Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 299 free, full-text research articles on human participants. First 3 results:

Langerhans Cell Histiocytosis Enters the Genomics Age.
 

Author(s): Michael Jeng

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):140-1.

 

Last Updated: 18 Feb 2016

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A Case Report: The Diagnosis and Therapeutic Evaluation for a Rare Disease of Langerhans Cell Histiocytosis Involving Thyroid.
 

Author(s): Ye-Feng Cai, Qing-Xuan Wang, Chun-Jue Ni, Si-Yang Dong, Lin Lv, Quan Li, En-Dong Chen, Xiao-Hua Zhang

Journal: Medicine (Baltimore). 2015 Nov;94(44):e1891.

 

Langerhans cell histiocytosis (LCH) involving the thyroid gland is extremely rare. Currently, the diagnosis and therapeutic evaluation for LCH involving thyroid is a challenge.We reported a rare case of LCH involving thyroid, presenting as painless thyroid goiters, and successfully ...

Last Updated: 11 Nov 2015

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Cladribine and cytarabine in refractory multisystem Langerhans cell histiocytosis: results of an international phase 2 study.
 

Author(s): Jean Donadieu, Frederic Bernard, Max van Noesel, Mohamed Barkaoui, Odile Bardet, Rosella Mura, Maurizio Arico, Christophe Piguet, Virginie Gandemer, Corinne Armari Alla, Niels Clausen, Eric Jeziorski, Anne Lambilliote, Sheila Weitzman, Jan Inge Henter, Cor Van Den Bos,

Journal: Blood. 2015 Sep;126(12):1415-23.

 

An international phase 2 study combining cladribine and cytarabine (Ara-C) was initiated for patients with refractory, risk-organ-positive Langerhans cell histiocytosis (LCH) in 2005. The protocol, comprising at least two 5-day courses of Ara-C (1 g/m(2) per day) plus cladribine (9 ...

Last Updated: 19 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 45 free, full-text review articles on human participants. First 3 results:

Langerhans Cell Histiocytosis: Emerging Insights and Clinical Implications.
 

Author(s): Daniel J Zinn, Rikhia Chakraborty, Carl E Allen

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):122-32, 139.

 

Langerhans cell histiocytosis is a disorder characterized by lesions that include CD207+ dendritic cells along with an inflammatory infiltrate. Langerhans cell histiocytosis has a highly variable clinical presentation, ranging from a single lesion to potentially fatal disseminated ...

Last Updated: 18 Feb 2016

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Pulmonary Langerhans cell histiocytosis with cervical lymph node involvement, and coexistence with pulmonary tuberculosis and right pneumothorax: a case report and review of literature.
 

Author(s): Limin Gao, Huifang Li, Gandi Li, Weiping Liu, Jinnan Li, Wenyan Zhang

Journal:

 

We report an uncommon 22-year-old male Pulmonary Langerhans Cell Histiocytosis (PLCH) case which co-existed with pulmonary tuberculosis (TB). Unlike the common PLCH cases, this PLCH case has cervical lymph node involvement and right pneumothorax. The diagnosis was established by the ...

Last Updated: 14 May 2015

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Interleukin-1 loop model for pathogenesis of Langerhans cell histiocytosis.
 

Author(s): Ichiro Murakami, Michiko Matsushita, Takeshi Iwasaki, Satoshi Kuwamoto, Masako Kato, Keiko Nagata, Yasushi Horie, Kazuhiko Hayashi, Toshihiko Imamura, Akira Morimoto, Shinsaku Imashuku, Jean Gogusev, Francis Jaubert, Katsuyoshi Takata, Takashi Oka, Tadashi Yoshino

Journal:

 

We propose Langerhans cell histiocytosis (LCH) is an inflammatory process that is prolonged by mutations. We hypothesize that Merkel cell polyomavirus (MCPyV) infection triggers an interleukin-1 (IL-1) activation loop that underlies the pathogenesis of LCH. Langerhans cells (LCs) ...

Last Updated: 19 Apr 2015

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 19 Nov 2015

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Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

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Last Updated: 4 Aug 2015

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