Kleine Levin syndrome

Common Name(s)

Kleine Levin syndrome

Kleine Levin syndrome is a rare disorder characterized by episodes of excessive sleep. Affected individuals may sleep for up to 20 hours per day during an episode. These episodes usually last for a few days to a few weeks. An episode may start abruptly and is sometimes associated with flu-like symptoms. During an episode, people with Kleine Levin syndrome can also display abnormal behavior, such as excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive. Affected individuals do not experience any of these features between episodes, and they may not be able to remember everything that happened during an episode. The time between episodes varies among individuals with this condition. Kleine Levin syndrome primarily affects adolescent males, but it also affects females. It may be caused by abnormal function of the hypothalamus and thalamus, parts of the brain that control appetite and sleep. Episodes usually decrease in frequency and intensity after about eight to 12 years.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kleine Levin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kleine Levin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kleine Levin syndrome" returned 26 free, full-text research articles on human participants. First 3 results:

Treatment of Kleine-Levin syndrome with acetazolamide.
 

Author(s): Blaire Kapson, Sumiti Nayar, Rebecca Spiegel

Journal:

 

Kleine-Levin syndrome (KLS) is a rare and disabling disorder characterized by recurrent episodes of hypersomnia as well as cognitive and behavioral abnormalities. Sadly, the treatment options are very limited and often ineffective. To our knowledge, there have been no reports in the ...

Last Updated: 15 Oct 2014

Go To URL
Feeling unreal: a functional imaging study in patients with Kleine-Levin syndrome.
 

Author(s): Aurelie Kas, Sophie Lavault, Marie-Odile Habert, Isabelle Arnulf

Journal: Brain. 2014 Jul;137(Pt 7):2077-87.

 

Kleine-Levin syndrome is characterized by relapsing-remitting episodes of severe hypersomnia, cognitive impairment, apathy, derealization and behavioural disturbances. Between episodes, patients have normal sleep, mood and behaviour. Functional imaging studies performed in small series ...

Last Updated: 21 Jun 2014

Go To URL
Further experience using clarithromycin in patients with Kleine-Levin syndrome.
 

Author(s): Lynn Marie Trotti, Donald L Bliwise, David B Rye

Journal:

 

Last Updated: 15 Apr 2014

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kleine Levin syndrome" returned 3 free, full-text review articles on human participants. First 3 results:

First attack of Kleine-Levin syndrome triggered by influenza B mimicking influenza-associated encephalopathy.
 

Author(s): Minori Kodaira, Kanji Yamamoto

Journal: Intern. Med.. 2012 ;51(12):1605-8.

 

Six days after the onset of influenza B symptoms, a 14-year-old Japanese boy presented with encephalopathy-like symptoms, somnolence, irritability, and childishness, which we first considered was an atypical type of influenza-associated encephalopathy because the infection symptoms ...

Last Updated: 25 Jun 2012

Go To URL
Kleine-Levin syndrome: history and brief review.
 

Author(s): J M S Pearce

Journal: Eur. Neurol.. 2008 ;60(4):212-4.

 

Episodic hypersomnia, compulsive excessive eating and erotic behaviour, with schizophrenic-like mental symptoms are the hallmarks of the rare Kleine-Levin syndrome. This paper traces the origins of its description back to the 18th century and the changing concepts of its complex organic-psychogenic ...

Last Updated: 24 Sep 2008

Go To URL
Kleine-Levin syndrome: a systematic review of 186 cases in the literature.
 

Author(s): I Arnulf, J M Zeitzer, J File, N Farber, E Mignot

Journal: Brain. 2005 Dec;128(Pt 12):2763-76.

 

Kleine-Levin syndrome (KLS) is a rare disorder with symptoms that include periodic hypersomnia, cognitive and behavioural disturbances. Large series of patients are lacking. In order to report on various KLS symptoms, identify risk factors and analyse treatment response, we performed ...

Last Updated: 28 Nov 2005

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

There are currently no open clinical trials for this condition.