Limbic encephalitis

Common Name(s)

Limbic encephalitis

Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Delayed diagnosis is common, but improvements are being made to assist in early detection. Early diagnosis may improve the outcome of limbic encephalitis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

Logo
Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

Last Updated: 25 Mar 2013

View Details
Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

Logo
Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

http://www.aealliance.org

Last Updated: 25 Mar 2013

View Details
Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

http://www.encephalitisglobal.org

Last Updated: 19 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Limbic encephalitis" returned 133 free, full-text research articles on human participants. First 3 results:

A Case of Seronegative Limbic Encephalitis with Multiple Sclerosis: A Possible Overlapping Syndrome.
 

Author(s): Zerrin Karaaslan, Özlem Mercan, Erdem Tüzün, Handan Mısırlı, Recai Türkoğlu

Journal:

 

BACKGROUND Autoimmune encephalitis might coexist in patients with autoimmune demyelinating disorders. CASE REPORT We report on a case of a 45-year-old female multiple sclerosis (MS) patient presenting with acute onset short-term memory loss, altered mental status, inflammatory cerebrospinal ...

Last Updated: 18 Jan 2017

Go To URL
Limbic Encephalitis Associated with Sjögren's Syndrome: Report of Three Cases.
 

Author(s): Arzu Çoban, Selen Özyurt, Kaan Meriç, Handan Mısırlı, Erdem Tüzün, Recai Türkoğlu

Journal: Intern. Med.. 2016 ;55(16):2285-9.

 

Sjögren's syndrome (SS) may be complicated by neurological manifestations. We herein report three women (age range 26-60 years old) who all presented with limbic encephalitis (LE) as the predominant clinical feature 3 months to 15 years after the diagnosis of SS. The 26-year-old ...

Last Updated: 15 Aug 2016

Go To URL
Clinical analysis of leucine-rich glioma inactivated-1 protein antibody associated with limbic encephalitis onset with seizures.
 

Author(s): Zhimei Li, Tao Cui, Weixiong Shi, Qun Wang

Journal: Medicine (Baltimore). 2016 Jul;95(28):e4244.

 

We summarized the clinical characteristics of patients presenting with seizures and limbic encephalitis (LE) associated with leucine-rich glioma inactivated-1 protein antibody (LGI1) in order help recognize and treat this condition at its onset.We analyzed clinical, video electroencephalogram ...

Last Updated: 19 Jul 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Limbic encephalitis" returned 12 free, full-text review articles on human participants. First 3 results:

Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review.
 

Author(s): Yu Uneno, Akira Yokoyama, Yoshitaka Nishikawa, Taro Funakoshi, Yoshinao Ozaki, Ikuo Aoyama, Kiichiro Baba, Daisuke Yamaguchi, Shuko Morita, Yukiko Mori, Masashi Kanai, Hisanori Kinoshita, Takeshi Inoue, Nobukatsu Sawamoto, Riki Matsumoto, Shigemi Matsumoto, Manabu Muto

Journal: Intern. Med.. ;55(18):2605-9.

 

Paraneoplastic neurological syndromes (PNSs) are rare nervous system dysfunctions in cancer patients, which are primarily observed with small-cell lung cancer, gynecological cancer, and thymoma. We herein present an uncommon case of PNS in an anti-Hu antibody-positive patient with ...

Last Updated: 16 Sep 2016

Go To URL
Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable.
 

Author(s): Adham Jammoul, Yuebing Li, Alexander Rae-Grant

Journal: Cleve Clin J Med. 2016 Jan;83(1):43-53.

 

Autoantibody-mediated encephalitis is a heterogeneous group of recently identified disorders, all caused by autoimmunity directed against components of the central nervous system. Despite severe and even prolonged neurologic deficits, dramatic improvements may occur with aggressive treatment.

Last Updated: 14 Jan 2016

Go To URL
Recognizing Autoimmune-Mediated Encephalitis in the Differential Diagnosis of Limbic Disorders.
 

Author(s): A J da Rocha, R H Nunes, A C M Maia, L L F do Amaral

Journal: AJNR Am J Neuroradiol. 2015 Dec;36(12):2196-205.

 

Limbic encephalitis is far more common than previously thought. It is not always associated with cancer, and it is potentially treatable. Autoantibodies against various neuronal cell antigens may arise independently or in association with cancer and cause autoimmune damage to the ...

Last Updated: 16 Dec 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Antibodies Causing Epilepsy Syndromes: The ACES Study.
 

Status: Recruiting

Condition Summary: Auto-immune Encephalitis; Epilepsy

 

Last Updated: 13 Jun 2016

Go to URL