Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

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Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

Last Updated: 30 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

Logo
Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

http://www.lipodystrophyunited.org/

Last Updated: 30 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 314 free, full-text research articles on human participants. First 3 results:

A very rare cause of acute pancreatitis: Berardinelli-Seip congenital lipodystrophy.
 

Author(s): Ali İşlek, Ersin Sayar, Aygen Yılmaz, Özgür Duman, Reha Artan

Journal: Turk J Gastroenterol. 2014 Dec;25 Suppl 1():216-9.

 

Pancreatitis is among rare diseases in pediatrics clinics. It is usually presented with a sign of underlying systemic disease. Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare disease characterized by near absence of adipose tissue resulting in apparent muscle hypertrophy ...

Last Updated: 27 Apr 2015

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[Familial partial lipodystrophy type 1. A rare or underdiagnosed syndrome?].
 

Author(s): Jimena Soutelo, Mariana Grüneisen, Clara Fritz, Laura Sordo, Yanina Powazniak, Rubén Lutfi

Journal: Medicina (B Aires). 2015 ;75(1):41-3.

 

Familial partial lipodystrophy (FPL) type 1 is a syndrome characterized by loss of subcutaneous fat in arms and legs and an excess of body fat in face, neck, and torso. This rare syndrome is usually diagnosed when patients present cardiovascular complications or pancreatitis due to ...

Last Updated: 1 Feb 2015

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Metabolic syndrome in relation to cardiorespiratory fitness, active and sedentary behavior in HIV+ Hispanics with and without lipodystrophy.
 

Author(s): Farah A Ramírez-Marrero, Jorge L Santana-Bagur, Michael J Joyner, Jorge Rodríguez-Zayas, Walter Frontera

Journal: P R Health Sci J. 2014 Dec;33(4):163-9.

 

Hispanics in Puerto Rico (PR) have a high prevalence of metabolic syndrome (met-syn), partially explained by low physical activity (PA) and possibly low cardiorespiratory fitness (VO2peak). Met-syn is also associated with lipodystrophy in HIV infected (HIV+) adults taking antiretroviral ...

Last Updated: 7 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 32 free, full-text review articles on human participants. First 3 results:

Membranous lipodystrophy: case report and review of the literature.
 

Author(s): Fatma Akpinar, Ektan Demir, Duygu Dusmez Apa

Journal: An Bras Dermatol. ;90(3 Suppl 1):115-7.

 

Membranous lipodystrophy is a distinct type of membranocystic fat necrosis. It is associated with many local and systemic diseases, including vascular disorders. The histopathological changes which characterize this phenomenon are variably sized cysts in the fat lobules of the subcutaneous ...

Last Updated: 28 Aug 2015

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Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints.
 

Author(s): Alexander J Rodríguez, Teresa Neeman, Aaron G Giles, Claudio A Mastronardi, Gilberto Paz Filho

Journal: Arq Bras Endocrinol Metabol. 2014 Nov;58(8):783-97.

 

The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence ...

Last Updated: 3 Dec 2014

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Towards a mechanistic understanding of lipodystrophy and seipin functions.
 

Author(s): Kenneth Wee, Wulin Yang, Shigeki Sugii, Weiping Han

Journal:

 

CGL (Congenital generalized lipodystrophy) is a genetic disorder characterized by near complete loss of adipose tissue along with increased ectopic fat storage in other organs including liver and muscle. Of the four CGL types, BSCL2 (Berardinelli-Seip Congenital lipodystrophy type ...

Last Updated: 23 Oct 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lipodystrophy Connect Patient Registry
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 14 Oct 2015

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Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 4 Nov 2015

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Last Updated: 23 Dec 2015

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