Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 130 free, full-text research articles on human participants. First 3 results:

Genotyping Candida albicans from Candida leukoplakia and non-Candida leukoplakia shows no enrichment of multilocus sequence typing clades but enrichment of ABC genotype C in Candida leukoplakia.
 

Author(s): Mohammed H Abdulrahim, Brenda A McManus, Stephen R Flint, David C Coleman

Journal:

 

Oral leukoplakias are histopathologically-diagnosed as Candida leukoplakia or non-Candida leukoplakia by the presence or absence of hyphae in the superficial epithelium. Candida leukoplakia lesions have significantly increased malignant potential. Candida albicans is the most prevalent ...

Last Updated: 23 Sep 2013

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A phase I trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia.
 

Author(s): Stuart J Wong, Bruce Campbell, Becky Massey, Denis P Lynch, Ezra E W Cohen, Elizabeth Blair, Rebecca Selle, Julia Shklovskaya, Borko D Jovanovic, Silvia Skripkauskas, Alexander Dew, Peter Kulesza, Vamsi Parimi, Raymond C Bergan, Eva Szabo

Journal: Oral Oncol.. 2013 Sep;49(9):970-6.

 

Photodynamic therapy with aminolevulinic acid (ALA PDT) for oral leukoplakia has shown promising effects in regression of oral leukoplakia. Although ALA has been extensively studied and is an ideal photosensitizer, the optimal light dose for treatment of oral leukoplakia has not been ...

Last Updated: 14 Aug 2013

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The combination of SMAD4 expression and histological grade of dysplasia is a better predictor for the malignant transformation of oral leukoplakia.
 

Author(s): Rong-Hui Xia, Xiao-Meng Song, Xiao-Jing Wang, Jiang Li, Li Mao

Journal:

 

Oral leukoplakia (OL) is the most common premalignancy in the oral cavity and can progress to oral squamous cell carcinoma (OSCC). SMAD4 is a tumor suppressor implicated in multiple cancer types including OSCC. To assess the role of SMAD4 in oral leukoplakia malignant transformation, ...

Last Updated: 4 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 8 free, full-text review articles on human participants. First 3 results:

Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia).
 

Author(s): M A M Sitheeque, L P Samaranayake

Journal: Crit. Rev. Oral Biol. Med.. 2003 ;14(4):253-67.

 

Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging ...

Last Updated: 8 Aug 2003

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma of the Oral Cavity; Leukoplakia Oral

 

Last Updated: 4 Apr 2013

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Least Invasive Nonlinear Light Microscopy
 

Status: Recruiting

Condition Summary: Oral Leukoplakia; Oral Cancer

 

Last Updated: 14 Dec 2009

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Photodynamic Therapy for Oral Precursor Lesions
 

Status: Recruiting

Condition Summary: Leukoplakia; Lichen

 

Last Updated: 22 Dec 2011

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