Liver disease

Common Name(s)

Liver disease

Liver disease is any type of damage to the liver that causes it not to function properly. The liver is an organ that helps digest food and remove toxins from the body. There are over 100 types of liver disease. Most forms of liver disease can either be inherited (genetic) or caused by virus or parasite infection, autoimmune diseases, alcohol abuse, or obesity. Damage to the liver can cause scarring (cirrhosis) and this scarring can eventually cause liver failure. Liver failure is very serious and is life-threatening.

There are many symptoms of liver disease. People with liver disease may have skin and eyes that look yellow (jaundice), stomach pain, and swelling in the stomach, legs, or ankles. Their urine is often very dark and they have pale colored or bloody feces. Individuals with liver disease may also have itchy skin, fatigue, nausea, vomiting, loss of appetite, and may bruise easily.

Risk factors for liver disease include sharing needles, exposure to other people’s blood and body fluids, and unprotected sex, tattoos, and body piercings. Other risk factors include heavy alcohol use, obesity, diabetes, and high levels of triglycerides, a type of fat, in your blood.

To diagnose liver disease, your doctor will ask about your health history. They might also use imaging tests, test your blood, and test tissue samples. Some liver problems may be treated by healthy lifestyle changes. Some people with liver disease may need prescribed medication or surgery. If liver disease results in liver failure, a liver transplant may be necessary. Research is ongoing, so talk with your doctor and specialists about the most current treatment options. Support groups are a good source of information and can help connect you with others living with liver disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

Last Updated: 26 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

http://www.alagille.org

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

http://alpha1.org/

Last Updated: 26 Aug 2015

View Details

 

General Support Organizations

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General Resources

ALGSA CONNECT Patient Registry

Registry open to anyone with ALGS.

Updated 25 May 2013

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Blogs

ALGSA President's Blog

Cindy Luxhoj Hahn's weekly blog about being a parent of a child with ALGS and running the ALGSA.

Updated 25 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver disease" returned 3770 free, full-text research articles on human participants. First 3 results:

"Non alcoholic fatty liver disease and eNOS dysfunction in humans".
 

Author(s): Marcello Persico, Mario Masarone, Antonio Damato, Mariateresa Ambrosio, Alessandro Federico, Valerio Rosato, Tommaso Bucci, Albino Carrizzo, Carmine Vecchione

Journal:

 

NAFLD is associated to Insulin Resistance (IR). IR is responsible for Endothelial Dysfunction (ED) through the impairment of eNOS function. Although eNOS derangement has been demonstrated in experimental models, no studies have directly shown that eNOS dysfunction is associated with ...

Last Updated: 7 Mar 2017

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Thromboelastographic Evaluation of Coagulation in Patients With Liver Disease.
 

Author(s): Kyung Hwa Shin, In Suk Kim, Hyun Ji Lee, Hyung Hoi Kim, Chulhun L Chang, Young Mi Hong, Ki Tae Yoon, Mong Cho

Journal: Ann Lab Med. 2017 May;37(3):204-212.

 

The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting.

Last Updated: 22 Feb 2017

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Disease spectrum of alcoholic liver disease in Beijing 302 Hospital from 2002 to 2013: A large tertiary referral hospital experience from 7422 patients.
 

Author(s): Ang Huang, Binxia Chang, Yin Sun, Huiming Lin, Baosen Li, Guangju Teng, Zheng-Sheng Zou

Journal: Medicine (Baltimore). 2017 Feb;96(7):e6163.

 

Alcohol consumption in China has substantially increased over the last 3 decades and the number of patients with alcoholic liver disease (ALD) is rising at an alarming rate. However, accurate and representative data on time trends in its hospitalization rates are not available. The ...

Last Updated: 16 Feb 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Liver disease" returned 989 free, full-text review articles on human participants. First 3 results:

Progressive familial intrahepatic cholestasis: A comprehensive review of a challenging liver disease.
 

Author(s): Kavita Gaur, Puja Sakhuja

Journal: Indian J Pathol Microbiol. ;60(1):2-7.

 

Cholestatic liver disease in children represents a diagnostic and therapeutic challenge. The requirement of a multidisciplinary approach, high levels of professional expertise, and the costs of genetic testing are a few of the reasons why such patients may suffer for want of an accurate ...

Last Updated: 14 Feb 2017

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[Liver involvement in Rendu-Osler disease: a case report and review of literature].
 

Author(s): Hanen Loukil, Mouna Snoussi, Hela Fourati, Faten Frikha, Raida Ben Salah, Moez Jallouli, Sameh Marzouk, Zeineb Mnif, Zouhir Bahloul

Journal:

 

A 48 years-old-woman was admitted for anectric cholestasis. A history of recurrent personal and familial epistaxis was noted. Biologic findings revealed iron deficiency anemia and moderate cholestasis. Viral serologic tests, antimitochondrie and anti smooth muscle antibodies were ...

Last Updated: 3 Feb 2017

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Schisandrin B: A Double-Edged Sword in Nonalcoholic Fatty Liver Disease.
 

Author(s): Pou Kuan Leong, Kam Ming Ko

Journal: Oxid Med Cell Longev. 2016 ;2016():6171658.

 

Nonalcoholic fatty liver disease (NAFLD) is a spectrum of liver lesions ranging from hepatic steatosis, nonalcoholic steatohepatitis, hepatic cirrhosis, and hepatocellular carcinoma. The high global prevalence of NAFLD has underlined the important public health implications of this ...

Last Updated: 16 Nov 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 21 Oct 2016

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Hepatic Venous Pressure Gradient and Platelet Activation in Chronic Liver Disease
 

Status: Recruiting

Condition Summary: Chronic Liver Disease

 

Last Updated: 30 Nov 2015

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Last Updated: 21 May 2015

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