Lipodystrophy

Common Name(s)

Lipodystrophy

Lipodystrophy refers to a collection of conditions caused by a problem with fat (lipid) metabolism. These conditions can be subclassified in a variety of ways. For example there are generalized, localized, congenital, and acquired forms of lipodystrophy. These conditions are characterized by the destruction (atrophy) of fatty (adipose) tissue. In many of the lipodystrophies there is a redistribution of body fat resulting in the fat collecting primarily in the center of the body.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

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Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

Last Updated: 30 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lipodystrophy" for support, advocacy or research.

Logo
Lipodystrophy United

​Lipodystrophy United is an organization of committed individuals living strong with Lipodystrophy. Our mission is to provide an interactive community, facilitating support & education for anyone affected by this rare disease. We serve as a resource & to increase awareness in the general population as well as the medical & insurance communities. We advocate & act as a catalyst for new patient diagnosis by assisting healthcare professionals in understanding Lipodystrophy trends, physical attributes & clinical symptoms in order to aid in the advancement of knowledge, treatment & future research.

http://www.lipodystrophyunited.org/

Last Updated: 30 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lipodystrophy" returned 270 free, full-text research articles on human participants. First 3 results:

Metabolic syndrome in relation to cardiorespiratory fitness, active and sedentary behavior in HIV+ Hispanics with and without lipodystrophy.
 

Author(s): Farah A Ramírez-Marrero, Jorge L Santana-Bagur, Michael J Joyner, Jorge Rodríguez-Zayas, Walter Frontera

Journal: P R Health Sci J. 2014 Dec;33(4):163-9.

 

Hispanics in Puerto Rico (PR) have a high prevalence of metabolic syndrome (met-syn), partially explained by low physical activity (PA) and possibly low cardiorespiratory fitness (VO2peak). Met-syn is also associated with lipodystrophy in HIV infected (HIV+) adults taking antiretroviral ...

Last Updated: 7 Jan 2015

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Longitudinal evaluation of manual lymphatic drainage for the treatment of gynoid lipodystrophy.
 

Author(s): Bianca Schonvvetter, Juliana Laudicéia Marques Soares, Ediléia Bagatin

Journal: An Bras Dermatol. ;89(5):712-8.

 

The gynoidlypodystrophy, known as cellulitis or cellulite, refers to a condition that gives the skin an undulating and uneven appearance, affecting 80-90% of women after puberty.

Last Updated: 4 Sep 2014

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Clinical and molecular characterization of a novel PLIN1 frameshift mutation identified in patients with familial partial lipodystrophy.
 

Author(s): Kristina Kozusko, Venessa H M Tsang, William Bottomley, Yoon-Hi Cho, Sheetal Gandotra, Michael Mimmack, Koini Lim, Iona Isaac, Satish Patel, Vladimir Saudek, Stephen O'Rahilly, Shubha Srinivasan, Jerry R Greenfield, Ines Barroso, Lesley V Campbell, David B Savage

Journal: Diabetes. 2015 Jan;64(1):299-310.

 

Perilipin 1 is a lipid droplet coat protein predominantly expressed in adipocytes, where it inhibits basal and facilitates stimulated lipolysis. Loss-of-function mutations in the PLIN1 gene were recently reported in patients with a novel subtype of familial partial lipodystrophy, ...

Last Updated: 24 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lipodystrophy" returned 28 free, full-text review articles on human participants. First 3 results:

Leptin replacement therapy for the treatment of non-HAART associated lipodystrophy syndromes: a meta-analysis into the effects of leptin on metabolic and hepatic endpoints.
 

Author(s): Alexander J Rodríguez, Teresa Neeman, Aaron G Giles, Claudio A Mastronardi, Gilberto Paz Filho

Journal: Arq Bras Endocrinol Metabol. 2014 Nov;58(8):783-97.

 

The clinical manifestations of lipodystrophy syndromes (LS) are hypoleptinemia, hyperglycemia, insulin resistance, dyslipidemia and hepatic steatosis. Leptin replacement therapy (LRT) is effective at improving these pathologies. Currently, there are no data compiling the evidence ...

Last Updated: 3 Dec 2014

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Towards a mechanistic understanding of lipodystrophy and seipin functions.
 

Author(s): Kenneth Wee, Wulin Yang, Shigeki Sugii, Weiping Han

Journal:

 

CGL (Congenital generalized lipodystrophy) is a genetic disorder characterized by near complete loss of adipose tissue along with increased ectopic fat storage in other organs including liver and muscle. Of the four CGL types, BSCL2 (Berardinelli-Seip Congenital lipodystrophy type ...

Last Updated: 23 Oct 2014

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Chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature syndrome: a report of a novel mutation and review of the literature.
 

Author(s): J Kluk, M Rustin, P A Brogan, E Omoyinmi, D M Rowczenio, L C Willcocks, L Melly, H J Lachmann

Journal: Br. J. Dermatol.. 2014 Jan;170(1):215-7.

 

Last Updated: 21 Jan 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Short-term Effects of Leptin in People With Lipodystrophy
 

Status: Recruiting

Condition Summary: Lipodystrophy

 

Last Updated: 10 Jun 2015

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Last Updated: 18 Jun 2014

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Phase 2 Study of Obeticholic Acid for Lipodystrophy Patients
 

Status: Not yet recruiting

Condition Summary: Familial Partial Lipodystrophy

 

Last Updated: 28 Apr 2015

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