Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 257 free, full-text research articles on human participants. First 3 results:

[Multimodality imaging of Langerhans Cell Histiocytosis ].
 

Author(s): S Schneeweiß, H Bösmüller, S D Ioanoviciu, M Horger

Journal: Rofo. 2015 May;187(5):313-8.

 

Last Updated: 12 May 2015

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Antiphospholipid syndrome and Langerhans cell histiocytosis: an exceptional association.
 

Author(s): Hamida Kwas, Ines Zendah, Ayda Bayoudh, Asma Zidi, Habib Ghédira

Journal: Tunis Med. 2014 Nov;92(11):697-8.

 

Last Updated: 14 Apr 2015

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[Cladribine for 13 cases refractory high-risk children Langerhans cell histiocytosis].
 

Author(s): Tao Hu, Rong Liu, Junhui Li, Jing Cao, Lei Zhang, Juanjuan Li, Wei Fan, Dixiao Zhong, Xiaodong Shi

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Nov;35(11):985-9.

 

To observe the efficacy and adverse reaction of the improvement program of cladribine combined with cytarabine (2-CdA+Ara-C) in treatment of children with refractory high-risk Langerhans cell histiocytosis (LCH).

Last Updated: 24 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 37 free, full-text review articles on human participants. First 3 results:

[Specific locations of Langerhans cell histiocytosis in the child, scapula and pubis: report of two cases].
 

Author(s): Karima Atarraf, Lamiae Chater, Mounir Arroud, My Abderrahman Afifi

Journal:

 

Last Updated: 5 Dec 2014

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Langerhans cell histiocytosis.
 

Author(s): Nanette Grana

Journal: Cancer Control. 2014 Oct;21(4):328-34.

 

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Its clinical presentation is variable and ranges from isolated skin or bone disease to a life-threatening multisystem condition. LCH can occur at any age but is more frequent in the pediatric ...

Last Updated: 14 Oct 2014

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Blood spotlight on Langerhans cell histiocytosis.
 

Author(s): Christine Delprat, Maurizio Aricò

Journal: Blood. 2014 Aug;124(6):867-72.

 

Langerhans cell histiocytosis (LCH) is a rare disease affecting people of any age, with widely variable clinical manifestations and different outcomes. The precise chain of events driving lesional granuloma formation has remained elusive for many years. There is evidence for inherited ...

Last Updated: 8 Aug 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 21 Apr 2015

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Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

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Last Updated: 4 Aug 2015

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