Perihilar cholangiocarcinoma

Common Name(s)

Perihilar cholangiocarcinoma, Klatskin tumor, Perihilar bile duct cancer, Hilar cholangiocarcinoma

Klatskin tumors are tumors that affect the upper part of the bile duct where it divides to enter the right and left parts of the liver. One or both sides may be affected. Individuals with Klatskin tumors often present with jaundice and/or abnormal liver tests. Treatment may involve surgical removal of the tumor. Not all tumors can be removed. Prognosis for cases that cannot be removed (non-resectable tumors) is poor.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

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Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

Last Updated: 1 May 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

Logo
Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

http://www.cholangiocarcinoma.org

Last Updated: 1 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Perihilar cholangiocarcinoma" returned 11 free, full-text research articles on human participants. First 3 results:

A new clinically based staging system for perihilar cholangiocarcinoma.
 

Author(s): Roongruedee Chaiteerakij, William S Harmsen, Carlos Romero Marrero, Mohammed M Aboelsoud, Albert Ndzengue, Joseph Kaiya, Terry M Therneau, William Sanchez, Gregory J Gores, Lewis R Roberts

Journal: Am. J. Gastroenterol.. 2014 Dec;109(12):1881-90.

 

Current staging systems for perihilar cholangiocarcinoma (pCCA) are inadequate, as they are based on surgical pathology and therefore not relevant to unresectable patients. Clinical trials for potential targeted therapies for pCCA are hampered by the lack of an accurate, nonoperative ...

Last Updated: 4 Dec 2014

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Excellent quality of life after liver transplantation for patients with perihilar cholangiocarcinoma who have undergone neoadjuvant chemoradiation.
 

Author(s): Sarwa Darwish Murad, Julie K Heimbach, Gregory J Gores, Charles B Rosen, Joanne T Benson, W Ray Kim

Journal: Liver Transpl.. 2013 May;19(5):521-8.

 

Patients with perihilar cholangiocarcinoma (CCA) undergoing neoadjuvant chemoradiation followed by liver transplantation (LT) have excellent survival. However, little is known about their quality of life (QOL). We assessed the QOL of these patients and compared it to the QOL of patients ...

Last Updated: 26 Apr 2013

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Comparison of the sixth and the seventh editions of the UICC classification for perihilar cholangiocarcinoma.
 

Author(s): Benjamin Juntermanns, Georgios Charalambos Sotiropoulos, Sonia Radunz, Henning Reis, Matthias Heuer, Hideo Andreas Baba, Ali Canbay, Martin Schuler, Guido Gerken, Andreas Paul, Gernot Maximilian Kaiser

Journal: Ann. Surg. Oncol.. 2013 Jan;20(1):277-84.

 

The seventh edition of the TNM classification separates extrahepatic bile duct tumors into perihilar and distal tumors and further changes the definition of the TNM classification. The impact of the seventh edition on stage-based prognostic prediction for patients with perihilar cholangiocarcinoma ...

Last Updated: 24 Dec 2012

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Perihilar cholangiocarcinoma" returned 2 free, full-text review articles on human participants. First 3 results:

Current diagnostic and management options in perihilar cholangiocarcinoma.
 

Author(s): Sumera Rizvi, Gregory J Gores

Journal: Digestion. 2014 ;89(3):216-24.

 

Cholangiocarcinomas (CCAs) are heterogeneous biliary tract tumors with dismal prognosis. Perihilar CCA (pCCA) involves the large bile ducts of the hepatic hilum, and is the most common type of CCA. Primary sclerosing cholangitis (PSC) is an established risk factor for pCCA. Although ...

Last Updated: 19 Jun 2014

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Management of perihilar cholangiocarcinoma in the era of multimodal therapy.
 

Author(s): Vicente Valero, David Cosgrove, Joseph M Herman, Timothy M Pawlik

Journal: Expert Rev Gastroenterol Hepatol. 2012 Aug;6(4):481-95.

 

Perihilar cholangiocarcinoma (CCA) is the second most common primary malignant tumor of the liver. In the USA, there are approximately 3000 cases of CCA diagnosed annually, with approximately 50-70% of these tumors arising at the hilar plate of the biliary tree. Risk factors include ...

Last Updated: 29 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 29 Apr 2015

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