Anaplastic large cell lymphoma

Common Name(s)

Anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma (NHL), which is a kind of blood cancer, that involves abnormal T-cells (please also visit: Non-Hodgkin Lymphoma.). T cells are a type of white blood cell in your body that help fight diseases. These abnormal T-cells may build up in the lymph nodes (small oval-shaped immune system organs) causing them to swell. Common symptoms include painless swelling in the neck, armpit, or groin due to the enlarged lymph nodes. Other symptoms include loss of appetite, tiredness, night sweats, fevers, or weight loss. ALCL can initially appear in either skin, lymph nodes or other organs throughout the body. When it appears in the skin, it is called primary cutaneous ALCL and has a less aggressive disease course. ALCL is diagnosed through the examination of any enlarged lymph nodes. Further inspection may be required through a biopsy in which doctors will remove the lymph node itself. Other tests include bone marrow samples, blood tests, x-rays or scans. ALCL is divided into two types at present, depending on whether or not their cells have an abnormal form of a protein on their surface called "anaplastic lymphoma kinase" (ALK). ALK- positive ALCL is considered more likely to affect children or young adults and responds well to standard chemotherapy treatments, putting most patients in long-term remission. ALK-negative ALCL more likely affects individuals over 60 and although it responds well to treatment at first, it is more likely to return. The causes of ALCL are currently unknown. However, it is neither infectious nor can it be passed on to other people. The main treatment for ALCL is chemotherapy, but radiotherapy and/or stem cell treatment may be recommended. Talk to your doctor to see if you or a family member has been diagnosed with this condition to find the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic large cell lymphoma" returned 344 free, full-text research articles on human participants. First 3 results:

Two Relapsed Stage III Childhood Anaplastic Large Cell Lymphoma Patients with NPM-ALK Fusion in Bone Marrow from Initial Diagnosis.
 

Author(s): Yui Kanazawa, Yuka Yamashita, Mitsuhiro Fujiwara, Michiko Muraoka, Kana Washio, Kiichiro Kanamitsu, Hisashi Ishida, Takae Nakano, Miho Yamada, Keizo Horibe, Takehiro Tanaka, Tadashi Yoshino, Akira Shimada

Journal: Acta Med. Okayama. 2016 Dec;70(6):503-506.

 

Childhood anaplastic large cell lymphoma (ALCL) accounts for approx. 10-30% of cases of non-Hodgkin lymphoma, and the ALCL99 study reported 60-75 disease-free survival; however, a relatively high relapse rate was observed (25-30% ). We report 2 patients with Stage III ALCL who relapsed ...

Last Updated: 22 Dec 2016

Go To URL
Primary central nervous system ALK-positive anaplastic large cell lymphoma in an adult: A rare case report.
 

Author(s): Xiaoqin Dong, Jun Li, Na Huo, Yan Wang, Zhao Wu, Xiaohong Lin, Hong Zhao

Journal: Medicine (Baltimore). 2016 Dec;95(49):e5534.

 

Anaplastic large cell lymphoma (ALCL) is an aggressive non-Hodgkin lymphoma. It mostly invades lymph nodes with extranodal involvement observed in the soft tissue, bone, and skin.

Last Updated: 8 Dec 2016

Go To URL
A case of Primary Bone Anaplastic Large Cell Lymphoma.
 

Author(s): Kyung Hyun Kim, Yun Hwa Jung, Chi Wha Han, In Sook Woo, Jong Ho Son

Journal:

 

BACKGROUND Anaplastic large cell lymphoma (ALCL) is a relatively rare subtype of non-Hodgkin's lymphoma (NHL). Like other types of NHL, ALCL primarily involves the nodal area, and sometimes it can involve several extra-nodal sites such as skin, soft tissue, and lungs. However, extensive ...

Last Updated: 12 Oct 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic large cell lymphoma" returned 36 free, full-text review articles on human participants. First 3 results:

Primary rare anaplastic large cell lymphoma, ALK positive in small intestine: case report and review of the literature.
 

Author(s): Qinghua Cao, Fang Liu, Shurong Li, Ni Liu, Lihui Li, Changzhao Li, Tingsheng Peng

Journal:

 

Primary anaplastic large cell lymphoma, ALK positive in small intestine is clinically rare and the clinical, radiological and pathological information are generally not available. Here, we report a case of 32-year-old male with ALK positive anaplastic large cell lymphoma ...

Last Updated: 10 Sep 2016

Go To URL
Successful Chemo-Radiotherapy for Primary Anaplastic Large Cell Lymphoma of the Lung: A Case Report and Literature Review.
 

Author(s): Qian Zhao, Yongmei Liu, Huijiao Chen, Yan Zhang, Zedong Du, Jin Wang, Yongsheng Wang

Journal:

 

Primary anaplastic large cell lymphoma (ALCL) of the lung is an extremely rare disease. This disease is a great challenge for pneumologists due to its nonspecific clinical presentations and radiological findings. Appropriate invasive biopsy and immunohistochemistry are important for ...

Last Updated: 8 Feb 2016

Go To URL
Adult systemic anaplastic large-cell lymphoma: recommendations for diagnosis and management.
 

Author(s): Nabila Bennani-Baiti, Stephen Ansell, Andrew L Feldman

Journal: Expert Rev Hematol. 2016 ;9(2):137-50.

 

Systemic anaplastic large-cell lymphomas (sALCLs) comprise a heterogeneous group of relatively rare T-cell non-Hodgkin lymphomas (NHLs) characterized by CD30 expression and other unifying pathologic features. Anaplastic lymphoma kinase (ALK) fusions are present in about 50% of cases. ...

Last Updated: 4 Feb 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Ceritinib With Brentuximab Vedotin in Treating Patients With ALK-Positive Anaplastic Large Cell Lymphoma
 

Status: Not yet recruiting

Condition Summary: Anaplastic Large Cell Lymphoma, ALK-Positive; Systemic Anaplastic Large Cell Lymphoma

 

Last Updated: 27 Mar 2017

Go to URL
Brentuximab Vedotin (Recombinant) for IV Infusion - Special Drug Use Surveillance (All-case Surveillance) "Relapsed or Refractory CD30+ Hodgkin's Lymphoma or Anaplastic Large Cell Lymphoma"
 

Status: Recruiting

Condition Summary: Relapsed or Refractory CD30+ Hodgkin's Lymphoma or Anaplastic Large Cell Lymphoma

 

Last Updated: 24 Aug 2016

Go to URL
Brentuximab Vedotin and Bendamustine for the Treatment of Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma (ALCL)
 

Status: Recruiting

Condition Summary: Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma

 

Last Updated: 1 Feb 2017

Go to URL