Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

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Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

Last Updated: 30 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

Logo
Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

http://www.lipodystrophyunited.org/

Last Updated: 30 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 266 free, full-text research articles on human participants. First 3 results:

Metabolic syndrome in relation to cardiorespiratory fitness, active and sedentary behavior in HIV+ Hispanics with and without lipodystrophy.
 

Author(s): Farah A Ramírez-Marrero, Jorge L Santana-Bagur, Michael J Joyner, Jorge Rodríguez-Zayas, Walter Frontera

Journal: P R Health Sci J. 2014 Dec;33(4):163-9.

 

Hispanics in Puerto Rico (PR) have a high prevalence of metabolic syndrome (met-syn), partially explained by low physical activity (PA) and possibly low cardiorespiratory fitness (VO2peak). Met-syn is also associated with lipodystrophy in HIV infected (HIV+) adults taking antiretroviral ...

Last Updated: 7 Jan 2015

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Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy.
 

Author(s): Kristina Kozusko, Venessa H M Tsang, William Bottomley, Yoon-Hi Cho, Sheetal Gandotra, Michael Mimmack, Koini Lim, Iona Isaac, Satish Patel, Vladimir Saudek, Stephen O'Rahilly, Shubha Srinivasan, Jerry R Greenfield, Ines Barroso, Lesley V Campbell, David B Savage

Journal: Diabetes. 2015 Jan;64(1):299-310.

 

Perilipin 1 is a lipid droplet coat protein predominantly expressed in adipocytes, where it inhibits basal and facilitates stimulated lipolysis. Loss-of-function mutations in the PLIN1 gene were recently reported in patients with a novel subtype of familial partial lipodystrophy, ...

Last Updated: 24 Dec 2014

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Altered miRNA processing disrupts brown/white adipocyte determination and associates with lipodystrophy.
 

Author(s): Marcelo A Mori, Thomas Thomou, Jeremie Boucher, Kevin Y Lee, Susanna Lallukka, Jason K Kim, Martin Torriani, Hannele Yki-Järvinen, Steven K Grinspoon, Aaron M Cypess, C Ronald Kahn

Journal: J. Clin. Invest.. 2014 Aug;124(8):3339-51.

 

miRNAs are important regulators of biological processes in many tissues, including the differentiation and function of brown and white adipocytes. The endoribonuclease dicer is a major component of the miRNA-processing pathway, and in adipose tissue, levels of dicer have been shown ...

Last Updated: 2 Aug 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 25 free, full-text review articles on human participants. First 3 results:

Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome: a report of a novel mutation and review of the literature.
 

Author(s): J Kluk, M Rustin, P A Brogan, E Omoyinmi, D M Rowczenio, L C Willcocks, L Melly, H J Lachmann

Journal: Br. J. Dermatol.. 2014 Jan;170(1):215-7.

 

Last Updated: 21 Jan 2014

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Role of mitochondria in HIV infection and associated metabolic disorders: focus on nonalcoholic fatty liver disease and lipodystrophy syndrome.
 

Author(s): P Pérez-Matute, L Pérez-Martínez, J R Blanco, J A Oteo

Journal: Oxid Med Cell Longev. 2013 ;2013():493413.

 

Highly active antiretroviral therapy (HAART) has considerably improved the prognosis of HIV-infected patients. However, prolonged use of HAART has been related to long-term adverse events that can compromise patient health such as HIV-associated lipodystrophy syndrome (HALS) and nonalcoholic ...

Last Updated: 23 Aug 2013

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Systematic review of antiretroviral-associated lipodystrophy: lipoatrophy, but not central fat gain, is an antiretroviral adverse drug reaction.
 

Author(s): Reneé de Waal, Karen Cohen, Gary Maartens

Journal:

 

Lipoatrophy and/or central fat gain are observed frequently in patients on antiretroviral therapy (ART). Both are assumed to be antiretroviral adverse drug reactions.

Last Updated: 31 May 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Therapeutic Approaches to HAART-Induced Lipodystrophy
 

Status: Recruiting

Condition Summary: HIV Infections; Lipodystrophy

 

Last Updated: 19 Jun 2013

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Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 12 Aug 2014

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Last Updated: 18 Jun 2014

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