Perihilar cholangiocarcinoma

Common Name(s)

Perihilar cholangiocarcinoma, Klatskin tumor, Perihilar bile duct cancer, Hilar cholangiocarcinoma

Klatskin tumors are tumors that affect the upper part of the bile duct where it divides to enter the right and left parts of the liver. One or both sides may be affected. Individuals with Klatskin tumors often present with jaundice and/or abnormal liver tests. Treatment may involve surgical removal of the tumor. Not all tumors can be removed. Prognosis for cases that cannot be removed (non-resectable tumors) is poor.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

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Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

Last Updated: 1 May 2015

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Perihilar cholangiocarcinoma" for support, advocacy or research.

Logo
Cholangiocarcinoma Foundation

Our mission is to find a cure and improve the quality of life for those affected by cholangiocarcinoma

http://www.cholangiocarcinoma.org

Last Updated: 1 May 2015

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Perihilar cholangiocarcinoma" returned 23 free, full-text research articles on human participants. First 3 results:

Low-power photodynamic therapy induces survival signaling in perihilar cholangiocarcinoma cells.
 

Author(s): Ruud Weijer, Mans Broekgaarden, Rowan F van Golen, Esther Bulle, Esther Nieuwenhuis, Aldo Jongejan, Perry D Moerland, Antoine H C van Kampen, Thomas M van Gulik, Michal Heger

Journal:

 

Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxidative stress, culminating in the destruction of tumor tissue and microvasculature ...

Last Updated: 26 Dec 2015

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Recurrence Rate and Pattern of Perihilar Cholangiocarcinoma after Curative Intent Resection.
 

Author(s): Bas Groot Koerkamp, Jimme K Wiggers, Peter J Allen, Marc G Besselink, Leslie H Blumgart, Olivier R C Busch, Robert J Coelen, Michael I D'Angelica, Ronald P DeMatteo, Dirk J Gouma, T Peter Kingham, William R Jarnagin, Thomas M van Gulik

Journal: J. Am. Coll. Surg.. 2015 Dec;221(6):1041-9.

 

The aim of this study was to investigate the rate and pattern of recurrence after curative intent resection of perihilar cholangiocarcinoma (PHC).

Last Updated: 27 Nov 2015

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Preoperative biliary drainage in perihilar cholangiocarcinoma: identifying patients who require percutaneous drainage after failed endoscopic drainage.
 

Author(s): Jimme K Wiggers, Bas Groot Koerkamp, Robert J Coelen, Erik A Rauws, Mark A Schattner, C Yung Nio, Karen T Brown, Mithat Gonen, Susan van Dieren, Krijn P van Lienden, Peter J Allen, Marc G H Besselink, Olivier R C Busch, Michael I D'Angelica, Robert P DeMatteo, Dirk J Gouma, T Peter Kingham, William R Jarnagin, Thomas M van Gulik

Journal: Endoscopy. 2015 Dec;47(12):1124-31.

 

Preoperative biliary drainage is often initiated with endoscopic retrograde cholangiopancreatography (ERCP) in patients with potentially resectable perihilar cholangiocarcinoma (PHC), but additional percutaneous transhepatic catheter (PTC) drainage is frequently required. This study ...

Last Updated: 3 Dec 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Perihilar cholangiocarcinoma" returned 2 free, full-text review articles on human participants. First 3 results:

Current diagnostic and management options in perihilar cholangiocarcinoma.
 

Author(s): Sumera Rizvi, Gregory J Gores

Journal: Digestion. 2014 ;89(3):216-24.

 

Cholangiocarcinomas (CCAs) are heterogeneous biliary tract tumors with dismal prognosis. Perihilar CCA (pCCA) involves the large bile ducts of the hepatic hilum, and is the most common type of CCA. Primary sclerosing cholangitis (PSC) is an established risk factor for pCCA. Although ...

Last Updated: 19 Jun 2014

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Management of perihilar cholangiocarcinoma in the era of multimodal therapy.
 

Author(s): Vicente Valero, David Cosgrove, Joseph M Herman, Timothy M Pawlik

Journal: Expert Rev Gastroenterol Hepatol. 2012 Aug;6(4):481-95.

 

Perihilar cholangiocarcinoma (CCA) is the second most common primary malignant tumor of the liver. In the USA, there are approximately 3000 cases of CCA diagnosed annually, with approximately 50-70% of these tumors arising at the hilar plate of the biliary tree. Risk factors include ...

Last Updated: 29 Aug 2012

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Last Updated: 1 Sep 2016

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Efficacy and Safety Study of PDT Using Deuteporfin for Unresectable Advanced Perihilar Cholangiocarcinoma
 

Status: Recruiting

Condition Summary: Hilar Cholangiocarcinoma

 

Last Updated: 9 Nov 2016

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Effectiveness of Prophylactic Antibiotics to Prevent Post Endoscopic Retrograde Cholangio Pancreatography Bacteremia in Biliary Obstruction Patient
 

Status: Not yet recruiting

Condition Summary: Biliary Obstructive Disease Such as Choledocholithiasis; Benign Biliary Stricture; Peri-ampullary Cancer; Bile Duct Cancer Resectable; Klatskin Tumor

 

Last Updated: 4 Nov 2016

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