Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 300 free, full-text research articles on human participants. First 3 results:

Severe sclerosing cholangitis after Langerhans cell histiocytosis treated by liver transplantation: An adult case report.
 

Author(s): Yunhua Tang, Zhiheng Zhang, Maogen Chen, Weiqiang Ju, Dongping Wang, Fei Ji, Qingqi Ren, Zhiyong Guo, Xiaoshun He

Journal: Medicine (Baltimore). 2017 Mar;96(9):e5994.

 

Langerhans cell histiocytosis (LCH) is a rare hematopoietic disorder of unknown pathogenesis. LCH diseases may occur in a single organ or multisystem organ. The patients with multisystem involvement usually have a poor prognosis. Liver involvement in multisystem LCH results in severe ...

Last Updated: 1 Mar 2017

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[Pulmonary Langerhans' cell histiocytosis (PLCH) revealed by pneumothorax: about a case].
 

Author(s): Hafsa Sajiai, Mariam Rachidi, Hind Serhane, Salma Aitbatahar, Lamyae Amro

Journal:

 

Langerhans cell histiocytosis is a rare disease of unknown etiology characterized by the infiltration of Langerhans cells in one or more organs. It has a polymorphic clinical presentation. We report the case of Mr R.Y, age 22, with 8 pack year history of smoking, admitted to hospital ...

Last Updated: 3 Feb 2017

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Predictor Variables of Developing Anterior Pituitary Deficiencies in a Group of Paediatric Patients with Central Diabetes Insipidus and Langerhans Cell Histiocytosis.
 

Author(s): Elisa Vaiani, Carmen Malossetti, Lina Margarita Vega, Pedro Zubizarreta, Jorge Braier, Alicia Belgorosky

Journal: Horm Res Paediatr. 2017 ;87(1):51-57.

 

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Central diabetes insipidus (CDI) is the most frequent endocrine manifestation and is a known risk factor for the development of further anterior pituitary hormone deficiencies (APD). However, ...

Last Updated: 12 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 51 free, full-text review articles on human participants. First 3 results:

Langerhans Cell Histiocytosis and Langerhans Cell Sarcoma: Current Understanding and Differential Diagnosis.
 

Author(s): Hirokazu Nakamine, Mitsunori Yamakawa, Tadashi Yoshino, Takaya Fukumoto, Yasunori Enomoto, Itaru Matsumura

Journal: J Clin Exp Hematop. 2016 ;56(2):109-118.

 

Langerhans cell (LC) histiocytosis (LCH) and LC sarcoma (LCS) are proliferative processes consisting of cells having morphologic and phenotypic features of Langerhans cells (LCs), although the latter may have lost some of these features. Because neoplastic nature of LCH as well as ...

Last Updated: 16 Dec 2016

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Langerhans cell histiocytosis in adults: a case report and review of the literature.
 

Author(s): Cuihong Lian, Yuan Lu, Siyuan Shen

Journal: Oncotarget. 2016 Apr;7(14):18678-83.

 

Langerhans cell histiocytosis (LCH) is a proliferative disease of histiocyte-like cells that generally affects children. Immunohistochemistry is essential to obtain the correct diagnosis, and treatment protocols are controversial.

Last Updated: 14 Jul 2016

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Langerhans Cell Histiocytosis: Emerging Insights and Clinical Implications.
 

Author(s): Daniel J Zinn, Rikhia Chakraborty, Carl E Allen

Journal: Oncology (Williston Park, N.Y.). 2016 Feb;30(2):122-32, 139.

 

Langerhans cell histiocytosis is a disorder characterized by lesions that include CD207+ dendritic cells along with an inflammatory infiltrate. Langerhans cell histiocytosis has a highly variable clinical presentation, ranging from a single lesion to potentially fatal disseminated ...

Last Updated: 18 Feb 2016

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 25 Apr 2017

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Last Updated: 17 Nov 2016

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Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

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