Langerhans cell histiocytosis

Common Name(s)

Langerhans cell histiocytosis, Eosinophilic Granuloma, Hand-Schuller-Christian disease

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection. In people with LCH, these cells multiply excessively and build up in certain areas of the body, causing tumors called granulomas to form. The symptoms vary among affected individuals, and the cause of LCH is unknown. In most cases, this condition is not life-threatening. Some people do experience life-long problems associated with LCH.
 

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Langerhans cell histiocytosis" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Langerhans cell histiocytosis" returned 218 free, full-text research articles on human participants. First 3 results:

[Renal AA amyloidosis during Langerhans' cell histiocytosis: case report].
 

Author(s): Mondher Ounissi, Hermine Danielle Fouda, Hafedh Hedri, Karima Boubaker, Samia Barbouch, Mohamed Mongi Bacha, Rym Goucha, Ezzeddine Abderrahim, Hedi Ben Maiz, Adel Kheder

Journal: Tunis Med. 2013 Oct;91(10):613-4.

 

Last Updated: 27 Nov 2013

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"Blueberry muffin" rash and large right thigh mass: a unique presentation of Langerhans cell histiocytosis.
 

Author(s): Erica G Lau, Shelly Stepenaskie, Rebecca Moran, Robert Quinn, Prasad Matthew, Aimee C Smidt

Journal:

 

Langerhans cell histiocytosis (LCH) is a clonal proliferation of bone marrow derived antigen-presenting cells that can involve a spectrum of cutaneous findings, with or without internal organ involvement. Neonatal LCH almost always presents with skin findings, usually petechial papules ...

Last Updated: 9 Sep 2013

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[Efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis].
 

Author(s): Ming-hui Duan, Xiao Han, Jian Li, Bing Han, Wei Zhang, Tie-nan Zhu, Jun-ling Zhuang, Dao-bin Zhou

Journal: Zhonghua Xue Ye Xue Za Zhi. 2013 Jun;34(6):482-4.

 

To analyze efficacy of radiotherapy for adult patients with Langerhans cell histiocytosis (LCH).

Last Updated: 5 Jul 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Langerhans cell histiocytosis" returned 36 free, full-text review articles on human participants. First 3 results:

The adverse prognostic hallmarks in identical twins with Langerhans cell histiocytosis: a clinical report and literature review.
 

Author(s): Damin Chai, Yisheng Tao, Zhengqi Bao, Li Yang, Zhenzhong Feng, Li Ma, Limei Liang, Xinwen Zhou

Journal: Tohoku J. Exp. Med.. 2013 ;230(4):219-25.

 

Langerhans cell histiocytosis (LCH) is characterized by uncontrolled proliferation of Langerhans cells accompanying eosinophils. It often attacks children under 10 years of age. LCH in identical twins is very rare and its prognosis is different. Here we report identical-twin sisters ...

Last Updated: 8 Aug 2013

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Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net.
 

Author(s): Michael Girschikofsky, Maurizio Arico, Diego Castillo, Anthony Chu, Claus Doberauer, Joachim Fichter, Julien Haroche, Gregory A Kaltsas, Polyzois Makras, Angelo V Marzano, Mathilde de Menthon, Oliver Micke, Emanuela Passoni, Heinrich M Seegenschmiedt, Abdellatif Tazi, Kenneth L McClain

Journal:

 

Langerhans Cell Histiocytosis (LCH) is an orphan disease of clonal dendritic cells which may affect any organ of the body. Most of the knowledge about the diagnosis and therapy is based on pedriatic studies. Adult LCH patients are often evaluated by physicians who focus on only the ...

Last Updated: 30 May 2013

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Langerhans cell histiocytosis of the orbit: five clinicopathologic cases and review of the literature.
 

Author(s): Martina C Herwig, Ted Wojno, Qing Zhang, Hans E Grossniklaus

Journal: Surv Ophthalmol. ;58(4):330-40.

 

Langerhans cell histiocytosis (LCH) is a proliferation of Langerhans cells intermixed with inflammatory cells, in particular eosinophils, that may manifest as unisystem (unifocal or multifocal) or multisystem disease. Orbital involvement typically manifests as a solitary lesion that ...

Last Updated: 17 Jun 2013

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

LCH-IV, International Collaborative Treatment Protocol for Children and Adolescents With Langerhans Cell Histiocytosis
 

Status: Not yet recruiting

Condition Summary: Langerhans Cell Histiocytosis

 

Last Updated: 30 Jul 2014

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CD34+ Stem Cell Selection for Patients Receiving Allogeneic Stem Cell Transplantation for Non-Malignant Disease
 

Status: Recruiting

Condition Summary: Bone Marrow Failure Syndrome; Severe Aplastic Anemia; Severe Congenital Neutropenia; Amegakaryocytic Thrombocytopenia; Diamond-Blackfan Anemia; Schwachman Diamond Syndrome; Primary Immunodeficiency Syndromes; Acquired Immunodeficiency Syndromes; Histiocytic Syndrome; Familial Hemophagocytic Lymphocytosis; Lymphohistiocytosis; Macrophage Activation Syndrome; Langerhans Cell Histiocytosis (LCH); Hemoglobinopathies; Sickle Cell Disease; Sickle Cell-beta-thalassemia

 

Last Updated: 17 Oct 2013

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Evaluation of Efficacy and Tolerance of Cladribine in Symptomatic Pulmonary Langerhans Cell Histiocytosis
 

Status: Recruiting

Condition Summary: Langerhans Cell Histiocytosis of Lung

 

Last Updated: 20 Jun 2014

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