Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 250 free, full-text research articles on human participants. First 3 results:

Prevalence and factors associated with lipodystrophy in AIDS patients.
 

Author(s): Lunara Basqueroto Della Justina, Magali Chaves Luiz, Rosemeri Maurici, Fabiana Schuelter-Trevisol

Journal: Rev. Soc. Bras. Med. Trop.. ;47(1):30-7.

 

The published literature shows an increased occurrence of adverse events, such as human immunodeficiency virus (HIV)-associated lipodystrophy syndrome, that are associated with the continuous use of antiretroviral therapy. This study was performed to estimate the prevalence and factors ...

Last Updated: 7 Mar 2014

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Novel PTRF mutation in a child with mild myopathy and very mild congenital lipodystrophy.
 

Author(s): Anna Ardissone, Cinzia Bragato, Lorella Caffi, Flavia Blasevich, Sabrina Maestrini, Maria Luisa Bianchi, Lucia Morandi, Isabella Moroni, Marina Mora

Journal:

 

Mutations in the PTRF gene, coding for cavin-1, cause congenital generalized lipodystrophy type 4 (CGL4) associated with myopathy. In CGL4, symptoms are variable comprising, in addition to myopathy, smooth and skeletal muscle hypertrophy, cardiac arrhythmias, and skeletal abnormalities. ...

Last Updated: 15 Nov 2013

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Lipodystrophy caused by repetitive pegylated interferon injection.
 

Author(s): Hiroshi Numao, Masayuki Baba

Journal: Intern. Med.. 2013 ;52(17):1991.

 

Last Updated: 2 Sep 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 26 free, full-text review articles on human participants. First 3 results:

Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome.
 

Author(s): P Pérez-Matute, L Pérez-Martínez, J R Blanco, J A Oteo

Journal: Oxid Med Cell Longev. 2013 ;2013():493413.

 

Highly active antiretroviral therapy (HAART) has considerably improved the prognosis of HIV-infected patients. However, prolonged use of HAART has been related to long-term adverse events that can compromise patient health such as HIV-associated lipodystrophy syndrome (HALS) and nonalcoholic ...

Last Updated: 23 Aug 2013

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Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction.
 

Author(s): Reneé de Waal, Karen Cohen, Gary Maartens

Journal:

 

Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug reactions.

Last Updated: 31 May 2013

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Nakajo-Nishimura syndrome: an autoinflammatory disorder showing pernio-like rashes and progressive partial lipodystrophy.
 

Author(s): Nobuo Kanazawa

Journal: Allergol Int. 2012 Jun;61(2):197-206.

 

Nakajo-Nishimura syndrome (ORPHA2615; also registered as Nakajo syndrome in OMIM#256040) is a distinct inherited inflammatory and wasting disease, originally reported from Japan. This disease usually begins in early infancy with a pernio-like rash, especially in winter. The patients ...

Last Updated: 28 May 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapeutic Approaches to HAART-Induced Lipodystrophy
 

Status: Recruiting

Condition Summary: HIV Infections; Lipodystrophy

 

Last Updated: 19 Jun 2013

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Identification of a New Gene Involved in Hereditary Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 5 Feb 2014

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Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 11 Apr 2014

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