Liver disease

Common Name(s)

Liver disease

Liver disease is any type of damage to the liver that causes it not to function properly. The liver is an organ that helps digest food and remove toxins from the body. There are over 100 types of liver disease. Most forms of liver disease can either be inherited (genetic) or caused by virus or parasite infection, autoimmune diseases, alcohol abuse, or obesity. Damage to the liver can cause scarring (cirrhosis) and this scarring can eventually cause liver failure. Liver failure is very serious and is life-threatening.

There are many symptoms of liver disease. People with liver disease may have skin and eyes that look yellow (jaundice), stomach pain, and swelling in the stomach, legs, or ankles. Their urine is often very dark and they have pale colored or bloody feces. Individuals with liver disease may also have itchy skin, fatigue, nausea, vomiting, loss of appetite, and may bruise easily.

Risk factors for liver disease include sharing needles, exposure to other people’s blood and body fluids, and unprotected sex, tattoos, and body piercings. Other risk factors include heavy alcohol use, obesity, diabetes, and high levels of triglycerides, a type of fat, in your blood.

To diagnose liver disease, your doctor will ask about your health history. They might also use imaging tests, test your blood, and test tissue samples. Some liver problems may be treated by healthy lifestyle changes. Some people with liver disease may need prescribed medication or surgery. If liver disease results in liver failure, a liver transplant may be necessary. Research is ongoing, so talk with your doctor and specialists about the most current treatment options. Support groups are a good source of information and can help connect you with others living with liver disease.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

Last Updated: 26 Aug 2015

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Liver disease" for support, advocacy or research.

Hepatitis Foundation International

Hepatitis Foundation International is dedicated to promoting wellness and healthy lifestyles for all individuals in order to reduce the incidence of preventable diseases that affect the liver’s health including: obesity, diabetes, fatty liver, high cholesterol, cardiovascular disease, hepatitis, HIV/AIDS, and substance abuse. We inform, educate, and empower by making available reliable and up-to-date information.

http://www.HepatitisFoundation.org

Last Updated: 23 Feb 2015

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Alagille Syndrome Alliance

The purpose of the Alliance is to be the main networking resource and source of information for people with ALGS, their families, friends, and health care providers. The Alliance is also dedicated to increasing public awareness of ALGS and supporting research efforts on behalf of the ALGS community.

http://www.alagille.org

Last Updated: 25 May 2013

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Alpha-1 Foundation

The Alpha-1 Foundation is dedicated to providing the leadership and resources that will result in increased research, improved health, worldwide detection, and a cure for Alpha-1 Antitrypsin Deficiency.

http://alpha1.org/

Last Updated: 26 Aug 2015

View Details

 

General Support Organizations

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General Resources

ALGSA CONNECT Patient Registry

Registry open to anyone with ALGS.

Updated 25 May 2013

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Blogs

ALGSA President's Blog

Cindy Luxhoj Hahn's weekly blog about being a parent of a child with ALGS and running the ALGSA.

Updated 25 May 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Liver disease" returned 3784 free, full-text research articles on human participants. First 3 results:

No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial.
 

Author(s): Ilaria Barchetta, Maria Del Ben, Francesco Angelico, Michele Di Martino, Antonio Fraioli, Giuseppe La Torre, Rosella Saulle, Ludovica Perri, Sergio Morini, Claudio Tiberti, Laura Bertoccini, Flavia Agata Cimini, Francesca Panimolle, Carlo Catalano, Marco Giorgio Baroni, Maria Gisella Cavallo

Journal:

 

Non-alcoholic fatty liver disease (NAFLD) is the most common hepatic disorder worldwide, reaching prevalence up to 90 % in obese patients with type 2 diabetes (T2D), and representing an independent risk factor for cardiovascular mortality. Furthermore, the coexistence of T2D and NAFLD ...

Last Updated: 29 Jun 2016

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Correlation between Helicobacter pylori infection and polymorphism of adiponectin gene promoter
-11391G/A, superoxide dismutase gene in
nonalcoholic fatty liver disease.
 

Author(s): Chaoxian Zhang, Like Guo, Yongmei Qin, Guangyan Li

Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2016 Apr;41(4):359-66.

 

To investigate the correlation between Helicobacter pylori (H. Pylori) infection and polymorphism of adiponectin gene promoter -11391G/A, extracellular superoxide dismutase (EC-SOD) gene in nonalcoholic fatty liver disease (NAFLD).


Last Updated: 31 May 2016

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The longitudinal effect of the aldehyde dehydrogenase 2*2 allele on the risk for nonalcoholic fatty liver disease.
 

Author(s): K Oniki, K Morita, T Watanabe, A Kajiwara, K Otake, K Nakagawa, Y Sasaki, Y Ogata, J Saruwatari

Journal:

 

Aldehyde dehydrogenase 2 (ALDH2) detoxifies toxic aldehydes and has a key role in protecting the liver. An elevated gamma-glutamyl transferase (GGT) level is related to oxidative stress and nonalcoholic fatty liver disease (NAFLD). We herein investigated the association between inactive ...

Last Updated: 24 May 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Liver disease" returned 966 free, full-text review articles on human participants. First 3 results:

Intensive care management of patients with liver disease: proceedings of a single-topic conference sponsored by the Brazilian Society of Hepatology.
 

Author(s): Paulo Lisboa Bittencourt, Carlos Terra, Edison Roberto Parise, Alberto Queiroz Farias, , Vincent Arroyo, Javier Fernandez, Gustavo Pereira, Luiz Marcelo Maubouisson, Guilherme Marques Andrade, Fernando Gomes de Barros Costa, Liana Codes, Antônio Ricardo Andrade, Angelo Matos, André Torres, Fernanda Couto, Ivan Zyngier

Journal: Arq Gastroenterol. 2015 Dec;52 Suppl 1():55-72.

 

Survival rates of critically ill patients with liver disease has sharply increased in recent years due to several improvements in the management of decompensated cirrhosis and acute liver failure. This is ascribed to the incorporation of evidence-based strategies from clinical trials ...

Last Updated: 10 Mar 2016

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MicroRNAs as Biomarkers for Liver Disease and Hepatocellular Carcinoma.
 

Author(s): C Nelson Hayes, Kazuaki Chayama

Journal:

 

Serum levels of liver enzymes, such as alanine transaminase, aspartate transaminase, and α-fetoprotein, provide insight into liver function and are used during treatment of liver disease, but such information is limited. In the case of hepatocellular carcinoma (HCC), which is often ...

Last Updated: 1 Mar 2016

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Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis?
 

Author(s): Alessandro Mantovani, Paolo Gisondi, Amedeo Lonardo, Giovanni Targher

Journal:

 

Over the past 10 years, it has become increasingly evident that nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects multiple extra-hepatic organ systems and interacts with the regulation of several metabolic and immunological pathways. In this review we ...

Last Updated: 10 Feb 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Autologous Bone Marrow Stem Cells Infusion for the Treatment of Liver Diseases.
 

Status: Recruiting

Condition Summary: Liver Diseases

 

Last Updated: 21 Oct 2016

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Hepatic Venous Pressure Gradient and Platelet Activation in Chronic Liver Disease
 

Status: Recruiting

Condition Summary: Chronic Liver Disease

 

Last Updated: 30 Nov 2015

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Last Updated: 21 May 2015

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