Anaplastic large cell lymphoma

Common Name(s)

Anaplastic large cell lymphoma

Anaplastic large cell lymphoma (ALCL) is a type of non-Hodgkin lymphoma (NHL), which is a kind of blood cancer, that involves abnormal T-cells (please also visit: Non-Hodgkin Lymphoma.). T cells are a type of white blood cell in your body that help fight diseases. These abnormal T-cells may build up in the lymph nodes (small oval-shaped immune system organs) causing them to swell. Common symptoms include painless swelling in the neck, armpit, or groin due to the enlarged lymph nodes. Other symptoms include loss of appetite, tiredness, night sweats, fevers, or weight loss. ALCL can initially appear in either skin, lymph nodes or other organs throughout the body. When it appears in the skin, it is called primary cutaneous ALCL and has a less aggressive disease course. ALCL is diagnosed through the examination of any enlarged lymph nodes. Further inspection may be required through a biopsy in which doctors will remove the lymph node itself. Other tests include bone marrow samples, blood tests, x-rays or scans. ALCL is divided into two types at present, depending on whether or not their cells have an abnormal form of a protein on their surface called "anaplastic lymphoma kinase" (ALK). ALK- positive ALCL is considered more likely to affect children or young adults and responds well to standard chemotherapy treatments, putting most patients in long-term remission. ALK-negative ALCL more likely affects individuals over 60 and although it responds well to treatment at first, it is more likely to return. The causes of ALCL are currently unknown. However, it is neither infectious nor can it be passed on to other people. The main treatment for ALCL is chemotherapy, but radiotherapy and/or stem cell treatment may be recommended. Talk to your doctor to see if you or a family member has been diagnosed with this condition to find the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic large cell lymphoma" for support, advocacy or research.

National Bone Marrow Transplant Link

The mission of the National Bone Marrow Transplant Link is to help patients, caregivers, and families cope with the social and emotional challenges of bone marrow/stem cell transplant from diagnosis through survivorship by providing vital information and personalized support services.

http://www.nbmtlink.org

Last Updated: 20 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic large cell lymphoma" returned 302 free, full-text research articles on human participants. First 3 results:

Pericardial involvement as an initial presentation of anaplastic large cell lymphoma.
 

Author(s): Purushothaman Muthusamy, Stephen Ebrom, Stephen D Cohle, Nasir Khan

Journal: Can Fam Physician. 2014 Jul;60(7):638-41.

 

Last Updated: 15 Jul 2014

Go To URL
Anaplastic lymphoma kinase (ALK) positive diffuse large B cell lymphoma in a 20 year old: a rare entity.
 

Author(s): Ritesh Sachdev, Shalini Goel, Sunil Gupta, Nitin Sood

Journal: Indian J Pathol Microbiol. ;57(1):157-8.

 

Last Updated: 17 Apr 2014

Go To URL
Brain metastasis of ALK positive anaplastic large cell lymphoma after a long-term disease free survival in an old adult.
 

Author(s): Cai-Xia Wang, Hai Wang, Jie Li, Heng-Hui Ma, Bo Yu, Shan-Shan Shi, Xiao-Jun Zhou, Qun-Li Shi

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a subtype of non-Hodgkin lymphoma composed of CD30-positive cells and now recognized as three different entities: primary cutaneous ALCL, primary systemic anaplastic lymphoma kinase (ALK)-positive (ALK+) ALCL and primary ALK-negative (ALK-) ...

Last Updated: 3 Apr 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic large cell lymphoma" returned 29 free, full-text review articles on human participants. First 3 results:

Primary cutaneous anaplastic large cell lymphoma occurring in an atopic dermatitis patient: a case report with review of the literature with emphasis on their association.
 

Author(s): Mitsuaki Ishida, Keiko Hodohara, Miyuki Yoshii, Hiroko Okuno, Akiko Horinouchi, Ayaka Shirakawa, Ayumi Harada, Muneo Iwai, Keiko Yoshida, Akiko Kagotani, Takashi Yoshida, Hidetoshi Okabe

Journal:

 

Although the risk of malignant lymphoma in patients with atopic dermatitis (AD) remains controversial, an increased risk of malignant T-cell lymphoma in patients with AD has been reported. Primary cutaneous anaplastic large cell lymphoma (C-ALCL) is a relatively common distinct clinicopathological ...

Last Updated: 12 May 2014

Go To URL
ALK-negative anaplastic large cell lymphoma primarily involving the bronchus: a case report and literature review.
 

Author(s): Xiangdong Xu

Journal:

 

Anaplastic large cell lymphoma (ALCL) is a mature T cell lymphoma with characteristic morphologic, immunophenotypic and cytogenetic features. Current WHO classification includes anaplastic lymphoma kinase (ALK)-positive and ALK-negative variants. ALCL rarely presents with obstructive ...

Last Updated: 15 Jan 2014

Go To URL
Beyond NPM-anaplastic lymphoma kinase driven lymphomagenesis: alternative drivers in anaplastic large cell lymphoma.
 

Author(s): Fabrizio Tabbò, Maurilio Ponzoni, Raul Rabadan, Francesco Bertoni, Giorgio Inghirami,

Journal: Curr. Opin. Hematol.. 2013 Jul;20(4):374-81.

 

Anaplastic large cell lymphomas (ALCLs) are rare entities whose somatic genetic lesions have been identified only in a subset of patients. Thus, an integrated and massive discovery programme is required to define their tumourigenic alterations and to design more successful tailored therapies.

Last Updated: 6 Jun 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Brentuximab Vedotin or Crizotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage II-IV Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Stage II Childhood Anaplastic Large Cell Lymphoma; Stage III Childhood Anaplastic Large Cell Lymphoma; Stage IV Childhood Anaplastic Large Cell Lymphoma

 

Last Updated: 30 Apr 2015

Go to URL
Brentuximab Vedotin and Bendamustine for the Treatment of Hodgkin Lymphoma and Anaplastic Large Cell Lymphoma (ALCL)
 

Status: Recruiting

Condition Summary: Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma

 

Last Updated: 14 Jan 2015

Go to URL
Study of Brentuximab Vedotin in Patients With Relapsed or Refractory Systemic Anaplastic Large Cell Lymphoma
 

Status: Recruiting

Condition Summary: Anaplastic Large-cell Lymphoma

 

Last Updated: 23 Feb 2015

Go to URL