Leptospirosis

Common Name(s)

Leptospirosis

Leptospirosis is an infectious bacterial disease that affects both humans and animals. Humans become infected through direct contact with the urine of infected animals or through urine-contaminated environments, where the bacteria enter into the system through cuts and abrasions of the skin or through the eyes, nose, and mouth. Leptospirosis occurs worldwide, but is most prevalent in tropical and subtropical regions, with outbreaks common following excessive rainfall or flooding. Signs and symptoms of leptospirosis can range from a mild flu-like illness to a more serious and sometimes fatal disease. In the early stages, symptoms include high fever, severe headache, muscle pain, chills, redness of the eyes, hives, abdominal pain, jaundice, hemorrhages in the skin, vomiting, diarrhea, and rash.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leptospirosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leptospirosis" returned 673 free, full-text research articles on human participants. First 3 results:

Risk factors for human acute leptospirosis in northern Tanzania.
 

Author(s): Michael J Maze, Shama Cash-Goldwasser, Matthew P Rubach, Holly M Biggs, Renee L Galloway, Katrina J Sharples, Kathryn J Allan, Jo E B Halliday, Sarah Cleaveland, Michael C Shand, Charles Muiruri, Rudovick R Kazwala, Wilbrod Saganda, Bingileki F Lwezaula, Blandina T Mmbaga, Venance P Maro, John A Crump

Journal:

 

Leptospirosis is a major cause of febrile illness in Africa but little is known about risk factors for human infection. We conducted a cross-sectional study to investigate risk factors for acute leptospirosis and Leptospira seropositivity among patients with fever attending referral ...

Last Updated: 31 Dec 1969

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The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines.
 

Author(s): Naohiko Matsushita, Chris Fook Sheng Ng, Yoonhee Kim, Motoi Suzuki, Nobuo Saito, Koya Ariyoshi, Eumelia P Salva, Efren M Dimaano, Jose B Villarama, Winston S Go, Masahiro Hashizume

Journal:

 

Leptospirosis is a worldwide bacterial zoonosis. Outbreaks of leptospirosis after heavy rainfall and flooding have been reported. However, few studies have formally quantified the effect of weather factors on leptospirosis incidence. We estimated the association between rainfall and ...

Last Updated: 31 Dec 1969

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Thai-Lepto-on-admission probability (THAI-LEPTO) score as an early tool for initial diagnosis of leptospirosis: Result from Thai-Lepto AKI study group.
 

Author(s): Theerapon Sukmark, Nuttha Lumlertgul, Sadudee Peerapornratana, Kamol Khositrangsikun, Kriang Tungsanga, Visith Sitprija, Nattachai Srisawat,

Journal:

 

Leptospirosis is one of the most important zoonosis in the tropics. Currently, specific laboratory diagnostic test for leptospirosis such as polymerase chain reaction (PCR) or direct culture cannot be applied at the primary care setting especially in the resource- limited countries. ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leptospirosis" returned 68 free, full-text review articles on human participants. First 3 results:

Pathology and pathogenesis of human leptospirosis: a commented review.
 

Author(s): Thales De Brito, Ana Maria Gonçalves da Silva, Patrícia Antonia Estima Abreu

Journal: Rev. Inst. Med. Trop. Sao Paulo. 2018 ;60():e23.

 

Leptospirosis is an acute bacterial septicemic febrile disease caused by pathogenic leptospires, which affect humans and animals in all parts of the world. Transmission can occur by direct contact with infected animals or, more commonly, through indirect contact with water or soil ...

Last Updated: 31 Dec 1969

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A systematic review of human and animal leptospirosis in the Pacific Islands reveals pathogen and reservoir diversity.
 

Author(s): Vanina Guernier, Cyrille Goarant, Jackie Benschop, Colleen L Lau

Journal:

 

The Pacific Islands have environmental conditions highly favourable for transmission of leptospirosis, a neglected zoonosis with highest incidence in the tropics, and Oceania in particular. Recent reports confirm the emergence and outbreaks of leptospirosis in the Pacific Islands, ...

Last Updated: 31 Dec 1969

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A process for developing multisectoral strategies for zoonoses: the case of leptospirosis in Fiji.
 

Author(s): Simon A Reid, Anna Rodney, Mike Kama, Peter S Hill

Journal:

 

Zoonotic diseases such as leptospirosis occur as a result of the often complex interactions that exist at the human-animal-environment interface. The most obvious consequence of this complexity is the need for the health sector to partner with institutions in other sectors of society ...

Last Updated: 31 Dec 1969

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Immune Response After Leptospirosis Infection
 

Status: Not yet recruiting

Condition Summary: Leptospirosis

 

Last Updated: 8 Sep 2016

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Last Updated: 19 Mar 2018

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