Anaplastic astrocytoma

Common Name(s)

Anaplastic astrocytoma

Anaplastic astrocytoma is a rare cancerous brain tumor that grows from star shaped cells called astrocytes. Astrocytes make up the protective tissue of the brain. Astrocytoma tumors are characterized by "grade" (grade I-IV) which is based on how normal or abnormal the tumor cells appear as well as how fast the tumor is growing. With this system, grade I shows the cells are abnormal but not yet cancerous. Anaplastic astrocytoma is considered a a grade III tumor and requires more aggressive treatment. Astrocytoma tumors are characterized by tentacle-like projections that grow into surround tissues making them more difficult to remove during surgery. Initial symptoms may include headaches, memory loss, depressed mental state, and/or seizures. Other neurological deficits or changes may appear depending on where the tumors spread. Currently there is no known cause for this type of tumor, although a small proportion of individuals (< 5%) may develop anaplastic astrocytoma due to hereditary factors. Anaplasitc astrocyomas tend to occur more frequently in males than females and generally after age 45. Treatment procedures involve surgery first, and then radiation therapy to remove any remaining tumor tissue. Chemotherapy may be necessary if the tumor returns. If you or a family member has been diagnosed with an anaplastic astrosytoma, talk with your doctors and specialists to learn about the most current treatment options available.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

Last Updated: 21 Nov 2014

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anaplastic astrocytoma" for support, advocacy or research.

Accelerate Brain Cancer Cure

Our Mission: to invest in research aimed at finding the fastest possible route to a cure. We are focused on speeding the pace of research that will lead to new brain tumor therapies and, ultimately, a cure. We take an aggressive, venture funding approach not typically seen in the nonprofit sector. We have an enterprising attitude, we promote scientific collaboration and we're committed to measurable results.

http://www.abc2.org

Last Updated: 7 Jan 2013

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National Brain Tumor Society

National Brain Tumor Society is fiercely committed to finding better treatments, and ultimately a cure, for people living with a brain tumor today and anyone who will be diagnosed tomorrow. This means effecting change in the system at all levels. It’s time to build on progress and transform tomorrow, today.

http://braintumor.org/

Last Updated: 21 Nov 2014

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anaplastic astrocytoma" returned 49 free, full-text research articles on human participants. First 3 results:

An infant with hyperalertness, hyperkinesis, and failure to thrive: a rare diencephalic syndrome due to hypothalamic anaplastic astrocytoma.
 

Author(s): Alessia Stival, Maurizio Lucchesi, Silvia Farina, Anna Maria Buccoliero, Francesca Castiglione, Lorenzo Genitori, Maurizio de Martino, Iacopo Sardi

Journal:

 

Diencephalic Syndrome is a rare clinical condition of failure to thrive despite a normal caloric intake, hyperalertness, hyperkinesis, and euphoria usually associated with low-grade hypothalamic astrocytomas.

Last Updated: 4 Sep 2015

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Evaluation of RANO response criteria compared to clinician evaluation in WHO grade III anaplastic astrocytoma: implications for clinical trial reporting and patterns of failure.
 

Author(s): Tomas Kazda, John G Hardie, Deanna H Pafundi, Timothy J Kaufmann, Debra H Brinkmann, Nadia N Laack

Journal: J. Neurooncol.. 2015 Mar;122(1):197-203.

 

The utility of current response criteria has not been established in anaplastic astrocytoma (AA). We retrospectively reviewed MR images for 20 patients with AA and compared RANO-based approaches to clinician impression described as follow: (1) standard RANO-based criteria met by growth ...

Last Updated: 10 Mar 2015

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A model of a patient-derived IDH1 mutant anaplastic astrocytoma with alternative lengthening of telomeres.
 

Author(s): Alexandra Borodovsky, Alan K Meeker, Ewen F Kirkness, Qi Zhao, Charles G Eberhart, Gary L Gallia, Gregory J Riggins

Journal: J. Neurooncol.. 2015 Feb;121(3):479-87.

 

Mutations in isocitrate dehydrogenase 1 (IDH1) have been found in the vast majority of low grade and progressive infiltrating gliomas and are characterized by the production of 2-hydroxyglutarate from α-ketoglutarate. Recent investigations of malignant gliomas have identified additional ...

Last Updated: 9 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anaplastic astrocytoma" returned 0 free, full-text review articles on human participants.

 
 
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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients
 

Status: Not yet recruiting

Condition Summary: Anaplastic Astrocytoma; Recurrent Anaplastic Astrocytoma

 

Last Updated: 7 Jun 2016

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Immunophenotyping From Blood of Patients With Malignant Gliomas
 

Status: Recruiting

Condition Summary: Anaplastic Astrocytoma; Glioblastoma Multiforme

 

Last Updated: 23 Oct 2015

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Repeated Super-selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Relapsed GBM and AA
 

Status: Recruiting

Condition Summary: Glioblastoma Multiforme; Anaplastic Astrocytoma

 

Last Updated: 25 Jul 2016

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