Leukoplakia

Common Name(s)

Leukoplakia

Leukoplakia is a condition in which thickened, white patches form on the tongue, gums, inside of the cheek, or sometimes on the outer female genitals. Although the sores can vary in appearance, they are usually white or gray; thick; and slightly raised with a hard surface. The condition is thought to be caused by irritation, but the cause is not always known. Tobacco is considered to be the main cause of its development in the mouth. Most patches are benign, but a small percentage show early signs of cancer. Removing the source of irritation may cause the condition to go away, but surgery to remove the sore(s) may be necessary in some cases.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leukoplakia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leukoplakia" returned 185 free, full-text research articles on human participants. First 3 results:

Treatment of oral leukoplakia with photodynamic therapy: A pilot study.
 

Author(s): Niranzena Panneer Selvam, Jayachandran Sadaksharam, Ganesan Singaravelu, Rajasekaran Ramu

Journal: J Cancer Res Ther. ;11(2):464-7.

 

Oral leukoplakia (OL) is the most common potentially malignant disorder that may transform into oral carcinoma. By treating leukoplakia in its incipient stage, the risk of occurrence of oral carcinoma can be prevented. In this aspect, photodynamic therapy (PDT) can serve as a useful ...

Last Updated: 7 Jul 2015

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Identification of Gene and MicroRNA Signatures for Oral Cancer Developed from Oral Leukoplakia.
 

Author(s): Guanghui Zhu, Yuan He, Shaofang Yang, Beimin Chen, Min Zhou, Xin-Jian Xu

Journal: Biomed Res Int. 2015 ;2015():841956.

 

In clinic, oral leukoplakia (OLK) may develop into oral cancer. However, the mechanism underlying this transformation is still unclear. In this work, we present a new pipeline to identify oral cancer related genes and microRNAs (miRNAs) by integrating both gene and miRNA expression ...

Last Updated: 11 Jun 2015

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Quantitative risk stratification of oral leukoplakia with exfoliative cytology.
 

Author(s): Yao Liu, Jianying Li, Xiaoyong Liu, Xudong Liu, Waqaar Khawar, Xinyan Zhang, Fan Wang, Xiaoxin Chen, Zheng Sun

Journal:

 

Exfoliative cytology has been widely used for early diagnosis of oral squamous cell carcinoma (OSCC). Test outcome is reported as "negative", "atypical" (defined as abnormal epithelial changes of uncertain diagnostic significance), and "positive" (defined as definitive cellular evidence ...

Last Updated: 18 May 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leukoplakia" returned 8 free, full-text review articles on human participants. First 3 results:

Proliferative verrucous leukoplakia: a proposal for diagnostic criteria.
 

Author(s): Rocio Cerero-Lapiedra, David Baladé-Martínez, Luis-Alberto Moreno-López, Germán Esparza-Gómez, José V Bagán

Journal:

 

Proliferative verrucous leukoplakia (PVL) is a rare form of oral leukoplakia, which was first described in 1985 by Hansen et al. Since then, various published case series have presented PVL as a disease with aggressive biological behaviour due to its high probability of recurrence ...

Last Updated: 2 Nov 2010

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Betel quid not containing tobacco and oral leukoplakia: a report on a cross-sectional study in Papua New Guinea and a meta-analysis of current evidence.
 

Author(s): Steven J Thomas, Ross Harris, Andrew R Ness, Joachim Taulo, Robert Maclennan, Noah Howes, Christopher J Bain

Journal: Int. J. Cancer. 2008 Oct;123(8):1871-6.

 

Leukoplakia is an asymptomatic, potentially malignant change in the oral mucosa. Previous studies have reported that smoking and betel quid chewing are associated with increased risk of leukoplakia; few studies have reported on these associations in populations where betel quid does ...

Last Updated: 22 Aug 2008

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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Tobacco Cessation Intervention Study for Oral Diseases
 

Status: Recruiting

Condition Summary: Smoking Cessation; Mouth Diseases; Periodontal Diseases; Leukoplakia; Lichen Planus; Keratosis; Implant

 

Last Updated: 8 Apr 2016

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Infectious Aetiology of Potentially Malignant Disorders and Squamous Cell Carcinomas of the Oral Cavity
 

Status: Recruiting

Condition Summary: Squamous Cell Carcinoma of the Oral Cavity; Leukoplakia Oral

 

Last Updated: 4 Apr 2013

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Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
 

Status: Not yet recruiting

Condition Summary: Erythroplakia; Hyperplasia; Mild Dysplasia; Moderate Dysplasia; Oral Cavity Carcinoma; Oral Leukoplakia; Severe Dysplasia

 

Last Updated: 20 Apr 2016

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