Locked-in syndrome

Common Name(s)

Locked-in syndrome

Locked-in syndrome is a rare neurological disorder. Signs and symptoms include paralysis of voluntary muscles in the body, except for those that control eye movement.Individuals with locked-in syndrome are conscious and can think and reason, but are unable to speak or move.  It may be caused by brain stem stroke, traumatic brain injury, diseases of the circulatory system, diseases that destroy the myelin sheath surrounding nerve cells, or medication overdose.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Locked-in syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Locked-in syndrome" returned 44 free, full-text research articles on human participants. First 3 results:

A Case Report of Locked-in Syndrome Due to Bilateral Vertebral Artery Dissection After Cervical Spine Manipulation Treated by Arterial Embolectomy.
 

Author(s): Jiang-Qiong Ke, Bo Yin, Fang-Wang Fu, Sheng-Min Shao, Yan Lin, Qi-Qiang Dong, Xiao-Tong Wang, Guo-Qing Zheng

Journal: Medicine (Baltimore). 2016 Feb;95(5):e2693.

 

Cervical spine manipulation (CSM) is a commonly spinal manipulative therapies for the relief of cervical spine-related conditions worldwide, but its use remains controversial. CSM may carry the potential for serious neurovascular complications, primarily due to vertebral artery dissection ...

Last Updated: 5 Feb 2016

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[Brain-computer interfaces, Locked-In syndrome, and disorders of consciousness].
 

Author(s): Damien Lesenfants, Camille Chatelle, Steven Laureys, Quentin Noirhomme

Journal: Med Sci (Paris). 2015 Oct;31(10):904-11.

 

Detecting signs of consciousness in patients with severe brain injury constitutes a real challenge for clinicians. The current gold standard in clinical diagnosis is the behavioral scale relying on motor abilities, which are often impaired or nonexistent in these patients. In this ...

Last Updated: 20 Oct 2015

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Quality of life in patients with locked-in syndrome: Evolution over a 6-year period.
 

Author(s): Marie-Christine Rousseau, Karine Baumstarck, Marine Alessandrini, VĂ©ronique Blandin, Thierry Billette de Villemeur, Pascal Auquier

Journal:

 

Improved knowledge of the quality of life (QoL) of locked-in syndrome (LIS) patients have implications for managing their care, and assists clinicians in choosing the most appropriate interventions. We performed a survey of a population of LIS patients to describe the course of the ...

Last Updated: 18 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Locked-in syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

The patient's journey: living with locked-in syndrome.
 

Author(s): Nick Chisholm, Grant Gillett

Journal: BMJ. 2005 Jul;331(7508):94-7.

 

Last Updated: 8 Jul 2005

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Locked-in syndrome.
 

Author(s): Eimear Smith, Mark Delargy

Journal: BMJ. 2005 Feb;330(7488):406-9.

 

Last Updated: 18 Feb 2005

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The locked-in syndrome: a review and presentation of two chronic cases.
 

Author(s): P Dollfus, P L Milos, A Chapuis, P Real, M Orenstein, J W Soutter

Journal: Paraplegia. 1990 Jan;28(1):5-16.

 

The locked-in syndrome (LIS) is a state of an upper motor neurone quadriplegia involving the cranial nerve pairs with usually a lateral gaze palsy, paralytic mutism, full consciousness and awareness by the patient of his environment. A historical presentation of the LIS is given as ...

Last Updated: 2 Mar 1993

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Feasibility of mindBEAGLE in Disorders of Consciousness or Locked-In Syndrome
 

Status: Recruiting

Condition Summary: Consciousness Disorders; Locked-In Syndrome

 

Last Updated: 11 May 2016

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Brain Computer Interface Complete locked-in State Communication
 

Status: Recruiting

Condition Summary: Complete Locked-in State

 

Last Updated: 29 Nov 2016

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First Study With a Brain Implant to Help Locked-in Patients Communicate at Home
 

Status: Recruiting

Condition Summary: Locked-In Syndrome

 

Last Updated: 8 Nov 2016

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