Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 304 free, full-text research articles on human participants. First 3 results:

BRAF V600 mutations in Langerhans cell histiocytosis with a simple and unique assay.
 

Author(s): Michiko Tatsuno, Yoko Shioda, Hideto Iwafuchi, Shigeki Yamazaki, Kenta Iijima, Chiaki Takahashi, Hiromi Ono, Kiyono Uchida, Osamu Okamura, Mamoru Matubayashi, Torayuki Okuyama, Kimikazu Matsumoto, Takako Yoshioka, Atsuko Nakazawa

Journal:

 

BRAF (V-raf murine sarcoma viral oncogene homolog B1) is a serine-threonine protein kinase involved in cell survival, proliferation, and differentiation. The most common missense mutation of BRAF (mainly V600E) contributes to the incidence of various cancers, including Langerhans ...

Last Updated: 20 Apr 2016

Go To URL
Pulmonary Langerhans Cell Histiocytosis-associated Pulmonary Hypertension Showing a Drastic Improvement Following Smoking Cessation.
 

Author(s): Yoshiaki Kinoshita, Kentaro Watanabe, Atsuhiko Sakamoto, Kouko Hidaka

Journal: Intern. Med.. 2016 ;55(5):491-5.

 

Pulmonary Langerhans cell histiocytosis (PLCH) is a rare, smoking-related, interstitial lung disease, and pulmonary hypertension (PH) is associated with mortality. We herein report a case of PLCH complicated by severe PH and respiratory impairment. After developing PH, the patient ...

Last Updated: 3 Mar 2016

Go To URL
Langerhans Cell Histiocytosis Enters the Genomics Age.
 

Author(s): Michael Jeng

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):140-1.

 

Last Updated: 18 Feb 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 54 free, full-text review articles on human participants. First 3 results:

Langerhans Cell Histiocytosis: Emerging Insights and Clinical Implications.
 

Author(s): Daniel J Zinn, Rikhia Chakraborty, Carl E Allen

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):122-32, 139.

 

Langerhans cell histiocytosis is a disorder characterized by lesions that include CD207+ dendritic cells along with an inflammatory infiltrate. Langerhans cell histiocytosis has a highly variable clinical presentation, ranging from a single lesion to potentially fatal disseminated ...

Last Updated: 18 Feb 2016

Go To URL
Solitary Langerhans cell histiocytosis in an adult: case report and literature review.
 

Author(s): Cíntia Ferreira Gonçalves, Marília Oliveira Morais, Rita de Cássia Gonçalves Alencar, Aline Carvalho Batista, Elismauro Francisco Mendonça

Journal:

 

Langerhans cell histiocytosis (LCH) is a disease that often affects children, but can also occur in adults and smokers. Oral manifestations are unusual and are characterized by bone pain, tooth mobility, necrotic ulcers and local edema. The aim of this paper is to describe a clinical ...

Last Updated: 11 Jan 2016

Go To URL
Cell(s) of Origin of Langerhans Cell Histiocytosis.
 

Author(s): Matthew Collin, Venetia Bigley, Kenneth L McClain, Carl E Allen

Journal: Hematol. Oncol. Clin. North Am.. 2015 Oct;29(5):825-38.

 

Langerhans cell histiocytosis (LCH) is heterogeneous disease characterized by common histology of inflammatory lesions containing Langerin(+) (CD207) histiocytes. Emerging data support a model in which MAPK activation in self-renewing hematopoietic progenitors may drive disseminated ...

Last Updated: 14 Oct 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 4 Aug 2016

Go to URL

Last Updated: 17 Nov 2016

Go to URL
Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

Go to URL