Lathyrism

Common Name(s)

Lathyrism

Lathyrism is a condition caused by eating certain legumes that contains toxic chemicals affecting the nervous system. The toxic chemicals lead to a loss of function in the nerves in the lower body. Individuals with this condition may experience leg weakness, leg paralysis, rigid muscles, shaking of the muscles, and severe pain. Species of legumes that could cause this condition include Lathyrus sativa, cicera, ochrus and clymenum. Diagnosis may include a physical exam and blood tests to look for toxins. Treatment depends on the severity of the symptoms. Nerve specialists may provide patients with neurotransmissive drugs that can help bring nerve function back to normal. Physical therapists may create exercise plans for individuals to strengthen their lower body muscles.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lathyrism" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lathyrism" returned 1 free, full-text research articles on human participants. First 3 results:

Lathyrism-induced alterations in collagen cross-links influence the mechanical properties of bone material without affecting the mineral.
 

Author(s): E P Paschalis, D N Tatakis, S Robins, P Fratzl, I Manjubala, R Zoehrer, S Gamsjaeger, B Buchinger, A Roschger, R Phipps, A L Boskey, E Dall'Ara, P Varga, P Zysset, K Klaushofer, P Roschger

Journal: Bone. 2011 Dec;49(6):1232-41.

 

In the present study a rat animal model of lathyrism was employed to decipher whether anatomically confined alterations in collagen cross-links are sufficient to influence the mechanical properties of whole bone. Animal experiments were performed under an ethics committee approved ...

Last Updated: 21 Nov 2011

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lathyrism" returned 1 free, full-text review articles on human participants. First 3 results:

In search of a new therapeutic target for the treatment of genetically triggered thoracic aortic aneurysms and cardiovascular conditions: insights from human and animal lathyrism.
 

Author(s): Hisham M F Sherif

Journal: Interact Cardiovasc Thorac Surg. 2010 Sep;11(3):271-6.

 

Lathyrism, or the effect of certain plants on connective tissue disruption, particularly involving the vascular and skeletal systems, especially aortic dissection/rupture, has been well documented in animals. Its impact on the pathogenesis of connective tissue diseases in humans is ...

Last Updated: 19 Aug 2010

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.