Klippel Trenaunay syndrome

Common Name(s)

Klippel Trenaunay syndrome, Klippel-Trenaunay Syndrome

Klippel Trenaunay syndrome is a condition that affects the development of blood vessels, soft tissues, and bones. This condition has three characteristic features: a red birthmark called a port-wine stain, abnormal overgrowth of soft tissues and bones, and vein malformations. A port-wine stain is a type of birthmark caused by swelling of the small blood vessels near the surface of the skin. The overgrowth of bones and soft tissues usually begins in infancy and is most often limited to one leg. However, overgrowth can also affect the arms or, rarely, the trunk. The abnormal growth can cause pain, a feeling of heaviness, and reduced movement in the affected area. The vein malformations include varicose veins and malformations of deep veins in the limbs. The cause of Klippel-Trenaunay syndrome is unknown. This condition is almost always sporadic, which means that it occurs in people with no history of the disorder in their family.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Klippel Trenaunay syndrome" for support, advocacy or research.

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Klippel-Trenaunay Support Group

The Group's mission is to provide support for K-T Syndrome patients and their families.

Last Updated: 9 Nov 2012

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Klippel Trenaunay syndrome" for support, advocacy or research.

Logo
Klippel-Trenaunay Support Group

The Group's mission is to provide support for K-T Syndrome patients and their families.

http://www.k-t.org

Last Updated: 9 Nov 2012

View Details

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Klippel Trenaunay syndrome" returned 103 free, full-text research articles on human participants. First 3 results:

Sciatic nerve hypertrophy with Klippel-Trenaunay syndrome: a case report.
 

Author(s): Ilker Ilhanli, Ozlem Keskin, Erhan Arslan, Mehmet Ekiz

Journal: Turk Neurosurg. 2015 ;25(3):500-2.

 

A 73-year-old female patient who had severe neuropathic pain due to sciatic nerve hypertrophy with the Klippel-Trenaunay Syndrome has been presented. Localized hypertrophic neuropathy is in one region and characterized by concentric proliferation of Schwann cells around the axon. ...

Last Updated: 3 Jun 2015

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Glioblastoma multiforme in Klippel-Trenaunay-Weber syndrome: a case report.
 

Author(s): Tevfik Yilmaz, Ulas Cikla, Alice Kirst, Mustafa K Baskaya

Journal:

 

Klippel-Trenaunay-Weber syndrome (KTWS) is a rare syndrome in which patients usually present with cutaneous hemangiomas, venous varicosities, and bone and soft tissue hypertrophy of the affected limb. Intracranial lesions in patients with KTWS are extremely rare, and are generally ...

Last Updated: 1 May 2015

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Klippel-Trenaunay syndrome presenting with acanthocytosis and splenic and retroperitoneal lymphangioma: a case report.
 

Author(s): Milinda Withana, Chaturaka Rodrigo, Mitrakrishnan Chrishan Shivanthan, Sachini Warnakulasooriya, Manu Wimalachandra, Lallindra Gooneratne, Senaka Rajapakse

Journal:

 

Klippel-Trenaunay syndrome is a rare congenital mesodermal abnormality characterized by bone and soft tissue hypertrophy, extensive hemangioma and venous abnormalities. We report the case of a patient with two additional rare clinical manifestations in the background of Klippel-Trenaunay ...

Last Updated: 10 Dec 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Klippel Trenaunay syndrome" returned 9 free, full-text review articles on human participants. First 3 results:

[Klippel-Trenaunay syndrome and pregnancy: difficult choice of delivery from a case and a review of the literature].
 

Author(s): A Koch, G Aïssi, A Gaudineau, N Sananes, R Murtada, R Favre, I Nisand

Journal: J Gynecol Obstet Biol Reprod (Paris). 2014 Sep;43(7):483-7.

 

Klippel-Trenaunay syndrome (SKT) is a rare disease characterized by cutaneous haemangiomas, capillary malformations venous (venous varicosities), bone and soft tissue hypertrophy affecting one or more limbs. It is often associated with hemorrhagic and thrombotic complications, especially ...

Last Updated: 6 Aug 2014

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Conus medullaris-cauda arteriovenous malformation and Klippel-Trenaunay syndrome: what is the treatment goal?
 

Author(s): Donatella Sgubin, Ryuichi Kanai, Francesco Di Paola, Alessandro Perin, Pierluigi Longatti

Journal: Neurol. Med. Chir. (Tokyo). 2013 ;53(2):110-4.

 

A 29-year-old man with Klippel-Trenaunay syndrome (KTS) presented with a symptomatic conus medullaris-cauda arteriovenous malformation (AVM) manifesting as back and right limb pain, which abruptly worsened with the onset of right limb weakness and urinary retention. He was treated ...

Last Updated: 26 Feb 2013

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Klippel-Trenaunay syndrome and spinal arteriovenous malformations: an erroneous association.
 

Author(s): A I Alomari, D B Orbach, J B Mulliken, A Bisdorff, S J Fishman, A Norbash, R Alokaili, D J Lord, P E Burrows

Journal: AJNR Am J Neuroradiol. 2010 Oct;31(9):1608-12.

 

KTS is a rare limb overgrowth disorder with slow-flow vascular anomalies. This study examines the presumed association between KTS and spinal AVMs.

Last Updated: 11 Oct 2010

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Innovative Approaches to Gauge Progression of Sturge-Weber Syndrome
 

Status: Recruiting

Condition Summary: Sturge-Weber Syndrome

 

Last Updated: 12 Oct 2015

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Adjunctive Everolimus (RAD 001) Therapy for Epilepsy in Children With Sturge-Weber Syndrome (SWS)
 

Status: Recruiting

Condition Summary: Sturge Weber Syndrome

 

Last Updated: 15 Dec 2015

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Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
 

Status: Recruiting

Condition Summary: Sturge Weber Syndrome; Port-wine Mark

 

Last Updated: 18 Dec 2015

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