Amyotrophic Lateral Sclerosis

Common Name(s)

Amyotrophic Lateral Sclerosis, Amyotrophic Lateral Sclerosis (ALS), Lou Gehrig's disease

Amyotrophic lateral sclerosis (ALS), also referred to as "Lou Gehrig's disease" is a disease of the motor nerve cells in the brain and spinal cord. ALS is caused by progressive loss of motor nerves in these areas and affects approximately 1 out of 100,000 people. The diagnosis of ALS is usually based on clinical features, electrodiagnostic testing (EMG), and exclusion of other health conditions with related symptoms.  Most people with amyotrophic lateral sclerosis have a form of the condition that is described as sporadic or noninherited. The cause of sporadic amyotrophic lateral sclerosis is largely unknown but probably involves a combination of genetic and environmental factors. About 10 percent of people with amyotrophic lateral sclerosis have a familial form of the condition, which is caused by an inherited genetic mutation.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

Last Updated: 8 Oct 2013

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

Last Updated: 29 May 2015

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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

Last Updated: 24 Nov 2009

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

Last Updated: 20 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Amyotrophic Lateral Sclerosis" for support, advocacy or research.

ALS Association

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig’s Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa.org/

Last Updated: 2 May 2014

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Irish Motor Neurone Disease Assoication

To encourage and promote the best methods of care, education, research and treatment for people with Motor Neurone Disease throughout the State of Ireland, contributing to worldwide efforts in research and development of treatment. To establish and promote models of good practice in the delivery of specialised services to our patients, their families and carers, setting standards of excellence. To communicate widely knowledge of Motor Neurone Disease and related disorders in order to raise awareness in the wider community.

http://www.imnda.ie

Last Updated: 8 Oct 2013

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Les Turner ALS Foundation

To support medical research into the cause, treatment and cure of ALS; clinical and support services for patients and families living; and dissemination of information about ALS.

http://www.lesturnerals.org

Last Updated: 31 Dec 2012

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Muscular Dystrophy Association

MDA is the nonprofit health agency dedicated to curing muscular dystrophy, ALS and related diseases by funding worldwide research. The Association also provides comprehensive health care and support services, advocacy and education.

http://www.mdausa.org

Last Updated: 29 May 2015

View Details
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National Endowment for Alzheimer's Research

At NEAR, our mission is to investigate the underlying causes of Alzheimer's and to develop rapid clinical interventions both for Alzheimer's and other brain disorders. A secondary mission is to promote public awareness and education with respect to Alzheimer's disease and related dementia, and to encourage the involvement of individuals, businesses, foundations, and government in finding a cure.

http://www.memorymatters.org

Last Updated: 20 Dec 2012

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Scottish Motor Neurone Disease Association

We want to make Scotland a place where those living with motor neurone disease/amyotrophic lateral sclerosis can expect consistent, high standards of care and where we work directly towards a cure.

http://www.scotmnd.org.uk

Last Updated: 24 Nov 2009

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The ALS Association - Evergreen Chapter

Leading the fight to treat and cure ALS through global research and nationwide advocacy while also empowering people with Lou Gehrig's Disease and their families to live fuller lives by providing them with compassionate care and support.

http://www.alsa-ec.org

Last Updated: 12 Jun 2013

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United Spinal Association

United Spinal Association’s mission is to improve the quality of life of all people living with spinal cord injuries and disorders (SCI/D). United Spinal never loses sight of our founders' grassroots efforts to provide a voice to the disability community and to transform the public’s perception of wheelchair users. Now the largest non-profit organization dedicated to helping people living with SCI/D, United Spinal is committed to providing active-lifestyle information, peer support and advocacy that empowers individuals to achieve their highest potential in all facets of life.

http://www.unitedspinal.org

Last Updated: 20 Feb 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Amyotrophic Lateral Sclerosis" returned 1047 free, full-text research articles on human participants. First 3 results:

How we developed, at the Centre/Institute for Neuromuscular Diseases, differential diagnostics of Spinal Muscle Atrophies / Amyotrophic Lateral Sclerosis (SMA/ALS) and tried to influence the development of the disease.
 

