Anal cancer

Common Name(s)

Anal cancer

Anal Cancer is a type of cancer that affects the anal canal. Cancer is uncontrolled cell growth due to genetic changes. Cancer cells can invade surrounding tissues. The anus is a passage that connects the rectum, the end of the large intestines, to the outside part of the body. Symptoms include anal/rectal bleeding, lumps around the anal opening, recurring anal pain, anal itching, change in bowel habits, narrowing of the stools, anal discharge, and swollen lymph nodes (glands) in the anal or groin areas. Twenty percent (20%) of anal cancer cases show no symptoms. Although anal cancer most commonly affects individuals over the age 55, it is possible for anal cancer to occur at younger ages. People who are diagnosed with HPV (see also human papilloma virus) have an increased risk of developing this cancer. Other risk factors include unprotected sex, anal sex, smoking, weakened immune systems, open anal wounds, and pelvic radiation. Treatment of anal cancers includes surgery, radiation therapy, and chemotherapy, all which are very effective in curing the cancer. Diagnosis is usually done through an anal canal examination, stool tests, or colonoscopies, and can usually be found during a yearly physical check-up. If you or a family member has been diagnosed with anal cancer, talk with your doctor to learn about the most up to date treatment options.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

Last Updated: 29 Jul 2015

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Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

Last Updated: 6 Nov 2012

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Anal cancer" for support, advocacy or research.

4th Angel Mentoring Program

Learning that you have cancer can be an overwhelming experience – one that leaves you frightened, vulnerable and alone. The 4th Angel Mentoring Program offers free, one-on-one, confidential outreach and support from someone who has successfully made the same journey you are about to begin – the journey towards recovery. This specially trained volunteer and cancer survivor – your 4th Angel – is someone who will talk and listen in a supportive setting. The 4th Angel Mentoring Program is telephone based, so you can be connect with an angel anywhere in the country. 4th Angel Mentoring Program is part of The Scott Hamilton CARES Initiative, a national non-profit organizat

http://www.4thangel.org

Last Updated: 12 Dec 2012

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Cancer Hope Network

To provide one-on-one support to people undergoing treatment for cancer and to their families. We provide this support by training individuals who have recovered from cancer and matching them with cancer patients currently undergoing a similar experience. Through this matching process, we strive to instill hope and to make a difference in their fight against cancer.

http://www.CancerHopeNetwork.org

Last Updated: 29 Jul 2015

View Details
Stupid Cancer

Founded by and for young adult survivors, the I'm Too Young For This! Cancer Foundation (i[2]y), is the nation's leading grassroots advocate for the next generation of cancer survivors and their caregivers in their late teens, 20s and 30s. A TIME Magazine Best 50 Website, we have helped bring the cause of 'young adult cancer' to the national spotlight and rallied a brand new generation of activists to give voice to our forgotten population. Our mission is to empower young adults affected by cancer.

http://stupidcancer.org

Last Updated: 6 Nov 2012

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Anal cancer" returned 118 free, full-text research articles on human participants. First 3 results:

Influence of human papillomavirus and p16(INK4a) on treatment outcome of patients with anal cancer.
 

Author(s): Stefan Alexander Koerber, Clara Schoneweg, Alla Slynko, David Krug, Matthias F Haefner, Klaus Herfarth, Juergen Debus, Florian Sterzing, Magnus von Knebel Doeberitz, Elena-Sophie Prigge, Miriam Reuschenbach

Journal: Radiother Oncol. 2014 Dec;113(3):331-6.

 

The purpose of this study was to evaluate HPV-DNA and p16(INK4a) (p16) expression as prognostic markers for outcome in patients with anal cancer.

Last Updated: 16 Dec 2014

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Risk factors of synchronous inguinal lymph nodes metastasis for lower rectal cancer involving the anal canal.
 

Author(s): Renjie Wang, Peng Wu, Debing Shi, Hongtu Zheng, Liyong Huang, Weilie Gu, Ye Xu, Sanjun Cai, Guoxiang Cai

Journal:

 

The aim of the study is to identify the risk factors of synchronous ILN metastasis for lower rectal cancer involving the anal canal.

Last Updated: 21 Nov 2014

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Radiation therapy of anal canal cancer: from conformal therapy to volumetric modulated arc therapy.
 

Author(s): Angelo Tozzi, Luca Cozzi, Cristina Iftode, Annamaria Ascolese, Maria Concetta Campisi, Elena Clerici, Tiziana Comito, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Pietro Mancosu, Piera Navarria, Stefano Tomatis, Elisa Villa, Marta Scorsetti

Journal:

 

To appraise the role of volumetric modulated arc (RapidArc, RA) in the treatment of anal canal carcinoma (ACC).

Last Updated: 24 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Anal cancer" returned 28 free, full-text review articles on human participants. First 3 results:

Clinical experience of SIB-IMRT in anal cancer and selective literature review.
 

Author(s): Stefan Janssen, Christoph Glanzmann, Peter Bauerfeind, Sonja Stieb, Gabriela Studer, Michelle Brown, Oliver Riesterer

Journal:

 

To evaluate feasibility and outcome of our institutional SIB-IMRT schedule in patients with anal cancer and to selectively review the literature on different SIB-IMRT schedules.

Last Updated: 26 Sep 2014

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Regional and national guideline recommendations for digital ano-rectal examination as a means for anal cancer screening in HIV positive men who have sex with men: a systematic review.
 

Author(s): Jason J Ong, Marcus Chen, Andrew E Grulich, Christopher K Fairley

Journal:

 

Although anal cancer is common in HIV positive men who have sex with men, few centres offer systematic screening. Regular digital ano-rectal examination (DARE) is a type of screening that has been recommended by some experts. How widely this forms part of HIV management guidelines is unclear.

Last Updated: 16 Aug 2014

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Diagnostic performance of positron emission tomography/computed tomography using fluorine-18 fluorodeoxyglucose in detecting locoregional nodal involvement in patients with anal canal cancer: a systematic review and meta-analysis.
 

Author(s): Carmelo Caldarella, Salvatore Annunziata, Giorgio Treglia, Ramin Sadeghi, Narjes Ayati, Luca Giovanella

Journal:

 

The diagnostic performance of positron emission tomography using (18)F-fluorodeoxyglucose (FDG-PET) in detecting nodal involvement in patients with anal canal cancer (ACC) has been investigated by several studies with conflicting results. The aim of our study is to systematically ...

Last Updated: 27 Mar 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 21 Jul 2015

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Functional Outcomes Following Anal Cancer Treatment
 

Status: Not yet recruiting

Condition Summary: Anal Cancer

 

Last Updated: 13 May 2013

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