Legg-Calve-Perthes disease

Common Name(s)

Legg-Calve-Perthes disease, Coxa plana

Legg-Calve-Perthes disease occurs when the ball of the thighbone in the hip doesnÕt get enough blood, causing the bone to die. Early symptoms may include mildly painful limp, pain down the inner thigh to the knee, some restriction of hip movement, pain at extremes of movement, and tenderness over the hip joint. Treatment may include a brief period of bed rest (1 to 3 days) followed by bracing. Rarely bracing may be required for 2 to 3 years. Chance of recovery (prognosis) varies, but tends to be better for younger patients (e.g., less than 6 years of age). Some people with this syndrome go on to develop degenerative arthritis. The cause of the condition is unknown.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Legg-Calve-Perthes disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Legg-Calve-Perthes disease" returned 50 free, full-text research articles on human participants. First 3 results:

Legg-Calvé-Perthes disease and the risk of ADHD, depression, and mortality.
 

Author(s): Yasmin D Hailer, Olle Nilsson

Journal: Acta Orthop. 2014 Sep;85(5):501-5.

 

Hyperactive behavior pattern (such as attention deficit hyperactivity disorder (ADHD)) is proposed to be present in individuals with Legg-Calvé-Perthes disease (LCPD). We investigated whether individuals with LCPD have a higher risk of ADHD, depression, and mortality.

Last Updated: 30 Sep 2014

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A novel p. Gly630Ser mutation of COL2A1 in a Chinese family with presentations of Legg-Calvé-Perthes disease or avascular necrosis of the femoral head.
 

Author(s): Na Li, Jian Yu, Xiang Cao, Qiu-Yue Wu, Wei-Wei Li, Tian-Fu Li, Cui Zhang, Ying-Xia Cui, Xiao-Jun Li, Zhi-Min Yin, Xin-Yi Xia

Journal:

 

Mutations in the type II collagen gene are associated with certain human disorders, collectively termed type II collagenopathies. They include Legg-Calvé-Perthes disease (LCPD) and avascular necrosis of the femoral head (ANFH). These two diseases are skeletal dysplasias, inherited ...

Last Updated: 21 Jun 2014

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What is the usefulness of the fragmentation pattern of the femoral head in managing Legg-Calvé-Perthes disease?
 

Author(s): Hui Taek Kim, Seung Hun Woo, Jae Hoon Jang, Seung Geun Lee, Harry K W Kim, Richard Browne

Journal: Clin Orthop Surg. 2014 Jun;6(2):223-9.

 

Within the lateral pillar classification of the Legg-Calvé-Perthes (LCP) disease, hips seem quite variable in the pattern of fragmentation as seen in radiographs. The purpose of this study was to determine: if it is possible to reliably subdivide the lateral pillar groups into femoral ...

Last Updated: 6 Jun 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Legg-Calve-Perthes disease" returned 6 free, full-text review articles on human participants. First 3 results:

Legg-Calvé-Perthes disease: an overview with recent literature.
 

Author(s): Sonia Chaudhry, Donna Phillips, David Feldman

Journal: Bull Hosp Jt Dis (2013). 2014 ;72(1):18-27.

 

The evolving knowledge on Legg-Calvé-Perthes (LCP) demonstrates the utility of studying a rare disease systematically by piecing together the biology and mechanics of this condition and applying clinical observations to improve patient care. As treatments of less common diseases ...

Last Updated: 24 Aug 2014

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Do femoral or salter innominate osteotomies improve femoral head sphericity in Legg-Calvé-Perthes disease? A meta-analysis.
 

Author(s): Neil Saran, Renjit Varghese, Kishore Mulpuri

Journal: Clin. Orthop. Relat. Res.. 2012 Sep;470(9):2383-93.

 

Recently, the authors of two prospective multicenter observational studies recommended surgery to improve head sphericity in older children, whereas large retrospective observational studies suggest that surgery does not improve head sphericity in older children. Thus, the treatment ...

Last Updated: 9 Aug 2012

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Evidence for using bisphosphonate to treat Legg-Calvé-Perthes disease.
 

Author(s): Megan L Young, David G Little, Harry K W Kim

Journal: Clin. Orthop. Relat. Res.. 2012 Sep;470(9):2462-75.

 

The rationale for using bisphosphonate (BP) therapy for Legg-Calvé-Perthes disease (LCPD) is the potential to prevent substantial femoral head deformity during the fragmentation phase by inhibiting osteoclastic bone resorption. However, it is unclear whether BP therapy decreases ...

Last Updated: 9 Aug 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
 

Status: Recruiting

Condition Summary: Legg Calve Perthes Disease

 

Last Updated: 12 May 2015

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Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient Population
 

Status: Recruiting

Condition Summary: Osteoarthritis; Avascular Necrosis; Traumatic Arthritis; Rheumatoid Arthritis; Legg-perthes Disease

 

Last Updated: 20 Jul 2015

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