Landau-Kleffner syndrome

Common Name(s)

Landau-Kleffner syndrome

Landau-Kleffner syndrome (LKS) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (EEG). The disorder usually occurs in children between age 5 and 7. Typically, children with LKS develop normally but then lose their language skills for no apparent reason. While many of the affected individuals have seizures, some do not. The disorder is difficult to diagnose and may be misdiagnosed as autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder, attention deficit disorder, mental retardation, childhood schizophrenia, or emotional/behavioral problems. Treatment for LKS usually consists of medications, such as anticonvulsants and corticosteroids, and speech therapy, which should be started early. Some affected children may have a permanent severe language disorder, while others may regain much of their language abilities (although it may take months or years).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Landau-Kleffner syndrome" for support, advocacy or research.

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CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

Last Updated: 12 Oct 2013

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Landau-Kleffner syndrome" for support, advocacy or research.

Logo
CNS Foundation

CNS Foundation's Mission is Three-fold: - Expedite scientific research to find treatments and cures for the more than 14 million children living with some form of neurological disorder - Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology - Educate the public, and public officials, on the critical importance of funding pediatric neurological disorder research

http://www.cnsfoundation.org

Last Updated: 12 Oct 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Landau-Kleffner syndrome" returned 8 free, full-text research articles on human participants. First 3 results:

General anesthesia for a child with Landau-Kleffner syndrome, a case report.
 

Author(s): Biswajit Ghosh, David Carsten

Journal: Anesth Prog. 2010 ;57(3):109-11.

 

Landau-Kleffner syndrome is a rare, epileptiform disorder with a pathognomonic sudden aphasia, epilepsy, and electroencephalographic abnormalities. It was first described in 1957. No case reports are included in the anesthesia literature. This case report describes a 9-year-old male ...

Last Updated: 16 Sep 2010

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[Landau-Kleffner syndrome: an analysis of 10 cases in Venezuela].
 

Author(s): J Guevara-Campos, L González-de Guevara

Journal: Rev Neurol. ;44(11):652-6.

 

Landau-Kleffner syndrome is characterised by acquired aphasia and encephalographic alterations that may or may not be accompanied by epileptic seizures. AIM. To analyse the clinical and encephalographic features and response to treatment of 10 patients with Landau-Kleffner syndrome.

Last Updated: 8 Jun 2007

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Landau-Kleffner syndrome: a case report.
 

Author(s): C Raybarman

Journal: Neurol India. 2002 Jun;50(2):212-3.

 

A healthy 5 year old boy developed aphasia, attention disorder and hyperkinesia preceded by transient formed visual hallucinations and emotional outburst, immediately after a stressful event of forced separation from his father. EEG showed generalized epileptiform activity. He was ...

Last Updated: 22 Jul 2002

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Landau-Kleffner syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

The pathophysiological mechanisms of cognitive and behavioral disturbances in children with Landau-Kleffner syndrome or epilepsy with continuous spike-and-waves during slow-wave sleep.
 

Author(s): Lotte Nieuwenhuis, Joost Nicolai

Journal: Seizure. 2006 Jun;15(4):249-58.

 

Epilepsy with continuous spike- and -waves during slow-wave sleep and Landau-Kleffner syndrome are two rare childhood epilepsy syndromes. The underlying pathophysiology remains unknown. The current opinions about epidemiologic risk factors, genetic predisposition, EEG and MEG findings, ...

Last Updated: 12 May 2006

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The Landau-Kleffner syndrome.
 

Author(s): R E Appleton

Journal: Arch. Dis. Child.. 1995 May;72(5):386-7.

 

Last Updated: 22 Aug 1995

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.