Anaplastic astrocytoma

Common Name(s)

Anaplastic astrocytoma

Anaplastic astrocytoma is a rare cancerous brain tumor that grows from star shaped cells called astrocytes. Astrocytes make up the protective tissue of the brain. Astrocytoma tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. With this system, grade I shows the cells are abnormal but not yet cancerous. Anaplastic astrocytoma is considered a a grade III tumor and requires more aggressive treatment. Astrocytoma tumors are characterized by tentacle-like projections that grow into surround tissues making them more difficult to remove during surgery. Initial symptoms may include headaches, memory loss, depressed mental state, and/or seizures. Other neurological deficits or changes may appear depending on where the tumors spread. Currently there is no known cause for this type of tumor, although a small proportion of individuals (< 5%) may develop anaplastic astrocytoma due to hereditary factors. Anaplasitc astrocyomas tend to occur more frequently in males than females and generally after age 45. Treatment procedures involve surgery first, and then radiation therapy to remove any remaining tumor tissue. Chemotherapy may be necessary if the tumor returns. If you or a family member has been diagnosed with an anaplastic astrosytoma, talk with your doctors and specialists to learn about the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic astrocytoma" returned 46 free, full-text research articles on human participants. First 3 results:

A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres.
 

Author(s): Alexandra Borodovsky, Alan K Meeker, Ewen F Kirkness, Qi Zhao, Charles G Eberhart, Gary L Gallia, Gregory J Riggins

Journal: J. Neurooncol.. 2015 Feb;121(3):479-87.

 

Mutations in isocitrate dehydrogenase 1 (IDH1) have been found in the vast majority of low grade and progressive infiltrating gliomas and are characterized by the production of 2-hydroxyglutarate from α-ketoglutarate. Recent investigations of malignant gliomas have identified additional ...

Last Updated: 9 Feb 2015

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The impact of concurrent temozolomide with adjuvant radiation and IDH mutation status among patients with anaplastic astrocytoma.
 

Author(s): Sani H Kizilbash, Caterina Giannini, Jesse S Voss, Paul A Decker, Robert B Jenkins, John Hardie, Nadia N Laack, Ian F Parney, Joon H Uhm, Jan C Buckner

Journal: J. Neurooncol.. 2014 Oct;120(1):85-93.

 

This study assesses the controversial role of temozolomide (TMZ) concurrent with adjuvant radiation (RT) in patients with anaplastic astrocytoma (AA). The impact of isocitrate dehydrogenase (IDH) status on therapy and outcomes is also examined. All adult patients diagnosed with AA ...

Last Updated: 27 Sep 2014

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A 16-gene signature distinguishes anaplastic astrocytoma from glioblastoma.
 

Author(s): Soumya Alige Mahabala Rao, Sujaya Srinivasan, Irene Rosita Pia Patric, Alangar Sathyaranjandas Hegde, Bangalore Ashwathnarayanara Chandramouli, Arivazhagan Arimappamagan, Vani Santosh, Paturu Kondaiah, Manchanahalli R Sathyanarayana Rao, Kumaravel Somasundaram

Journal:

 

Anaplastic astrocytoma (AA; Grade III) and glioblastoma (GBM; Grade IV) are diffusely infiltrating tumors and are called malignant astrocytomas. The treatment regimen and prognosis are distinctly different between anaplastic astrocytoma and glioblastoma patients. Although histopathology ...

Last Updated: 29 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic astrocytoma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Temozolomide and Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Anaplastic Astrocytoma
 

Status: Recruiting

Condition Summary: Glioblastoma Multiforme/Anaplastic Astrocytoma

 

Last Updated: 15 Nov 2011

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Phase I/II Trial of Safety and Anti-tumor Efficacy of AXL1717(Picropodophyllin) in the Treatment of Recurrent Malignant Astrocytomas
 

Status: Recruiting

Condition Summary: Glioblastoma; Gliosarcoma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Anaplastic Oligoastrocytoma; Anaplastic Ependymoma

 

Last Updated: 8 Jan 2015

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Phase I Study of Safety and Immunogenicity of ADU-623
 

Status: Recruiting

Condition Summary: Astrocytic Tumors; Glioblastoma Multiforme; Anaplastic Astrocytoma; Brain Tumor

 

Last Updated: 4 Sep 2015

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