Kleine Levin syndrome

Common Name(s)

Kleine Levin syndrome

Kleine Levin syndrome is a rare disorder characterized by episodes of excessive sleep. Affected individuals may sleep for up to 20 hours per day during an episode. These episodes usually last for a few days to a few weeks. An episode may start abruptly and is sometimes associated with flu-like symptoms. During an episode, people with Kleine Levin syndrome can also display abnormal behavior, such as excessive food intake, irritability, childishness, disorientation, hallucinations, and an abnormally uninhibited sex drive. Affected individuals do not experience any of these features between episodes, and they may not be able to remember everything that happened during an episode. The time between episodes varies among individuals with this condition. Kleine Levin syndrome primarily affects adolescent males, but it also affects females. It may be caused by abnormal function of the hypothalamus and thalamus, parts of the brain that control appetite and sleep. Episodes usually decrease in frequency and intensity after about eight to 12 years.
 

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Kleine Levin syndrome" for support, advocacy or research.

There are currently no organizations listed in Disease InfoSearch that support this condition. Create a listing.

 

 

General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Kleine Levin syndrome" returned 22 free, full-text research articles on human participants. First 3 results:

Thalamic activation in the Kleine-Levin syndrome.
 

Author(s): Maria Engström, Thomas Karlsson, Anne-Marie Landtblom

Journal:

 

The objective of this study was to investigate if combined measures of activation in the thalamus and working memory capacity could guide the diagnosis of Kleine-Levin Syndrome (KLS). A second objective was to obtain more insight into the neurobiological causes of KLS.

Last Updated: 5 Feb 2014

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Kleine-levin syndrome treated with clarithromycin.
 

Author(s): Elham Rezvanian, Nathaniel F Watson

Journal:

 

Kleine-Levin syndrome (KLS) is a rare sleep disorder characterized by periodic hypersomnia and various degrees of cognitive and behavioral disturbance, hyperphagia, and hypersexuality. Effective treatment is challenging. Stimulants marginally address sleepiness, but may increase irritability ...

Last Updated: 15 Nov 2013

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Low thalamic NAA-concentration corresponds to strong neural activation in working memory in Kleine-Levin syndrome.
 

Author(s): Patrick Vigren, Anders Tisell, Maria Engström, Thomas Karlsson, Olof Leinhard Dahlqvist, Peter Lundberg, Anne-Marie Landtblom

Journal: PLoS ONE. 2013 ;8(2):e56279.

 

Kleine Levin Syndrome (KLS) is a rare disorder of periodic hypersomnia and behavioural disturbances in young individuals. It has previously been shown to be associated with disturbances of working memory (WM), which, in turn, was associated with higher activation of the thalamus with ...

Last Updated: 1 Mar 2013

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Kleine Levin syndrome" returned 2 free, full-text review articles on human participants. First 3 results:

First attack of Kleine-Levin syndrome triggered by influenza B mimicking influenza-associated encephalopathy.
 

Author(s): Minori Kodaira, Kanji Yamamoto

Journal: Intern. Med.. 2012 ;51(12):1605-8.

 

Six days after the onset of influenza B symptoms, a 14-year-old Japanese boy presented with encephalopathy-like symptoms, somnolence, irritability, and childishness, which we first considered was an atypical type of influenza-associated encephalopathy because the infection symptoms ...

Last Updated: 25 Jun 2012

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Kleine-Levin syndrome: a systematic review of 186 cases in the literature.
 

Author(s): I Arnulf, J M Zeitzer, J File, N Farber, E Mignot

Journal: Brain. 2005 Dec;128(Pt 12):2763-76.

 

Kleine-Levin syndrome (KLS) is a rare disorder with symptoms that include periodic hypersomnia, cognitive and behavioural disturbances. Large series of patients are lacking. In order to report on various KLS symptoms, identify risk factors and analyse treatment response, we performed ...

Last Updated: 28 Nov 2005

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Symptoms, Diagnosis, and Treatment

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Clinical Trial Information This information is provided by ClinicalTrials.gov

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