Liver disease

Common Name(s)

Liver disease

Liver disease is any type of damage to the liver that causes it not to function properly. The liver is an organ that helps digest food and remove toxins from the body. There are over 100 types of liver disease. Most forms of liver disease can either be inherited (genetic) or caused by virus or parasite infection, autoimmune diseases, alcohol abuse, or obesity. Damage to the liver can cause scarring (cirrhosis) and this scarring can eventually cause liver failure. Liver failure is very serious and is life-threatening.

There are many symptoms of liver disease. People with liver disease may have skin and eyes that look yellow (jaundice), stomach pain, and swelling in the stomach, legs, or ankles. Their urine is often very dark and they have pale colored or bloody feces. Individuals with liver disease may also have itchy skin, fatigue, nausea, vomiting, loss of appetite, and may bruise easily.

Risk factors for liver disease include sharing needles, exposure to other people’s blood and body fluids, and unprotected sex, tattoos, and body piercings. Other risk factors include heavy alcohol use, obesity, diabetes, and high levels of triglycerides, a type of fat, in your blood.

To diagnose liver disease, your doctor will ask about your health history. They might also use imaging tests, test your blood, and test tissue samples. Some liver problems may be treated by healthy lifestyle changes. Some people with liver disease may need prescribed medication or surgery. If liver disease results in liver failure, a liver transplant may be necessary. Research is ongoing, so talk with your doctor and specialists about the most current treatment options. Support groups are a good source of information and can help connect you with others living with liver disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

Last Updated: 26 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

http://www.alagille.org

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

http://alpha1.org/

Last Updated: 26 Aug 2015

View Details

 

General Support Organizations

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General Resources

ALGSA CONNECT Patient Registry

Registry open to anyone with ALGS.

Updated 25 May 2013

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Blogs

ALGSA President's Blog

Cindy Luxhoj Hahn's weekly blog about being a parent of a child with ALGS and running the ALGSA.

Updated 25 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver disease" returned 4447 free, full-text research articles on human participants. First 3 results:

HSD17B13 and Chronic Liver Disease in Blacks and Hispanics.
 

Author(s): Julia Kozlitina, Stefan Stender, Helen H Hobbs, Jonathan C Cohen

Journal: N. Engl. J. Med.. 2018 11;379(19):1876-1877.

 

Last Updated: 31 Dec 1969

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Nonalcoholic fatty liver disease with prolactin-secreting pituitary adenoma in an adolescent: A case report.
 

Author(s): Yugo Takaki, Tatsuki Mizuochi, Junko Nishioka, Keisuke Eda, Shuichi Yatsuga, Yushiro Yamashita

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12879.

 

Nonalcoholic fatty liver disease (NAFLD), among the commonest chronic liver disorders in children and adolescents, is considered a reflection of the current obesity epidemic in children and adults. This liver disease has been linked with various metabolic disorders, but not with prolactinoma ...

Last Updated: 31 Dec 1969

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Increased risk of osteoporosis in patients with nonalcoholic fatty liver disease: A population-based retrospective cohort study.
 

Author(s): Hon-Jhe Chen, Hao-Yu Yang, Kuang-Chieh Hsueh, Cheng-Che Shen, Ru-Yi Chen, Hsien-Chung Yu, Tzu-Lin Wang

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12835.

 

The study aims to investigate the association between nonalcoholic fatty liver disease (NAFLD) and osteoporosis.We employed a retrospective cohort study design using the National Health Insurance Research Database in Taiwan. Our study included 2 cohorts: 4318 patients with NAFLD and ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Liver disease" returned 1237 free, full-text review articles on human participants. First 3 results:

Exercise as an intervention for patients with end-stage liver disease: Systematic review.
 

Author(s): Cameron T Locklear, Pegah Golabi, Lynn Gerber, Zobair M Younossi

Journal: Medicine (Baltimore). 2018 Oct;97(42):e12774.

 

Various etiologies of chronic liver disease often result in cirrhosis. Beside obvious liver-related complications, cirrhosis also leads to loss of muscle mass and decreased exercise capacity. In this study, our aim was to conduct a systematic review of literature to investigate the ...

Last Updated: 31 Dec 1969

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The Misunderstood Coagulopathy of Liver Disease: A Review for the Acute Setting.
 

Author(s): Michael F Harrison

Journal: West J Emerg Med. 2018 Sep;19(5):863-871.

 

The international normalized ratio (INR) represents a clinical tool to assess the effectiveness of vitamin-K antagonist therapy. However, it is often used in the acute setting to assess the degree of coagulopathy in patients with hepatic cirrhosis or acute liver failure. This often ...

Last Updated: 31 Dec 1969

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Non-alcoholic fatty liver disease and the risk of urolithiasis: A systematic review and meta-analysis.
 

Author(s): Shaoyou Qin, Song Wang, Xu Wang, Jiangbin Wang

Journal: Medicine (Baltimore). 2018 Aug;97(35):e12092.

 

There is growing evidence that nonalcoholic fatty liver disease (NAFLD) is associated with a higher risk of urolithiasis, but it has not yet been determined that this association is reproducible and consistent across different studies. We performed a systematic review and meta-analysis ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 21 Oct 2016

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Thermal Imaging in Liver Disease.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 8 Sep 2017

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Last Updated: 15 Oct 2018

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