Chronic kidney disease

Common Name(s)

Chronic kidney disease

Chronic kidney disease (CKD), otherwise known as chronic renal failure, occurs when the kidneys become damaged and lose the ability to properly filter out waste from the blood stream. Conditions such as diabetes, high blood pressure, glomerulonephritis, and polycystic kidney disease have all been linked to the development of CKD.

Symptoms of CKD may include fatigue, poor appetite, anemia (low blood count), nausea, swollen feet, irritated skin, increased need to urinate, shortness of breath, high blood pressure, trouble concentrating, and weakening bones. Early stages often do not show symptoms; therefore, regular checkups are critical for elderly and high risk individuals. A diagnosis can be determined through a blood test, urine test, imaging test, or the removal of sample tissue (biopsy).

While CKD can develop in anyone of any age, adults 65 years or older, and those who are African American, Hispanic, Pacific Islander, and American Indian are most at risk. Other risk factors include smoking, obesity, heart disease, high cholesterol, and having a family history of kidney failure.

There are five stages of CKD, each stage representing a gradual loss of function. End stage kidney failure, the fifth stage, is irreversible and fatal, so prevention and immediate intervention is critical. Depending on the cause, CKD can be treated if the source of the complication can be fixed. If this is not the case, treatment options focus on lessening the symptoms and slowing the progression of the disease. If the condition progresses to the point where the kidneys cannot function on their own, treatments may resort to artificial filtering (dialysis) or a kidney transplant. If you or a loved one has been diagnosed with CKD, talk with your doctor about treatment options. Support groups are also good sources of support and information.

Source: Advocacy organizations associated with the condition.

 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic kidney disease" for support, advocacy or research.

Alport Syndrome Foundation

Our MISSION is to educate and support patients and their families that have been affected by this genetic kidney disease with the goal of funding research to find more effective treatment protocols and a cure for Alport Syndrome.

Last Updated: 15 Apr 2014

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American Association of Kidney Patients

Dedicated to improving the quality of life for kidney patients through education, advocacy and fostering patient communities.

Last Updated: 5 May 2014

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Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

Last Updated: 14 Mar 2013

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National Kidney Foundation

The National Kidney Foundation, a major voluntary nonprofit health organization, is dedicated to preventing kidney and urinary tract diseases, improving the health and well-being of individuals and families affected by kidney disease and increasing the availability of all organs for transplantation.

Last Updated: 23 Jun 2015

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The Cain Foundation for Branchio-oto-renal Syndrome (BOR)

The CAIN FOUNDATION, a voluntary based Charity. Our mission is to represent the interests of many people affected by Branchio-oto-renal Syndrome and to improve their quality of life by providing support and information related to this Syndrome. We seek to educate both Medical Practitioners and the public by promoting Branchio-oto-renal (BOR) Syndrome awareness. Vision to Educate. Mission to Care.

Last Updated: 12 Oct 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Chronic kidney disease" for support, advocacy or research.

Alport Syndrome Foundation

Our MISSION is to educate and support patients and their families that have been affected by this genetic kidney disease with the goal of funding research to find more effective treatment protocols and a cure for Alport Syndrome.

http://www.alportsyndrome.org

Last Updated: 15 Apr 2014

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American Association of Kidney Patients

Dedicated to improving the quality of life for kidney patients through education, advocacy and fostering patient communities.

http://www.aakp.org

Last Updated: 5 May 2014

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Bardet Biedl Syndrome Family Association

Our Mission: Improve the lives of families affected by BBS through information, support and by advancing research and therapy Our Vision: Effective support, therapy, and treatment for all people affected by Bardet Biedl Syndrome

http://www.bardetbiedl.org/

Last Updated: 14 Mar 2013

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National Kidney Foundation

The National Kidney Foundation, a major voluntary nonprofit health organization, is dedicated to preventing kidney and urinary tract diseases, improving the health and well-being of individuals and families affected by kidney disease and increasing the availability of all organs for transplantation.

http://www.kidney.org

Last Updated: 23 Jun 2015

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The Cain Foundation for Branchio-oto-renal Syndrome (BOR)

The CAIN FOUNDATION, a voluntary based Charity. Our mission is to represent the interests of many people affected by Branchio-oto-renal Syndrome and to improve their quality of life by providing support and information related to this Syndrome. We seek to educate both Medical Practitioners and the public by promoting Branchio-oto-renal (BOR) Syndrome awareness. Vision to Educate. Mission to Care.

http://www.thecainfoundation.com

Last Updated: 12 Oct 2013

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General Support Organizations

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Chronic kidney disease" returned 3036 free, full-text research articles on human participants. First 3 results:

Baseline Chronic Kidney Disease and Ischemic Method of Partial Nephrectomy Are Important Factors for the Short- and Long-Term Deterioration in Renal Function for Renal Cell Carcinoma Staged T1-T2: A Retrospective Single Center Study.
 

