Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 250 free, full-text research articles on human participants. First 3 results:

Antiphospholipid syndrome and Langerhans cell histiocytosis: an exceptional association.
 

Author(s): Hamida Kwas, Ines Zendah, Ayda Bayoudh, Asma Zidi, Habib Ghédira

Journal: Tunis Med. 2014 Nov;92(11):697-8.

 

Last Updated: 14 Apr 2015

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[Cladribine for 13 cases refractory high-risk children Langerhans cell histiocytosis].
 

Author(s): Tao Hu, Rong Liu, Junhui Li, Jing Cao, Lei Zhang, Juanjuan Li, Wei Fan, Dixiao Zhong, Xiaodong Shi

Journal: Zhonghua Xue Ye Xue Za Zhi. 2014 Nov;35(11):985-9.

 

To observe the efficacy and adverse reaction of the improvement program of cladribine combined with cytarabine (2-CdA+Ara-C) in treatment of children with refractory high-risk Langerhans cell histiocytosis (LCH).

Last Updated: 24 Nov 2014

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Polyclonal T-cells express CD1a in Langerhans cell histiocytosis (LCH) lesions.
 

Author(s): Jennifer A West, Sharon L Olsen, Jenée M Mitchell, Ross E Priddle, Jennifer M Luke, Selma Olsson Akefeldt, Jan-Inge Henter, Christopher Turville, George Kannourakis

Journal:

 

Langerhans cell histiocytosis (LCH) is a complex and poorly understood disorder that has characteristics of both inflammatory and neoplastic disease. By using eight-colour flow cytometry, we have identified a previously unreported population of CD1a(+)/CD3(+) T-cells in LCH lesions. ...

Last Updated: 25 Oct 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 35 free, full-text review articles on human participants. First 3 results:

Langerhans cell histiocytosis.
 

Author(s): Nanette Grana

Journal: Cancer Control. 2014 Oct;21(4):328-34.

 

Langerhans cell histiocytosis (LCH) is a rare histiocytic disorder of unknown etiopathogenesis. Its clinical presentation is variable and ranges from isolated skin or bone disease to a life-threatening multisystem condition. LCH can occur at any age but is more frequent in the pediatric ...

Last Updated: 14 Oct 2014

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The adverse prognostic hallmarks in identical twins with Langerhans cell histiocytosis: a clinical report and literature review.
 

Author(s): Damin Chai, Yisheng Tao, Zhengqi Bao, Li Yang, Zhenzhong Feng, Li Ma, Limei Liang, Xinwen Zhou

Journal: Tohoku J. Exp. Med.. 2013 ;230(4):219-25.

 

Langerhans cell histiocytosis (LCH) is characterized by uncontrolled proliferation of Langerhans cells accompanying eosinophils. It often attacks children under 10 years of age. LCH in identical twins is very rare and its prognosis is different. Here we report identical-twin sisters ...

Last Updated: 8 Aug 2013

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[Non-Langerhans cell histiocytosis: a case report and literature review].
 

Author(s): Li-juan Zhang, Quan-de Lin, Li-hua Dong, Xue Gao, Yu-fu Li, Xu-dong Wei, Yong-ping Song

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jul;34(7):634-6.

 

Last Updated: 2 Aug 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase II Study of Clofarabine in Patients With Recurrent or Refractory Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 21 Apr 2015

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Methotrexate and Cytosine in Adult Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 10 Mar 2015

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LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 30 Jul 2014

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