Anal cancer

Common Name(s)

Anal cancer

Anal Cancer is a type of cancer that affects the anal canal. Cancer is uncontrolled cell growth due to genetic changes. Cancer cells can invade surrounding tissues. The anus is a passage that connects the rectum, the end of the large intestines, to the outside part of the body. Symptoms include anal/rectal bleeding, lumps around the anal opening, recurring anal pain, anal itching, change in bowel habits, narrowing of the stools, anal discharge, and swollen lymph nodes (glands) in the anal or groin areas. Twenty percent (20%) of anal cancer cases show no symptoms. Although anal cancer most commonly affects individuals over the age 55, it is possible for anal cancer to occur at younger ages. People who are diagnosed with HPV (see also human papilloma virus) have an increased risk of developing this cancer. Other risk factors include unprotected sex, anal sex, smoking, weakened immune systems, open anal wounds, and pelvic radiation. Treatment of anal cancers includes surgery, radiation therapy, and chemotherapy, all which are very effective in curing the cancer. Diagnosis is usually done through an anal canal examination, stool tests, or colonoscopies, and can usually be found during a yearly physical check-up. If you or a family member has been diagnosed with anal cancer, talk with your doctor to learn about the most up to date treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anal cancer" returned 164 free, full-text research articles on human participants. First 3 results:

The role of pharmacologic modulation of autophagy on anal cancer development in an HPV mouse model of carcinogenesis.
 

Author(s): Brooks L Rademacher, Kristina A Matkowskyj, Louise M Meske, Alexis Romero, Hana Sleiman, Evie H Carchman

Journal: Virology. 2017 Jul;507():82-88.

 

Autophagy is an intracellular, catabolic process that maintains cellular health. We examined the response of pharmacologic modulation of autophagy in an HPV mouse model of anal carcinogenesis. K14E6/E7 mice were treated with the topical carcinogen DMBA weekly and assessed for tumors ...

Last Updated: 21 Apr 2017

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Diagnostic performance of magnetic resonance imaging and 3D endoanal ultrasound in detection, staging and assessment post treatment, in anal cancer.
 

Author(s): Alfonso Reginelli, Vincenza Granata, Roberta Fusco, Francesco Granata, Daniela Rega, Luca Roberto, Gianluca Pellino, Antonio Rotondo, Francesco Selvaggi, Francesco Izzo, Antonella Petrillo, Roberto Grassi

Journal: Oncotarget. 2017 Apr;8(14):22980-22990.

 

We compared Magnetic Resonance Imaging (MRI) and 3D Endoanal Ultrasound (EAUS) imaging performance to confirm anal carcinoma and to monitor treatment response.58 patients with anal cancer were retrospectively enrolled. All patients underwent clinical examination, anoscopic examination; ...

Last Updated: 2 Feb 2017

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Initial Results from the Royal College of Radiologists' UK National Audit of Anal Cancer Radiotherapy 2015.
 

Author(s): R Muirhead, K Drinkwater, S M O'Cathail, R Adams, R Glynne-Jones, M Harrison, M A Hawkins, D Sebag-Montefiore, D C Gilbert

Journal: Clin Oncol (R Coll Radiol). 2017 Mar;29(3):188-197.

 

UK guidance was recently developed for the treatment of anal cancer using intensity-modulated radiotherapy (IMRT). We audited the current use of radiotherapy in UK cancer centres for the treatment of anal cancer against such guidance. We describe the acute toxicity of IMRT in comparison ...

Last Updated: 4 Nov 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anal cancer" returned 33 free, full-text review articles on human participants. First 3 results:

Biomarkers in anal cancer: from biological understanding to stratified treatment.
 

Author(s): Christopher M Jones, Vicky Goh, David Sebag-Montefiore, Duncan C Gilbert

Journal: Br. J. Cancer. 2017 Jan;116(2):156-162.

 

Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with ...

Last Updated: 6 Dec 2016

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The Human Papillomavirus Vaccine: Current Perspective and Future Role in Prevention and Treatment of Anal Intraepithelial Neoplasia and Anal Cancer.
 

Author(s): Felix A Mensah, Mudresh R Mehta, James S Lewis, A Craig Lockhart

Journal: Oncologist. 2016 Apr;21(4):453-60.

 

The incidences of human papillomavirus (HPV)-related anal cancer and its precursor lesion, anal intraepithelial neoplasia, are rising in the U.S. and globally. Five-year survival rates with current modalities of treatment for anal cancer are generally favorable for localized and regional ...

Last Updated: 19 Jul 2016

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Screening to prevent anal cancer: Current thinking and future directions.
 

Author(s): Joel M Palefsky

Journal: Cancer Cytopathol. 2015 Sep;123(9):509-10.

 

Last Updated: 17 Sep 2015

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Refractory Metastatic Anal Cancer
 

Status: Recruiting

Condition Summary: Anal Cancer

 

Last Updated: 23 Nov 2016

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Shared Decision Making With Anal Cancer Patients on Radiation Dose
 

Status: Recruiting

Condition Summary: Anal Cancer

 

Last Updated: 15 Nov 2017

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Anal Cancer Radiotherapy Study
 

Status: Recruiting

Condition Summary: Anal Cancer

 

Last Updated: 4 Sep 2013

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