Light chain deposition disease

Common Name(s)

Light chain deposition disease

Light chain deposition disease involves our immune system. It is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. Immunoglobulins, also known as antibodies, are special proteins made by immune cells. While an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. Early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. Light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Light chain deposition disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Light chain deposition disease" returned 49 free, full-text research articles on human participants. First 3 results:

Natural history and outcome of light chain deposition disease.
 

Author(s): Rabya H Sayed, Ashutosh D Wechalekar, Janet A Gilbertson, Paul Bass, Shameem Mahmood, Sajitha Sachchithanantham, Marianna Fontana, Ketna Patel, Carol J Whelan, Helen J Lachmann, Philip N Hawkins, Julian D Gillmore

Journal: Blood. 2015 Dec;126(26):2805-10.

 

Light chain deposition disease (LCDD) is characterized by the deposition of monotypic immunoglobulin light chains in the kidney, resulting in renal dysfunction. Fifty-three patients with biopsy-proven LCDD were prospectively followed at the UK National Amyloidosis Center. Median age ...

Last Updated: 25 Dec 2015

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Monoclonal gammopathy of renal significance with light-chain deposition disease diagnosed postrenal transplant: a diagnostic and therapeutic challenge.
 

Author(s): Aruna Nambirajan, Dipankar Bhowmik, Geetika Singh, Sanjay Kumar Agarwal, Amit Kumar Dinda

Journal: Transpl. Int.. 2015 Mar;28(3):375-9.

 

Patients with light-chain deposition disease (LCDD) frequently do not meet criteria for myeloma. In such cases, despite low tumor burden, the circulating monoclonal immunoglobulins cause renal damage, are responsible for post-transplant recurrence, and are rightly categorized as monoclonal ...

Last Updated: 14 Feb 2015

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Isolated intracerebral light chain deposition disease: novel imaging and pathologic findings.
 

Author(s): John-Paul J Yu, David M Wilson, Edward F Chang, Jennifer Cotter, Arie Perry, Anuj Mahindra, Christine M Glastonbury

Journal: Clin Imaging. ;38(6):868-71.

 

Light chain deposition disease (LCDD) is a rare clinicopathologic entity first described in 1976 and is characterized by a monoclonal gammopathy resulting in nonamyloid immunoglobulin light chain tissue deposition. Only four cases of intracerebral LCDD have been previously reported, ...

Last Updated: 2 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Light chain deposition disease" returned 3 free, full-text review articles on human participants. First 3 results:

Light-Chain Deposition Disease Successfully Treated with Bortezomib in an Elderly Patient: A Case Report and Review of the Literature.
 

Author(s): Yukihiro Wada, Masayuki Iyoda, Tomohiro Saito, Noriko Arai-Nunota, Ken Iseri, Eiko Tomita, Misa Ikeda, Yutaka Yamaguchi, Takanori Shibata

Journal: Intern. Med.. 2015 ;54(22):2893-8.

 

We herein report the case of an elderly patient with light-chain deposition disease (LCDD) successfully treated with bortezomib. An 83-year-old woman was admitted because of nephrotic syndrome. She was diagnosed to have monoclonal gammopathy of undetermined significance (IgG-κ type) ...

Last Updated: 16 Nov 2015

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[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease].
 

Author(s): Antonio J Gonzalez-Rodriguez, Rebeca Bella-Navarro, Dolores Ramon Quiles, Esperanza Jorda-Cuevas

Journal:

 

Cutis laxa is a rare entity characterized clinically by redundant skin that gives an appearance of premature aging. The appearance relates to a loss of elasticity because of the destruction of elastic fibers that affects the skin and other organs. It may be associated with inflammatory ...

Last Updated: 23 May 2014

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Light chain deposition disease: a model of glomerulosclerosis defined at the molecular level.
 

Author(s): P M Ronco, M A Alyanakian, B Mougenot, P Aucouturier

Journal: J. Am. Soc. Nephrol.. 2001 Jul;12(7):1558-65.

 

Last Updated: 25 Jun 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease; Primary Systemic Amyloidosis

 

Last Updated: 12 Feb 2016

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Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma
 

Status: Recruiting

Condition Summary: Extramedullary Plasmacytoma; Isolated Plasmacytoma of Bone; Light Chain Deposition Disease; Primary Systemic Amyloidosis; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma

 

Last Updated: 18 Nov 2014

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Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease; Smoldering Plasma Cell Myeloma

 

Last Updated: 25 Aug 2016

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