Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 235 free, full-text research articles on human participants. First 3 results:

Images in clinical medicine. Langerhans'-cell histiocytosis.
 

Author(s): Bhakti Mehta, Rajkumar Venkatramani

Journal: N. Engl. J. Med.. 2014 Sep;371(11):1050.

 

Last Updated: 11 Sep 2014

Go To URL
Oral Langerhans cell histiocytosis: case report with follow-up of ten years.
 

Author(s): Emeline das Neves de Araújo Lima, Eliakim Medeiros Alves de Araújo, Patrícia Teixeira de Oliveira, Ana Miryam Costa de Medeiros

Journal: Braz J Otorhinolaryngol. ;80(4):366-7.

 

Last Updated: 3 Sep 2014

Go To URL
Synchronous and metachronous thyroid cancer in relation to Langerhans cell histiocytosis; involvement of V600E BRAF-mutation?
 

Author(s): Maria Moschovi, Maria Adamaki, Spiros Vlahopoulos, Carlos Rodriguez-Galindo

Journal: Pediatr Blood Cancer. 2015 Jan;62(1):173-4.

 

Last Updated: 21 Nov 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 36 free, full-text review articles on human participants. First 3 results:

The adverse prognostic hallmarks in identical twins with Langerhans cell histiocytosis: a clinical report and literature review.
 

Author(s): Damin Chai, Yisheng Tao, Zhengqi Bao, Li Yang, Zhenzhong Feng, Li Ma, Limei Liang, Xinwen Zhou

Journal: Tohoku J. Exp. Med.. 2013 ;230(4):219-25.

 

Langerhans cell histiocytosis (LCH) is characterized by uncontrolled proliferation of Langerhans cells accompanying eosinophils. It often attacks children under 10 years of age. LCH in identical twins is very rare and its prognosis is different. Here we report identical-twin sisters ...

Last Updated: 8 Aug 2013

Go To URL
[Non-Langerhans cell histiocytosis: a case report and literature review].
 

Author(s): Li-juan Zhang, Quan-de Lin, Li-hua Dong, Xue Gao, Yu-fu Li, Xu-dong Wei, Yong-ping Song

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jul;34(7):634-6.

 

Last Updated: 2 Aug 2013

Go To URL
Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net.
 

Author(s): Michael Girschikofsky, Maurizio Arico, Diego Castillo, Anthony Chu, Claus Doberauer, Joachim Fichter, Julien Haroche, Gregory A Kaltsas, Polyzois Makras, Angelo V Marzano, Mathilde de Menthon, Oliver Micke, Emanuela Passoni, Heinrich M Seegenschmiedt, Abdellatif Tazi, Kenneth L McClain

Journal:

 

Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells which may affect any organ of the body. Most of the knowledge about the diagnosis and therapy is based on pedriatic studies. Adult LCH patients are often evaluated by physicians who focus on only the ...

Last Updated: 30 May 2013

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 21 Apr 2015

Go to URL
Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

Go to URL
LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 30 Jul 2014

Go to URL