Chronic kidney disease

Common Name(s)

Chronic kidney disease

Chronic kidney disease (CKD), otherwise known as chronic renal failure, occurs when the kidneys become damaged and lose the ability to properly filter out waste from the blood stream. Conditions such as diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease have all been linked to the development of CKD.

Symptoms of CKD may include fatigue, poor appetite, anemia (low blood count), nausea, swollen feet, irritated skin, increased need to urinate, shortness of breath, high blood pressure, trouble concentrating, and weakening bones. Early stages often do not show symptoms; therefore, regular checkups are critical for elderly and high risk individuals. A diagnosis can be determined through a blood test, urine test, imaging test, or the removal of sample tissue (biopsy).

While CKD can develop in anyone of any age, adults 65 years or older, and those who are African American, Hispanic, Pacific Islander, and American Indian are most at risk. Other risk factors include smoking, obesity, heart disease, high cholesterol, and having a family history of kidney failure.

There are five stages of CKD, each stage representing a gradual loss of function. End stage kidney failure, the fifth stage, is irreversible and fatal, so prevention and immediate intervention is critical. Depending on the cause, CKD can be treated if the source of the complication can be fixed. If this is not the case, treatment options focus on lessening the symptoms and slowing the progression of the disease. If the condition progresses to the point where the kidneys cannot function on their own, treatments may resort to artificial filtering (dialysis) or a kidney transplant. If you or a loved one has been diagnosed with CKD, talk with your doctor about treatment options. Support groups are also good sources of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic kidney disease" for support, advocacy or research.

Alport Syndrome Foundation

Our MISSION is to educate and support patients and their families that have been affected by this genetic kidney disease with the goal of funding research to find more effective treatment protocols and a cure for Alport Syndrome.

Last Updated: 15 Apr 2014

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American Association of Kidney Patients

Dedicated to improving the quality of life for kidney patients through education, advocacy and fostering patient communities.

Last Updated: 5 May 2014

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Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

Last Updated: 14 Mar 2013

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National Kidney Foundation

The National Kidney Foundation, a major voluntary nonprofit health organization, is dedicated to preventing kidney and urinary tract diseases, improving the health and well-being of individuals and families affected by kidney disease and increasing the availability of all organs for transplantation.

Last Updated: 23 Jun 2015

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The Cain Foundation for Branchio-oto-renal Syndrome (BOR)

The CAIN FOUNDATION, a voluntary based Charity. Our mission is to represent the interests of many people affected by Branchio-oto-renal Syndrome and to improve their quality of life by providing support and information related to this Syndrome. We seek to educate both Medical Practitioners and the public by promoting Branchio-oto-renal (BOR) Syndrome awareness. Vision to Educate. Mission to Care.

Last Updated: 12 Oct 2013

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General Support Organizations

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic kidney disease" for support, advocacy or research.

Alport Syndrome Foundation

Our MISSION is to educate and support patients and their families that have been affected by this genetic kidney disease with the goal of funding research to find more effective treatment protocols and a cure for Alport Syndrome.

http://www.alportsyndrome.org

Last Updated: 15 Apr 2014

View Details
American Association of Kidney Patients

Dedicated to improving the quality of life for kidney patients through education, advocacy and fostering patient communities.

http://www.aakp.org

Last Updated: 5 May 2014

View Details
Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

http://www.bardetbiedl.org/

Last Updated: 14 Mar 2013

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National Kidney Foundation

The National Kidney Foundation, a major voluntary nonprofit health organization, is dedicated to preventing kidney and urinary tract diseases, improving the health and well-being of individuals and families affected by kidney disease and increasing the availability of all organs for transplantation.

http://www.kidney.org

Last Updated: 23 Jun 2015

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The Cain Foundation for Branchio-oto-renal Syndrome (BOR)

The CAIN FOUNDATION, a voluntary based Charity. Our mission is to represent the interests of many people affected by Branchio-oto-renal Syndrome and to improve their quality of life by providing support and information related to this Syndrome. We seek to educate both Medical Practitioners and the public by promoting Branchio-oto-renal (BOR) Syndrome awareness. Vision to Educate. Mission to Care.

http://www.thecainfoundation.com

Last Updated: 12 Oct 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic kidney disease" returned 3087 free, full-text research articles on human participants. First 3 results:

Accuracy of glomerular filtration rate equations for chronic kidney disease patients at the G3a stage: a single-center cross-sectional study.
 

