Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 194 free, full-text research articles on human participants. First 3 results:

Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study.
 

Author(s): Alessandra Dutra da Silva, Bruna Jalfim Maraschin, Natalia Koerich Laureano, Natália Daroit, Fernanda Brochier, Leonardo Bündrich, Fernanda Visioli, Pantelis Varvaki Rados

Journal:

 

To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over ...

Last Updated: 8 Mar 2017

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Retrospective analysis of the clinical behavior of oral hairy leukoplakia in 215 HIV-seropositive patients.
 

Author(s): Daniela Assis do Vale, Fabiana Martins E Martins, Paulo Henrique Braz da Silva, Karem López Ortega

Journal:

 

Oral manifestations are common findings in human immunodeficiency virus (HIV) infected patients and frequently influence the overall health. Oral hairy leukoplakia (OHL) is strongly associated with HIV infection demonstrating its relationship with the individual's immune status and ...

Last Updated: 30 Nov 2016

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A Novel Mutation in the DNA Binding Domain of NFKB is Associated with Speckled Leukoplakia.
 

Author(s): Giri Valanthan Veda Govindarajan, Lokesh Bhanumurthy, Anandh Balasubramanian, Arvind Ramanathan

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(7):3627-9.

 

Activation and inactivation of nuclear factor of kappa light chain gene enhancer in B cells (NFKB) is tightly regulated to ensure effective onset and cessation of defensive inflammatory signaling. However, mutations within NFKB, or change in activation and inactivation molecules have ...

Last Updated: 11 Aug 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 8 free, full-text review articles on human participants. First 3 results:

Proliferative verrucous leukoplakia: An update.
 

Author(s): Anita Munde, Ravindra Karle

Journal: J Cancer Res Ther. ;12(2):469-73.

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behavior due to its high probability of recurrence ...

Last Updated: 27 Jul 2016

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Oral leukoplakia, the ongoing discussion on definition and terminology.
 

Author(s): Isaäc van der Waal

Journal:

 

In the past decades several definitions of oral leukoplakia have been proposed, the last one, being authorized by the World Health Organization (WHO), dating from 2005. In the present treatise an adjustment of that definition and the 1978 WHO definition is suggested, being : "A predominantly ...

Last Updated: 27 Oct 2015

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Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Photodynamic Therapy for Oral Precursor Lesions
 

Status: Recruiting

Condition Summary: Leukoplakia; Lichen

 

Last Updated: 12 May 2015

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Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
 

Status: Recruiting

Condition Summary: Erythroplakia; Hyperplasia; Mild Dysplasia; Moderate Dysplasia; Oral Cavity Carcinoma; Oral Leukoplakia; Severe Dysplasia

 

Last Updated: 31 Jan 2017

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Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 29 Jul 2016

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