Large B cell diffuse lymphoma

Common Name(s)

Large B cell diffuse lymphoma

Large B cell diffuse lymphoma is a rare form of immune system cancer characterized by abnormal development and overproduction of B cells, a type of white blood cell. B cells are essential to the immune system because they produce antibodies that are responsible for recognizing foreign material and signalling the body to attack them. Individuals with this disorder may experience symptoms such as enlarged lymph nodes, fatigue, night sweats, and higher frequency of illness. Doctors often diagnose this form of cancer early, since symptoms are apparent. Treatment depends on the stage of the cancer. If the cancer has progressed, doctors may suggest patients undergo chemotherapy or radiotherapy to destroy cancerous B cells.

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Large B cell diffuse lymphoma" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Large B cell diffuse lymphoma" returned 788 free, full-text research articles on human participants. First 3 results:

Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development.
 

Author(s): Krystyna Mazan-Mamczarz, X Frank Zhao, Bojie Dai, James J Steinhardt, Raymond J Peroutka, Kimberly L Berk, Ari L Landon, Mariola Sadowska, Yongqing Zhang, Elin Lehrmann, Kevin G Becker, Rita Shaknovich, Zhenqiu Liu, Ronald B Gartenhaus

Journal:

 

Deregulation of the translational machinery is emerging as a critical contributor to cancer development. The contribution of microRNAs in translational gene control has been established however; the role of microRNAs in disrupting the cap-dependent translation regulation complex has ...

Last Updated: 5 Feb 2014

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High-throughput combinatorial screening identifies drugs that cooperate with ibrutinib to kill activated B-cell-like diffuse large B-cell lymphoma cells.
 

Author(s): Lesley A Mathews Griner, Rajarshi Guha, Paul Shinn, Ryan M Young, Jonathan M Keller, Dongbo Liu, Ian S Goldlust, Adam Yasgar, Crystal McKnight, Matthew B Boxer, Damien Y Duveau, Jian-Kang Jiang, Sam Michael, Tim Mierzwa, Wenwei Huang, Martin J Walsh, Bryan T Mott, Paresma Patel, William Leister, David J Maloney, Christopher A Leclair, Ganesha Rai, Ajit Jadhav, Brian D Peyser, Christopher P Austin, Scott E Martin, Anton Simeonov, Marc Ferrer, Louis M Staudt, Craig J Thomas

Journal: Proc. Natl. Acad. Sci. U.S.A.. 2014 Feb;111(6):2349-54.

 

The clinical development of drug combinations is typically achieved through trial-and-error or via insight gained through a detailed molecular understanding of dysregulated signaling pathways in a specific cancer type. Unbiased small-molecule combination (matrix) screening represents ...

Last Updated: 12 Feb 2014

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Diffuse large B-cell lymphoma of the kidney: a rare neoplasm.
 

Author(s): Ram Narayan Das, Shatavisha Dasgupta, Soumya Mondal, Debraj Saha, Uttara Chatterjee

Journal: Indian J Pathol Microbiol. ;56(4):449-52.

 

Primary renal lymphoma is a rare neoplasm, but it should be kept in mind in the differential diagnosis of renal neoplasms. A middle aged man presented with symptoms of weight loss, anorexia and fullness of the abdomen after meals. On clinical and radiological examination, a renal ...

Last Updated: 20 Jan 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Large B cell diffuse lymphoma" returned 61 free, full-text review articles on human participants. First 3 results:

Targeting the epigenome and other new strategies in diffuse large B-cell lymphoma: beyond R-CHOP.
 

Author(s): Leandro Cerchietti, John P Leonard

Journal: Hematology Am Soc Hematol Educ Program. 2013 ;2013():591-5.

 

Diffuse large B-cell lymphoma, the most common lymphoma subtype, is curable in the majority of patients. However, one of the greatest unmet needs in lymphoma treatment remains novel approaches to prevent relapsed or refractory disease. Genomic profiling has provided important prognostic ...

Last Updated: 9 Dec 2013

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CD56 positive diffuse large B-cell lymphoma: a case report and literature review.
 

Author(s): Mi Jin Gu, Jung Ok Ha

Journal:

 

CD56 positive B-cell lymphoma is very rare. We experienced a case of CD56 positive diffuse large B-cell lymphoma, occurred in a young child. A 5-year-old girl complained with snoring and open mouth breathing. No any abnormality in laboratory or physical examination was present, except ...

Last Updated: 2 Dec 2013

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Diffuse large B-cell lymphoma of the uterus suspected of having transformed from a marginal zone B-cell lymphoma harboring trisomy 18: a case report and review of the literature.
 

Author(s): Kei-Ji Sugimoto, Hidenori Imai, Asami Shimada, Mutsumi Wakabayashi, Yasunobu Sekiguchi, Noriko Nakamura, Tomohiro Sawada, Hiroshi Izumi, Yasunori Ota, Norio Komatsu, Masaaki Noguchi

Journal:

 

The patient was a 72-year-old female with the chief complaint of abdominal fullness. A giant primary myoma of the uterine cervix was suspected, and total hysterectomy was performed. Based on a postoperative histopathological examination of the tumor a diagnosis of diffuse large B-cell ...

Last Updated: 2 Dec 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Study in Patients With Primary Breast Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Large B Cell Diffuse Lymphoma

 

Last Updated: 27 Jan 2014

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FLT-PET/CT vs FDG-PET/CT for Therapy Monitoring of Diffuse Large B-cell Lymphoma
 

Status: Recruiting

Condition Summary: Lymphoma; Lymphoma, Non-Hodgkin; Large B Cell Diffuse Lymphoma

 

Last Updated: 14 Feb 2014

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ACP-196, a Btk Inhibitor, for Treatment of Novo Activated B-cell (ABC) Subtype of Diffuse Large B-Cell Lymphoma
 

Status: Recruiting

Condition Summary: Activated B-cell Diffuse Large B-Cell Lymphoma (ABC DLBCL)

 

Last Updated: 4 Aug 2014

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