Author(s): Yanna Dou, Xiran Sun, Dong Liu, Li Zhang, Jing Xiao, Genyang Cheng, Dahai Yu, Zhanzheng Zhao

Journal:

 

Kidney disease improving global outcomes provided a new classification for chronic kidney disease (CKD) by subdividing the G3 stage into G3a and G3b stages based on glomerular filtration rate (GFR) in 2012. Currently, a few methods are used to evaluate GFR, including measured GFR ...

Last Updated: 25 Feb 2017

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Cystatin-C is associated with partial recovery of kidney function and progression to chronic kidney disease in living kidney donors: Observational study.
 

Author(s): Ji-Yeon Bang, Seon-Ok Kim, Sae-Gyul Kim, Jun-Gol Song, Gyu Sam Hwang

Journal: Medicine (Baltimore). 2017 Feb;96(5):e6037.

 

Donor nephrectomy in living-donor kidney transplantation may result in hyperfiltration injury in remnant kidney; however, its clinical implication in partial recovery of kidney function (PRKF) in remnant kidney and chronic kidney disease (CKD) progression remains unclear. Thus, we ...

Last Updated: 2 Feb 2017

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Cystatin C is Better than Serum Creatinine for Estimating Glomerular Filtration Rate to Detect Osteopenia in Chronic Kidney Disease Patients.
 

Author(s): Young Eun Kwon, Mi Jung Lee, Kyoung Sook Park, Seung Hyeok Han, Tae Hyun Yoo, Kook Hwan Oh, Joongyub Lee, Kyu Beck Lee, Wookyung Chung, Yeong Hoon Kim, Curie Ahn, Kyu Hun Choi

Journal: Yonsei Med. J.. 2017 Mar;58(2):380-387.

 

Recent studies have reported that loss of bone mass is associated with renal function decline and increased fracture risks in chronic kidney disease (CKD) patients. The aim of this study was to investigate the best estimated glomerular filtration rate (eGFR) equation to detect osteopenia ...

Last Updated: 25 Jan 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic kidney disease" returned 744 free, full-text review articles on human participants. First 3 results:

Hepatitis C Treatment in Chronic Kidney Disease Patients: The Kidney Disease Improving Global Outcomes Perspective.
 

Author(s): Michel Jadoul, Paul Martin

Journal: Blood Purif.. 2017 ;43(1-3):206-209.

 

Hepatitis C virus (HCV) infection is a very common infection found among hemodialysis (HD) and kidney transplant patients. It is associated with substantial morbidity and mortality. Direct-acting antiviral agents (DAAs) have much better efficacy (sustained viral response (SVR)) and ...

Last Updated: 23 Jan 2017

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Electrolyte and Acid-Base Disorders in Chronic Kidney Disease and End-Stage Kidney Failure.
 

Author(s): Tsering Dhondup, Qi Qian

Journal: Blood Purif.. 2017 ;43(1-3):179-188.

 

The kidneys play a pivotal role in the regulation of electrolyte and acid-base balance. With progressive loss of kidney function, derangements in electrolytes and acid-base inevitably occur and contribute to poor patient outcomes. As chronic kidney disease (CKD) has become a worldwide ...

Last Updated: 23 Jan 2017

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Uric Acid, Vascular Stiffness, and Chronic Kidney Disease: Is There a Link?
 

Author(s): Juan C Ramirez-Sandoval, L Gabriela Sanchez-Lozada, Magdalena Madero

Journal: Blood Purif.. 2017 ;43(1-3):189-195.

 

Controversy exists with regard to the causal role of hyperuricemia in chronic kidney disease. Vascular stiffness may be the link that explains the relation between hyperuricemia and kidney disease. Hyperuricemia is associated with a number of effects on the vascular endothelium and ...

Last Updated: 23 Jan 2017

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Clearance of 25-hydroxyvitamin D in Chronic Kidney Disease
 

Status: Recruiting

Condition Summary: Chronic Kidney Disease

 

Last Updated: 17 Feb 2017

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Inspiratory Muscle Training in Chronic Kidney Disease
 

Status: Not yet recruiting

Condition Summary: Chronic Kidney Disease

 

Last Updated: 12 Mar 2017

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Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease
 

Status: Recruiting

Condition Summary: Chronic Kidney Disease

 

Last Updated: 20 Mar 2017

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