Anaplastic Ependymoma

Common Name(s)

Anaplastic Ependymoma

An ependymoma is a tumor that forms when cells in the central nervous system (including the brain and spinal cord) begin to multiple rapidly.  An anaplastic ependymoma is one in which the cells are significantly unusual and grow very quickly.  Ependymomas can occur at any age; when they occur in children, they are more frequently located in the brain, whereas they are more often found in the spinal cord of affected adults.  Symptoms of an ependymoma depend on the age of the patient and the size and location of the tumor.  Though the exact cause of ependymoma is not yet known, it is thought that changes (mutations) in certain genes allow the cells to begin growing quickly.  Treatment for ependymoma begins with surgery to remove as much of the tumor as possible, and may include other therapies as well.  Of all individuals diagnosed with an ependymoma, approximately half are alive five years after their initial diagnosis.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic Ependymoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic Ependymoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic Ependymoma" returned 12 free, full-text research articles on human participants. First 3 results:

Supratentorial extraventricular anaplastic ependymoma with extracranial metastasis.
 

Author(s): Laura A Pachella, Carlos Kamiya-Matsuoka, Eva Lu T Lee, Adriana Olar, W K Alfred Yung

Journal: J Clin Neurosci. 2015 Mar;22(3):605-7.

 

Ependymoma is a relatively rare malignancy accounting for 2.0% of all primary central nervous system tumors in adults. Extracranial metastasis is a very uncommon complication of gliomas, especially of anaplastic ependymomas. The objective of this paper is to show that ependymomas ...

Last Updated: 10 Feb 2015

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Supratentorial extraventricular anaplastic ependymoma in a child.
 

Author(s): Muhammad Faisal Khilji, Rana Shoaib Hamid, Asim Qureshi

Journal:

 

A young child presented to the emergency department of a tertiary care hospital with on and off headache, focal seizures involving the left side of the body, weakness of left upper and lower limbs and vomiting for 2 weeks. Examination showed an alert child with grade 4/5 powers in ...

Last Updated: 13 Mar 2014

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A headache presenting in the emergency room, a clinical manifestation of an unfortunate diagnosis (grade III left frontal anaplastic ependymoma with 1p deletion).
 

Author(s): B J Flores-Robles, A R Hurtarte-Sandoval, R M Harrison, C C Cuevas

Journal:

 

An 18-year-old girl presented with a headache and behavioural changes. She was found to have a frontal mass. Neuroimaging revealed an intra-axial mass, located at the left frontal cortical/subcortical region approximately 6×7, 5×7, 5 cm (TxApxL), having a heterogeneous density with ...

Last Updated: 5 Aug 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic Ependymoma" returned 2 free, full-text review articles on human participants. First 3 results:

Supratentorial extraventricular anaplastic ependymoma in an adult with repeated intratumoral hemorrhage.
 

Author(s): Naotaka Iwamoto, Yasuo Murai, Yoichiro Yamamoto, Koji Adachi, Akira Teramoto

Journal: Brain Tumor Pathol. 2014 Apr;31(2):138-43.

 

We report the case of a 61-year-old man with supratentorial extraventricular anaplastic ependymoma who presented with repeated intratumoral hemorrhage. The patient was admitted with headache. Computed tomography and magnetic resonance imaging showed an enhancing mass with intratumoral ...

Last Updated: 21 Apr 2014

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Recurrent posterior fossa anaplastic ependymoma with prominent chondroid metaplasia: a case report and review of literature.
 

Author(s): Nandita Ghosal, Ganesh Murthy, Ravi Dadlani, Alangar Sathya Hegde, Devendra Singh

Journal: Indian J Pathol Microbiol. ;53(4):787-9.

 

We report an unusual case of a recurrent fourth ventricular anaplastic ependymoma with prominent chondroid metaplasia in a 16-year-old male. On initial presentation, the patient had a WHO Grade II tumor. However, at recurrence 1 year later, the tumor progressed to WHO Grade III tumor ...

Last Updated: 3 Nov 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Pediatric Study With Dabrafenib in HGG Patients
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma; Giant Cell Glioblastoma; Gliosarcoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma; Choroid Plexus Carcinoma; Anaplastic Ganglioglioma; Pineal Parenchymal Tumor; Pineoblastoma; Medulloblastoma; PNET; Rhabdoid Tumor; Perineurioma; MPNST; Malignant Meningloma; Anaplastic Hemangiopericytoma

 

Last Updated: 9 Sep 2016

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Carboplatin and Bevacizumab for Recurrent Ependymoma
 

Status: Recruiting

Condition Summary: Ependymoma; Anaplastic Ependymoma

 

Last Updated: 21 Sep 2016

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Phase I/II Trial of Safety and Anti-tumor Efficacy of AXL1717(Picropodophyllin) in the Treatment of Recurrent Malignant Astrocytomas
 

Status: Recruiting

Condition Summary: Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma

 

Last Updated: 8 Jan 2015

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