Limbic encephalitis

Common Name(s)

Limbic encephalitis

Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Delayed diagnosis is common, but improvements are being made to assist in early detection. Early diagnosis may improve the outcome of limbic encephalitis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

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Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

Last Updated: 25 Mar 2013

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Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

Last Updated: 19 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

Logo
Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

http://www.aealliance.org

Last Updated: 25 Mar 2013

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Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

http://www.encephalitisglobal.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Limbic encephalitis" returned 138 free, full-text research articles on human participants. First 3 results:

Anti-Ma2-associated limbic encephalitis with coexisting chronic inflammatory demyelinating polyneuropathy in a patient with non-Hodgkin lymphoma: A case report.
 

Author(s): Weina Ju, Baochang Qi, Xu Wang, Yu Yang

Journal: Medicine (Baltimore). 2017 Oct;96(40):e8228.

 

We report the rare case of a 74-year-old man with anti-Ma2-associated paraneoplastic neurologic syndrome (PNS), and review and analyze the clinical manifestations, diagnosis, and treatment of the disease.

Last Updated: 31 Dec 1969

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Delayed LGI1 seropositivity in voltage-gated potassium channel (VGKC)-complex antibody limbic encephalitis.
 

Author(s): Michael Sweeney, Jonathan Galli, Scott McNally, Anne Tebo, Thomas Haven, Perla Thulin, Stacey L Clardy

Journal:

 

We utilise a clinical case to highlight why exclusion of voltage-gated potassium channel (VGKC)-complex autoantibody testing in serological evaluation of patients may delay or miss the diagnosis. A 68-year-old man presented with increasing involuntary movements consistent with faciobrachial ...

Last Updated: 31 Dec 1969

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Focal CA3 hippocampal subfield atrophy following LGI1 VGKC-complex antibody limbic encephalitis.
 

Author(s): Thomas D Miller, Trevor T-J Chong, Anne M Aimola Davies, Tammy W C Ng, Michael R Johnson, Sarosh R Irani, Angela Vincent, Masud Husain, Saiju Jacob, Paul Maddison, Christopher Kennard, Penny A Gowland, Clive R Rosenthal

Journal: Brain. 2017 May;140(5):1212-1219.

 

Magnetic resonance imaging has linked chronic voltage-gated potassium channel (VGKC) complex antibody-mediated limbic encephalitis with generalized hippocampal atrophy. However, autoantibodies bind to specific rodent hippocampal subfields. Here, human hippocampal subfield (subiculum, ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Limbic encephalitis" returned 12 free, full-text review articles on human participants. First 3 results:

Paraneoplastic Limbic Encephalitis in a Human Epidermal Growth Factor Receptor-2-positive Gastric Cancer Patient Treated with Trastuzumab-combined Chemotherapy: A Case Report and Literature Review.
 

Author(s): Yu Uneno, Akira Yokoyama, Yoshitaka Nishikawa, Taro Funakoshi, Yoshinao Ozaki, Ikuo Aoyama, Kiichiro Baba, Daisuke Yamaguchi, Shuko Morita, Yukiko Mori, Masashi Kanai, Hisanori Kinoshita, Takeshi Inoue, Nobukatsu Sawamoto, Riki Matsumoto, Shigemi Matsumoto, Manabu Muto

Journal: Intern. Med.. ;55(18):2605-9.

 

Paraneoplastic neurological syndromes (PNSs) are rare nervous system dysfunctions in cancer patients, which are primarily observed with small-cell lung cancer, gynecological cancer, and thymoma. We herein present an uncommon case of PNS in an anti-Hu antibody-positive patient with ...

Last Updated: 31 Dec 1969

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Autoantibody-mediated encephalitis: Not just paraneoplastic, not just limbic, and not untreatable.
 

Author(s): Adham Jammoul, Yuebing Li, Alexander Rae-Grant

Journal: Cleve Clin J Med. 2016 Jan;83(1):43-53.

 

Autoantibody-mediated encephalitis is a heterogeneous group of recently identified disorders, all caused by autoimmunity directed against components of the central nervous system. Despite severe and even prolonged neurologic deficits, dramatic improvements may occur with aggressive treatment.

Last Updated: 31 Dec 1969

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Recognizing Autoimmune-Mediated Encephalitis in the Differential Diagnosis of Limbic Disorders.
 

Author(s): A J da Rocha, R H Nunes, A C M Maia, L L F do Amaral

Journal: AJNR Am J Neuroradiol. 2015 Dec;36(12):2196-205.

 

Limbic encephalitis is far more common than previously thought. It is not always associated with cancer, and it is potentially treatable. Autoantibodies against various neuronal cell antigens may arise independently or in association with cancer and cause autoimmune damage to the ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Antibodies Causing Epilepsy Syndromes: The ACES Study.
 

Status: Recruiting

Condition Summary: Auto-immune Encephalitis; Epilepsy

 

Last Updated: 25 Jul 2017

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