Light chain deposition disease

Common Name(s)

Light chain deposition disease

Light chain deposition disease involves our immune system. It is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. Immunoglobulins, also known as antibodies, are special proteins made by immune cells. While an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. Early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. Light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Light chain deposition disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Light chain deposition disease" returned 47 free, full-text research articles on human participants. First 3 results:

Light Chain Deposition Disease Diagnosed with Laser Micro-dissection, Liquid Chromatography, and Tandem Mass Spectrometry of Nodular Glomerular Lesions.
 

Author(s): Tomomichi Kasagi, Hironobu Nobata, Keisuke Suzuki, Naoto Miura, Shogo Banno, Akiyoshi Takami, Taro Yamashita, Yukio Ando, Hirokazu Imai

Journal: Intern. Med.. ;56(1):61-66.

 

A 42-year-old man developed nephrotic syndrome and rapidly progressive renal failure. Kidney biopsy demonstrated nodular glomerulosclerosis, negative Congo red staining, and no deposition of light or heavy chains. Laser micro-dissection and liquid chromatography with tandem mass spectrometry ...

Last Updated: 4 Jan 2017

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Five Sequential Evaluations of Renal Histology in a Patient with Light Chain Deposition Disease.
 

Author(s): Toshiharu Ueno, Koichi Kikuchi, Ryo Hazue, Koki Mise, Keiichi Sumida, Noriko Hayami, Tatsuya Suwabe, Junichi Hoshino, Naoki Sawa, Kenji Arizono, Shigeko Hara, Kenmei Takaichi, Takeshi Fujii, Kenichi Ohashi, Yoshifumi Ubara

Journal: Intern. Med.. ;55(20):2993-2999.

 

A 58-year-old man was referred to our institution for an evaluation of nephrotic range proteinuria. Renal biopsy showed a marked expansion of the mesangial matrix and thickening of glomerular basement membrane (GBM) in periodic acid-silver methenamine (PAM). Immunofluorescence (IF) ...

Last Updated: 17 Oct 2016

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A Case of Cardiac Light Chain Deposition Disease in a Patient with Solitary Plasmacytoma.
 

Author(s): Meera Mohan, Murat Gokden, Neriman Gokden, Carolina Schinke

Journal:

 

Light chain deposition disease is a systemic disease characterized by deposition of immunoglobin light chains in various organs. Cardiac involvement of light chain deposition disease, also known as cardiac nonamyloidotic immunoglobin deposition disease (CIDD), is a rare clinical entity, ...

Last Updated: 18 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Light chain deposition disease" returned 3 free, full-text review articles on human participants. First 3 results:

Light-Chain Deposition Disease Successfully Treated with Bortezomib in an Elderly Patient: A Case Report and Review of the Literature.
 

Author(s): Yukihiro Wada, Masayuki Iyoda, Tomohiro Saito, Noriko Arai-Nunota, Ken Iseri, Eiko Tomita, Misa Ikeda, Yutaka Yamaguchi, Takanori Shibata

Journal: Intern. Med.. 2015 ;54(22):2893-8.

 

We herein report the case of an elderly patient with light-chain deposition disease (LCDD) successfully treated with bortezomib. An 83-year-old woman was admitted because of nephrotic syndrome. She was diagnosed to have monoclonal gammopathy of undetermined significance (IgG-κ type) ...

Last Updated: 16 Nov 2015

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[Acquired cutis laxa associated with monoclonal gammopathy and lambda light chain deposition disease].
 

Author(s): Antonio J Gonzalez-Rodriguez, Rebeca Bella-Navarro, Dolores Ramon Quiles, Esperanza Jorda-Cuevas

Journal:

 

Cutis laxa is a rare entity characterized clinically by redundant skin that gives an appearance of premature aging. The appearance relates to a loss of elasticity because of the destruction of elastic fibers that affects the skin and other organs. It may be associated with inflammatory ...

Last Updated: 23 May 2014

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Light chain deposition disease: a model of glomerulosclerosis defined at the molecular level.
 

Author(s): P M Ronco, M A Alyanakian, B Mougenot, P Aucouturier

Journal: J. Am. Soc. Nephrol.. 2001 Jul;12(7):1558-65.

 

Last Updated: 25 Jun 2001

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

First-line Pomalidomide, Bortezomib, and Dexamethasone For AL Amyloidosis or LCDD
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease; Primary Systemic Amyloidosis

 

Last Updated: 12 Feb 2016

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Lenalidomide or Observation in Treating Patients With Asymptomatic High-Risk Smoldering Multiple Myeloma
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease; Smoldering Plasma Cell Myeloma

 

Last Updated: 22 Feb 2017

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Autologous Stem Cell Transplant Followed By Maintenance Therapy in Treating Elderly Patients With Multiple Myeloma
 

Status: Recruiting

Condition Summary: Extramedullary Plasmacytoma; Isolated Plasmacytoma of Bone; Light Chain Deposition Disease; Primary Systemic Amyloidosis; Stage I Multiple Myeloma; Stage II Multiple Myeloma; Stage III Multiple Myeloma

 

Last Updated: 20 Feb 2017

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