Locked-in syndrome" returned 35 free, full-text research articles on human participants. First 3 results:

Brain-computer interface with language model-electroencephalography fusion for locked-in syndrome.
 

Author(s): Barry S Oken, Umut Orhan, Brian Roark, Deniz Erdogmus, Andrew Fowler, Aimee Mooney, Betts Peters, Meghan Miller, Melanie B Fried-Oken

Journal: Neurorehabil Neural Repair. 2014 May;28(4):387-94.

 

Some noninvasive brain-computer interface (BCI) systems are currently available for locked-in syndrome (LIS) but none have incorporated a statistical language model during text generation.

Last Updated: 15 Apr 2014

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A comparison of two spelling Brain-Computer Interfaces based on visual P3 and SSVEP in Locked-In Syndrome.
 

Author(s): Adrien Combaz, Camille Chatelle, Arne Robben, Gertie Vanhoof, Ann Goeleven, Vincent Thijs, Marc M Van Hulle, Steven Laureys

Journal:

 

We study the applicability of a visual P3-based and a Steady State Visually Evoked Potentials (SSVEP)-based Brain-Computer Interfaces (BCIs) for mental text spelling on a cohort of patients with incomplete Locked-In Syndrome (LIS).

Last Updated: 2 Oct 2013

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Locked-in syndrome as a presentation of snakebite.
 

Author(s): Chandrika Azad, Vidushi Mahajan, Kana Ram Jat

Journal: Indian Pediatr. 2013 Jul;50(7):695-7.

 

Snake bite is a common condition in tropical countries. Neurotoxic features of snake bite vary from early morning neuroparalytic syndrome to various cranial nerve palsies. Locked in syndrome (LIS) is a rare presentation. We present four children that had LIS; three patients had total ...

Last Updated: 14 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Locked-in syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

The patient's journey: living with locked-in syndrome.
 

Author(s): Nick Chisholm, Grant Gillett

Journal: BMJ. 2005 Jul;331(7508):94-7.

 

Last Updated: 8 Jul 2005

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Locked-in syndrome.
 

Author(s): Eimear Smith, Mark Delargy

Journal: BMJ. 2005 Feb;330(7488):406-9.

 

Last Updated: 18 Feb 2005

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The locked-in syndrome: a review and presentation of two chronic cases.
 

Author(s): P Dollfus, P L Milos, A Chapuis, P Real, M Orenstein, J W Soutter

Journal: Paraplegia. 1990 Jan;28(1):5-16.

 

The locked-in syndrome (LIS) is a state of an upper motor neurone quadriplegia involving the cranial nerve pairs with usually a lateral gaze palsy, paralytic mutism, full consciousness and awareness by the patient of his environment. A historical presentation of the LIS is given as ...

Last Updated: 2 Mar 1993

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
 

Status: Recruiting

Condition Summary: Locked-In Syndrome

 

Last Updated: 22 Aug 2014

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BrainGate2: Feasibility Study of an Intracortical Neural Interface System for Persons With Tetraplegia
 

Status: Recruiting

Condition Summary: Tetraplegia; Spinal Cord Injuries; Amyotrophic Lateral Sclerosis; Brain Stem Infarctions; Locked in Syndrome

 

Last Updated: 24 Mar 2014

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