Large B cell diffuse lymphoma

Common Name(s)

Large B cell diffuse lymphoma

Large B cell diffuse lymphoma is a rare form of immune system cancer characterized by abnormal development and overproduction of B cells, a type of white blood cell. B cells are essential to the immune system because they produce antibodies that are responsible for recognizing foreign material and signalling the body to attack them. Individuals with this disorder may experience symptoms such as enlarged lymph nodes, fatigue, night sweats, and higher frequency of illness. Doctors often diagnose this form of cancer early, since symptoms are apparent. Treatment depends on the stage of the cancer. If the cancer has progressed, doctors may suggest patients undergo chemotherapy or radiotherapy to destroy cancerous B cells.

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Advocacy and Support Organizations

 

Condition Specific Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large B cell diffuse lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large B cell diffuse lymphoma" returned 808 free, full-text research articles on human participants. First 3 results:

A phase II study of dacetuzumab (SGN-40) in patients with relapsed diffuse large B-cell lymphoma (DLBCL) and correlative analyses of patient-specific factors.
 

Author(s): Sven de Vos, Andres Forero-Torres, Stephen M Ansell, Brad Kahl, Bruce D Cheson, Nancy L Bartlett, Richard R Furman, Jane N Winter, Henry Kaplan, John Timmerman, Nancy C Whiting, Jonathan G Drachman, Ranjana Advani

Journal:

 

Patients with DLBCL who are ineligible for or have relapsed after aggressive salvage chemotherapy have a poor prognosis. CD40 is expressed on multiple B-cell neoplasms including DLBCL and is a potential target for immunotherapy. Dacetuzumab (SGN-40), a non-blocking, partial agonist, ...

Last Updated: 21 Jun 2014

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SPIB and BATF provide alternate determinants of IRF4 occupancy in diffuse large B-cell lymphoma linked to disease heterogeneity.
 

Author(s): Matthew A Care, Mario Cocco, Jon P Laye, Nicholas Barnes, Yuanxue Huang, Ming Wang, Sharon Barrans, Ming Du, Andrew Jack, David R Westhead, Gina M Doody, Reuben M Tooze

Journal: Nucleic Acids Res.. 2014 ;42(12):7591-610.

 

Interferon regulatory factor 4 (IRF4) is central to the transcriptional network of activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL), an aggressive lymphoma subgroup defined by gene expression profiling. Since cofactor association modifies transcriptional regulatory ...

Last Updated: 4 Jul 2014

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Diffuse large B-cell lymphoma: changing treatment paradigms.
 

Author(s): Connie Lee Batlevi, Anas Younes

Journal: Oncology (Williston Park, N.Y.). 2014 Apr;28(4):339-41.

 

Last Updated: 20 May 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large B cell diffuse lymphoma" returned 70 free, full-text review articles on human participants. First 3 results:

Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy.
 

Author(s): Antonino Carbone, Annunziata Gloghini, Yok-Lam Kwong, Anas Younes

Journal: Ann. Hematol.. 2014 Aug;93(8):1263-77.

 

Diffuse large B cell lymphoma (DLBCL) comprises specific subtypes, disease entities, and other not otherwise specified (NOS) lymphomas. This review will focus on DLBCL NOS because of their prevalence and their heterogeneity with respect to morphology, clinical presentation, biology, ...

Last Updated: 4 Jul 2014

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Appropriate management of molecular subtypes of diffuse large B-cell lymphoma.
 

Author(s): Kieron Dunleavy, Wyndham H Wilson

Journal: Oncology (Williston Park, N.Y.). 2014 Apr;28(4):326-34.

 

In recent years, we have made huge strides in our understanding of the molecular complexity of diffuse large B-cell lymphoma (DLBCL). New technologies, such as gene expression profiling, RNA interference screening, and DNA sequencing, have identified several new signaling pathways ...

Last Updated: 20 May 2014

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Primary gingival diffuse large B-cell lymphoma: a case report and a review of the literature.
 

Author(s): Kei-Ji Sugimoto, Asami Shimada, Hiroko Sakurai, Mutsumi Wakabayashi, Hidenori Imai, Yasunobu Sekiguchi, Noriko Nakamura, Tomohiro Sawada, Hiroshi Izumi, Yasunori Ota, Norio Komatsu, Masaaki Noguchi

Journal:

 

The patient was a 73-year-old male who came to our hospital with a chief complaint of pain and swelling of the left side of his jaw. Computed tomography revealed a mass in his left gingiva but no bone destruction. No lesions were observed at any other sites, and an incisional biopsy ...

Last Updated: 15 Jan 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study in Patients With Primary Breast Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Large B Cell Diffuse Lymphoma

 

Last Updated: 27 Jan 2014

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FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Lymphoma; Lymphoma, Non-Hodgkin; Large B Cell Diffuse Lymphoma

 

Last Updated: 14 Feb 2014

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ACP-196, a Btk Inhibitor, for Treatment of Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL)

 

Last Updated: 19 Sep 2014

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