Author(s): Anica Jušić

Journal: Acta Myol. 2014 Oct;33(2):111-4.

 

In our research, we placed the emphasis on delimiting fatal diseases against those that have some similar symptoms, but can be improved, even completely cured. More often we succeeded in differentiating the local compressive factor. In our search for early symptoms, we also found ...

Last Updated: 24 Feb 2015

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Futsch/MAP1B mRNA is a translational target of TDP-43 and is neuroprotective in a Drosophila model of amyotrophic lateral sclerosis.
 

Author(s): Alyssa N Coyne, Bhavani Bagevalu Siddegowda, Patricia S Estes, Jeffrey Johannesmeyer, Tina Kovalik, Scott G Daniel, Antony Pearson, Robert Bowser, Daniela C Zarnescu

Journal: J. Neurosci.. 2014 Nov;34(48):15962-74.

 

TDP-43 is an RNA-binding protein linked to amyotrophic lateral sclerosis (ALS) that is known to regulate the splicing, transport, and storage of specific mRNAs into stress granules. Although TDP-43 has been shown to interact with translation factors, its role in protein synthesis ...

Last Updated: 27 Nov 2014

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Delayed disease onset and extended survival in the SOD1G93A rat model of amyotrophic lateral sclerosis after suppression of mutant SOD1 in the motor cortex.
 

Author(s): Gretchen M Thomsen, Genevieve Gowing, Jessica Latter, Maximus Chen, Jean-Philippe Vit, Kevin Staggenborg, Pablo Avalos, Mor Alkaslasi, Laura Ferraiuolo, Shibi Likhite, Brian K Kaspar, Clive N Svendsen

Journal: J. Neurosci.. 2014 Nov;34(47):15587-600.

 

Sporadic amyotrophic lateral sclerosis (ALS) is a fatal disease with unknown etiology, characterized by a progressive loss of motor neurons leading to paralysis and death typically within 3-5 years of onset. Recently, there has been remarkable progress in understanding inherited forms ...

Last Updated: 21 Nov 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Amyotrophic Lateral Sclerosis" returned 148 free, full-text review articles on human participants. First 3 results:

Ensuring continued progress in biomarkers for amyotrophic lateral sclerosis.
 

Author(s): Martin R Turner, Michael Benatar

Journal: Muscle Nerve. 2015 Jan;51(1):14-8.

 

Multiple candidate biomarkers for amyotrophic lateral sclerosis (ALS) have emerged across a range of platforms. Replication of results, however, has been absent in all but a few cases, and the range of control samples has been limited. If progress toward clinical translation is to ...

Last Updated: 16 Dec 2014

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Tale of two diseases: amyotrophic lateral sclerosis and frontotemporal dementia.
 

Author(s): Ashok Verma

Journal: Neurol India. ;62(4):347-51.

 

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) were independently described in clinical and pathological details more than a century ago. Recent breakthrough discoveries identifying common genes that are causal to either ALS or FTD or an overlapping ALS-FTD ...

Last Updated: 20 Sep 2014

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Quantifying disease progression in amyotrophic lateral sclerosis.
 

Author(s): Neil G Simon, Martin R Turner, Steve Vucic, Ammar Al-Chalabi, Jeremy Shefner, Catherine Lomen-Hoerth, Matthew C Kiernan

Journal: Ann. Neurol.. 2014 Nov;76(5):643-57.

 

Amyotrophic lateral sclerosis (ALS) exhibits characteristic variability of onset and rate of disease progression, with inherent clinical heterogeneity making disease quantitation difficult. Recent advances in understanding pathogenic mechanisms linked to the development of ALS impose ...

Last Updated: 30 Oct 2014

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Clinical Trial Information This information is provided by ClinicalTrials.gov

The National Amyotrophic Lateral Sclerosis Registry
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis

 

Last Updated: 26 Sep 2014

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Early Stage Amyotrophic Lateral Sclerosis Phrenic Stimulation
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Respiratory Insufficiency

 

Last Updated: 23 Apr 2015

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Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis
 

Status: Recruiting

Condition Summary: Amyotrophic Lateral Sclerosis; Chronic Respiratory Failure

 

Last Updated: 26 Mar 2010

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