Leishmaniasis

Common Name(s)

Leishmaniasis

Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. There are several different forms of leishmaniasis. The most common are cutaneous and visceral. The cutaneous type causes skin sores. The visceral type affects internal organs such as the spleen, liver and bone marrow. People with this form usually have fever, weight loss, and an enlarged spleen and liver. Visceral disease can be deadly without proper treatment. Leishmaniasis is found in parts of the Middle East, Central America, South American, Asia, Africa, and southern Europe. Most of these countries are in the tropics and subtropics. It is possible but very unlikely to get this disease in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leishmaniasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leishmaniasis" returned 2263 free, full-text research articles on human participants. First 3 results:

Leishmaniasis in high-burden countries: an epidemiological update based on data reported in 2014.
 

Author(s):

Journal: Wkly. Epidemiol. Rec.. 2016 Jun;91(22):287-96.

 

Last Updated: 3 Jun 2016

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Successful Treatment of Human Visceral Leishmaniasis Restores Antigen-Specific IFN-γ, but not IL-10 Production.
 

Author(s): Emebet Adem, Fitsumbirhan Tajebe, Mulusew Getahun, Amare Kiflie, Ermias Diro, Asrat Hailu, Ziv Shkedy, Bewketu Mengesha, Tadele Mulaw, Saba Atnafu, Tekalign Deressa, Biniam Mathewos, Ebba Abate, Manuel Modolell, Markus Munder, Ingrid Müller, Yegnasew Takele, Pascale Kropf

Journal:

 

One of the key immunological characteristics of active visceral leishmaniasis (VL) is a profound immunosuppression and impaired production of Interferon-γ (IFN-γ). However, recent studies from Bihar in India showed using a whole blood assay, that whole blood cells have maintained ...

Last Updated: 11 Mar 2016

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Seasonal Dynamics of Phlebotomine Sand Fly Species Proven Vectors of Mediterranean Leishmaniasis Caused by Leishmania infantum.
 

Author(s): Bulent Alten, Carla Maia, Maria Odete Afonso, Lenea Campino, Maribel Jiménez, Estela González, Ricardo Molina, Anne Laure Bañuls, Jorian Prudhomme, Baptiste Vergnes, Celine Toty, Cécile Cassan, Nil Rahola, Magali Thierry, Denis Sereno, Gioia Bongiorno, Riccardo Bianchi, Cristina Khoury, Nikolaos Tsirigotakis, Emmanouil Dokianakis, Maria Antoniou, Vasiliki Christodoulou, Apostolos Mazeris, Mehmet Karakus, Yusuf Ozbel, Suha K Arserim, Ozge Erisoz Kasap, Filiz Gunay, Gizem Oguz, Sinan Kaynas, Nikoloz Tsertsvadze, Lamzira Tskhvaradze, Ekaterina Giorgobiani, Marina Gramiccia, Petr Volf, Luigi Gradoni

Journal:

 

The recent geographical expansion of phlebotomine vectors of Leishmania infantum in the Mediterranean subregion has been attributed to ongoing climate changes. At these latitudes, the activity of sand flies is typically seasonal; because seasonal phenomena are also sensitive to general ...

Last Updated: 23 Feb 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leishmaniasis" returned 211 free, full-text review articles on human participants. First 3 results:

The Cure Rate after Placebo or No Therapy in American Cutaneous Leishmaniasis: A Systematic Review and Meta-Analysis.
 

Author(s): Gláucia Fernandes Cota, Marcos Roberto de Sousa, Tatiani Oliveira Fereguetti, Priscila Said Saleme, Thais Kawagoe Alvarisa, Ana Rabello

Journal:

 

There are few drugs with proven efficacy in cutaneous leishmaniasis (CL), and pentavalent antimonial derivatives are still the main first-line therapeutic agents worldwide, despite their recognized high toxicities. Randomized controlled clinical trials assessing the efficacy and safety ...

Last Updated: 20 Feb 2016

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Post-kala-azar dermal leishmaniasis and leprosy: case report and literature review.
 

Author(s): Maria Angela Bianconcini Trindade, Lana Luiza da Cruz Silva, Lucia Maria Almeida Braz, Valdir Sabbaga Amato, Bernard Naafs, Mirian Nacagami Sotto

Journal:

 

Post-kala-azar dermal leishmaniasis (PKDL) is a dermal complication of visceral leishmaniasis (VL), which may occur after or during treatment. It has been frequently reported from India and the Sudan, but its occurrence in South America has been rarely reported. It may mimic leprosy ...

Last Updated: 23 Nov 2015

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Theranostic applications of phage display to control leishmaniasis: selection of biomarkers for serodiagnostics, vaccination, and immunotherapy.
 

Author(s): Eduardo Antonio Ferraz Coelho, Miguel Angel Chávez-Fumagalli, Lourena Emanuele Costa, Carlos Alberto Pereira Tavares, Manuel Soto, Luiz Ricardo Goulart

Journal: Rev. Soc. Bras. Med. Trop.. ;48(4):370-9.

 

Phage display is a high-throughput subtractive proteomic technology used for the generation and screening of large peptide and antibody libraries. It is based on the selection of phage-fused surface-exposed peptides that recognize specific ligands and demonstrate desired functionality ...

Last Updated: 28 Aug 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Low Antimonial Dosage in American Mucosal Leishmaniasis
 

Status: Recruiting

Condition Summary: Mucosal Leishmaniasis; Mucocutaneous Leishmaniasis

 

Last Updated: 30 May 2016

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Compassionate Use of Sodium Stibogluconate (Pentostam) for Cutaneous and Mucocutaneous New World Leishmaniasis
 

Status: Available

Condition Summary: Leishmaniasis, Cutaneous; Leishmaniasis, Mucocutaneous

 

Last Updated: 12 Dec 2014

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Last Updated: 22 May 2016

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