Anaplastic oligodendroglioma

Common Name(s)

Anaplastic oligodendroglioma

Anaplastic oligodendroglioma is a rare form of brain cancer caused by tumors from oligodendrocytes. Oligodendrocytes is a type of cell that make up the supportive tissue (glial tissue) of the brain. Brain tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. Anaplastic oligodendroglioma is a grade III tumor which means it is more likely to grow and spread quickly than a lower grade of tumor. Symptoms may include seizures, headaches, and personality changes. Other symptoms may vary depending on the location and size of the tumors including short-term memory loss, visual loss, motor weakness, and language problems. Because of the slow growth of these tumors, oligodendrogliomas may be present much earlier than it is diagnosed. Most cases of oligodendrolgliomas occur in adults ages 50-60 and is more common in males than females. Oligodendroglioma's are rare and only account for about 4% of all primary brain tumors. The exact cause is currently unknown however genetic changes may contribute to the development of these tumors. The main treatment for this type of cancer is a combination of chemotherapy and radiotherapy. Surgery may be required if the tumor is returns. Diagnoses may be done through a CT or MRI scan, however the main confirmation of the tumor is best done with a biopsy, in which the doctor removes a part or all of the tumor for examination. If you or a family member has been diagnosed with an anaplastic oligodendroglioma, talk with your doctors and specialists to learn about the most current treatment options available. Support groups are also a good source of information and may help you connect with others also affected by anaplastic oligodendrogliomas.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic oligodendroglioma" returned 20 free, full-text research articles on human participants. First 3 results:

A novel, diffusely infiltrative xenograft model of human anaplastic oligodendroglioma with mutations in FUBP1, CIC, and IDH1.
 

Author(s): Barbara Klink, Hrvoje Miletic, Daniel Stieber, Peter C Huszthy, Jaime Alberto Campos Valenzuela, Jaime Alberto Campos Valenzuela, Jörg Balss, Jian Wang, Manja Schubert, Per Øystein Sakariassen, Terje Sundstrøm, Anja Torsvik, Mads Aarhus, Rupavathana Mahesparan, Andreas von Deimling, Lars Kaderali, Simone P Niclou, Evelin Schröck, Rolf Bjerkvig, Janice M Nigro

Journal: PLoS ONE. 2013 ;8(3):e59773.

 

Oligodendroglioma poses a biological conundrum for malignant adult human gliomas: it is a tumor type that is universally incurable for patients, and yet, only a few of the human tumors have been established as cell populations in vitro or as intracranial xenografts in vivo. Their ...

Last Updated: 25 Mar 2013

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Phase III trial of chemoradiotherapy for anaplastic oligodendroglioma: long-term results of RTOG 9402.
 

Author(s): Gregory Cairncross, Meihua Wang, Edward Shaw, Robert Jenkins, David Brachman, Jan Buckner, Karen Fink, Luis Souhami, Normand Laperriere, Walter Curran, Minesh Mehta

Journal: J. Clin. Oncol.. 2013 Jan;31(3):337-43.

 

Anaplastic oligodendrogliomas, pure (AO) and mixed (anaplastic oligoastrocytoma [AOA]), are chemosensitive, especially if codeleted for 1p/19q, but whether patients live longer after chemoradiotherapy is unknown.

Last Updated: 21 Jan 2013

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Adjuvant procarbazine, lomustine, and vincristine chemotherapy in newly diagnosed anaplastic oligodendroglioma: long-term follow-up of EORTC brain tumor group study 26951.
 

Author(s): Martin J van den Bent, Alba A Brandes, Martin J B Taphoorn, Johan M Kros, Mathilde C M Kouwenhoven, Jean-Yves Delattre, Hans J J A Bernsen, Marc Frenay, Cees C Tijssen, Wolfgang Grisold, László Sipos, Roelien H Enting, Pim J French, Winand N M Dinjens, Charles J Vecht, Anouk Allgeier, Denis Lacombe, Thierry Gorlia, Khê Hoang-Xuan

Journal: J. Clin. Oncol.. 2013 Jan;31(3):344-50.

 

Anaplastic oligodendroglioma are chemotherapy-sensitive tumors. We now present the long-term follow-up findings of a randomized phase III study on the addition of six cycles of procarbazine, lomustine, and vincristine (PCV) chemotherapy to radiotherapy (RT).

Last Updated: 21 Jan 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic oligodendroglioma" returned 1 free, full-text review articles on human participants. First 3 results:

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review.
 

Author(s): Gang Li, Zhiguo Zhang, Jianghong Zhang, Tianbo Jin, Hongjuan Liang, Li Gong, Guangbin Cui, Haixia Yang, Shiming He, Yongsheng Zhang, Guodong Gao

Journal:

 

It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.

