Anaplastic oligodendroglioma

Common Name(s)

Anaplastic oligodendroglioma

Anaplastic oligodendroglioma is a rare form of brain cancer caused by tumors from oligodendrocytes. Oligodendrocytes is a type of cell that make up the supportive tissue (glial tissue) of the brain. Brain tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. Anaplastic oligodendroglioma is a grade III tumor which means it is more likely to grow and spread quickly than a lower grade of tumor. Symptoms may include seizures, headaches, and personality changes. Other symptoms may vary depending on the location and size of the tumors including short-term memory loss, visual loss, motor weakness, and language problems. Because of the slow growth of these tumors, oligodendrogliomas may be present much earlier than it is diagnosed. Most cases of oligodendrolgliomas occur in adults ages 50-60 and is more common in males than females. Oligodendroglioma's are rare and only account for about 4% of all primary brain tumors. The exact cause is currently unknown however genetic changes may contribute to the development of these tumors. The main treatment for this type of cancer is a combination of chemotherapy and radiotherapy. Surgery may be required if the tumor is returns. Diagnoses may be done through a CT or MRI scan, however the main confirmation of the tumor is best done with a biopsy, in which the doctor removes a part or all of the tumor for examination. If you or a family member has been diagnosed with an anaplastic oligodendroglioma, talk with your doctors and specialists to learn about the most current treatment options available. Support groups are also a good source of information and may help you connect with others also affected by anaplastic oligodendrogliomas.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic oligodendroglioma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic oligodendroglioma" returned 21 free, full-text research articles on human participants. First 3 results:

Molecular classification of anaplastic oligodendroglioma using next-generation sequencing: a report of the prospective randomized EORTC Brain Tumor Group 26951 phase III trial.
 

Author(s): Hendrikus J Dubbink, Peggy N Atmodimedjo, Johan M Kros, Pim J French, Marc Sanson, Ahmed Idbaih, Pieter Wesseling, Roelien Enting, Wim Spliet, Cees Tijssen, Winand N M Dinjens, Thierry Gorlia, Martin J van den Bent

Journal: Neuro-oncology. 2016 Mar;18(3):388-400.

 

Histopathological diagnosis of diffuse gliomas is subject to interobserver variation and correlates modestly with major prognostic and predictive molecular abnormalities. We investigated a series of patients with locally diagnosed anaplastic oligodendroglial tumors included in the ...

Last Updated: 26 Feb 2016

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TCF12 is mutated in anaplastic oligodendroglioma.
 

Author(s): Karim Labreche, Iva Simeonova, Aurélie Kamoun, Vincent Gleize, Daniel Chubb, Eric Letouzé, Yasser Riazalhosseini, Sara E Dobbins, Nabila Elarouci, Francois Ducray, Aurélien de Reyniès, Diana Zelenika, Christopher P Wardell, Mathew Frampton, Olivier Saulnier, Tomi Pastinen, Sabrina Hallout, Dominique Figarella-Branger, Caroline Dehais, Ahmed Idbaih, Karima Mokhtari, Jean-Yves Delattre, Emmanuelle Huillard, G Mark Lathrop, Marc Sanson, Richard S Houlston,

Journal:

 

Anaplastic oligodendroglioma (AO) are rare primary brain tumours that are generally incurable, with heterogeneous prognosis and few treatment targets identified. Most oligodendrogliomas have chromosomes 1p/19q co-deletion and an IDH mutation. Here we analysed 51 AO by whole-exome ...

Last Updated: 13 Jun 2015

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Novel MSH6 mutations in treatment-naïve glioblastoma and anaplastic oligodendroglioma contribute to temozolomide resistance independently of MGMT promoter methylation.
 

Author(s): Stephanie A Nguyen, Owen D M Stechishin, H Artee Luchman, Xueqing Q Lun, Donna L Senger, Stephen M Robbins, J Gregory Cairncross, Samuel Weiss

Journal: Clin. Cancer Res.. 2014 Sep;20(18):4894-903.

 

The current standard of care for glioblastoma (GBM) involves a combination of surgery, radiotherapy, and temozolomide chemotherapy, but this regimen fails to achieve long-term tumor control. Resistance to temozolomide is largely mediated by expression of the DNA repair enzyme MGMT; ...

Last Updated: 16 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic oligodendroglioma" returned 1 free, full-text review articles on human participants. First 3 results:

Occipital anaplastic oligodendroglioma with multiple organ metastases after a short clinical course: a case report and literature review.
 

Author(s): Gang Li, Zhiguo Zhang, Jianghong Zhang, Tianbo Jin, Hongjuan Liang, Li Gong, Guangbin Cui, Haixia Yang, Shiming He, Yongsheng Zhang, Guodong Gao

Journal:

 

It is generally believed that malignant gliomas never metastasize outside the central nervous system (CNS). However, the notion that oligodendrogliomas (OGDs) cells cannot spread outside CNS is being challenged.

Last Updated: 6 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Carboplatin, Melphalan, Etoposide Phosphate, Mannitol, and Sodium Thiosulfate in Treating Patients With Previously Treated Brain Tumors
 

Status: Recruiting

Condition Summary: Adult Anaplastic Oligodendroglioma; Adult Mixed Glioma; Adult Oligodendroglioma; Oligoastrocytoma; Recurrent Adult Brain Neoplasm

 

Last Updated: 19 Jun 2017

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Last Updated: 2 Jul 2017

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Carboplatin in Treating Patients With Recurrent High-Grade Gliomas
 

Status: Recruiting

Condition Summary: Adult Anaplastic Astrocytoma; Adult Anaplastic Oligodendroglioma; Recurrent Adult Brain Tumor

 

Last Updated: 25 Sep 2017

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