Leptospirosis

Common Name(s)

Leptospirosis

Leptospirosis is an infectious bacterial disease that affects both humans and animals. Humans become infected through direct contact with the urine of infected animals or through urine-contaminated environments, where the bacteria enter into the system through cuts and abrasions of the skin or through the eyes, nose, and mouth. Leptospirosis occurs worldwide, but is most prevalent in tropical and subtropical regions, with outbreaks common following excessive rainfall or flooding. Signs and symptoms of leptospirosis can range from a mild flu-like illness to a more serious and sometimes fatal disease. In the early stages, symptoms include high fever, severe headache, muscle pain, chills, redness of the eyes, hives, abdominal pain, jaundice, hemorrhages in the skin, vomiting, diarrhea, and rash.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leptospirosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leptospirosis" returned 650 free, full-text research articles on human participants. First 3 results:

Environmental risk of leptospirosis infections in the Netherlands: Spatial modelling of environmental risk factors of leptospirosis in the Netherlands.
 

Author(s): Ente J J Rood, Marga G A Goris, Roan Pijnacker, Mirjam I Bakker, Rudy A Hartskeerl

Journal:

 

Leptospirosis is a globally emerging zoonotic disease, associated with various climatic, biotic and abiotic factors. Mapping and quantifying geographical variations in the occurrence of leptospirosis and the surrounding environment offer innovative methods to study disease transmission ...

Last Updated: 24 Oct 2017

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Platelet dysfunction contributes to bleeding complications in patients with probable leptospirosis.
 

Author(s): Rahajeng N Tunjungputri, Muhammad Hussein Gasem, Willemijn van der Does, Pandu H Sasongko, Bambang Isbandrio, Rolf T Urbanus, Philip G de Groot, Andre van der Ven, Quirijn de Mast

Journal:

 

Severe leptospirosis is frequently complicated by a hemorrhagic diathesis, of which the pathogenesis is still largely unknown. Thrombocytopenia is common, but often not to the degree that spontaneous bleeding is expected. We hypothesized that the hemorrhagic complications are not ...

Last Updated: 21 Sep 2017

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Rapid, actionable diagnosis of urban epidemic leptospirosis using a pathogenic Leptospira lipL32-based real-time PCR assay.
 

Author(s): Irina N Riediger, Robyn A Stoddard, Guilherme S Ribeiro, Sueli M Nakatani, Suzana D R Moreira, Irene Skraba, Alexander W Biondo, Mitermayer G Reis, Alex R Hoffmaster, Joseph M Vinetz, Albert I Ko, Elsio A Wunder

Journal:

 

With a conservatively estimated 1 million cases of leptospirosis worldwide and a 5-10% fatality rate, the rapid diagnosis of leptospirosis leading to effective clinical and public health decision making is of high importance, and yet remains a challenge.

Last Updated: 15 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leptospirosis" returned 63 free, full-text review articles on human participants. First 3 results:

The Use of Chemoprophylaxis after Floods to Reduce the Occurrence and Impact of Leptospirosis Outbreaks.
 

Author(s): Maria Cristina Schneider, Jorge Velasco-Hernandez, Kyung-Duk Min, Deise Galan Leonel, David Baca-Carrasco, Matthew E Gompper, Rudy Hartskeerl, Claudia Munoz-Zanzi

Journal:

 

Record-breaking and devastating rainfall events have occurred in the past decade. Rain and floods are considered the main risk factors for leptospirosis and several outbreaks have been reported following extreme weather events. In such situations, one possible intervention to prevent ...

Last Updated: 7 Jun 2017

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Molecular diagnostics for human leptospirosis.
 

Author(s): Jesse J Waggoner, Benjamin A Pinsky

Journal: Curr. Opin. Infect. Dis.. 2016 Oct;29(5):440-5.

 

The definitive diagnosis of leptospirosis, which results from infection with spirochetes of the genus Leptospira, currently relies on the use of culture, serological testing (microscopic agglutination testing), and molecular detection. The purpose of this review is to describe new ...

Last Updated: 31 Aug 2016

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Micronutrients and Leptospirosis: A Review of the Current Evidence.
 

Author(s): Heather S Herman, Saurabh Mehta, Washington B Cárdenas, Anna M Stewart-Ibarra, Julia L Finkelstein

Journal:

 

Leptospirosis is one of the most widespread zoonoses and represents a major threat to human health. Due to the high burden of disease, limitations in diagnostics, and limited coverage and availability of effective human and veterinary vaccines, leptospirosis remains an important neglected ...

Last Updated: 8 Jul 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

French West Indies Leptospirosis Study
 

Status: Recruiting

Condition Summary: Leptospirosis

 

Last Updated: 29 Feb 2016

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Immune Response After Leptospirosis Infection
 

Status: Not yet recruiting

Condition Summary: Leptospirosis

 

Last Updated: 8 Sep 2016

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Last Updated: 29 Feb 2016

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