Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

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Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

Last Updated: 30 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

Logo
Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

http://www.lipodystrophyunited.org/

Last Updated: 30 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 305 free, full-text research articles on human participants. First 3 results:

People living with HIV on ART have accurate perception of lipodystrophy signs: a cross-sectional study.
 

Author(s): Paulo R Alencastro, Nemora T Barcellos, Fernando H Wolff, Maria Letícia R Ikeda, Fabiana Schuelter-Trevisol, Ajácio B M Brandão, Sandra C Fuchs

Journal:

 

The prevalence of lipodystrophy ranges from 31 to 65%, depending on the criteria adopted for diagnosis. The usual methods applied in the diagnosis vary from self-perception, medical examination, skinfolds measurements, or even imaging assessment for confirmation of fat distribution ...

Last Updated: 14 Jan 2017

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Novel subtype of congenital partial lipodystrophy with mandibular hypoplasia, sensorineural deafness and short stature of unknown genetic origin.
 

Author(s): Haruka Sasaki, Kumiko Ohkubo, Kunihisa Kobayashi, Yuji Tajiri, Satoshi Ugi, Atsunori Kashwagi

Journal: J Diabetes Investig. 2017 Jan;8(1):121-122.

 

The unique clinical manifestations of congenital partial lipodystrophy are herein reported due to its rarity.

Last Updated: 5 Jan 2017

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Limb-girdle muscular dystrophy with severe heart failure overlapping with lipodystrophy in a patient with LMNA mutation p.Ser334del.
 

Author(s): Agnieszka Madej-Pilarczyk, Adam Niezgoda, Magdalena Janus, Romuald Wojnicz, Michał Marchel, Anna Fidziańska, Stefan Grajek, Irena Hausmanowa-Petrusewicz

Journal: J. Appl. Genet.. 2017 Feb;58(1):87-91.

 

Laminopathies, a group of heterogeneous disorders associated with lamin A/C gene (LMNA) mutations, encompass a wide spectrum of clinical phenotypes, which may present as separate disease or as overlapping syndromes. We describe a 35-year-old female in whom a novel sporadic heterozygous ...

Last Updated: 2 Sep 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 32 free, full-text review articles on human participants. First 3 results:

Metreleptin for injection to treat the complications of leptin deficiency in patients with congenital or acquired generalized lipodystrophy.
 

Author(s): Cristina Adelia Meehan, Elaine Cochran, Andrea Kassai, Rebecca J Brown, Phillip Gorden

Journal: Expert Rev Clin Pharmacol. 2016 ;9(1):59-68.

 

The lipodystrophies represent a class of diseases characterized by leptin deficiency. Leptin deficiency is associated with a severe form of the metabolic syndrome characterized by dyslipidemia, insulin resistance, diabetes, and ovarian dysfunction. Metreleptin is the pharmaceutical ...

Last Updated: 27 Nov 2015

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Membranous lipodystrophy: case report and review of the literature.
 

Author(s): Fatma Akpinar, Ektan Demir, Duygu Dusmez Apa

Journal: An Bras Dermatol. ;90(3 Suppl 1):115-7.

 

Membranous lipodystrophy is a distinct type of membranocystic fat necrosis. It is associated with many local and systemic diseases, including vascular disorders. The histopathological changes which characterize this phenomenon are variably sized cysts in the fat lobules of the subcutaneous ...

Last Updated: 28 Aug 2015

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HIV/AIDS and lipodystrophy: implications for clinical management in resource-limited settings.
 

Author(s): Julia L Finkelstein, Pooja Gala, Rosemary Rochford, Marshall J Glesby, Saurabh Mehta

Journal:

 

Lipodystrophy is a term used to describe a metabolic complication of fat loss, fat gain, or a combination of fat loss and gain, which is associated with some antiretroviral (ARV) therapies given to HIV-infected individuals. There is limited research on lipodystrophy in low- and middle-income ...

Last Updated: 19 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lipodystrophy Connect Patient Registry
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 7 Nov 2016

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Last Updated: 24 Jan 2017

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Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 10 Mar 2017

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