Anaplastic large cell lymphoma

Common Name(s)

Anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma (NHL), which is a kind of blood cancer, that involves abnormal T-cells (please also visit: Non-Hodgkin Lymphoma.). T cells are a type of white blood cell in your body that help fight diseases. These abnormal T-cells may build up in the lymph nodes (small oval-shaped immune system organs) causing them to swell. Common symptoms include painless swelling in the neck, armpit, or groin due to the enlarged lymph nodes. Other symptoms include loss of appetite, tiredness, night sweats, fevers, or weight loss. ALCL can initially appear in either skin, lymph nodes or other organs throughout the body. When it appears in the skin, it is called primary cutaneous ALCL and has a less aggressive disease course. ALCL is diagnosed through the examination of any enlarged lymph nodes. Further inspection may be required through a biopsy in which doctors will remove the lymph node itself. Other tests include bone marrow samples, blood tests, x-rays or scans. ALCL is divided into two types at present, depending on whether or not their cells have an abnormal form of a protein on their surface called "anaplastic lymphoma kinase" (ALK). ALK- positive ALCL is considered more likely to affect children or young adults and responds well to standard chemotherapy treatments, putting most patients in long-term remission. ALK-negative ALCL more likely affects individuals over 60 and although it responds well to treatment at first, it is more likely to return. The causes of ALCL are currently unknown. However, it is neither infectious nor can it be passed on to other people. The main treatment for ALCL is chemotherapy, but radiotherapy and/or stem cell treatment may be recommended. Talk to your doctor to see if you or a family member has been diagnosed with this condition to find the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic large cell lymphoma" returned 356 free, full-text research articles on human participants. First 3 results:

A rare case of primary anaplastic large cell lymphoma of the central nervous system.
 

Author(s): Lakshmaiah C Kuntegowdenahalli, Linu Abraham Jacob, Ashok S Komaranchath, Usha Amirtham

Journal: J Cancer Res Ther. ;11(4):943-5.

 

Primary central nervous system lymphoma (PCNSL) is an uncommon variant of extranodal non-Hodgkin's lymphoma, confined to the central nervous system (CNS) and is usually seen in immunocompromised patients. The vast majority of cases are of the B-cell type and T-cell PCNSL is rare. ...

Last Updated: 17 Feb 2016

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Anaplastic large cell lymphoma arises in thymocytes and requires transient TCR expression for thymic egress.
 

Author(s): Tim I M Malcolm, Patrick Villarese, Camilla J Fairbairn, Laurence Lamant, Amélie Trinquand, C Elizabeth Hook, G A Amos Burke, Laurence Brugières, Katherine Hughes, Dominique Payet, Olaf Merkel, Ana-Iris Schiefer, Ibraheem Ashankyty, Shahid Mian, Mariusz Wasik, Martin Turner, Lukas Kenner, Vahid Asnafi, Elizabeth Macintyre, Suzanne D Turner

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a peripheral T-cell lymphoma presenting mostly in children and young adults. The natural progression of this disease is largely unknown as is the identity of its true cell of origin. Here we present a model of peripheral ALCL pathogenesis where ...

Last Updated: 12 Jan 2016

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Primary cutaneous anaplastic large cell lymphoma in a child simulating primary cutaneous Hodgkin's disease.
 

Author(s): Vikram K Mahajan, Rashmi Jindal

Journal: Indian J Dermatol Venereol Leprol. ;82(1):98-101.

 

Last Updated: 5 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic large cell lymphoma" returned 38 free, full-text review articles on human participants. First 3 results:

Successful Chemo-Radiotherapy for Primary Anaplastic Large Cell Lymphoma of the Lung: A Case Report and Literature Review.
 

Author(s): Qian Zhao, Yongmei Liu, Huijiao Chen, Yan Zhang, Zedong Du, Jin Wang, Yongsheng Wang

Journal:

 

Primary anaplastic large cell lymphoma (ALCL) of the lung is an extremely rare disease. This disease is a great challenge for pneumologists due to its nonspecific clinical presentations and radiological findings. Appropriate invasive biopsy and immunohistochemistry are important for ...

Last Updated: 8 Feb 2016

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[Molecular pathogenesis of peripheral T-cell lymphoma (1): angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified and anaplastic large cell lymphoma].
 

Author(s): Lucile Couronné, Christian Bastard, Philippe Gaulard, Olivier Hermine, Olivier Bernard

Journal: Med Sci (Paris). 2015 Oct;31(10):841-52.

 

Peripheral T-cell lymphomas (PTCL) belong to the group of non-Hodgkin lymphoma and particularly that of mature T/NK cells lymphoproliferative neoplasms. The 2008 WHO classification describes different PTCL entities with varying prevalence. With the exception of the histological subtype ...

Last Updated: 20 Oct 2015

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Anaplastic lymphoma kinase-positive diffuse large B-cell lymphoma presenting in nasal cavity: a case report and review of literature.
 

Author(s): Ji Chen, Xiaoli Feng, Mei Dong

Journal:

 

Anaplastic lymphoma kinase (ALK)-positive diffuse large B-cell lymphoma (DLBCL) is a rare subtype of non-Hodgkin's lymphoma (NHL) with distinct morphologic and immunohistochemical features. We reported a 57-year-old female with ALK-positive DLBCL in her left nasal cavity. Histologically, ...

Last Updated: 14 May 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Study of Treatment ALK(+) Systemic Anaplastic Large Cell Lymphoma With Crizotinib
 

Status: Recruiting

Condition Summary: Systemic Anaplastic Large-Cell Lymphoma

 

Last Updated: 13 Sep 2015

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Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Anaplastic Large-cell Lymphoma

 

Last Updated: 23 Feb 2015

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Ceritinib With Brentuximab Vedotin in Treating Patients With ALK-Positive Anaplastic Large Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Anaplastic Large Cell Lymphoma, ALK-Positive; Systemic Anaplastic Large Cell Lymphoma

 

Last Updated: 26 Sep 2016

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