Large B cell diffuse lymphoma

Common Name(s)

Large B cell diffuse lymphoma

Large B cell diffuse lymphoma is a rare form of immune system cancer characterized by abnormal development and overproduction of B cells, a type of white blood cell. B cells are essential to the immune system because they produce antibodies that are responsible for recognizing foreign material and signalling the body to attack them. Individuals with this disorder may experience symptoms such as enlarged lymph nodes, fatigue, night sweats, and higher frequency of illness. Doctors often diagnose this form of cancer early, since symptoms are apparent. Treatment depends on the stage of the cancer. If the cancer has progressed, doctors may suggest patients undergo chemotherapy or radiotherapy to destroy cancerous B cells.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large B cell diffuse lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large B cell diffuse lymphoma" returned 862 free, full-text research articles on human participants. First 3 results:

Diffuse large B-cell lymphoma in leukemic phase.
 

Author(s): Biswadip Hazarika

Journal: Blood. 2014 Sep;124(13):2159.

 

Last Updated: 6 Nov 2014

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Distinct isoform of FABP7 revealed by screening for retroelement-activated genes in diffuse large B-cell lymphoma.
 

Author(s): Frances E Lock, Rita Rebollo, Katharine Miceli-Royer, Liane Gagnier, Sabrina Kuah, Artem Babaian, Maialen Sistiaga-Poveda, C Benjamin Lai, Oksana Nemirovsky, Isabel Serrano, Christian Steidl, Mohammad M Karimi, Dixie L Mager

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Aug;111(34):E3534-43.

 

Remnants of ancient transposable elements (TEs) are abundant in mammalian genomes. These sequences harbor multiple regulatory motifs and hence are capable of influencing expression of host genes. In response to environmental changes, TEs are known to be released from epigenetic repression ...

Last Updated: 27 Aug 2014

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Expression of histone deacetylases in diffuse large B-cell lymphoma and its clinical significance.
 

Author(s): Sung Hak Lee, Changyoung Yoo, Soyoung Im, Ji-Han Jung, Hyun Joo Choi, Jinyoung Yoo

Journal:

 

Histone deacetylase inhibitors are a new class of drugs used in treatment of malignant tumors. Diffuse large B-cell lymphoma (DLBCL) is the most common type of B-cell lymphoma, and it accounts for more than 40% of all B-cell lymphomas. In this study, we aimed to determine the expression ...

Last Updated: 31 Jul 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large B cell diffuse lymphoma" returned 70 free, full-text review articles on human participants. First 3 results:

Next generation sequencing and the management of diffuse large B-cell lymphoma: from whole exome analysis to targeted therapy.
 

Author(s): Fabrice Jardin

Journal: Discov Med. ;18(97):51-65.

 

Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma, accounting for 30-40% of newly diagnosed non-Hodgkin lymphomas. Historically, DLBCL has been thought to involve recurrent translocations of the IGH gene and the deregulation of rearranged oncogenes. Recent ...

Last Updated: 5 Aug 2014

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Diffuse large B cell lymphoma: using pathologic and molecular biomarkers to define subgroups for novel therapy.
 

Author(s): Antonino Carbone, Annunziata Gloghini, Yok-Lam Kwong, Anas Younes

Journal: Ann. Hematol.. 2014 Aug;93(8):1263-77.

 

Diffuse large B cell lymphoma (DLBCL) comprises specific subtypes, disease entities, and other not otherwise specified (NOS) lymphomas. This review will focus on DLBCL NOS because of their prevalence and their heterogeneity with respect to morphology, clinical presentation, biology, ...

Last Updated: 4 Jul 2014

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Appropriate management of molecular subtypes of diffuse large B-cell lymphoma.
 

Author(s): Kieron Dunleavy, Wyndham H Wilson

Journal: Oncology (Williston Park, N.Y.). 2014 Apr;28(4):326-34.

 

In recent years, we have made huge strides in our understanding of the molecular complexity of diffuse large B-cell lymphoma (DLBCL). New technologies, such as gene expression profiling, RNA interference screening, and DNA sequencing, have identified several new signaling pathways ...

Last Updated: 20 May 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study in Patients With Primary Breast Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Large B Cell Diffuse Lymphoma

 

Last Updated: 17 Oct 2014

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FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Lymphoma; Lymphoma, Non-Hodgkin; Large B Cell Diffuse Lymphoma

 

Last Updated: 14 Feb 2014

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ACP-196, a Btk Inhibitor, for Treatment of de Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL)

 

Last Updated: 11 Feb 2015

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