Localized scleroderma

Common Name(s)

Localized scleroderma

Localized scleroderma is characterized by thickening of the skin from excessive collagen deposits. Collagen is a protein normally present in our skin that provides structural support. However, when too much collagen is made, the skin becomes stiff and hard. Localized types of scleroderma are those limited to the skin and related tissues and, in some cases, the muscle below. Internal organs are not affected by localized scleroderma, and localized scleroderma can never progress to the systemic form of the disease. Often, localized conditions improve or go away on their own over time, but the skin changes and damage that occur when the disease is active can be permanent. For some people, localized scleroderma is serious and disabling.

There are two generally recognized types of localized scleroderma: morphea and linear.

 

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

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Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

Last Updated: 6 May 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Localized scleroderma" for support, advocacy or research.

Logo
Raynaud's & Scleroderma Ireland

• To improve the lives of patients, their families and carers by providing support, advice and information. • To increase the awareness of Raynaud’s and Scleroderma amongst healthcare professionals, Government and Statutory agencies and the general public. • To work in partnership with appropriate healthcare professionals and agencies to promote and co-ordinate the attainment of the objectives of the strategy. • Maintain a working environment that fosters communication, teamwork and diversity among all members of staff- permanent, temporary and voluntary

http://www.irishraynauds.com

Last Updated: 6 May 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Localized scleroderma" returned 60 free, full-text research articles on human participants. First 3 results:

[Localized Scleroderma of Lower Extremities:Clinical and Magnetic Resonance Imaging Features].
 

Author(s): Feng-dan Wang, Hong-wei Wang, Zhi-hong Wu, Bo Hou, Bo Jiang, Yan Zhang, Feng Feng, Zheng-yu Jin, Xie Yuan

Journal: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2015 Aug;37(4):392-7.

 

To evaluate the clinical and musculoskeletal characteristics of localized scleroderma with lower extremities affected.

Last Updated: 13 Nov 2015

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Peripheral blood cytokine and chemokine profiles in juvenile localized scleroderma: T-helper cell-associated cytokine profiles.
 

Author(s): Kathryn S Torok, Katherine Kurzinski, Christina Kelsey, Jonathan Yabes, Kelsey Magee, Abbe N Vallejo, Thomas Medsger, Carol A Feghali-Bostwick

Journal: Semin. Arthritis Rheum.. 2015 Dec;45(3):284-93.

 

To evaluate peripheral blood T-helper (TH) cell-associated cytokine and chemokine profiles in localized scleroderma (LS), and correlate them with clinical disease features, including disease activity parameters.

Last Updated: 23 Nov 2015

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Assessment of esophageal involvement in systemic sclerosis and morphea (localized scleroderma) by clinical, endoscopic, manometric and pH metric features: a prospective comparative hospital based study.
 

Author(s): Tasleem Arif, Qazi Masood, Jaswinder Singh, Iffat Hassan

Journal:

 

Systemic sclerosis (SSc) is a generalized disorder of unknown etiology affecting the connective tissue of the body. It affects the skin and various internal organs. Gastrointestinal tract involvement is seen in almost 90% of the patients. Esophagus is the most frequently affected ...

Last Updated: 18 Apr 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Localized scleroderma" returned 9 free, full-text review articles on human participants. First 3 results:

Localized scleroderma presenting as port-wine stains: report of two cases and a literature review.
 

Author(s): Hiroyuki Kanoh, En Shu, Yoshiro Ichiki, Mariko Seishima

Journal: Acta Derm. Venereol.. 2015 Nov;95(8):1003-4.

 

Last Updated: 4 Nov 2015

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Localized scleroderma: clinical spectrum and therapeutic update.
 

Author(s): Mariana Figueiroa Careta, Ricardo Romiti

Journal: An Bras Dermatol. ;90(1):62-73.

 

Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea ...

Last Updated: 12 Feb 2015

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Pediatric scleroderma: systemic or localized forms.
 

Author(s): Kathryn S Torok

Journal: Pediatr. Clin. North Am.. 2012 Apr;59(2):381-405.

 

Pediatric scleroderma includes 2 major groups of clinical entities, systemic sclerosis (SSc) and localized scleroderma (LS). Although both share a common pathophysiology, their clinical manifestations differ. LS is typically confined to the skin and underlying subcutis, with up to ...

Last Updated: 7 May 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Genetic Variants in Linear Localized Scleroderma
 

Status: Recruiting

Condition Summary: Morphea

 

Last Updated: 4 Feb 2016

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Morphea in Adults and Children (MAC) Cohort Study: A Morphea Registry and DNA Repository
 

Status: Recruiting

Condition Summary: Scleroderma, Localized; Morphea; Frontal Linear Scleroderma en Coup de Sabre; Scleroderma, Circumscribed; Scleroderma, Linear

 

Last Updated: 2 Dec 2014

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Scleroderma Registry & Repository at the Hospital for Special Surgery
 

Status: Recruiting

Condition Summary: Scleroderma

 

Last Updated: 17 Feb 2016

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