Lambert Eaton myasthenic syndrome

Common Name(s)

Lambert Eaton myasthenic syndrome, Lambert-Eaton Syndrome

Lambert Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction. The neuromuscular junction is the site where nerve cells meet muscle cells and help activate the muscles. This syndrome occurs when antibodies interfere with electrical impulses between the nerve and muscle cells. It may be associated with other autoimmune diseases, or more commonly coincide with or precede a diagnosis of cancer such as small cell lung cancer. Symptoms may include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. Treatment of a underlying disorder or cancer is the first priority of treatment.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 15 Jul 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lambert Eaton myasthenic syndrome" for support, advocacy or research.

Logo
Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 15 Jul 2015

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lambert Eaton myasthenic syndrome" returned 51 free, full-text research articles on human participants. First 3 results:

Palliative care for a patient with Lambert-Eaton myasthenic syndrome: role of 3,4-diaminopyridine.
 

Author(s): Kwok-Ying Chan, Richard Shek-Kwan Chang, Vikki Wai-Kee Lau, Man-Lui Chan, Theresa Lai

Journal: Ann Palliat Med. 2016 Oct;5(4):311-314.

 

Lambert-Eaton myasthenic syndrome (LEMS) is an uncommon autoimmune idiopathic or paraneoplastic syndrome producing antibodies against voltage presynaptic calcium channels. According to previous studies, many patients with LEMS experience remission in both the clinical symptoms of ...

Last Updated: 10 Aug 2016

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Relapse of both small cell lung cancer and Lambert-Eaton myasthenic syndrome after a 13-year disease-free survival period.
 

Author(s): Fumio Asano, Keisuke Watanabe, Masaharu Shinkai, Yoshitaka Tei, Kei Mishina, Mikiko Tanabe, Hiroshi Ishii, Masahiro Shinoda, Tadasuke Shimokawaji, Makoto Kudo, Takeshi Kaneko

Journal:

 

Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic syndrome and only 3% of small cell lung carcinoma (SCLC) patients have LEMS. Moreover, the recurrence of SCLC after a disease-free survival (DFS) of more than 10 years is rare. We report a patient who had a recurrence of ...

Last Updated: 2 Jul 2016

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Lambert-Eaton myasthenic syndrome in patients with small cell lung cancer: Report of five cases.
 

Author(s): Yueqiao Hao, Jinmeng Hu, Yajun Zhang, Weichao Liu, Shanshan Lu, Min Zhang

Journal: J Cancer Res Ther. 2015 Aug;11 Suppl 1():C95-6.

 

To further evaluate the clinical characteristics of small cell lung cancer (SCLC) with Lambert-Eaton syndrome.

Last Updated: 1 Sep 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lambert Eaton myasthenic syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

Synaptic Pathophysiology and Treatment of Lambert-Eaton Myasthenic Syndrome.
 

Author(s): Tyler B Tarr, Peter Wipf, Stephen D Meriney

Journal: Mol. Neurobiol.. 2015 Aug;52(1):456-63.

 

Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that disrupts the normally reliable neurotransmission at the neuromuscular junction (NMJ). This disruption is thought to result from an autoantibody-mediated removal of a subset of the P/Q-type Ca(2+) channels involved ...

Last Updated: 22 Jul 2015

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Lambert-Eaton myasthenic syndrome.
 

Author(s): U Seneviratne, R de Silva

Journal: Postgrad Med J. 1999 Sep;75(887):516-20.

 

The Lambert-Eaton myasthenic syndrome is a neuromuscular disorder characterised by defective neurotransmitter release at autonomic neurones and presynaptic terminals of the neuromuscular junction. It is caused by an IgG autoantibody formed against especially the P/Q type of voltage-gated ...

Last Updated: 18 Jan 2000

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An autoimmune channelopathy associated with cancer: Lambert-Eaton myasthenic syndrome.
 

Author(s): M Takamori

Journal: Intern. Med.. 1999 Feb;38(2):86-96.

 

The Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease that is often associated with lung cancer which shares a common antigenic protein with the motor nerve terminal. The myasthenic weakness is caused by an antibody-induced reduction in the release of acetylcholine ...

Last Updated: 18 Jun 1999

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Phase 3 Study to Evaluate Efficacy of Amifampridine Phosphate in Lambert-Eaton Myasthenic Syndrome (LEMS)
 

Status: Recruiting

Condition Summary: Lambert-Eaton Myasthenic Syndrome

 

Last Updated: 11 Jan 2017

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Treatment of Lambert-Eaton Syndrome With 3,4 Diaminopyridine
 

Status: Available

Condition Summary: Lambert-Eaton Myasthenic Syndrome

 

Last Updated: 7 Dec 2015

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Treatment of Lambert-Eaton Syndrome With 3,4 DAP
 

Status: Available

Condition Summary: Lambert Eaton Myasthenic Syndrome

 

Last Updated: 21 Feb 2017

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