Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 137 free, full-text research articles on human participants. First 3 results:

Role of CYP2E1 genetic polymorphism in the development of oral leukoplakia among tobacco users in North Indian population.
 

Author(s): S Gupta, O P Gupta, S Srivastava

Journal: Indian J Cancer. ;51(2):154-8.

 

The aim of the study to find out role of CYP2E1 genetic polymorphism in development of oral leukoplakia among tobacco users in North Indian population, this study was carried out at Department of Oral and Maxillofacial Pathology, King George's Medical University, Lucknow, UP.

Last Updated: 8 Aug 2014

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Diagnostic criteria in proliferative verrucous leukoplakia: evaluation.
 

Author(s): Begoña García-Chías, Laura Casado-De La Cruz, Germán-Carlos Esparza-Gómez, Rocío Cerero-Lapiedra

Journal:

 

to evaluate the ability of the diagnostic criteria proposed by Cerero et al in 2010 to perform an early diagnose in patients with proliferative verrucous leukoplakia.

Last Updated: 30 Jun 2014

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Recurrent genomic alterations in sequential progressive leukoplakia and oral cancer: drivers of oral tumorigenesis?
 

Author(s): Nilva K Cervigne, Jerry Machado, Rashmi S Goswami, Bekim Sadikovic, Grace Bradley, Bayardo Perez-Ordonez, Natalie Naranjo Galloni, Ralph Gilbert, Patrick Gullane, Jonathan C Irish, Igor Jurisica, Patricia P Reis, Suzanne Kamel-Reid

Journal: Hum. Mol. Genet.. 2014 May;23(10):2618-28.

 

A significant proportion (up to 62%) of oral squamous cell carcinomas (OSCCs) may arise from oral potential malignant lesions (OPMLs), such as leukoplakia. Patient outcomes may thus be improved through detection of lesions at a risk for malignant transformation, by identifying and ...

Last Updated: 18 Apr 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 7 free, full-text review articles on human participants. First 3 results:

Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Chronic hyperplastic candidosis/candidiasis (candidal leukoplakia).
 

Author(s): M A M Sitheeque, L P Samaranayake

Journal: Crit. Rev. Oral Biol. Med.. 2003 ;14(4):253-67.

 

Chronic hyperplastic candidosis/candidiasis (CHC; syn. candidal leukoplakia) is a variant of oral candidosis that typically presents as a white patch on the commissures of the oral mucosa. The major etiologic agent of the disease is the oral fungal pathogen Candida predominantly belonging ...

Last Updated: 8 Aug 2003

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma of the Oral Cavity; Leukoplakia Oral

 

Last Updated: 4 Apr 2013

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Least Invasive Nonlinear Light Microscopy
 

Status: Recruiting

Condition Summary: Oral Leukoplakia; Oral Cancer

 

Last Updated: 14 Dec 2009

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Photodynamic Therapy for Oral Precursor Lesions
 

Status: Recruiting

Condition Summary: Leukoplakia; Lichen

 

Last Updated: 22 Dec 2011

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