Localized scleroderma

Common Name(s)

Localized scleroderma

Localized scleroderma is characterized by thickening of the skin from excessive collagen deposits. Collagen is a protein normally present in our skin that provides structural support. However, when too much collagen is made, the skin becomes stiff and hard. Localized types of scleroderma are those limited to the skin and related tissues and, in some cases, the muscle below. Internal organs are not affected by localized scleroderma, and localized scleroderma can never progress to the systemic form of the disease. Often, localized conditions improve or go away on their own over time, but the skin changes and damage that occur when the disease is active can be permanent. For some people, localized scleroderma is serious and disabling.

There are two generally recognized types of localized scleroderma: morphea and linear.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

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Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Localized scleroderma" returned 47 free, full-text research articles on human participants. First 3 results:

Implantation of autologous fat globules in localized scleroderma and idiopathic lipoatrophy--report of five patients.
 

Author(s): Tiago Pina Zanelato, Giovana Marquesini, Paula Tavares Colpas, Renata Ferreira Magalhães, Aparecida Machado de Moraes

Journal: An Bras Dermatol. ;88(6 Suppl 1):120-3.

 

A large number of diseases may cause Atrophic skin disorders are caused by a large number of diseases, some of them idiopathic and others inflammatory, in which there is loss of volume of body segments. Localized scleroderma is a rare inflammatory dermatosis, manifested by atrophic ...

Last Updated: 18 Dec 2013

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The Localized Scleroderma Cutaneous Assessment Tool: responsiveness to change in a pediatric clinical population.
 

Author(s): Christina E Kelsey, Kathryn S Torok

Journal: J. Am. Acad. Dermatol.. 2013 Aug;69(2):214-20.

 

Lack of agreement on how to accurately capture disease outcomes in localized scleroderma (LS) has hindered the development of efficacious treatment protocols. The LS Cutaneous Assessment Tool (LoSCAT), consisting of the modified LS Skin Severity Index (mLoSSI) and the LS Damage Index, ...

Last Updated: 22 Jul 2013

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The downregulation of microRNA let-7a contributes to the excessive expression of type I collagen in systemic and localized scleroderma.
 

Author(s): Katsunari Makino, Masatoshi Jinnin, Ayaka Hirano, Keitaro Yamane, Mitsuhiko Eto, Takamitsu Kusano, Noritoshi Honda, Ikko Kajihara, Takamitsu Makino, Keisuke Sakai, Shinichi Masuguchi, Satoshi Fukushima, Hironobu Ihn

Journal: J. Immunol.. 2013 Apr;190(8):3905-15.

 

Systemic and localized scleroderma (SSc and LSc) is characterized by excessive deposition of collagen and tissue fibrosis in the skin. Although they have fundamental common characteristics including autoimmunity, little is known about the exact mechanism that mediates the excessive ...

Last Updated: 8 Apr 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Localized scleroderma" returned 7 free, full-text review articles on human participants. First 3 results:

Pediatric scleroderma: systemic or localized forms.
 

Author(s): Kathryn S Torok

Journal: Pediatr. Clin. North Am.. 2012 Apr;59(2):381-405.

 

Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to ...

Last Updated: 7 May 2012

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Cytokine profiles in localized scleroderma and relationship to clinical features.
 

Author(s): Katherine Kurzinski, Kathryn S Torok

Journal: Cytokine. 2011 Aug;55(2):157-64.

 

Localized scleroderma (LS) is a disfiguring autoimmune disease of the skin and underlying tissue that mainly affects the pediatric population. Inflammation of the tissue leads to fibrosis and atrophy, causing physical and psychological disability that can continue throughout childhood ...

Last Updated: 29 Jun 2011

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Pathogenesis and treatment modalities of localized scleroderma.
 

Author(s): Greta Valančienė, Daiva Jasaitienė, Skaidra Valiukevičienė

Journal: Medicina (Kaunas). 2010 ;46(10):649-56.

 

Localized scleroderma is a chronic inflammatory disease primarily of the dermis and subcutaneous fat that ultimately leads to a scar-like sclerosis of connective tissue. The disorder manifests as various plaques of different shape and size with signs of skin inflammation, sclerosis, ...

Last Updated: 11 Mar 2011

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Fractional Carbon Dioxide Laser Versus UVA 1 in Treatment of Localized Scleroderma
 

Status: Recruiting

Condition Summary: Localized Scleroderma

 

Last Updated: 9 Sep 2014

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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 8 Mar 2013

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Treatment Study Comparing UVA-1 Phototherapy Versus Placebo Treatment for Morphea
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Scleroderma, Circumscribed

 

Last Updated: 22 Feb 2013

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