Perihilar cholangiocarcinoma

Common Name(s)

Perihilar cholangiocarcinoma, Klatskin tumor, Perihilar bile duct cancer, Hilar cholangiocarcinoma

Klatskin tumors are tumors that affect the upper part of the bile duct where it divides to enter the right and left parts of the liver. One or both sides may be affected. Individuals with Klatskin tumors often present with jaundice and/or abnormal liver tests. Treatment may involve surgical removal of the tumor. Not all tumors can be removed. Prognosis for cases that cannot be removed (non-resectable tumors) is poor.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

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Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

Last Updated: 1 May 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

Logo
Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

http://www.cholangiocarcinoma.org

Last Updated: 1 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Perihilar cholangiocarcinoma" returned 27 free, full-text research articles on human participants. First 3 results:

External biliary drainage following major liver resection for perihilar cholangiocarcinoma: impact on development of liver failure and biliary leakage.
 

Author(s): Pim B Olthof, Robert J S Coelen, Jimme K Wiggers, Marc G H Besselink, Olivier R C Busch, Thomas M van Gulik

Journal: HPB (Oxford). 2016 Apr;18(4):348-53.

 

Preoperative biliary drainage is considered essential in perihilar cholangiocarcinoma (PHC) requiring major hepatectomy with biliary-enteric reconstruction. However, evidence for postoperative biliary drainage as to protect the anastomosis is currently lacking. This study investigated ...

Last Updated: 2 Apr 2016

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Value of E-PASS models for predicting postoperative morbidity and mortality in resection of perihilar cholangiocarcinoma and gallbladder carcinoma.
 

Author(s): Yoshio Haga, Atsushi Miyamoto, Yasuo Wada, Yuko Takami, Hitoshi Takeuchi

Journal: HPB (Oxford). 2016 Mar;18(3):271-8.

 

It has previously been reported that a general risk model, Estimation of Physiologic Ability and Surgical Stress (E-PASS), and its modified version, mE-PASS, had a high predictive power for postoperative mortality and morbidity in a variety of gastrointestinal surgeries. This study ...

Last Updated: 28 Mar 2016

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Perioperative blood transfusion is not associated with overall survival or time to recurrence after resection of perihilar cholangiocarcinoma.
 

Author(s): Annemiek M Dekker, Jimme K Wiggers, Robert J Coelen, Rowan F van Golen, Marc G H Besselink, Olivier R C Busch, Joanne Verheij, Markus W Hollmann, Thomas M van Gulik

Journal: HPB (Oxford). 2016 Mar;18(3):262-70.

 

Perioperative blood transfusions have been associated with worse oncological outcome in several types of cancer. The objective of this study was to assess the effect of perioperative blood transfusions on time to recurrence and overall survival (OS) in patients who underwent curative-intent ...

Last Updated: 28 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Perihilar cholangiocarcinoma" returned 2 free, full-text review articles on human participants. First 3 results:

Current diagnostic and management options in perihilar cholangiocarcinoma.
 

Author(s): Sumera Rizvi, Gregory J Gores

Journal: Digestion. 2014 ;89(3):216-24.

 

Cholangiocarcinomas (CCAs) are heterogeneous biliary tract tumors with dismal prognosis. Perihilar CCA (pCCA) involves the large bile ducts of the hepatic hilum, and is the most common type of CCA. Primary sclerosing cholangitis (PSC) is an established risk factor for pCCA. Although ...

Last Updated: 19 Jun 2014

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Management of perihilar cholangiocarcinoma in the era of multimodal therapy.
 

Author(s): Vicente Valero, David Cosgrove, Joseph M Herman, Timothy M Pawlik

Journal: Expert Rev Gastroenterol Hepatol. 2012 Aug;6(4):481-95.

 

Perihilar cholangiocarcinoma (CCA) is the second most common primary malignant tumor of the liver. In the USA, there are approximately 3000 cases of CCA diagnosed annually, with approximately 50-70% of these tumors arising at the hilar plate of the biliary tree. Risk factors include ...

Last Updated: 29 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Efficacy and Safety Study of PDT Using Deuteporfin for Unresectable Advanced Perihilar Cholangiocarcinoma
 

Status: Recruiting

Condition Summary: Hilar Cholangiocarcinoma

 

Last Updated: 9 Nov 2016

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Safety and Tumoricidal Effect of Low Dose Foscan PDT in Patients With Inoperable Bile Duct Cancers
 

Status: Recruiting

Condition Summary: Cholangiocarcinoma; Tumor; Klatskin Tumor

 

Last Updated: 21 Dec 2016

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Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient
 

Status: Not yet recruiting

Condition Summary: Biliary Obstructive Disease Such as Choledocholithiasis; Benign Biliary Stricture; Peri-ampullary Cancer; Bile Duct Cancer Resectable; Klatskin Tumor

 

Last Updated: 29 Dec 2016

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