Anaplastic large cell lymphoma

Common Name(s)

Anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma (NHL), which is a kind of blood cancer, that involves abnormal T-cells (please also visit: Non-Hodgkin Lymphoma.). T cells are a type of white blood cell in your body that help fight diseases. These abnormal T-cells may build up in the lymph nodes (small oval-shaped immune system organs) causing them to swell. Common symptoms include painless swelling in the neck, armpit, or groin due to the enlarged lymph nodes. Other symptoms include loss of appetite, tiredness, night sweats, fevers, or weight loss. ALCL can initially appear in either skin, lymph nodes or other organs throughout the body. When it appears in the skin, it is called primary cutaneous ALCL and has a less aggressive disease course. ALCL is diagnosed through the examination of any enlarged lymph nodes. Further inspection may be required through a biopsy in which doctors will remove the lymph node itself. Other tests include bone marrow samples, blood tests, x-rays or scans. ALCL is divided into two types at present, depending on whether or not their cells have an abnormal form of a protein on their surface called "anaplastic lymphoma kinase" (ALK). ALK- positive ALCL is considered more likely to affect children or young adults and responds well to standard chemotherapy treatments, putting most patients in long-term remission. ALK-negative ALCL more likely affects individuals over 60 and although it responds well to treatment at first, it is more likely to return. The causes of ALCL are currently unknown. However, it is neither infectious nor can it be passed on to other people. The main treatment for ALCL is chemotherapy, but radiotherapy and/or stem cell treatment may be recommended. Talk to your doctor to see if you or a family member has been diagnosed with this condition to find the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic large cell lymphoma" returned 296 free, full-text research articles on human participants. First 3 results:

Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult.
 

Author(s): Cai-Xia Wang, Hai Wang, Jie Li, Heng-Hui Ma, Bo Yu, Shan-Shan Shi, Xiao-Jun Zhou, Qun-Li Shi

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma composed of CD30-positive cells and now recognized as three different entities: primary cutaneous ALCL, primary systemic anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and primary ALK-negative (ALK-) ...

Last Updated: 3 Apr 2014

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Galectin-1-mediated cell adhesion, invasion and cell death in human anaplastic large cell lymphoma: regulatory roles of cell surface glycans.
 

Author(s): Osamu Suzuki, Masafumi Abe

Journal: Int. J. Oncol.. 2014 May;44(5):1433-42.

 

Galectin-1 is known to be one of the extracellular matrix proteins. To elucidate the biological roles of galectin-1 in cell adhesion and invasion of human anaplastic large cell lymphoma, we performed cell adhesion and invasion assays using the anaplastic large cell lymphoma cell line ...

Last Updated: 19 Mar 2014

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Anaplastic large cell lymphoma: a single institution experience from India.
 

Author(s): K C Lakshmaiah, B Guruprasad, Ashish Shah, S Kavitha, Linu Jacob Abraham, K Govindbabu, B S Aruna Kumari, L Appaji

Journal: J Cancer Res Ther. ;9(4):649-52.

 

Systemic anaplastic large cell lymphoma (ALCL) accounts for 2-8% of non-Hodgkin's lymphoma in adults and 10-15% in children. While there is ample data in the world literature about the clinical features and outcome of this disease, prognosis in Indian patients is largely unknown.

Last Updated: 12 Feb 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic large cell lymphoma" returned 27 free, full-text review articles on human participants. First 3 results:

ALK-negative anaplastic large cell lymphoma primarily involving the bronchus: a case report and literature review.
 

Author(s): Xiangdong Xu

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a mature T cell lymphoma with characteristic morphologic, immunophenotypic and cytogenetic features. Current WHO classification includes anaplastic lymphoma kinase (ALK)-positive and ALK-negative variants. ALCL rarely presents with obstructive ...

Last Updated: 15 Jan 2014

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Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma.
 

Author(s): Fabrizio Tabbò, Maurilio Ponzoni, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami,

Journal: Curr. Opin. Hematol.. 2013 Jul;20(4):374-81.

 

Anaplastic large cell lymphomas (ALCLs) are rare entities whose somatic genetic lesions have been identified only in a subset of patients. Thus, an integrated and massive discovery programme is required to define their tumourigenic alterations and to design more successful tailored therapies.

Last Updated: 6 Jun 2013

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Anaplastic large cell lymphoma, ALK-negative.
 

Author(s): Andrés J M Ferreri, Silvia Govi, Stefano A Pileri, Kerry J Savage

Journal: Crit. Rev. Oncol. Hematol.. 2013 Feb;85(2):206-15.

 

Anaplastic large cell lymphoma (ALCL), anaplastic lymphoma kinase (ALK)-negative (ALCL-ALK-) is a provisional entity in the WHO 2008 Classification that represents 2-3% of NHL and 12% of T-cell NHL. No particular risk factor has been clearly identified for ALCL, but a recent study ...

Last Updated: 23 Jan 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Stage II Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma

 

Last Updated: 15 Dec 2014

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Brentuximab Vedotin and Bendamustine for the Treatment of Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma (ALCL)
 

Status: Recruiting

Condition Summary: Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma

 

Last Updated: 9 Apr 2014

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A Phase 1 Study in Patients With Relapsed or Refractory Hodgkin Lymphoma or Systemic Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Hodgkin Lymphoma; Anaplastic Large-cell Lymphoma

 

Last Updated: 15 Jan 2014

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