Anaplastic astrocytoma

Common Name(s)

Anaplastic astrocytoma

Anaplastic astrocytoma is a rare cancerous brain tumor that grows from star shaped cells called astrocytes. Astrocytes make up the protective tissue of the brain. Astrocytoma tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. With this system, grade I shows the cells are abnormal but not yet cancerous. Anaplastic astrocytoma is considered a a grade III tumor and requires more aggressive treatment. Astrocytoma tumors are characterized by tentacle-like projections that grow into surround tissues making them more difficult to remove during surgery. Initial symptoms may include headaches, memory loss, depressed mental state, and/or seizures. Other neurological deficits or changes may appear depending on where the tumors spread. Currently there is no known cause for this type of tumor, although a small proportion of individuals (< 5%) may develop anaplastic astrocytoma due to hereditary factors. Anaplasitc astrocyomas tend to occur more frequently in males than females and generally after age 45. Treatment procedures involve surgery first, and then radiation therapy to remove any remaining tumor tissue. Chemotherapy may be necessary if the tumor returns. If you or a family member has been diagnosed with an anaplastic astrosytoma, talk with your doctors and specialists to learn about the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic astrocytoma" returned 52 free, full-text research articles on human participants. First 3 results:

Extracranial bone metastases from recurrent anaplastic astrocytoma on FDG PET/CT: A case report a care-compliant article.
 

Author(s): Zu-Gui Li, Hai-Yu Mu

Journal: Medicine (Baltimore). 2017 Jun;96(23):e7123.

 

Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography ...

Last Updated: 7 Jun 2017

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Design of a Phase I Clinical Trial to Evaluate M032, a Genetically Engineered HSV-1 Expressing IL-12, in Patients with Recurrent/Progressive Glioblastoma Multiforme, Anaplastic Astrocytoma, or Gliosarcoma.
 

Author(s): Daxa M Patel, Paul M Foreman, L Burt Nabors, Kristen O Riley, G Yancey Gillespie, James M Markert

Journal: Hum Gene Ther Clin Dev. 2016 Jun;27(2):69-78.

 

M032 is a second-generation oncolytic herpes simplex virus (oHSV) that selectively replicates in tumor cells. M032 kills tumor cells directly through oncolytic replication and then proceeds to infect tumor cells in proximity, continuing the process of tumor destruction. In addition ...

Last Updated: 18 Jun 2016

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The role of temozolomide in the management of patients with newly diagnosed anaplastic astrocytoma: a comparison of survival in the era prior to and following the availability of temozolomide.
 

Author(s): Roy E Strowd, Inas Abuali, Xiaobu Ye, Yao Lu, Stuart A Grossman

Journal: J. Neurooncol.. 2016 Mar;127(1):165-71.

 

Adding temozolomide (TMZ) to radiation for patients with newly-diagnosed anaplastic astrocytomas (AAs) is common clinical practice despite the lack of prospective studies demonstrating a survival advantage. Two retrospective studies, each with methodologic limitations, provide conflicting ...

Last Updated: 22 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic astrocytoma" returned 1 free, full-text review articles on human participants. First 3 results:

Adult anaplastic pilocytic astrocytoma - a diagnostic challenge? A case series and literature review.
 

Author(s): Michael Fiechter, Ekkehard Hewer, Urspeter Knecht, Roland Wiest, Jürgen Beck, Andreas Raabe, Markus F Oertel

Journal: Clin Neurol Neurosurg. 2016 Aug;147():98-104.

 

Anaplastic pilocytic astrocytoma (APA) is an exceptionally rare type of high-grade glioma in adults. Establishing histopathological diagnosis is challenging and its clinical and radiological appearance insidious. By this case series and first literature review we investigated the ...

Last Updated: 20 Jul 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Recurrent Anaplastic Astrocytoma

 

Last Updated: 21 Aug 2017

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Immunophenotyping From Blood of Patients With Malignant Gliomas
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma Multiforme

 

Last Updated: 24 Nov 2016

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Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
 

Status: Recruiting

Condition Summary: Glioblastoma Multiforme; Anaplastic Astrocytoma

 

Last Updated: 22 Aug 2017

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