Liver disease

Common Name(s)

Liver disease

Liver disease is any type of damage to the liver that causes it not to function properly. The liver is an organ that helps digest food and remove toxins from the body. There are over 100 types of liver disease. Most forms of liver disease can either be inherited (genetic) or caused by virus or parasite infection, autoimmune diseases, alcohol abuse, or obesity. Damage to the liver can cause scarring (cirrhosis) and this scarring can eventually cause liver failure. Liver failure is very serious and is life-threatening.

There are many symptoms of liver disease. People with liver disease may have skin and eyes that look yellow (jaundice), stomach pain, and swelling in the stomach, legs, or ankles. Their urine is often very dark and they have pale colored or bloody feces. Individuals with liver disease may also have itchy skin, fatigue, nausea, vomiting, loss of appetite, and may bruise easily.

Risk factors for liver disease include sharing needles, exposure to other people’s blood and body fluids, and unprotected sex, tattoos, and body piercings. Other risk factors include heavy alcohol use, obesity, diabetes, and high levels of triglycerides, a type of fat, in your blood.

To diagnose liver disease, your doctor will ask about your health history. They might also use imaging tests, test your blood, and test tissue samples. Some liver problems may be treated by healthy lifestyle changes. Some people with liver disease may need prescribed medication or surgery. If liver disease results in liver failure, a liver transplant may be necessary. Research is ongoing, so talk with your doctor and specialists about the most current treatment options. Support groups are a good source of information and can help connect you with others living with liver disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

Last Updated: 26 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

http://www.alagille.org

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

http://alpha1.org/

Last Updated: 26 Aug 2015

View Details

 

General Support Organizations

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General Resources

ALGSA CONNECT Patient Registry

Registry open to anyone with ALGS.

Updated 25 May 2013

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Blogs

ALGSA President's Blog

Cindy Luxhoj Hahn's weekly blog about being a parent of a child with ALGS and running the ALGSA.

Updated 25 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver disease" returned 3365 free, full-text research articles on human participants. First 3 results:

A Comparison of Brunt's Criteria, the Non-Alcoholic Fatty Liver Disease Activity Score (NAS), and a Proposed NAS Scoring that Includes Fibrosis in Non-Alcoholic Fatty Liver Disease Staging.
 

Author(s): Amarilys Santiago-Rolón, Dagmary Purcell, Kathia Rosado, Doris H Toro

Journal: P R Health Sci J. 2015 Dec;34(4):189-94.

 

The aim of this study was to determine the prevalence of NASH in veterans with metabolic syndrome and compare histologic grading using the Brunt criteria, the NAFLD activity score (NAS), and a proposed NAS scoring system that has been modified to include fibrosis staging.

Last Updated: 25 Nov 2015

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MTTP-297H polymorphism reduced serum cholesterol but increased risk of non-alcoholic fatty liver disease-a cross-sectional study.
 

Author(s): Pi-Jung Hsiao, Mei-Yueh Lee, Yeng-Tseng Wang, He-Jiun Jiang, Pi-Chen Lin, Yi-Hsin Connie Yang, Kung-Kai Kuo

Journal:

 

Microsomal triglyceride transfer protein (MTP) works to lipidate and assemble the apoB-containing lipoproteins in liver. It closely links up the hepatic secretion of lipid to regulate serum lipid and atherosclerosis. Cases of MTTP gene mutation is characterized by abetalipoproteinemia ...

Last Updated: 13 Oct 2015

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Selective Estrogen Receptor Modulator-Associated Nonalcoholic Fatty Liver Disease Improved Survival in Patients With Breast Cancer: A Retrospective Cohort Analysis.
 

Author(s): Qiufan Zheng, Fei Xu, Man Nie, Wen Xia, Tao Qin, Ge Qin, Xin An, Cong Xue, Roujun Peng, Zhongyu Yuan, Yanxia Shi, Shusen Wang

Journal: Medicine (Baltimore). 2015 Oct;94(40):e1718.

 

Selective estrogen receptor modulator (SERM)-associated nonalcoholic fatty liver disease (NAFLD) might be related to treatment efficacy in patients with breast cancer because of circulating estrogen antagonism. The aim of the study was to investigate the relationship between NAFLD ...

Last Updated: 9 Oct 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Liver disease" returned 846 free, full-text review articles on human participants. First 3 results:

Liver-specific magnetic resonance contrast medium in the evaluation of chronic liver disease.
 

Author(s): Marcio Augusto Correia Rodrigues dos Reis, Ronaldo Hueb Baroni

Journal: Einstein (Sao Paulo). ;13(2):326-9.

 

The hepatobiliary-specific contrast medium (gadoxetic acid - Primovist®) is primarily used to improve detection and characterization of focal hepatic lesions, such as in chronic liver disease patients with suspected hepatocellular carcinoma. Since the contrast medium is selectively ...

Last Updated: 9 Jul 2015

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Current solutions for obesity-related liver disorders: non-alcoholic fatty liver disease and non-alcoholic steatohepatitis.
 

Author(s): Asnat Raziel, Nasser Sakran, Amir Szold, David Goitein

Journal: Isr. Med. Assoc. J.. 2015 Apr;17(4):234-8.

 

Last Updated: 4 Jun 2015

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Liver involvement in pediatric celiac disease.
 

Author(s): Caterina Anania, Ester De Luca, Giovanna De Castro, Claudio Chiesa, Lucia Pacifico

Journal: World J. Gastroenterol.. 2015 May;21(19):5813-22.

 

Celiac disease (CD) is an intestinal inflammatory disease that manifests in genetically susceptible individuals when exposed to dietary gluten. It is a common chronic disorder, with a prevalence of 1% in Europe and North America. Although the disease primarily affects the gut, the ...

Last Updated: 28 May 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pasireotide LAR in Severe Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Somatostatin Analogs; Polycystic Liver Disease; Autosomal Dominant Polycystic Kidney Disease; Autosomal Dominant Polycystic Liver Disease

 

Last Updated: 6 Apr 2015

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Multicentre Prospective Cohort Study of Patients With Chronic Alcoholic and/or Metabolic Liver Disease
 

Status: Recruiting

Condition Summary: Liver Diseases, Alcoholic; Metabolic Diseases

 

Last Updated: 4 Mar 2015

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Ursodeoxycholic Acid as Treatment for Polycystic Liver Disease
 

Status: Recruiting

Condition Summary: Polycystic Liver Disease (PLD):; Polycystic Kidney, Autosomal Dominant; Polycystic Liver Disease

 

Last Updated: 5 Nov 2014

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