Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 198 free, full-text research articles on human participants. First 3 results:

Clinicopathological parameters associated with histological background and recurrence after surgical intervention of vocal cord leukoplakia.
 

Author(s): Weixin Cui, Wen Xu, Qingwen Yang, Rong Hu

Journal: Medicine (Baltimore). 2017 Jun;96(22):e7033.

 

Histological examination of biopsy shows usefulness in the diagnosis of vocal cord leukoplakia; however, in considerable amount of cases, the examination cannot provide definitive diagnosis of malignancy from benign conditions such as hyperplasia and dysplasia. The present work therefore ...

Last Updated: 31 May 2017

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Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study.
 

Author(s): Alessandra Dutra da Silva, Bruna Jalfim Maraschin, Natalia Koerich Laureano, Natália Daroit, Fernanda Brochier, Leonardo Bündrich, Fernanda Visioli, Pantelis Varvaki Rados

Journal:

 

To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over ...

Last Updated: 8 Mar 2017

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Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients.
 

Author(s): Daniela Assis do Vale, Fabiana Martins E Martins, Paulo Henrique Braz da Silva, Karem López Ortega

Journal:

 

Oral manifestations are common findings in human immunodeficiency virus (HIV) infected patients and frequently influence the overall health. Oral hairy leukoplakia (OHL) is strongly associated with HIV infection demonstrating its relationship with the individual's immune status and ...

Last Updated: 30 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 11 free, full-text review articles on human participants. First 3 results:

Interventions for treating oral leukoplakia to prevent oral cancer.
 

Author(s): Giovanni Lodi, Roberto Franchini, Saman Warnakulasuriya, Elena Maria Varoni, Andrea Sardella, Alexander R Kerr, Antonio Carrassi, L C I MacDonald, Helen V Worthington

Journal:

 

Oral leukoplakia is a relatively common oral lesion that, in a small proportion of people, precedes the development of oral cancer. Most leukoplakias are asymptomatic; therefore, the primary objective of treatment should be to prevent onset of cancer. This review updates our previous ...

Last Updated: 2 Aug 2016

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Proliferative verrucous leukoplakia: An update.
 

Author(s): Anita Munde, Ravindra Karle

Journal: J Cancer Res Ther. ;12(2):469-73.

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence ...

Last Updated: 27 Jul 2016

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Oral leukoplakia, the ongoing discussion on definition and terminology.
 

Author(s): Isaäc van der Waal

Journal:

 

In the past decades several definitions of oral leukoplakia have been proposed, the last one, being authorized by the World Health Organization (WHO), dating from 2005. In the present treatise an adjustment of that definition and the 1978 WHO definition is suggested, being : "A predominantly ...

Last Updated: 27 Oct 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 29 Jul 2016

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Clinical Evaluation of the OncAlert RAPID in Subjects Presenting for Evaluation and/or Initial Biopsy; Impact on Decision-Making
 

Status: Recruiting

Condition Summary: Palatal Neoplasms; Lip Neoplasm; Gingival Neoplasms; Leukoplakia, Oral; Tongue Neoplasms; Oropharyngeal Neoplasms; Oral Ulcer

 

Last Updated: 1 Aug 2017

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Fluorescence & Reflectance Imaging to Detect Oral Neoplasia
 

Status: Recruiting

Condition Summary: Oral Cancer

 

Last Updated: 17 Aug 2017

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