Anal cancer

Common Name(s)

Anal cancer

Anal Cancer is a type of cancer that affects the anal canal. Cancer is uncontrolled cell growth due to genetic changes. Cancer cells can invade surrounding tissues. The anus is a passage that connects the rectum, the end of the large intestines, to the outside part of the body. Symptoms include anal/rectal bleeding, lumps around the anal opening, recurring anal pain, anal itching, change in bowel habits, narrowing of the stools, anal discharge, and swollen lymph nodes (glands) in the anal or groin areas. Twenty percent (20%) of anal cancer cases show no symptoms. Although anal cancer most commonly affects individuals over the age 55, it is possible for anal cancer to occur at younger ages. People who are diagnosed with HPV (see also human papilloma virus) have an increased risk of developing this cancer. Other risk factors include unprotected sex, anal sex, smoking, weakened immune systems, open anal wounds, and pelvic radiation. Treatment of anal cancers includes surgery, radiation therapy, and chemotherapy, all which are very effective in curing the cancer. Diagnosis is usually done through an anal canal examination, stool tests, or colonoscopies, and can usually be found during a yearly physical check-up. If you or a family member has been diagnosed with anal cancer, talk with your doctor to learn about the most up to date treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anal cancer" returned 170 free, full-text research articles on human participants. First 3 results:

Social determinants of stage IV anal cancer and the impact of pelvic radiotherapy in the metastatic setting.
 

Author(s): Michael C Repka, Nima Aghdam, Andrew W Karlin, Keith R Unger

Journal: Cancer Med. 2017 Nov;6(11):2497-2506.

 

Anal cancer is a relatively rare malignancy, and a minority of patients present with metastatic disease in the United States. The National Cancer Database (NCDB) was used to identify factors associated with metastatic disease at presentation and evaluate the role of pelvic radiotherapy ...

Last Updated: 31 Dec 1969

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The role of pharmacologic modulation of autophagy on anal cancer development in an HPV mouse model of carcinogenesis.
 

Author(s): Brooks L Rademacher, Kristina A Matkowskyj, Louise M Meske, Alexis Romero, Hana Sleiman, Evie H Carchman

Journal: Virology. 2017 07;507():82-88.

 

Autophagy is an intracellular, catabolic process that maintains cellular health. We examined the response of pharmacologic modulation of autophagy in an HPV mouse model of anal carcinogenesis. K14E6/E7 mice were treated with the topical carcinogen DMBA weekly and assessed for tumors ...

Last Updated: 31 Dec 1969

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Preliminary results of a screening program for anal cancer and its precursors for HIV-infected men who have sex with men in Vigo-Spain.
 

Author(s): Mauricio Iribarren Díaz, Antonio Ocampo Hermida, Joaquín González-Carreró Fojón, Rebeca Longueira Suárez, Alberto Rivera Gallego, Enrique Casal Núñez, Antón Ocampo Álvarez, Edward R Cachay

Journal: Rev Esp Enferm Dig. 2017 Apr;109(4):242-249.

 

Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus ...

Last Updated: 31 Dec 1969

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anal cancer" returned 41 free, full-text review articles on human participants. First 3 results:

Cancer of the Anal Canal: Diagnosis, Staging and Follow-Up with MRI.
 

Author(s): Carole Durot, Anthony Dohan, Mourad Boudiaf, Vincent Servois, Philippe Soyer, Christine Hoeffel

Journal: Korean J Radiol. ;18(6):946-956.

 

Although a rare disease, anal cancer is increasingly being diagnosed in patients with risk factors, mainly anal infection with the human papilloma virus. Magnetic resonance imaging (MRI) with external phased-array coils is recommended as the imaging modality of choice to grade anal ...

Last Updated: 31 Dec 1969

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Biomarkers in anal cancer: from biological understanding to stratified treatment.
 

Author(s): Christopher M Jones, Vicky Goh, David Sebag-Montefiore, Duncan C Gilbert

Journal: Br. J. Cancer. 2017 Jan;116(2):156-162.

 

Squamous cell carcinomas of the anus and anal canal represent a model of a cancer and perhaps the first where level 1 evidence supported primary chemoradiotherapy (CRT) in treating locoregional disease with curative intent. The majority of tumours are associated with infection with ...

Last Updated: 31 Dec 1969

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Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer.
 

Author(s): Chia-Ching J Wang, Joseph Sparano, Joel M Palefsky

Journal: Surg. Oncol. Clin. N. Am.. 2017 01;26(1):17-31.

 

Anal cancer is an increasingly common non-AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer ...

Last Updated: 31 Dec 1969

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Pembrolizumab in Refractory Metastatic Anal Cancer
 

Status: Recruiting

Condition Summary: Anal Cancer

 

Last Updated: 23 Nov 2016

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Last Updated: 29 Mar 2018

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Shared Decision Making With Anal Cancer Patients on Radiation Dose
 

Status: Recruiting

Condition Summary: Anal Cancer

 

Last Updated: 15 Nov 2017

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