Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 187 free, full-text research articles on human participants. First 3 results:

A Novel Mutation in the DNA Binding Domain of NFKB is Associated with Speckled Leukoplakia.
 

Author(s): Giri Valanthan Veda Govindarajan, Lokesh Bhanumurthy, Anandh Balasubramanian, Arvind Ramanathan

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(7):3627-9.

 

Activation and inactivation of nuclear factor of kappa light chain gene enhancer in B cells (NFKB) is tightly regulated to ensure effective onset and cessation of defensive inflammatory signaling. However, mutations within NFKB, or change in activation and inactivation molecules have ...

Last Updated: 11 Aug 2016

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Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression.
 

Author(s): Tae Jun Kil, Hyun Sil Kim, Hyung Jun Kim, Woong Nam, In-Ho Cha

Journal: Asian Pac. J. Cancer Prev.. 2016 ;17(6):3001-6.

 

The cancer progression of oral leukoplakia is an important watchpoint in the follow-up observation of the patients. However, potential malignancies of oral leukoplakia cannot be estimated by histopathologic assessment alone. We evaluated genetic abnormalities at the level of copy ...

Last Updated: 30 Jun 2016

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Aberrant DKK3 expression in the oral leukoplakia and oral submucous fibrosis: a comparative immunohistochemical study.
 

Author(s): T Al-Dhohorah, M Mashrah, Z Yao, J Huang

Journal:

 

We aimed to assess and compare the expression of Dickkopf homolog 3 (DKK3), a possible tumor suppressor gene (TSG), in oral leukoplakia (OLK) and oral submucous fibrosis (OSF) using immunohistochemistry. Seventy-five cases of normal oral mucosa (NOM), OLK, OSF, and squamous cell carcinoma ...

Last Updated: 28 Jun 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 7 free, full-text review articles on human participants. First 3 results:

Oral leukoplakia, the ongoing discussion on definition and terminology.
 

Author(s): Isaäc van der Waal

Journal:

 

In the past decades several definitions of oral leukoplakia have been proposed, the last one, being authorized by the World Health Organization (WHO), dating from 2005. In the present treatise an adjustment of that definition and the 1978 WHO definition is suggested, being : "A predominantly ...

Last Updated: 27 Oct 2015

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Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence.
 

Author(s): Steven J Thomas, Ross Harris, Andrew R Ness, Joachim Taulo, Robert Maclennan, Noah Howes, Christopher J Bain

Journal: Int. J. Cancer. 2008 Oct;123(8):1871-6.

 

Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does ...

Last Updated: 22 Aug 2008

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Photodynamic Therapy for Oral Precursor Lesions
 

Status: Recruiting

Condition Summary: Leukoplakia; Lichen

 

Last Updated: 12 May 2015

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Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
 

Status: Recruiting

Condition Summary: Erythroplakia; Hyperplasia; Mild Dysplasia; Moderate Dysplasia; Oral Cavity Carcinoma; Oral Leukoplakia; Severe Dysplasia

 

Last Updated: 31 Jan 2017

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Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 29 Jul 2016

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