Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 175 free, full-text research articles on human participants. First 3 results:

Estimation of salivary lactate dehydrogenase in oral leukoplakia and oral squamous cell carcinoma: a biochemical study.
 

Author(s): Shrikant Patel, Rashmi Metgud

Journal: J Cancer Res Ther. ;11(1):119-23.

 

Enzyme Lactate Dehydrogenase (LDH) is found in the cells of almost all body tissues. The profile of salivary total LDH enzymes is similar to that found in oral epithelium, indicating that the major source of salivary LDH is probably the oral epithelium-shedding cells. Consequently, ...

Last Updated: 17 Apr 2015

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Tobacco use and oral leukoplakia: cross-sectional study among the Gond tribe in Madhya Pradesh.
 

Author(s): Surendra Kumar, Malaisamy Muniyandi

Journal: Asian Pac. J. Cancer Prev.. 2015 ;16(4):1515-8.

 

Leukoplakia is an asymptomatic and potentially malignant change in the oral mucosa and high frequencies have been reported among smokers. The present study concerned the prevalence of tobacco use and leukoplakia and also associations between the two.

Last Updated: 6 Mar 2015

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E-cadherin as a potential biomarker of malignant transformation in oral leukoplakia: a retrospective cohort study.
 

Author(s): Sandra Ventorin von Zeidler, Talitha de Souza Botelho, Elismauro Francisco Mendonça, Aline Carvalho Batista

Journal:

 

Numerous attempts have been made to establish and develop tumor markers that could determine the susceptibility of normal tissues to transform into cancerous ones. To determine whether altered expression patterns of E-cadherin could be an early event in the progression of potentially ...

Last Updated: 1 Jan 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 8 free, full-text review articles on human participants. First 3 results:

Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence.
 

Author(s): Steven J Thomas, Ross Harris, Andrew R Ness, Joachim Taulo, Robert Maclennan, Noah Howes, Christopher J Bain

Journal: Int. J. Cancer. 2008 Oct;123(8):1871-6.

 

Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does ...

Last Updated: 22 Aug 2008

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma of the Oral Cavity; Leukoplakia Oral

 

Last Updated: 4 Apr 2013

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Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
 

Status: Not yet recruiting

Condition Summary: Erythroplakia; Oral Cavity Carcinoma; Oral Leukoplakia

 

Last Updated: 31 Dec 2015

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Least Invasive Nonlinear Light Microscopy
 

Status: Recruiting

Condition Summary: Oral Leukoplakia; Oral Cancer

 

Last Updated: 14 Dec 2009

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