Lactic Acidosis

Common Name(s)

Lactic Acidosis

Description for this condition is not yet available.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lactic Acidosis" for support, advocacy or research.

United Mitochondrial Disease Foundation

The United Mitochondrial Disease Foundation strives to promote research and education for the diagnosis, treatment and cures of mitochondrial disorders and to provide support to affected individuals and families.

Last Updated: 28 Jul 2015

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Lactic Acidosis" for support, advocacy or research.

United Mitochondrial Disease Foundation

The United Mitochondrial Disease Foundation strives to promote research and education for the diagnosis, treatment and cures of mitochondrial disorders and to provide support to affected individuals and families.

http://www.umdf.org

Last Updated: 28 Jul 2015

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Lactic Acidosis" returned 286 free, full-text research articles on human participants. First 3 results:

The Dramatic Recovery of a Patient with Biguanide-associated Severe Lactic Acidosis Following Thiamine Supplementation.
 

Author(s): Shigeo Godo, Yoshitaro Yoshida, Motoo Fujita, Daisuke Kudo, Ryosuke Nomura, Hiroaki Shimokawa, Shigeki Kushimoto

Journal: Intern. Med.. 2017 ;56(4):455-459.

 

Biguanides are a drug of choice for the treatment of type 2 diabetes mellitus. Although they can cause lactic acidosis in susceptible patients with predisposing risk factors, the incidence of lactic acidosis is reported to be very low when they are used properly. We herein present ...

Last Updated: 16 Feb 2017

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Association between Metformin Use and Risk of Lactic Acidosis or Elevated Lactate Concentration in Type 2 Diabetes.
 

Author(s): Eun Young Lee, Sena Hwang, Yong Ho Lee, Seo Hee Lee, Young Mi Lee, Hua Pyong Kang, Eugene Han, Woonhyoung Lee, Byung Wan Lee, Eun Seok Kang, Bong Soo Cha, Hyun Chul Lee

Journal: Yonsei Med. J.. 2017 Mar;58(2):312-318.

 

Metformin can reduce diabetes-related complications and mortality. However, its use is limited because of potential lactic acidosis-associated adverse effects, particularly in renal impairment patients. We aimed to investigate the association of metformin use with lactic acidosis ...

Last Updated: 25 Jan 2017

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Adult-onset Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke (MELAS)-like Encephalopathy Diagnosed Based on the Complete Sequencing of Mitochondrial DNA Extracted from Biopsied Muscle without any Myopathic Changes.
 

Author(s): Masako Mukai, Eiichiro Nagata, Atsushi Mizuma, Mitsuhiko Yamano, Keizo Sugaya, Ichizo Nishino, Yu-Ichi Goto, Shunya Takizawa

Journal: Intern. Med.. ;56(1):95-99.

 

The clinical features of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) are not uniform. We herein report a male patient with unusual MELAS-like encephalopathy who had been experiencing isolated recurrent stroke-like episodes since he was ...

Last Updated: 4 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Lactic Acidosis" returned 33 free, full-text review articles on human participants. First 3 results:

Lactic acidosis: an update.
 

Author(s): Jansen Seheult, Gerard Fitzpatrick, Gerard Boran

Journal: Clin. Chem. Lab. Med.. 2017 Mar;55(3):322-333.

 

Lactate is one of the most crucial intermediates in carbohydrate and nonessential amino acid metabolism. The complexity of cellular interactions and metabolism means that lactate can be considered a waste product for one cell but a useful substrate for another. The presence of elevated ...

Last Updated: 15 Aug 2016

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Trimethoprim/Sulfamethoxazole-Induced Severe Lactic Acidosis: A Case Report and Review of the Literature.
 

Author(s): Marie Bulathsinghala, Kimberly Keefer, Andry Van de Louw

Journal: Medicine (Baltimore). 2016 Apr;95(17):e3478.

 

Propylene glycol (PG) is used as a solvent in numerous medications, including trimethoprim/sulfamethoxazole (TMP/SMX) and lorazepam, and is metabolized in the liver to lactic acid. Cases of lactic acidosis related to PG toxicity have been described and always involved large doses ...

Last Updated: 29 Apr 2016

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Metformin-associated lactic acidosis: Current perspectives on causes and risk.
 

Author(s): Ralph DeFronzo, G Alexander Fleming, Kim Chen, Thomas A Bicsak

Journal: Metab. Clin. Exp.. 2016 Feb;65(2):20-9.

 

Although metformin has become a drug of choice for the treatment of type 2 diabetes mellitus, some patients may not receive it owing to the risk of lactic acidosis. Metformin, along with other drugs in the biguanide class, increases plasma lactate levels in a plasma concentration-dependent ...

Last Updated: 17 Jan 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Investigation of the Correlation Between Plasma Concentration of Linezolid Antibiotic and Treatment Response and Adverse Reactions
 

Status: Recruiting

Condition Summary: Myelosuppression; Lactic Acidosis; Peripheral Neuropathy

 

Last Updated: 19 Apr 2017

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Lactate Acidosis in Postoperative Hearts
 

Status: Recruiting

Condition Summary: Post-cardiac Surgery; Hyperlactatemia

 

Last Updated: 31 Mar 2017

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Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest
 

Status: Not yet recruiting

Condition Summary: Cardiac Arrest; Shock; Lactic Acidosis; Thiamin Deficiency

 

Last Updated: 10 Apr 2017

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