Lewy body dementia

Common Name(s)

Lewy body dementia

Lewy bodies dementia is one of the most common types of dementia. The central feature of this condition is progressive cognitive decline, combined with three additional defining features: (1) fluctuations in alertness and attention, such as frequent drowsiness, lethargy, lengthy periods of time spent staring into space, or disorganized speech; (2) recurrent visual hallucinations, and (3) parkinsonian motor symptoms, such as rigidity and the loss of spontaneous movement. Although the exact cause of this condition is unknown, symptoms result from the build-up of abnormal structures, called Lewy bodies, inside the brain. This condition usually occurs sporadically, in people with no known family history of the disease. However, rare familial cases have been reported.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lewy body dementia" for support, advocacy or research.

Lewy Body Dementia Association

LBDA's Mission Through outreach, education and research, we support those affected by Lewy body dementias.

http://www.lbda.org

Last Updated: 20 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lewy body dementia" returned 33 free, full-text research articles on human participants. First 3 results:

Dysphagia in Lewy body dementia - a clinical observational study of swallowing function by videofluoroscopic examination.
 

Author(s): Elisabet Londos, Oskar Hanxsson, Ingrid Alm Hirsch, Anna Janneskog, Margareta Bülow, Sebastian Palmqvist

Journal:

 

Dysphagia, which can result in aspiration pneumonia and death, is a well-known problem in patients with dementia and Parkinson's disease. There are few studies on dysphagia in patients with dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD), especially studies ...

Last Updated: 11 Dec 2013

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[The use of clozapine and levodopa for the treatment of persistent visual hallucinations and parkinsonism in Lewy body dementia].
 

Author(s): A Archie, P Persoons, M Vandenbulcke

Journal: Tijdschr Psychiatr. 2013 ;55(4):287-91.

 

Visual hallucinations (VH) are sometimes difficult to treat in patients with Lewy body dementia (LBD). We describe the concurrent use of clozapine and levodopa for the treatment of persistent VH and parkinsonism in a patient with LBD and severely increased sensitivity to antipsychotics.

Last Updated: 18 Apr 2013

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Serum and cerebrospinal fluid levels of transthyretin in Lewy body disorders with and without dementia.
 

Author(s): Walter Maetzler, Youyong Tian, Stephanie Maria Baur, Tina Gauger, Bartholomäus Odoj, Benjamin Schmid, Claudia Schulte, Christian Deuschle, Susanna Heck, Anja Apel, Arthur Melms, Thomas Gasser, Daniela Berg

Journal: PLoS ONE. 2012 ;7(10):e48042.

 

Parkinson's disease (PD) without (non-demented, PDND) and with dementia (PDD), and dementia with Lewy bodies (DLB) are subsumed under the umbrella term Lewy body disorders (LBD). The main component of the underlying pathologic substrate, i.e. Lewy bodies and Lewy neurites, is misfolded ...

Last Updated: 7 Nov 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lewy body dementia" returned 5 free, full-text review articles on human participants. First 3 results:

Parkinson's disease with dementia, lewy-body disorders and alpha-synuclein: recent advances and a case report.
 

Author(s): Chuang-Kuo Wu

Journal: Acta Neurol Taiwan. 2011 Mar;20(1):4-14.

 

The advance in research on the dementia syndrome associated with Parkinson's disease recently gains momentum in part because Parkinson's disease inevitably causes declined cognition and then lead to poor quality of life. More importantly, dementia of Lewy bodies, now known as the ...

Last Updated: 11 May 2011

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Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions.
 

Author(s): Brit Mollenhauer, Hans Förstl, Günther Deuschl, Alexander Storch, Wolfgang Oertel, Claudia Trenkwalder

Journal: Dtsch Arztebl Int. 2010 Oct;107(39):684-91.

 

Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD) are the two most common types of dementing neurodegenerative disease after Alzheimer's disease (AD). Both of these conditions are often diagnosed late or not at all.

Last Updated: 21 Oct 2010

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Pathologic correlates of dementia in individuals with Lewy body disease.
 

Author(s): Joshua A Sonnen, Nadia Postupna, Eric B Larson, Paul K Crane, Shannon E Rose, Kathleen S Montine, James B Leverenz, Thomas J Montine

Journal: Brain Pathol.. 2010 May;20(3):654-9.

 

Cognitive impairment and dementia are more common in patients with Parkinson disease (PD) than age-matched controls and appear to become more frequent as PD progresses. However, estimates of dementia in patients with PD have varied widely, likely due in part to differences in case ...

Last Updated: 4 Jun 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Construction-LBD (Constructional Apraxia in Alzheimer's Disease (AD) and Lewy Body's Dementia (LBD))
 

Status: Recruiting

Condition Summary: Alzheimer's Disease; Lewy Body's Dementia

 

Last Updated: 18 Nov 2013

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Effects of Nucleus Basalis of Meynert Stimulation on Cognitive Disorders in Dementia With Lewy Bodies
 

Status: Recruiting

Condition Summary: Dementia With Lewy Bodies

 

Last Updated: 18 Jun 2014

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Donepezil Therapy and Changes of Symptoms and Glucose Metabolism in Patients With Dementia With Lewy Bodies (DLB)
 

Status: Recruiting

Condition Summary: Dementia With Lewy Bodies (DLB)

 

Last Updated: 16 Oct 2014

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