Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 188 free, full-text research articles on human participants. First 3 results:

[Determination of human papillomavirus in oral leukoplakia,oral lichen planus and oral squamous cell carcinoma].
 

Author(s): Jie Cao, Jian-qiu Jin, Da-jun Deng, Hong-wei Liu

Journal: Beijing Da Xue Xue Bao. 2016 Feb;48(1):84-8.

 

To investigate the possibility for human papillomavirus (HPV) infection to be a predictable signal for the carcinogenesis of oral mucosa by comparing the prevalences of HPV in each stage of oral mucosal carcinogenesis and to compare the sensitivity differences of the two methods in ...

Last Updated: 18 Feb 2016

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Comparison of Serum Fucose Levels in Leukoplakia and Oral Cancer Patients.
 

Author(s): Narendra Prakash Rai, Jayaprasad Anekar, Y M Shivaraja Shankara, Darshan Devang Divakar, Abdulaziz Abdullah Al Kheraif, Ravikumar Ramakrishnaiah, Roopa Sebastian, A C Raj, Ali Al-Hazmi, Shabil Mohamed Mustafa

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(17):7497-500.

 

Tumor markers, designated as a broad group of substances produced by malignancies, could be in the form of biochemical substances, immunological substances, cell surface changes and genetic alterations. Cancer, a disorder of cellular behavior is characterized by alteration of serum ...

Last Updated: 2 Dec 2015

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Leukoplakia, Oral Cavity Cancer Risk, and Cancer Survival in the U.S. Elderly.
 

Author(s): Elizabeth L Yanik, Hormuzd A Katki, Michael J Silverberg, M Michele Manos, Eric A Engels, Anil K Chaturvedi

Journal: Cancer Prev Res (Phila). 2015 Sep;8(9):857-63.

 

Screening for oral leukoplakia, an oral cavity cancer (OCC) precursor, could lead to earlier detection of OCC. However, the progression rate from leukoplakia to OCC and the benefits of leukoplakia screening for improving OCC outcomes are currently unclear. We conducted a case-cohort ...

Last Updated: 3 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 9 free, full-text review articles on human participants. First 3 results:

Oral leukoplakia, the ongoing discussion on definition and terminology.
 

Author(s): Isaäc van der Waal

Journal:

 

In the past decades several definitions of oral leukoplakia have been proposed, the last one, being authorized by the World Health Organization (WHO), dating from 2005. In the present treatise an adjustment of that definition and the 1978 WHO definition is suggested, being : "A predominantly ...

Last Updated: 27 Oct 2015

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Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence.
 

Author(s): Steven J Thomas, Ross Harris, Andrew R Ness, Joachim Taulo, Robert Maclennan, Noah Howes, Christopher J Bain

Journal: Int. J. Cancer. 2008 Oct;123(8):1871-6.

 

Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does ...

Last Updated: 22 Aug 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 29 Jul 2016

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Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma of the Oral Cavity; Leukoplakia Oral

 

Last Updated: 4 Apr 2013

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Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
 

Status: Recruiting

Condition Summary: Erythroplakia; Hyperplasia; Mild Dysplasia; Moderate Dysplasia; Oral Cavity Carcinoma; Oral Leukoplakia; Severe Dysplasia

 

Last Updated: 13 Jun 2016

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