Lambert Eaton myasthenic syndrome

Common Name(s)

Lambert Eaton myasthenic syndrome, Lambert-Eaton Syndrome

Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. Treatment of a underlying disorder or cancer is the first priority of treatment.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 8 Mar 2010

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 8 Mar 2010

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lambert Eaton myasthenic syndrome" returned 45 free, full-text research articles on human participants. First 3 results:

Fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography imaging in the investigation of Lambert-Eaton myasthenic syndrome.
 

Author(s): Vera L Braatz, Cláudia S K Kay, Paulo J Lorenzoni, Vinicius B Ludwig, Milton M Machota Junior, Sergio O Ioshii, Rosana H Scola, Lineu C Werneck

Journal: Arq Neuropsiquiatr. 2013 Sep;71(9A):643-4.

 

Last Updated: 21 Oct 2013

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Evaluation of a novel calcium channel agonist for therapeutic potential in Lambert-Eaton myasthenic syndrome.
 

Author(s): Tyler B Tarr, Waqas Malick, Mary Liang, Guillermo Valdomir, Michael Frasso, David Lacomis, Stephen W Reddel, Adolfo Garcia-Ocano, Peter Wipf, Stephen D Meriney

Journal: J. Neurosci.. 2013 Jun;33(25):10559-67.

 

We developed a novel calcium (Ca(2+)) channel agonist that is selective for N- and P/Q-type Ca(2+) channels, which are the Ca(2+) channels that regulate transmitter release at most synapses. We have shown that this new molecule (GV-58) slows the deactivation of channels, resulting ...

Last Updated: 20 Jun 2013

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Lambert-Eaton myasthenic syndrome and solitary cerebellar metastasis in a patient with occult small-cell lung cancer: a rare experience.
 

Author(s): Sayantan Ray, Nikhil Sonthalia, Supratip Kundu, Subhasis Maitra, Manjari Saha, Arunansu Talukdar

Journal:

 

The authors describe a case of 60-year-old male patient presented with a 6 month history of progressive weakness of all the four limbs, ataxia, droopy eyelids and bulbar features. Further laboratory and electrodiagnostic studies confirmed the diagnosis of Lambert-Eaton myasthenic ...

Last Updated: 18 May 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lambert Eaton myasthenic syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies.
 

Author(s): Maarten J Titulaer, Bethan Lang, Jan Jgm Verschuuren

Journal: Lancet Neurol. 2011 Dec;10(12):1098-107.

 

Lambert-Eaton myasthenic syndrome (LEMS) is a neuromuscular autoimmune disease that has served as a model for autoimmunity and tumour immunology. In LEMS, the characteristic muscle weakness is thought to be caused by pathogenic autoantibodies directed against voltage-gated calcium ...

Last Updated: 18 Nov 2011

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Lambert-Eaton myasthenic syndrome.
 

Author(s): U Seneviratne, R de Silva

Journal: Postgrad Med J. 1999 Sep;75(887):516-20.

 

The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltage-gated ...

Last Updated: 18 Jan 2000

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An autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.
 

Author(s): M Takamori

Journal: Intern. Med.. 1999 Feb;38(2):86-96.

 

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine ...

Last Updated: 18 Jun 1999

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Expanded Access Study of Amifampridine Phosphate in LEMS, Congenital Myasthenic Syndrome, or Downbeat Nystagmus Patients
 

Status: Available

Condition Summary: Lambert-Eaton Myasthenic Syndrome; Congenital Myasthenic Syndrome; Downbeat Nystagmus

 

Last Updated: 10 Jul 2014

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3,4-Diaminopyridine Use in Lambert-Eaton Myasthenic Syndrome(LEMS) and Congenital Myasthenic Syndromes (CMS)
 

Status: Recruiting

Condition Summary: Lambert-Eaton Myasthenic Syndrome; Congenital Myasthenic Syndrome

 

Last Updated: 22 May 2013

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Treatment of Lambert-Eaton Syndrome With 3,4 DAP
 

Status: Available

Condition Summary: Lambert Eaton Myasthenic Syndrome

 

Last Updated: 7 Nov 2012

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