Lambert Eaton myasthenic syndrome

Common Name(s)

Lambert Eaton myasthenic syndrome, Lambert-Eaton Syndrome

Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. Treatment of a underlying disorder or cancer is the first priority of treatment.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lambert Eaton myasthenic syndrome" returned 52 free, full-text research articles on human participants. First 3 results:

Lambert-Eaton myasthenic syndrome in patients with small cell lung cancer: Report of five cases.
 

Author(s): Yueqiao Hao, Jinmeng Hu, Yajun Zhang, Weichao Liu, Shanshan Lu, Min Zhang

Journal: J Cancer Res Ther. 2015 Aug;11 Suppl 1():C95-6.

 

To further evaluate the clinical characteristics of small cell lung cancer (SCLC) with Lambert-Eaton syndrome.

Last Updated: 1 Sep 2015

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Long-term observation of incremental response and antibodies to voltage-gated calcium channels in patients with Lambert-Eaton myasthenic syndrome: two case reports.
 

Author(s): Ilka Schneider, Malte E Kornhuber, Frank Hanisch

Journal:

 

Lambert-Eaton myasthenic syndrome is a rare autoimmune disorder of neuromuscular transmission due to the presence of antibodies to presynaptic P/Q-type voltage-gated calcium channels. The gold standard of therapy is the potassium channel blocker 3,4-diaminopyridine. To the best of ...

Last Updated: 18 Apr 2015

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Synaptotagmin 2 mutations cause an autosomal-dominant form of lambert-eaton myasthenic syndrome and nonprogressive motor neuropathy.
 

Author(s): David N Herrmann, Rita Horvath, Janet E Sowden, Michael Gonzalez, Michael Gonzales, Avencia Sanchez-Mejias, Zhuo Guan, Roger G Whittaker, Jorge L Almodovar, Maria Lane, Boglarka Bansagi, Angela Pyle, Veronika Boczonadi, Hanns Lochm├╝ller, Helen Griffin, Patrick F Chinnery, Thomas E Lloyd, J Troy Littleton, Stephan Zuchner

Journal: Am. J. Hum. Genet.. 2014 Sep;95(3):332-9.

 

Synaptotagmin 2 is a synaptic vesicle protein that functions as a calcium sensor for neurotransmission but has not been previously associated with human disease. Via whole-exome sequencing, we identified heterozygous missense mutations in the C2B calcium-binding domain of the gene ...

Last Updated: 6 Sep 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lambert Eaton myasthenic syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome.
 

Author(s): Tyler B Tarr, Peter Wipf, Stephen D Meriney

Journal: Mol. Neurobiol.. 2015 Aug;52(1):456-63.

 

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved ...

Last Updated: 22 Jul 2015

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Lambert-Eaton myasthenic syndrome.
 

Author(s): U Seneviratne, R de Silva

Journal: Postgrad Med J. 1999 Sep;75(887):516-20.

 

The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltage-gated ...

Last Updated: 18 Jan 2000

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An autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.
 

Author(s): M Takamori

Journal: Intern. Med.. 1999 Feb;38(2):86-96.

 

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine ...

Last Updated: 18 Jun 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Expanded Access Study Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS), Congenital Myasthenic Syndrome (CMS), or Downbeat Nystagmus Patients
 

Status: Available

Condition Summary: Lambert-Eaton Myasthenic Syndrome; Congenital Myasthenic Syndrome; Downbeat Nystagmus

 

Last Updated: 13 May 2016

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3,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS)
 

Status: Recruiting

Condition Summary: Lambert-Eaton Myasthenic Syndrome; Congenital Myasthenic Syndrome

 

Last Updated: 22 Jun 2016

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3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM)
 

Status: Available

Condition Summary: Lambert-Eaton Myasthenic Syndrome (LEMS); Congenital Myasthenia (CM)

 

Last Updated: 20 Apr 2015

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