Legg-Calve-Perthes disease

Common Name(s)

Legg-Calve-Perthes disease, Coxa plana

Legg-Calve-Perthes disease occurs when the ball of the thighbone in the hip doesnÕt get enough blood, causing the bone to die. Early symptoms may include mildly painful limp, pain down the inner thigh to the knee, some restriction of hip movement, pain at extremes of movement, and tenderness over the hip joint. Treatment may include a brief period of bed rest (1 to 3 days) followed by bracing. Rarely bracing may be required for 2 to 3 years. Chance of recovery (prognosis) varies, but tends to be better for younger patients (e.g., less than 6 years of age). Some people with this syndrome go on to develop degenerative arthritis. The cause of the condition is unknown.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Legg-Calve-Perthes disease" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Legg-Calve-Perthes disease" returned 61 free, full-text research articles on human participants. First 3 results:

Comparative study of serum proteomes in Legg-Calve-Perthes disease.
 

Author(s): Ruiyu Liu, Lihong Fan, Longbin Yin, Kunzheng Wang, Wusheng Miao, Qichun Song, Xiaoqian Dang, Hang Gao, Chuanyi Bai

Journal:

 

Legg-Calve-Perthes Disease (LCPD) is an idiopathic osteonecrosis of the developing femoral head complicated by pain and disability of the hip joint. To date, the pathological mechanisms of LCPD are not well-known. This study screened the changes in serum protein expression in patients with LCPD.

Last Updated: 6 Oct 2015

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Legg-Calvé-Perthes disease produces chronic hip synovitis and elevation of interleukin-6 in the synovial fluid.
 

Author(s): Nobuhiro Kamiya, Ryosuke Yamaguchi, Naga Suresh Adapala, Elena Chen, David Neal, Obrien Jack, Alec Thoveson, Paul Gudmundsson, Case Brabham, Olumide Aruwajoye, Hicham Drissi, Harry K W Kim

Journal: J. Bone Miner. Res.. 2015 Jun;30(6):1009-13.

 

Legg-Calvé-Perthes disease (LCPD) is a childhood hip disorder of ischemic osteonecrosis of the femoral head. Hip joint synovitis is a common feature of LCPD, but the nature and pathophysiology of the synovitis remain unknown. The purpose of this study was to determine the chronicity ...

Last Updated: 20 May 2015

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Head reduction osteotomy with additional containment surgery improves sphericity and containment and reduces pain in Legg-Calvé-Perthes disease.
 

Author(s): Klaus A Siebenrock, Helen Anwander, Corinne A Zurmühle, Moritz Tannast, Theddy Slongo, Simon D Steppacher

Journal: Clin. Orthop. Relat. Res.. 2015 Apr;473(4):1274-83.

 

Severe femoral head deformities in the frontal plane such as hips with Legg-Calvé-Perthes disease (LCPD) are not contained by the acetabulum and result in hinged abduction and impingement. These rare deformities cannot be addressed by resection, which would endanger head vascularity. ...

Last Updated: 6 Mar 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Legg-Calve-Perthes disease" returned 8 free, full-text review articles on human participants. First 3 results:

Legg-Calvé-Perthes disease: an overview with recent literature.
 

Author(s): Sonia Chaudhry, Donna Phillips, David Feldman

Journal: Bull Hosp Jt Dis (2013). 2014 ;72(1):18-27.

 

The evolving knowledge on Legg-Calvé-Perthes (LCP) demonstrates the utility of studying a rare disease systematically by piecing together the biology and mechanics of this condition and applying clinical observations to improve patient care. As treatments of less common diseases ...

Last Updated: 24 Aug 2014

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Do femoral or salter innominate osteotomies improve femoral head sphericity in Legg-Calvé-Perthes disease? A meta-analysis.
 

Author(s): Neil Saran, Renjit Varghese, Kishore Mulpuri

Journal: Clin. Orthop. Relat. Res.. 2012 Sep;470(9):2383-93.

 

Recently, the authors of two prospective multicenter observational studies recommended surgery to improve head sphericity in older children, whereas large retrospective observational studies suggest that surgery does not improve head sphericity in older children. Thus, the treatment ...

Last Updated: 9 Aug 2012

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[Femoroacetabular impingement related to Legg-Calvé-Perthes disease].
 

Author(s): Zoran Vukašinović, Duško Spasovski, Zorica Živković

Journal: Srp Arh Celok Lek. ;139(11-12):834-7.

 

Femoroacetabular impingement is an undesirable contact between acetabular rim and femoral neck and presents abnormality of proximal femoral part and acetabulum, as well. Two forms may appear: cam impingement and pincer impingement. Femoroacetabular impingement related to Legg-Calvé-Perthes ...

Last Updated: 17 Feb 2012

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Multicenter Prospective Cohort Study on Current Treatments of Legg-Calvé-Perthes Disease
 

Status: Recruiting

Condition Summary: Legg Calve Perthes Disease

 

Last Updated: 21 Apr 2016

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WOMAC Hip Score in Children and Adolescents With Perthes Disease
 

Status: Recruiting

Condition Summary: Legg-Calvé-Perthes Disease

 

Last Updated: 6 Jun 2016

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Evaluate E1 Wear, Clinical Performance of E1 Liner in THA in Korean Patient Population
 

Status: Recruiting

Condition Summary: Osteoarthritis; Avascular Necrosis; Traumatic Arthritis; Rheumatoid Arthritis; Legg-perthes Disease

 

Last Updated: 16 Feb 2016

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