Large granular lymphocyte leukemia

Common Name(s)

Large granular lymphocyte leukemia

Large granular lymphocyte (LGL) leukemia is a rare cancer of a type of white blood cells called lymphocytes. LGL leukemia causes a slow increase in white blood cells called T lymphocytes, or T cells, which originate in the lymph system and bone marrow and help to fight infection. This disease usually affects people in their sixties. Symptoms include anemia; low levels of platelets (thrombocytopenia) and infection-fighting neutrophils (neutropenia) in the blood; and an enlarged spleen. About one-third of patients are asymptomatic at the time of diagnosis. The exact cause of LGL leukemia is unknown. Doctors can diagnose this disease through a bone marrow biopsy, or by using a specialized technique in which various types of blood or bone marrow cells are separated, identified, and counted.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large granular lymphocyte leukemia" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large granular lymphocyte leukemia" returned 57 free, full-text research articles on human participants. First 3 results:

Dysregulated signaling, proliferation and apoptosis impact on the pathogenesis of TCRγδ+ T cell large granular lymphocyte leukemia.
 

Author(s): Martine J Kallemeijn, Dick de Ridder, Joyce Schilperoord-Vermeulen, Michèle Y van der Klift, Yorick Sandberg, Jacques J M van Dongen, Anton W Langerak

Journal:

 

TCRγδ+ T-LGL leukemia is a rare form of chronic mature T cell disorders in elderly, which is generally characterized by a persistently enlarged CD3+CD57+TCRγδ+ large granular lymphocyte population in the peripheral blood with a monoclonal phenotype. Clinically, the disease is ...

Last Updated: 13 Apr 2017

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Good syndrome presenting with CD8⁺ T-Cell large granular lymphocyte leukemia.
 

Author(s): Caroline Caperton, Sudhanshu Agrawal, Sudhir Gupta

Journal: Oncotarget. 2015 Nov;6(34):36577-86.

 

Good Syndrome is an adult-onset combined immunodeficiency defined by hypogammaglobulinemia, low or absent number of B cells, T cell deficiency and thymic tumor. We have characterized CD8+ T cells from a patient with Good syndrome that presented with CD8+T-cell large granular lymphocytic ...

Last Updated: 20 Nov 2015

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Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia.
 

Author(s): Francis R LeBlanc, Xin Liu, Jeremy Hengst, Todd Fox, Valerie Calvert, Emanuel F Petricoin, Jong Yun, David J Feith, Thomas P Loughran

Journal: Cancer Biol. Ther.. 2015 ;16(12):1830-40.

 

Sphingolipid metabolism has been identified as a potential therapeutic target in cancer. Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid metabolite produced by sphingosine kinases-1 and -2 (SPHK1 and SPHK2). Elevated SPHK1 has been found in numerous cancer types and ...

Last Updated: 20 Jan 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large granular lymphocyte leukemia" returned 11 free, full-text review articles on human participants. First 3 results:

The pathogenesis and treatment of large granular lymphocyte leukemia.
 

Author(s): Steven Nathaniel Steinway, Francis LeBlanc, Thomas P Loughran

Journal: Blood Rev.. 2014 May;28(3):87-94.

 

Large granular lymphocyte (LGL) leukemia is a spectrum of rare lymphoproliferative diseases of T lymphocytes and natural killer cells. These diseases frequently present with splenomegaly, neutropenia, and autoimmune diseases like rheumatoid arthritis. LGL leukemia is more commonly ...

Last Updated: 20 May 2014

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Large granular lymphocyte leukemia: from dysregulated pathways to therapeutic targets.
 

Author(s): Francis Leblanc, Dan Zhang, Xin Liu, Thomas P Loughran

Journal: Future Oncol. 2012 Jul;8(7):787-801.

 

Large granular lymphocyte (LGL) leukemia is a clonal lymphoproliferative disorder of cytotoxic lymphocytes characterized by an expansion of CD3(+) cytotoxic T lymphocytes or CD3(-) natural killer cells. Patients present with various cytopenias including neutropenia, anemia and thrombocytopenia. ...

Last Updated: 26 Jul 2012

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T-cell and natural killer-cell large granular lymphocyte leukemia neoplasias.
 

Author(s): Rebecca J Watters, Xin Liu, Thomas P Loughran

Journal: Leuk. Lymphoma. 2011 Dec;52(12):2217-25.

 

Large granular lymphocyte (LGL) leukemia is a rare disorder of cytotoxic lymphocytes. LGL cells play an integral role in the immune system and are divided into two major lineages of CD3(-)natural killer (NK) cells and CD3(+) T cells that circulate throughout the blood in search of ...

Last Updated: 25 Nov 2011

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Clinical Trial Information This information is provided by ClinicalTrials.gov

A Dose-Ranging Study of IV BNZ-1 in LGL Leukemia or Refractory CTCL
 

Status: Not yet recruiting

Condition Summary: LGL Leukemia; CTCL

 

Last Updated: 18 Aug 2017

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Alemtuzumab (Campath ) to Treat T-Large Granular Lymphocyte Leukemia
 

Status: Recruiting

Condition Summary: Lymphoproliferative Disorders

 

Last Updated: 30 Jun 2017

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