Laryngomalacia

Common Name(s)

Laryngomalacia

Laryngomalacia is an abnormality of the cartilage of the voice box (larynx) that is present at birth. The condition is characterized by "floppy" cartilage collapsing over the larynx when air is drawn into the lungs (inspiration), leading to airway obstruction. This obstruction causes a noise which may sound like nasal congestion or may be a more high-pitched sound (stridor). Airway sounds typically begin at 4-6 weeks of age. Affected infants have a higher risk of gastroesophageal reflux, and in severe cases may have feeding problems. In rare cases, hypoxemia or hypoventilation may interfere with normal growth and development. The cause of this condition is unknown, but it is thought to be due to delayed maturation of the supporting structures of the larynx. In more than 90% of cases it gradually improves on its own, and noises disappear by age 2 in virtually all infants.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Laryngomalacia" for support, advocacy or research.

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Laryngomalacia" returned 17 free, full-text research articles on human participants. First 3 results:

Congenital laryngomalacia is related to exercise-induced laryngeal obstruction in adolescence.
 

Author(s): Magnus Hilland, Ola Drange Røksund, Lorentz Sandvik, Øystein Haaland, Hans Jørgen Aarstad, Thomas Halvorsen, John-Helge Heimdal

Journal: Arch. Dis. Child.. 2016 May;101(5):443-8.

 

Congenital laryngomalacia (CLM) is the major cause of stridor in infants. Most cases are expected to resolve before 2 years of age, but long-term respiratory prospects are poorly described. We aimed to investigate if CLM was associated with altered laryngeal structure or function in later life.

Last Updated: 20 Apr 2016

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Surgical treatment of a case of adult epiglottic laryngomalacia.
 

Author(s): M Bartolomeo, A Bigi, P Pelliccia, M Makeieff

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2015 Feb;132(1):45-7.

 

Adult laryngomalacia is rare. It may be idiopathic or secondary to trauma or degenerative disease.

Last Updated: 20 Feb 2015

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Surgical treatment of severe laryngomalacia: a retrospective study of 11 case.
 

Author(s): José Antonio Pinto, Henrique Wambier, Elcio Izumi Mizoguchi, Leonardo Marques Gomes, Rodrigo Kohler, Renata Coutinho Ribeiro

Journal: Braz J Otorhinolaryngol. ;79(5):564-8.

 

Laryngomalacia is the most frequent congenital abnormality of the larynx, accounting for approximately 60-75% of congenital stridor cases. Despite its benign and self-limited aspects, 10% of cases require intervention. Currently, supraglottoplasty is considered the standard treatment ...

Last Updated: 21 Oct 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Laryngomalacia" returned 1 free, full-text review articles on human participants. First 3 results:

Management of laryngomalacia.
 

Author(s): S Ayari, G Aubertin, H Girschig, T Van Den Abbeele, F Denoyelle, V Couloignier, M Mondain

Journal: Eur Ann Otorhinolaryngol Head Neck Dis. 2013 Feb;130(1):15-21.

 

Laryngomalacia is the most common laryngeal disease of infancy. It is poorly tolerated in 10% of cases, requiring assessment and management, generally surgical. Surgery often consists of supraglottoplasty, for which a large number of technical variants have been described. This surgery, ...

Last Updated: 18 Feb 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

In Infants With Laryngomalacia, Does Acid-Blocking Medication Improve Respiratory Symptoms?
 

Status: Recruiting

Condition Summary: Laryngomalacia; Acid Reflux; Stridor

 

Last Updated: 4 Mar 2016

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Treatment of Children With Obstructive Sleep Apnea and Laryngomalacia: the Role of Laser Supraglottoplasty
 

Status: Recruiting

Condition Summary: Sleep Apnea, Obstructive; Respiration Disorders

 

Last Updated: 16 Nov 2016

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