Landau-Kleffner syndrome

Common Name(s)

Landau-Kleffner syndrome

Landau-Kleffner syndrome (LKS) is a rare, childhood neurological disorder characterized by the sudden or gradual development of aphasia (the inability to understand or express language) and an abnormal electro-encephalogram (EEG). The disorder usually occurs in children between age 5 and 7. Typically, children with LKS develop normally but then lose their language skills for no apparent reason. While many of the affected individuals have seizures, some do not. The disorder is difficult to diagnose and may be misdiagnosed as autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder, attention deficit disorder, mental retardation, childhood schizophrenia, or emotional/behavioral problems. Treatment for LKS usually consists of medications, such as anticonvulsants and corticosteroids, and speech therapy, which should be started early. Some affected children may have a permanent severe language disorder, while others may regain much of their language abilities (although it may take months or years).
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Landau-Kleffner syndrome" for support, advocacy or research.

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Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

Last Updated: 22 Apr 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Landau-Kleffner syndrome" for support, advocacy or research.

Logo
Pediatric Brain Foundation

Pediatric Brain Foundation's Mission is Three-fold: 1. Expedite scientific research to find treatments and cures for ALL of the more than 14 million children, in the U.S. alone, living with some form of neurological disorder 2. Provide families and health care professionals with up-to-date information and resources on the latest discoveries in pediatric neurology 3. Educate the public and public officials on the critical importance of funding pediatric neurological research

http://www.pediatricbrainfoundation.org

Last Updated: 22 Apr 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Landau-Kleffner syndrome" returned 35 free, full-text research articles on human participants. First 3 results:

Outcome following multiple subpial transection in Landau-Kleffner syndrome and related regression.
 

Author(s): Michelle Downes, Rebecca Greenaway, Maria Clark, J Helen Cross, Nicola Jolleff, William Harkness, Marios Kaliakatsos, Stewart Boyd, Steve White, Brian G R Neville

Journal: Epilepsia. 2015 Nov;56(11):1760-6.

 

To determine whether multiple subpial transection in the posterior temporal lobe has an impact on long-term outcome in children who have drug-resistant Landau-Kleffner syndrome (LKS) or other "electrical status epilepticus during sleep" (ESES)-related regression. Given the wide variability ...

Last Updated: 30 Oct 2015

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Landau-Kleffner Syndrome: An Acquired Epileptic Aphasia.
 

Author(s): Hsin-Yu Lo, Der-Shin Ke, Wun-Tsong Chaou

Journal: Acta Neurol Taiwan. 2015 Mar;24(1):34-5.

 

Last Updated: 16 Jul 2015

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Antiepileptic treatment in a child with Landau Kleffner syndrome: a case report.
 

Author(s): Cağatay Uğur, Nagihan Saday Duman, Omer Bektaş, Cihat Kağan Gürkan

Journal: Turk Psikiyatri Derg. 2014 ;25(4):282-6.

 

Landau-Kleffner Syndrome is a rare childhood disorder characterized by acquired aphasia and epileptiform EEG abnormalities. Hyperactivity and attention problems are common in LKS, and symptoms of Autism Spectrum Disorders (ASDs) may also coexist. Many different treatments have been ...

Last Updated: 9 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Landau-Kleffner syndrome" returned 6 free, full-text review articles on human participants. First 3 results:

Landau-Kleffner syndrome.
 

Author(s): Mia Tuft, Marte Årva, Marit Bjørnvold, John Aage Wilson, Karl O Nakken

Journal:

 

Last Updated: 2 Dec 2015

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Sign language in Landau-Kleffner syndrome.
 

Author(s): Thierry Deonna, Anne-Claude Prelaz-Girod, Claire Mayor-Dubois, Eliane Roulet-Perez

Journal: Epilepsia. 2009 Aug;50 Suppl 7():77-82.

 

This article reviews the history of sign language (SL) and the rationale for its use in children with profound auditory agnosia due to Landau-Kleffner syndrome (LKS), illustrated by studies of children and adults followed for many years and rare cases from the literature. The reasons ...

Last Updated: 17 Aug 2009

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Neuropsychological findings in Rolandic epilepsy and Landau-Kleffner syndrome.
 

Author(s): Marie-Noëlle Metz-Lutz, Melissa Filippini

Journal: Epilepsia. 2006 ;47 Suppl 2():71-5.

 

In an attempt to correlate neuropsychological deficits and various neurophysiological aspects of focal epileptic activity in benign childhood epilepsy, we have reviewed the findings of a longitudinal group study of benign childhood epilepsy with centrotemporal spikes (BCECTS) and ...

Last Updated: 19 Nov 2006

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Symptoms, Diagnosis, and Treatment

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There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.