Leishmaniasis

Common Name(s)

Leishmaniasis

Leishmaniasis is a parasitic disease spread by the bite of infected sand flies. There are several different forms of leishmaniasis. The most common are cutaneous and visceral. The cutaneous type causes skin sores. The visceral type affects internal organs such as the spleen, liver and bone marrow. People with this form usually have fever, weight loss, and an enlarged spleen and liver. Visceral disease can be deadly without proper treatment. Leishmaniasis is found in parts of the Middle East, Central America, South American, Asia, Africa, and southern Europe. Most of these countries are in the tropics and subtropics. It is possible but very unlikely to get this disease in the United States.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Leishmaniasis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Leishmaniasis" returned 2104 free, full-text research articles on human participants. First 3 results:

Leishmania major large RAB GTPase is highly immunogenic in individuals immune to cutaneous and visceral leishmaniasis.
 

Author(s): Rym Chamakh-Ayari, Mehdi Chenik, Ahmed Sahbi Chakroun, Narges Bahi-Jaber, Karim Aoun, Amel Meddeb-Garnaoui

Journal:

 

We previously identified a Leishmania (L.) major large RAB GTPase (LmlRAB), a new atypical RAB GTPase protein. It is highly conserved in Leishmania species while displaying low level of homology with mammalian homologues. Leishmania small RAB GTPases proteins have been involved in ...

Last Updated: 18 Apr 2017

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Psychosocial impact of scars due to cutaneous leishmaniasis on high school students in Errachidia province, Morocco.
 

Author(s): Issam Bennis, Séverine Thys, Hind Filali, Vincent De Brouwere, Hamid Sahibi, Marleen Boelaert

Journal:

 

In Morocco, cutaneous leishmaniasis (CL) is usually known to be a slowly healing localized skin disease, but in some cases, it can lead to mutilating scars. The outbreak of CL due to Leishmania major in the Errachidia province in southeastern Morocco between 2008 and 2010 left many ...

Last Updated: 7 Apr 2017

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Reactivation of cutaneous and mucocutaneous tegumentary leishmaniasis in rheumatoid arthritis patients: an emerging problem?
 

Author(s): Regina Maia de Souza, Heitor Franco de Andrade, Maria Irma Seixas Duarte, Lucia Maria Almeida Braz, Armando de Oliveira Schubach, Fátima Conceição Silva, Valdir Sabbaga Amato

Journal:

 

Rheumatoid arthritis (RA) is a chronic condition that is frequent in patients living in tropical areas exposed to leishmaniasis. RA therapy involves immunosuppressant drugs such as methotrexate (MTX), monoclonal antibodies (mAbs) and prednisone. We report an unusual presentation of ...

Last Updated: 5 Apr 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Leishmaniasis" returned 224 free, full-text review articles on human participants. First 3 results:

The history of leishmaniasis.
 

Author(s): Dietmar Steverding

Journal:

 

In this review article the history of leishmaniasis is discussed regarding the origin of the genus Leishmania in the Mesozoic era and its subsequent geographical distribution, initial evidence of the disease in ancient times, first accounts of the infection in the Middle Ages, and ...

Last Updated: 16 Feb 2017

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Cutaneous Leishmaniasis of the Eyelids: A Case Series with Molecular Identification and Literature Review.
 

Author(s): Iraj Mohammadpour, Mohammad Hossein Motazedian, Farhad Handjani, Gholam Reza Hatam

Journal: Korean J. Parasitol.. 2016 Dec;54(6):787-792.

 

Cutaneous leishmaniasis (CL) is a protozoan disease which is endemic in Iran. It is transmitted by the Phlebotomus sand fly. The eyelid is rarely involved possibly because the movement of the lids impedes the sand fly from biting the skin in this region. Here, we report 6 rare cases ...

Last Updated: 18 Jan 2017

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Asymptomatic infection with American cutaneous leishmaniasis: epidemiological and immunological studies.
 

Author(s): Fernando J Andrade-Narvaez, Elsy Nalleli Loría-Cervera, Erika I Sosa-Bibiano, Nicole R Van Wynsberghe

Journal: Mem. Inst. Oswaldo Cruz. 2016 Oct;111(10):599-604.

 

American cutaneous leishmaniasis (ACL) is a major public health problem caused by vector-borne protozoan intracellular parasites from the genus Leishmania, subgenera Viannia and Leishmania. Asymptomatic infection is the most common outcome after Leishmania inoculation. There is incomplete ...

Last Updated: 19 Oct 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Predicting Visceral Leishmaniasis in HIV Infected Patients
 

Status: Not yet recruiting

Condition Summary: Leishmaniasis, Visceral

 

Last Updated: 17 May 2017

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Last Updated: 22 May 2016

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Dedicated QT Study in Bolivian Patients Taking Impavido® (Miltefosine) for Mucocutaneous Leishmaniasis
 

Status: Recruiting

Condition Summary: Mucocutaneous Leishmaniasis

 

Last Updated: 28 Feb 2017

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