Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

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Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

Last Updated: 30 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

Logo
Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

http://www.lipodystrophyunited.org/

Last Updated: 30 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 331 free, full-text research articles on human participants. First 3 results:

A Prospective, Multicentre, Open-Label Single-Arm Exploratory Study to Evaluate Efficacy and Safety of Saroglitazar on Hypertriglyceridemia in HIV Associated Lipodystrophy.
 

Author(s): Alka Deshpande, Harsh Toshniwal, Shashank Joshi, Rajendrakumar H Jani

Journal:

 

This study was designed to explore the efficacy and safety of saroglitazar 4 mg on hypertriglyceridemia in patients with HIV associated lipodystrophy.

Last Updated: 21 Jan 2016

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Aerobic capacity and health-related quality of life in adults HIV-infected patients with and without lipodystrophy.
 

Author(s): Mansueto Gomes Neto, Cristiano Sena Conceição, Cecília Ogalha, Carlos Brites

Journal: Braz J Infect Dis. ;20(1):76-80.

 

HIV infection and its therapy which can affect their aerobic capacity and health-related quality of life of patients.

Last Updated: 27 Jan 2016

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HIV-1/HAART-Related Lipodystrophy Syndrome (HALS) Is Associated with Decreased Circulating sTWEAK Levels.
 

Author(s): Miguel López-Dupla, Elsa Maymó-Masip, Esteban Martínez, Pere Domingo, Manuel Leal, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Mireia Arnedo, Sara Ferrando-Martínez, Raúl Beltrán-Debón, Verónica Alba, Josep Ma Gatell, Joan Vendrell, Francesc Vidal, Matilde R Chacón

Journal:

 

Obesity and HIV-1/HAART-associated lipodystrophy syndrome (HALS) share clinical, pathological and mechanistic features. Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a multifunctional cytokine that plays an important role in obesity and related diseases. We sought ...

Last Updated: 15 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 37 free, full-text review articles on human participants. First 3 results:

Membranous lipodystrophy: case report and review of the literature.
 

Author(s): Fatma Akpinar, Ektan Demir, Duygu Dusmez Apa

Journal: An Bras Dermatol. ;90(3 Suppl 1):115-7.

 

Membranous lipodystrophy is a distinct type of membranocystic fat necrosis. It is associated with many local and systemic diseases, including vascular disorders. The histopathological changes which characterize this phenomenon are variably sized cysts in the fat lobules of the subcutaneous ...

Last Updated: 28 Aug 2015

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HIV/AIDS and lipodystrophy: implications for clinical management in resource-limited settings.
 

Author(s): Julia L Finkelstein, Pooja Gala, Rosemary Rochford, Marshall J Glesby, Saurabh Mehta

Journal:

 

Lipodystrophy is a term used to describe a metabolic complication of fat loss, fat gain, or a combination of fat loss and gain, which is associated with some antiretroviral (ARV) therapies given to HIV-infected individuals. There is limited research on lipodystrophy in low- and middle-income ...

Last Updated: 19 Jan 2015

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Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints.
 

Author(s): Alexander J Rodríguez, Teresa Neeman, Aaron G Giles, Claudio A Mastronardi, Gilberto Paz Filho

Journal: Arq Bras Endocrinol Metabol. 2014 Nov;58(8):783-97.

 

The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence ...

Last Updated: 3 Dec 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Lipodystrophy Connect Patient Registry
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 14 Oct 2015

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Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 6 Aug 2016

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Last Updated: 6 Aug 2016

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