Lactic Acidosis

Common Name(s)

Lactic Acidosis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lactic Acidosis" for support, advocacy or research.

United Mitochondrial Disease Foundation

The United Mitochondrial Disease Foundation strives to promote research and education for the diagnosis, treatment and cures of mitochondrial disorders and to provide support to affected individuals and families.

Last Updated: 28 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lactic Acidosis" for support, advocacy or research.

United Mitochondrial Disease Foundation

The United Mitochondrial Disease Foundation strives to promote research and education for the diagnosis, treatment and cures of mitochondrial disorders and to provide support to affected individuals and families.

http://www.umdf.org

Last Updated: 28 Jul 2015

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lactic Acidosis" returned 284 free, full-text research articles on human participants. First 3 results:

Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes.
 

Author(s): Masako Mukai, Eiichiro Nagata, Atsushi Mizuma, Mitsuhiko Yamano, Keizo Sugaya, Ichizo Nishino, Yu-Ichi Goto, Shunya Takizawa

Journal: Intern. Med.. ;56(1):95-99.

 

The clinical features of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) are not uniform. We herein report a male patient with unusual MELAS-like encephalopathy who had been experiencing isolated recurrent stroke-like episodes since he was ...

Last Updated: 4 Jan 2017

Go To URL
Lactic acidosis and the relationship with metformin usage: Case reports.
 

Author(s): Weiyi Huang, Ronald L Castelino, Gregory M Peterson

Journal: Medicine (Baltimore). 2016 Nov;95(46):e4998.

 

The principal objective of this study was to retrospectively review a series of cases of lactic acidosis (LA) in patients with type 2 diabetes mellitus (T2DM) and examine the relationship with the use of metformin. More generally, the study enabled an investigation of the profiles ...

Last Updated: 18 Nov 2016

Go To URL
Non-occlusive Mesenteric Ischemia with Diabetic Ketoacidosis and Lactic Acidosis Following the Administration of a Sodium Glucose Co-transporter 2 Inhibitor.
 

Author(s): Naoki Gocho, Ema Aoki, Chiho Okada, Kazuki Omura, Takeshi Hirashima, Natsuko Suzuki, Hideki Tanaka, Yasue Omori

Journal: Intern. Med.. 2016 ;55(13):1755-60.

 

We herein describe a patient with non-occlusive mesenteric ischemia (NOMI) potentially associated with the administration of a sodium glucose co-transporter 2 (SGLT2) inhibitor. A 60-year-old man with type 1 diabetes was transferred to our hospital due to vomiting and respiratory ...

Last Updated: 4 Jul 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lactic Acidosis" returned 33 free, full-text review articles on human participants. First 3 results:

Lactic acidosis: an update.
 

Author(s): Jansen Seheult, Gerard Fitzpatrick, Gerard Boran

Journal: Clin. Chem. Lab. Med.. 2017 Mar;55(3):322-333.

 

Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another. The presence of elevated ...

Last Updated: 15 Aug 2016

Go To URL
Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature.
 

Author(s): Marie Bulathsinghala, Kimberly Keefer, Andry Van de Louw

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3478.

 

Propylene glycol (PG) is used as a solvent in numerous medications, including trimethoprim/sulfamethoxazole (TMP/SMX) and lorazepam, and is metabolized in the liver to lactic acid. Cases of lactic acidosis related to PG toxicity have been described and always involved large doses ...

Last Updated: 29 Apr 2016

Go To URL
Metformin-associated lactic acidosis: Current perspectives on causes and risk.
 

Author(s): Ralph DeFronzo, G Alexander Fleming, Kim Chen, Thomas A Bicsak

Journal: Metab. Clin. Exp.. 2016 Feb;65(2):20-9.

 

Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin, along with other drugs in the biguanide class, increases plasma lactate levels in a plasma concentration-dependent ...

Last Updated: 17 Jan 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Lactate Acidosis in Postoperative Hearts
 

Status: Recruiting

Condition Summary: Post-cardiac Surgery; Hyperlactatemia

 

Last Updated: 15 Mar 2017

Go to URL
Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
 

Status: Not yet recruiting

Condition Summary: Cardiac Arrest; Shock; Lactic Acidosis; Thiamin Deficiency

 

Last Updated: 2 Mar 2017

Go to URL
Metformin Use in Chronic Kidney Disease: The CKD-Met Study
 

Status: Recruiting

Condition Summary: Type 2 Diabetes; Chronic Kidney Disease

 

Last Updated: 25 Jul 2016

Go to URL