Liver disease

Common Name(s)

Liver disease

Liver disease is any type of damage to the liver that causes it not to function properly. The liver is an organ that helps digest food and remove toxins from the body. There are over 100 types of liver disease. Most forms of liver disease can either be inherited (genetic) or caused by virus or parasite infection, autoimmune diseases, alcohol abuse, or obesity. Damage to the liver can cause scarring (cirrhosis) and this scarring can eventually cause liver failure. Liver failure is very serious and is life-threatening.

There are many symptoms of liver disease. People with liver disease may have skin and eyes that look yellow (jaundice), stomach pain, and swelling in the stomach, legs, or ankles. Their urine is often very dark and they have pale colored or bloody feces. Individuals with liver disease may also have itchy skin, fatigue, nausea, vomiting, loss of appetite, and may bruise easily.

Risk factors for liver disease include sharing needles, exposure to other people’s blood and body fluids, and unprotected sex, tattoos, and body piercings. Other risk factors include heavy alcohol use, obesity, diabetes, and high levels of triglycerides, a type of fat, in your blood.

To diagnose liver disease, your doctor will ask about your health history. They might also use imaging tests, test your blood, and test tissue samples. Some liver problems may be treated by healthy lifestyle changes. Some people with liver disease may need prescribed medication or surgery. If liver disease results in liver failure, a liver transplant may be necessary. Research is ongoing, so talk with your doctor and specialists about the most current treatment options. Support groups are a good source of information and can help connect you with others living with liver disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

Last Updated: 26 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

http://www.alagille.org

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

http://alpha1.org/

Last Updated: 26 Aug 2015

View Details

 

General Support Organizations

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General Resources

ALGSA CONNECT Patient Registry

Registry open to anyone with ALGS.

Updated 25 May 2013

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Blogs

ALGSA President's Blog

Cindy Luxhoj Hahn's weekly blog about being a parent of a child with ALGS and running the ALGSA.

Updated 25 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver disease" returned 4208 free, full-text research articles on human participants. First 3 results:

A novel index including SNPs for the screening of nonalcoholic fatty liver disease among elder Chinese: A population-based study.
 

Author(s): Huanhuan Yang, Guochong Chen, Chunli Song, Deming Li, Qinghua Ma, Guangliang Chen, Xinli Li

Journal: Medicine (Baltimore). 2018 Mar;97(13):e0272.

 

Presently noninvasive methods were employed to the diagnosis of nonalcoholic fatty liver disease (NAFLD), including fatty liver index (FLI), hepatic steatosis index (HSI), product of fasting triglyceride and glucose levels (TyG), and single nucleotide polymorphism (SNP), whereas the ...

Last Updated: 31 Dec 1969

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Components of metabolic syndrome increase the risk of mortality in nonalcoholic fatty liver disease (NAFLD).
 

Author(s): Pegah Golabi, Munkhzul Otgonsuren, Leyla de Avila, Mehmet Sayiner, Nila Rafiq, Zobair M Younossi

Journal: Medicine (Baltimore). 2018 Mar;97(13):e0214.

 

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the United States. Metabolic syndrome (MS) components are highly prevalent in NAFLD. Our aim is to assess the relationship of NAFLD and MS with long-term outcome of mortality.The Third National ...

Last Updated: 31 Dec 1969

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Role of IL-28B genetic variants in HCV-related liver disease severity in patients with different viral genotypes.
 

Author(s): Ching-I Huang, Chung-Feng Huang, Ming-Lun Yeh, Yi-Hung Lin, Po-Cheng Liang, Shang-Yin Vanson Liu, Meng-Hsuan Hsieh, Zu-Yau Lin, Shinn-Cherng Chen, Jee-Fu Huang, Wan-Long Chuang, Chia-Yen Dai, Ming-Lung Yu

Journal: Medicine (Baltimore). 2018 Mar;97(10):e9782.

 

Reports of the role of host interleukin 28B (IL-28B) genetic variants in liver disease severity in patients with chronic hepatitis C (CHC) have obtained conflicting results. The impact of IL-28B in Asian patients with different viral genotypes remains elusive.We try to elucidate the ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Liver disease" returned 1134 free, full-text review articles on human participants. First 3 results:

Organ-Organ Crosstalk and Alcoholic Liver Disease.
 

Author(s): Lauren G Poole, Christine E Dolin, Gavin E Arteel

Journal:

 

Alcohol consumption is a common custom worldwide, and the toxic effects of alcohol on several target organs are well-understood. Given the poor prognosis of treating clinically-relevant alcoholic liver disease (ALD) (i.e., alcoholic hepatitis (AH) and cirrhosis), additional research ...

Last Updated: 31 Dec 1969

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Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease.
 

Author(s): Chris Estes, Homie Razavi, Rohit Loomba, Zobair Younossi, Arun J Sanyal

Journal: Hepatology. 2018 01;67(1):123-133.

 

Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are highly prevalent in the United States, where they are a growing cause of cirrhosis and hepatocellular carcinoma (HCC) and increasingly an indicator for liver transplantation. A Markov model ...

Last Updated: 31 Dec 1969

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Association between Serum Uric Acid and Non-Alcoholic Fatty Liver Disease: A Meta-Analysis.
 

Author(s): Guntur Darmawan, Laniyati Hamijoyo, Irsan Hasan

Journal: Acta Med Indones. 2017 Apr;49(2):136-147.

 

non-alcoholic fatty liver disease (NAFLD) is known to be associated with some metabolic disorders. Recent studies suggested the role of uric acid in NAFLD through oxidative stress and inflammatory process. This study is aimed to evaluate the association between serum uric acid and NAFLD.

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 21 Oct 2016

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Thermal Imaging in Liver Disease.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 8 Sep 2017

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Last Updated: 4 Sep 2017

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