Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 201 free, full-text research articles on human participants. First 3 results:

Oral leukoplakia, a precancerous lesion of squamous cell carcinoma, in patients with long-term pegylated liposomal doxorubicin treatment.
 

Author(s): Hidetaka Nomura, Kimihiko Sakamoto, Takeru Sugihara, Shuhei Okamoto, Yoichi Aoki, Terumi Tanigawa, Maki Matoda, Kohei Omatsu, Hiroyuki Kanao, Kazuyoshi Kato, Kuniko Utsugi, Yuko Sugiyama, Nobuhiro Takeshima

Journal: Medicine (Baltimore). 2018 Feb;97(7):e9932.

 

Pegylated liposomal doxorubicin (PLD) has a good safety profile, but long-term use has been associated with development of squamous cell carcinoma of the tongue and oral cavity (SCCTO) in some patients. The study objective was to estimate the prevalence of oral leukoplakia, a known ...

Last Updated: 31 Dec 1969

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Association between oral leukoplakia and risk of upper gastrointestinal cancer death: A follow-up study of the Linxian General Population Trial.
 

Author(s): He Liang, Zhao Yang, Jian-Bing Wang, Pei Yu, Jin-Hu Fan, You-Lin Qiao, Philip R Taylor

Journal: Thorac Cancer. 2017 11;8(6):642-648.

 

This study was conducted to explore the association between oral leukoplakia (OL) and the risk of upper gastrointestinal cancer death in the Linxian General Population Trial Cohort.

Last Updated: 31 Dec 1969

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Genomic profile of oral squamous cell carcinomas with an adjacent leukoplakia or with an erythroleukoplakia that evolved after the treatment of primary tumor: A report of two cases.
 

Author(s): Ilda P Ribeiro, Francisco Marques, Leonor Barroso, Joana Rodrigues, Francisco Caramelo, Joana B Melo, Isabel M Carreira

Journal: Mol Med Rep. 2017 Nov;16(5):6780-6786.

 

Oral leukoplakia and erythroleukoplakia are common oral potentially malignant disorders diagnosed in the oral cavity. The specific outcome of these lesions remains to be elucidated, as their malignant transformation rate exhibits great variation. The ability to predict which of those ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 13 free, full-text review articles on human participants. First 3 results:

A plea to provide best evidence in trials under sample-size restrictions: the example of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients.
 

Author(s): Florian Lasch, Kristina Weber, Mwe Mwe Chao, Armin Koch

Journal:

 

In planning a clinical trial for demonstrating the efficacy of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients we had to discuss the need for a randomized controlled trial particularly under sample-size restrictions as very promising results were available ...

Last Updated: 31 Dec 1969

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Proliferative verrucous leukoplakia: diagnosis, management and current advances.
 

Author(s): Diogo Lenzi Capella, Jussara Maria Gonçalves, Adelino António Artur Abrantes, Liliane Janete Grando, Filipe Ivan Daniel

Journal: Braz J Otorhinolaryngol. ;83(5):585-593.

 

Proliferative verrucous leukoplakia is a multifocal and progressive lesion of the oral mucosa, with unknown etiology, and commonly resistant to all therapy attempts with frequent recurrences. It is characterized by a high rate of oral squamous cell carcinoma and verrucou carcinoma transformations.

Last Updated: 31 Dec 1969

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Interventions for treating oral leukoplakia to prevent oral cancer.
 

Author(s): Giovanni Lodi, Roberto Franchini, Saman Warnakulasuriya, Elena Maria Varoni, Andrea Sardella, Alexander R Kerr, Antonio Carrassi, L C I MacDonald, Helen V Worthington

Journal:

 

Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 29 Jul 2016

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Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
 

Status: Recruiting

Condition Summary: Palatal Neoplasms; Lip Neoplasm; Gingival Neoplasms; Leukoplakia, Oral; Tongue Neoplasms; Oropharyngeal Neoplasms; Oral Ulcer

 

Last Updated: 22 Mar 2018

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Fluorescence & Reflectance Imaging to Detect Oral Neoplasia
 

Status: Recruiting

Condition Summary: Oral Cancer

 

Last Updated: 17 Aug 2017

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