Light chain deposition disease

Common Name(s)

Light chain deposition disease

Light chain deposition disease involves our immune system. It is caused by an excess buildup of immunoglobulin light chain in our tissues and organs. Immunoglobulins, also known as antibodies, are special proteins made by immune cells. While an important part of our immune system, if these proteins become trapped in the tissues of the kidneys, lungs, skin, joints, or blood vessels, they can set off reactions that lead to tissue or organ inflammation (swelling) and damage. Early signs and symptoms of light chain deposition disease may include protein in the urine, high blood pressure, decreased kidney function, and nephrotic syndrome. Light chain deposition disease is often associated with multiple myeloma, monoclonal gammopathy of undetermined significance, or other disorders of abnormal overgrowth of lymph nodes.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Light chain deposition disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Light chain deposition disease" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Light chain deposition disease" returned 40 free, full-text research articles on human participants. First 3 results:

Primary cerebral low-grade B-cell lymphoma, monoclonal immunoglobulin deposition disease, cerebral light chain deposition disease and "aggregoma": an update on classification and diagnosis.
 

Author(s): Marco Skardelly, Georgios Pantazis, Sotirios Bisdas, Guenther C Feigl, Martin U Schuhmann, Marcos S Tatagiba, Rainer Ritz

Journal:

 

This work aims to add evidence and provide an update on the classification and diagnosis of monoclonal immunoglobulin deposition disease (MIDD) and primary central nervous system low-grade lymphomas. MIDD is characterized by the deposition of light and heavy chain proteins. Depending ...

Last Updated: 22 Aug 2013

Go To URL
Retinal pigment epithelial detachments and tears, and progressive retinal degeneration in light chain deposition disease.
 

Author(s): Leigh H Spielberg, John R Heckenlively, Anita M Leys

Journal: Br J Ophthalmol. 2013 May;97(5):627-31.

 

Light-chain deposition disease (LCDD) is a rare condition characterised by deposition of monoclonal immunoglobulin light chains (LCs) in tissues, resulting in varying degrees of organ dysfunction. This study reports the characteristic clinical ocular findings seen in advanced LCDD ...

Last Updated: 17 Apr 2013

Go To URL
Expanding the spectrum of monoclonal light chain deposition disease in muscle.
 

Author(s): Lyle W Ostrow, Andrea M Corse, Brett M Morrison, Carol A Huff, John A Carrino, Ahmet Hoke, Andrew L Mammen

Journal: Muscle Nerve. 2012 May;45(5):755-61.

 

The diagnosis of amyloid myopathy is delayed when monoclonal gammopathies are not detected on initial testing and muscle biopsies are nondiagnostic, and the EMG and symptoms can mimic an inflammatory myopathy.

Last Updated: 13 Apr 2012

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Light chain deposition disease" returned 1 free, full-text review articles on human participants. First 3 results:

Light chain deposition disease: a model of glomerulosclerosis defined at the molecular level.
 

Author(s): P M Ronco, M A Alyanakian, B Mougenot, P Aucouturier

Journal: J. Am. Soc. Nephrol.. 2001 Jul;12(7):1558-65.

 

Last Updated: 25 Jun 2001

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Pomalidomide, Bortezomib, and Dexamethasone as First-Line Treatment in Treating Patients With Amyloid Light-Chain Amyloidosis or Light Chain Deposition Disease
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease; Primary Systemic Amyloidosis

 

Last Updated: 15 May 2014

Go to URL
Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis
 

Status: Recruiting

Condition Summary: Light Chain Deposition Disease (LCDD or MIDD); Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD); Monoclonal Immunoglobulin Deposition Disease (MIDD); Amyloidosis

 

Last Updated: 8 Dec 2014

Go to URL

Last Updated: 21 Jul 2014

Go to URL