Last Updated: 6 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Combination Chemotherapy With BBBD Followed By Sodium Thiosulfate in Treating Patients With Anaplastic Oligodendroglioma or Oligoastrocytoma
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Mixed Oligoastrocytoma; Brain and Central Nervous System Tumors

 

Last Updated: 2 May 2014

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Temozolomide in Relapsed or Advanced Anaplastic Oligodendroglioma and Oligoastrocytoma: Single-arm, Phase II Trial
 

Status: Recruiting

Condition Summary: Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma

 

Last Updated: 23 May 2014

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18F-DOPA-PET in Planning Surgery in Patients With Gliomas
 

Status: Recruiting

Condition Summary: Acoustic Schwannoma; Adult Anaplastic (Malignant) Meningioma; Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Choroid Plexus Neoplasm; Adult Craniopharyngioma; Adult Diffuse Astrocytoma; Adult Ependymoblastoma; Adult Ependymoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Medulloblastoma; Adult Mixed Glioma; Adult Myxopapillary Ependymoma; Adult Oligodendroglioma; Adult Papillary Meningioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Pineoblastoma; Adult Pineocytoma; Adult Primary Melanocytic Lesion of Meninges; Adult Subependymal Giant Cell Astrocytoma; Adult Subependymoma; Childhood Cerebellar Anaplastic Astrocytoma; Childhood Cerebellar Astrocytoma; Childhood Cerebral Anaplastic Astrocytoma; Childhood Cerebral Astrocytoma; Childhood Choroid Plexus Neoplasm; Childhood Craniopharyngioma; Childhood Ependymoblastoma; Childhood Grade I Meningioma; Childhood Grade II Meningioma; Childhood Grade III Meningioma; Childhood Infratentorial Ependymoma; Childhood Mixed Glioma; Childhood Supratentorial Ependymoma; Malignant Adult Intracranial Hemangiopericytoma; Medulloepithelioma; Newly Diagnosed Childhood Ependymoma; Recurrent Adult Brain Neoplasm; Recurrent Childhood Anaplastic Astrocytoma; Recurrent Childhood Anaplastic Oligoastrocytoma; Recurrent Childhood Anaplastic Oligodendroglioma; Recurrent Childhood Brain Stem Glioma; Recurrent Childhood Cerebellar Astrocytoma; Recurrent Childhood Cerebral Astrocytoma; Recurrent Childhood Diffuse Astrocytoma; Recurrent Childhood Ependymoma; Recurrent Childhood Fibrillary Astrocytoma; Recurrent Childhood Gemistocytic Astrocytoma; Recurrent Childhood Giant Cell Glioblastoma; Recurrent Childhood Glioblastoma; Recurrent Childhood Gliomatosis Cerebri; Recurrent Childhood Gliosarcoma; Recurrent Childhood Medulloblastoma; Recurrent Childhood Oligoastrocytoma; Recurrent Childhood Oligodendroglioma; Recurrent Childhood Pilocytic Astrocytoma; Recurrent Childhood Pilomyxoid Astrocytoma; Recurrent Childhood Pineoblastoma; Recurrent Childhood Pleomorphic Xanthoastrocytoma; Recurrent Childhood Protoplasmic Astrocytoma; Recurrent Childhood Subependymal Giant Cell Astrocytoma; Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor; Recurrent Childhood Visual Pathway Glioma; Untreated Childhood Anaplastic Astrocytoma; Untreated Childhood Anaplastic Oligoastrocytoma; Untreated Childhood Anaplastic Oligodendroglioma; Untreated Childhood Brain Stem Glioma; Untreated Childhood Diffuse Astrocytoma; Untreated Childhood Fibrillary Astrocytoma; Untreated Childhood Gemistocytic Astrocytoma; Untreated Childhood Giant Cell Glioblastoma; Untreated Childhood Glioblastoma; Untreated Childhood Gliomatosis Cerebri; Untreated Childhood Gliosarcoma; Untreated Childhood Medulloblastoma; Untreated Childhood Oligoastrocytoma; Untreated Childhood Oligodendroglioma; Untreated Childhood Pilocytic Astrocytoma; Untreated Childhood Pilomyxoid Astrocytoma; Untreated Childhood Pineoblastoma; Untreated Childhood Pleomorphic Xanthoastrocytoma; Untreated Childhood Protoplasmic Astrocytoma; Untreated Childhood Subependymal Giant Cell Astrocytoma; Untreated Childhood Supratentorial Primitive Neuroectodermal Tumor; Untreated Childhood Visual Pathway Glioma

 

Last Updated: 17 Dec 2014

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