Large B cell diffuse lymphoma

Common Name(s)

Large B cell diffuse lymphoma

Large B cell diffuse lymphoma is a rare form of immune system cancer characterized by abnormal development and overproduction of B cells, a type of white blood cell. B cells are essential to the immune system because they produce antibodies that are responsible for recognizing foreign material and signalling the body to attack them. Individuals with this disorder may experience symptoms such as enlarged lymph nodes, fatigue, night sweats, and higher frequency of illness. Doctors often diagnose this form of cancer early, since symptoms are apparent. Treatment depends on the stage of the cancer. If the cancer has progressed, doctors may suggest patients undergo chemotherapy or radiotherapy to destroy cancerous B cells.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large B cell diffuse lymphoma" for support, advocacy or research.

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large B cell diffuse lymphoma" returned 917 free, full-text research articles on human participants. First 3 results:

Prognosis of patients with diffuse large B cell lymphoma not reaching complete response or relapsing after frontline chemotherapy or immunochemotherapy.
 

Author(s): Jordina Rovira, Alexandra Valera, Lluis Colomo, Xavier Setoain, Sonia Rodríguez, Alejandra Martínez-Trillos, Eva Giné, Ivan Dlouhy, Laura Magnano, Anna Gaya, Daniel Martínez, Antonio Martínez, Elías Campo, Armando López-Guillermo

Journal: Ann. Hematol.. 2015 May;94(5):803-12.

 

A retrospective study was performed to assess the outcome of patients with diffuse large B cell lymphoma (DLBCL) who did not achieve complete response or who relapsed before and after the use of rituximab. Clinical features and outcome of 816 (425 M/391 F; median age 63 years) patients ...

Last Updated: 26 Mar 2015

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Comment on: "clinical features, management, and prognosis of an international series of 161 patients with limited-stage diffuse large B-cell lymphoma of the bone (the IELSG-14 Study)".
 

Author(s): Richard Hoppe, Tim Illidge, Lena Specht, Ivan Vogelius, Joachim Yahalom

Journal: Oncologist. 2014 Dec;19(12):1289.

 

Last Updated: 6 Dec 2014

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Use of subsequent PET/CT in diffuse large B-cell lymphoma patients in complete remission following primary therapy.
 

Author(s): Xu Zhang, Wei Fan, Zhong-Jun Xia, Ying-Ying Hu, Xiao-Ping Lin, Ya-Rui Zhang, Zhi-Ming Li, Pei-Yan Liang, Yuan-Hua Li

Journal: Chin J Cancer. 2015 Feb;34(2):70-8.

 

Interim 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (I-PET/CT) is a powerful tool for monitoring the response to therapy in diffuse large B-cell lymphoma (DLBCL). This retrospective study aimed to determine when and how to use I-PET/CT in DLBCL. A ...

Last Updated: 25 Feb 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large B cell diffuse lymphoma" returned 82 free, full-text review articles on human participants. First 3 results:

[Primary bone marrow diffuse large B cell lymphoma: three case reports and literature review].
 

Author(s): Huimin Liu, Shuhua Yi, Enbin Liu, Zengjun Li, Hongju Zhang, Kun Ru, Dehui Zou, Lugui Qiu

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Oct;35(10):914-7.

 

To report the diagnosis, differential diagnosis and treatment of three rare cases of primary bone marrow diffuse large B cell lymphoma (DLBCL), and to improve the recognition of this disease.

Last Updated: 23 Oct 2014

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Inhibition of the PI3K/Akt/mTOR signaling pathway in diffuse large B-cell lymphoma: current knowledge and clinical significance.
 

Author(s): Agata Majchrzak, Magdalena Witkowska, Piotr Smolewski

Journal:

 

Diffuse large B-cell lymphoma (DLBCL) is one of the most common non-Hodgkin lymphomas in adults. The disease is very heterogeneous in its presentation, that is DLBCL patients may differ from each other not only in regard to histology of tissue infiltration, clinical course or response ...

Last Updated: 13 Sep 2014

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Hepatitis C virus and diffuse large B-cell lymphoma: Pathogenesis, behavior and treatment.
 

Author(s): Carlo Visco, Silvia Finotto

Journal: World J. Gastroenterol.. 2014 Aug;20(32):11054-61.

 

A significant association between hepatitis C virus (HCV) infection and B-cell lymphoma has been reported by epidemiological studies, most of them describing a strong relationship between indolent lymphomas and HCV. Furthermore, the curative potential of antiviral therapy on HCV related ...

Last Updated: 29 Aug 2014

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study in Patients With Primary Breast Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Large B Cell Diffuse Lymphoma

 

Last Updated: 17 Oct 2014

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FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Lymphoma; Lymphoma, Non-Hodgkin; Large B Cell Diffuse Lymphoma

 

Last Updated: 14 Feb 2014

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ACP-196, a Btk Inhibitor, for Treatment of de Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL)

 

Last Updated: 11 Feb 2015

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