Anaplastic Ganglioglioma

Common Name(s)

Anaplastic Ganglioglioma

Anaplastic ganglioglioma (AGG) is a very rare type of brain tumor that is a type of ganglioglioma. In general, gangliogliomas are classified as grade I or low grade tumors, meaning that they grow slowly and are considered benign. Anaplastic gangliogliomas, however, are considered grade III or high grade tumors, which means that they are usually aggressive, malignant tumors. The main treatment is removal of the entire tumor during surgery.  If the entire tumor is not removed, it has the potential to recur and may require additional surgery or treatments, such as radiation therapy or chemotherapy.  Unfortunately, because gangliogliomas are quite rare, there is limited information to show that radiation therapy or chemotherapy are effective treatments for this condition.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic Ganglioglioma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic Ganglioglioma" returned 4 free, full-text research articles on human participants. First 3 results:

Ganglioglioma with anaplastic transformation.
 

Author(s): Fabiano Reis, Guilherme Henrique Alves Vieira, Ricardo Schwingel, Vinicius Trindade Gonçalves, Luciano de Souza Queiroz

Journal: Arq Neuropsiquiatr. 2012 Sep;70(9):746-7.

 

Last Updated: 31 Dec 1969

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Anaplastic ganglioglioma with malignant features in both neuronal and glial components--case report.
 

Author(s): Tomoyuki Kawataki, Eiji Sato, Takashi Sato, Hiroyuki Kinouchi

Journal: Neurol. Med. Chir. (Tokyo). 2010 ;50(3):228-31.

 

A 34-year-old man presented with a case of anaplastic ganglioglioma with malignant features in both neuronal and glial components manifesting as seizure episodes over 11 months. The tumor was subtotally removed, followed by irradiation and chemotherapy. The histological diagnosis ...

Last Updated: 31 Dec 1969

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Anaplastic ganglioglioma of the cerebellopontine angle. Case report.
 

Author(s): Kazuhito Matsuzaki, Masaaki Uno, Teruyoshi Kageji, Takanori Hirose, Shinji Nagahiro

Journal: Neurol. Med. Chir. (Tokyo). 2005 Nov;45(11):591-5.

 

A 64-year-old woman presented with a rare anaplastic ganglioglioma in the right cerebellopontine angle manifesting as dizziness persisting for 2 weeks. Preoperative magnetic resonance (MR) imaging revealed a partially enhanced cystic lesion of the right cerebellopontine angle. The ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic Ganglioglioma" returned 3 free, full-text review articles on human participants. First 3 results:

Anaplastic ganglioglioma: a report of three cases and review of the literature.
 

Author(s): John Thomas Lucas, Andrew Jonathan Huang, Ryan T Mott, Glenn J Lesser, Stephen Bradley Tatter, Michael David Chan

Journal: J. Neurooncol.. 2015 May;123(1):171-7.

 

Gangliogliomas are rare tumors of the central nervous system that are thought to arise from a glioneuronal precursor and consist of both neuronal and glial elements. Grade III, or anaplastic ganglioglioma (AGG), most commonly affects children and young adults, generally arises in ...

Last Updated: 31 Dec 1969

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Anaplastic ganglioglioma: a very rare intramedullary spinal cord tumor.
 

Author(s): Christian Schneider, Jürg Vosbeck, Michael A Grotzer, Eugen Boltshauser, Karl F Kothbauer

Journal: Pediatr Neurosurg. 2012 ;48(1):42-7.

 

Gangliogliomas (GGs) are a small subset of intramedullary spinal cord tumors in children. The anaplastic variant (WHO grade III) appears to be an extreme rarity. A literature research revealed only 15 case reports of intramedullary anaplastic GGs (aGGs) and only 4 pediatric patients. ...

Last Updated: 31 Dec 1969

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Anaplastic ganglioglioma in a middle-aged woman: a case report with a review of the literature.
 

Author(s): Dong Ho Kang, Chul Hee Lee, Soo Hyun Hwang, In Sung Park, Jong Woo Han, Jin Myung Jung

Journal: J. Korean Med. Sci.. 2007 Sep;22 Suppl():S139-44.

 

We report a case of anaplastic ganglioglioma. A 45-yr-old woman was admitted with a 5-month history of headache and dizziness, both of which progressed slowly. Preoperative magnetic resonance imaging revealed a strong enhancing mass in the left frontal lobe extending to the cingulate ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Anaplastic Ependymoma; Anaplastic Ganglioglioma; Anaplastic Meningioma; Anaplastic Oligodendroglioma; Pleomorphic Xanthoastrocytoma, Anaplastic; Atypical Teratoid/Rhabdoid Tumor; Brain Cancer; Brain Tumor; Central Nervous System Neoplasms; Choroid Plexus Carcinoma; CNS Embryonal Tumor With Rhabdoid Features; Ganglioneuroblastoma of Central Nervous System; CNS Tumor; Embryonal Tumor of CNS; Ependymoma; Glioblastoma; Glioma; Glioma, Malignant; Medulloblastoma; Medulloblastoma; Unspecified Site; Medulloepithelioma; Neuroepithelial Tumor; Neoplasms; Neoplasms, Neuroepithelial; Papillary Tumor of the Pineal Region (High-grade Only); Pediatric Brain Tumor; Pineal Parenchymal Tumor of Intermediate Differentiation (High-grade Only); Pineoblastoma; Primitive Neuroectodermal Tumor; Recurrent Medulloblastoma; Refractory Brain Tumor; Neuroblastoma. CNS; Glioblastoma, IDH-mutant; Glioblastoma, IDH-wildtype; Medulloblastoma, Group 3; Medulloblastoma, Group 4; Glioma, High Grade; Neuroepithelial Tumor, High Grade; Medulloblastoma, SHH-activated and TP53 Mutant; Medulloblastoma, SHH-activated and TP53 Wildtype; Medulloblastoma, Chromosome 9q Loss; Medulloblastoma, Non-WNT Non-SHH, NOS; Medulloblastoma, Non-WNT/Non-SHH; Medulloblastoma, PTCH1 Mutation; Medulloblastoma, WNT-activated; Ependymoma, Recurrent; Glioma, Recurrent High Grade; Glioma, Recurrent Malignant; Embryonal Tumor, NOS; Glioma, Diffuse Midline, H3K27M-mutant; Embryonal Tumor With Multilayered Rosettes (ETMR); Ependymoma, NOS, WHO Grade III; Ependymoma, NOS, WHO Grade II; Medulloblastoma, G3/G4; Ependymoma, RELA Fusion Positive

 

Last Updated: 9 Apr 2018

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Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG
 

Status: Recruiting

Condition Summary: Diffuse Astrocytoma; Anaplastic Astrocytoma; Astrocytoma; Oligodendroglioma, Childhood; Anaplastic Oligodendroglioma; Glioblastoma; Pilocytic Astrocytoma; Giant Cell Astrocytoma; Pleomorphic Xanthoastrocytoma; Anaplastic Pleomorphic Xanthoastrocytoma; Angiocentric Glioma; Chordoid Glioma of Third Ventricle; Gangliocytoma; Ganglioglioma; Anaplastic Ganglioglioma; Dysplastic Gangliocytoma of Cerebrellum; Desmoplastic Infantile Astrocytoma and Ganglioglioma; Papillary Glioneuronal Tumor; Rosette-forming Glioneurona Tumor; Central Neurocytoma; Extraventricular Neurocytoma; Cerebellar Iponeurocytoma

 

Last Updated: 8 Mar 2018

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