Limbic encephalitis

Common Name(s)

Limbic encephalitis

Limbic encephalitis is a condition marked by the inflammation of the limbic system and other parts of the brain. The cardinal sign of limbic encephalitis is a severe impairment of short-term memory; however, symptoms may also include confusion, psychiatric symptoms, and seizures. The symptoms typically develop over a few weeks or months, but they may evolve over a few days. Delayed diagnosis is common, but improvements are being made to assist in early detection. Early diagnosis may improve the outcome of limbic encephalitis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

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Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

Last Updated: 25 Mar 2013

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Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

Last Updated: 19 Feb 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Limbic encephalitis" for support, advocacy or research.

Logo
Autoimmune Encephalitis Alliance

The Autoimmune Encephalitis Alliance improves the lives of patients with autoimmune encephalitis by promoting collaboration across clinical and basic research and by creating a community of patients, families and caregivers so that no one faces autoimmune encephalitis alone.

http://www.aealliance.org

Last Updated: 25 Mar 2013

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Encephalitis Global Inc.

Encephalitis Global (E Global) is a U.S.A. 501(c)(3) public charity formed in 2005 as an alliance connecting encephalitis survivors and caregivers around the world. E Global strives to raise awareness, aiming to promote swift diagnosis, to alleviate unnecessary suffering and to prevent untimely death.

http://www.encephalitisglobal.org

Last Updated: 19 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Limbic encephalitis" returned 80 free, full-text research articles on human participants. First 3 results:

Limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies as a cause of adult-onset mesial temporal lobe epilepsy.
 

Author(s): Tomoko Toyota, Naoki Akamatsu, Sadatoshi Tsuji, Shigeru Nishizawa

Journal: J. UOEH. 2014 Jun;36(2):129-33.

 

Recently, some reports have indicated that limbic encephalitis associated with anti-voltage-gated potassium channel complex antibodies (VGKC-Ab) is a cause of adult-onset mesial temporal lobe epilepsy (MTLE). We report a 53-year-old woman who had her first epileptic seizure at the ...

Last Updated: 16 Jun 2014

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Paraneoplastic CRMP-5 basal ganglionitis and limbic encephalitis in an elderly Indian lady.
 

Author(s): Boby Varkey Maramattom

Journal: Neurol India. ;61(5):534-5.

 

Last Updated: 22 Nov 2013

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Autoantibodies to epilepsy-related LGI1 in limbic encephalitis neutralize LGI1-ADAM22 interaction and reduce synaptic AMPA receptors.
 

Author(s): Toshika Ohkawa, Yuko Fukata, Miwako Yamasaki, Taisuke Miyazaki, Norihiko Yokoi, Hiroshi Takashima, Masahiko Watanabe, Osamu Watanabe, Masaki Fukata

Journal: J. Neurosci.. 2013 Nov;33(46):18161-74.

 

More than 30 mutations in LGI1, a secreted neuronal protein, have been reported with autosomal dominant lateral temporal lobe epilepsy (ADLTE). Although LGI1 haploinsufficiency is thought to cause ADLTE, the underlying molecular mechanism that results in abnormal brain excitability ...

Last Updated: 14 Nov 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Limbic encephalitis" returned 7 free, full-text review articles on human participants. First 3 results:

Are onconeural antibodies a clinical phenomenology in paraneoplastic limbic encephalitis?
 

Author(s): Hongliang Zhang, Chunkui Zhou, Limin Wu, Fengming Ni, Jie Zhu, Tao Jin

Journal: Mediators Inflamm.. 2013 ;2013():172986.

 

Paraneoplastic neurological syndromes (PNSs) occur in patients with cancer and can cause clinical symptoms and signs of dysfunction of the nervous system that are not due to a local effect of the tumor or its metastases. Most of these clinical syndromes in adults are associated with ...

Last Updated: 28 Aug 2013

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[Recent concept of limbic encephalitis: progress in anti-NMDA receptor encephalitis].
 

Author(s): Shigeaki Suzuki, Morinobu Seki, Norihiro Suzuki

Journal: Nihon Rinsho Meneki Gakkai Kaishi. 2013 ;36(2):86-94.

 

Patients with limbic encephalitis usually present with rapidly progressive short-term memory deficits, psychiatric symptoms, and seizures. The recent concept of limbic encephalitis has been expanded. Especially, various types of autoimmune limbic encephalitis are associated with autoantibodies ...

Last Updated: 30 Apr 2013

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Diagnostic value of CSF findings in antibody-associated limbic and anti-NMDAR-encephalitis.
 

Author(s): Michael P Malter, Christian E Elger, Rainer Surges

Journal: Seizure. 2013 Mar;22(2):136-40.

 

In people with suspected inflammatory CNS disease, cerebrospinal fluid (CSF) is commonly analyzed. Antibody-associated limbic encephalitis (ab-LE) and anti-NMDAR-encephalitis are recognized as two major syndromes of autoimmune epilepsies. Here, we investigated the diagnostic value ...

Last Updated: 6 Feb 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.