Leptospirosis

Common Name(s)

Leptospirosis

Leptospirosis is an infectious bacterial disease that affects both humans and animals. Humans become infected through direct contact with the urine of infected animals or through urine-contaminated environments, where the bacteria enter into the system through cuts and abrasions of the skin or through the eyes, nose, and mouth. Leptospirosis occurs worldwide, but is most prevalent in tropical and subtropical regions, with outbreaks common following excessive rainfall or flooding. Signs and symptoms of leptospirosis can range from a mild flu-like illness to a more serious and sometimes fatal disease. In the early stages, symptoms include high fever, severe headache, muscle pain, chills, redness of the eyes, hives, abdominal pain, jaundice, hemorrhages in the skin, vomiting, diarrhea, and rash.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leptospirosis" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leptospirosis" returned 639 free, full-text research articles on human participants. First 3 results:

Human leptospirosis in Seychelles: A prospective study confirms the heavy burden of the disease but suggests that rats are not the main reservoir.
 

Author(s): Leon Biscornet, Koussay Dellagi, Frédéric Pagès, Jastin Bibi, Jeanine de Comarmond, Julien Mélade, Graham Govinden, Maria Tirant, Yann Gomard, Vanina Guernier, Erwan Lagadec, Jimmy Mélanie, Gérard Rocamora, Gildas Le Minter, Julien Jaubert, Patrick Mavingui, Pablo Tortosa

Journal:

 

Leptospirosis is a bacterial zoonosis caused by pathogenic Leptospira for which rats are considered as the main reservoir. Disease incidence is higher in tropical countries, especially in insular ecosystems. Our objectives were to determine the current burden of leptospirosis in Seychelles, ...

Last Updated: 28 Aug 2017

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Assessing the performance of remotely-sensed flooding indicators and their potential contribution to early warning for leptospirosis in Cambodia.
 

Author(s): Julia Ledien, Sopheak Sorn, Sopheak Hem, Rekol Huy, Philippe Buchy, Arnaud Tarantola, Julien Cappelle

Journal:

 

Remote sensing can contribute to early warning for diseases with environmental drivers, such as flooding for leptospirosis. In this study we assessed whether and which remotely-sensed flooding indicator could be used in Cambodia to study any disease for which flooding has already ...

Last Updated: 13 Jul 2017

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Immunoprotective properties of recombinant LigA and LigB in a hamster model of acute leptospirosis.
 

Author(s): Karen V Evangelista, Kristel Lourdault, James Matsunaga, David A Haake

Journal:

 

Leptospirosis is the most widespread zoonosis and is considered a major public health problem worldwide. Currently, there is no widely available vaccine against leptospirosis for use in humans. A purified, recombinant subunit vaccine that includes the last six immunoglobulin-like ...

Last Updated: 13 Jul 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leptospirosis" returned 61 free, full-text review articles on human participants. First 3 results:

Micronutrients and Leptospirosis: A Review of the Current Evidence.
 

Author(s): Heather S Herman, Saurabh Mehta, Washington B Cárdenas, Anna M Stewart-Ibarra, Julia L Finkelstein

Journal:

 

Leptospirosis is one of the most widespread zoonoses and represents a major threat to human health. Due to the high burden of disease, limitations in diagnostics, and limited coverage and availability of effective human and veterinary vaccines, leptospirosis remains an important neglected ...

Last Updated: 8 Jul 2016

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Global Morbidity and Mortality of Leptospirosis: A Systematic Review.
 

Author(s): Federico Costa, José E Hagan, Juan Calcagno, Michael Kane, Paul Torgerson, Martha S Martinez-Silveira, Claudia Stein, Bernadette Abela-Ridder, Albert I Ko

Journal:

 

Leptospirosis, a spirochaetal zoonosis, occurs in diverse epidemiological settings and affects vulnerable populations, such as rural subsistence farmers and urban slum dwellers. Although leptospirosis is a life-threatening disease and recognized as an important cause of pulmonary ...

Last Updated: 18 Sep 2015

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Environmental and Behavioural Determinants of Leptospirosis Transmission: A Systematic Review.
 

Author(s): Mwanajaa Abdalla Mwachui, Lisa Crump, Rudy Hartskeerl, Jakob Zinsstag, Jan Hattendorf

Journal:

 

Leptospirosis is one of the most widespread zoonotic diseases, which is of global medical and veterinary importance, and also a re-emerging infectious disease. The main tracks of transmission are known; however, the relative importance of each of the components and the respective ...

Last Updated: 18 Sep 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

French West Indies Leptospirosis Study
 

Status: Recruiting

Condition Summary: Leptospirosis

 

Last Updated: 29 Feb 2016

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Immune Response After Leptospirosis Infection
 

Status: Not yet recruiting

Condition Summary: Leptospirosis

 

Last Updated: 8 Sep 2016

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Last Updated: 29 Feb 2016

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