Author(s): Sung Han Kim, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung

Journal: Biomed Res Int. 2016 ;2016():5398381.

 

The renal functions of 215 patients (24 with benign renal mass, the rest with RCC staged T1-T2) who underwent partial nephrectomy (PN) between 2003 and 2014 were evaluated to identify predictors of short- and long-term deterioration in renal function after PN among renal cell carcinoma ...

Last Updated: 11 Jan 2017

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Association of anthropometric measures of obesity and chronic kidney disease in elderly women.
 

Author(s): Andrzej Jaroszynski, Tadeusz Dereziński, Anna Jaroszyńska, Tomasz Zapolski, Beata Wąsikowska, Andrzej Wysokiński, Arkadiusz Jawień, Wojciech Załuska, Andrzej Horoch

Journal: Ann Agric Environ Med. 2016 12;23(4):636-640.

 

Growing evidence suggests that obesity is an important contributor to the development of chronic kidney disease (CKD). The relationship between obesity and CKD is complex and not completely understood, and the best anthropometric index of obesity in predicting CKD is controversial. ...

Last Updated: 29 Dec 2016

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Upregulation of Oxidative Stress Related Genes in a Chronic Kidney Disease Attributed to Specific Geographical Locations of Sri Lanka.
 

Author(s): Saravanabavan Sayanthooran, Dhammika N Magana-Arachchi, Lishanthe Gunerathne, Tilak D J Abeysekera, Suneth S Sooriyapathirana

Journal: Biomed Res Int. 2016 ;2016():7546265.

 

Objective. To infer the influence of internal and external oxidative stress in chronic kidney disease patients of unknown etiology (CKDu) in Sri Lanka, by analyzing expression of genes related directly or indirectly to oxidative stress: glutamate-cysteine ligase catalytic subunit ...

Last Updated: 15 Dec 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Chronic kidney disease" returned 728 free, full-text review articles on human participants. First 3 results:

Self-Management Programs on eGFR, Depression, and Quality of Life among Patients with Chronic Kidney Disease: A Meta-Analysis.
 

Author(s): Mei-Chen Lee, Shu-Fang Vivienne Wu, Nan-Chen Hsieh, Juin-Ming Tsai

Journal: Asian Nurs Res (Korean Soc Nurs Sci). 2016 Dec;10(4):255-262.

 

Chronic kidney disease (CKD) is a condition characterized by the gradual loss of kidney function over time. Self-management programs have been widely applied to chronic disease education programs, which are designed to delay deteriorating kidney functions, preclude depression, and ...

Last Updated: 6 Jan 2017

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Transcriptomics: A Step behind the Comprehension of the Polygenic Influence on Oxidative Stress, Immune Deregulation, and Mitochondrial Dysfunction in Chronic Kidney Disease.
 

Author(s): Simona Granata, Alessandra Dalla Gassa, Gloria Bellin, Antonio Lupo, Gianluigi Zaza

Journal: Biomed Res Int. 2016 ;2016():9290857.

 

Chronic kidney disease (CKD) is an increasing and global health problem with a great economic burden for healthcare system. Therefore to slow down the progression of this condition is a main objective in nephrology. It has been extensively reported that microinflammation, immune system ...

Last Updated: 15 Jul 2016

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Impact of coronary artery bypass surgery and percutaneous coronary intervention on mortality in patients with chronic kidney disease and on dialysis: A systematic review and meta-analysis.
 

Author(s): Pravesh Kumar Bundhun, Akash Bhurtu, Meng-Hua Chen

Journal: Medicine (Baltimore). 2016 Jul;95(27):e4129.

 

Controversies have been observed among previously published and recently published studies comparing coronary artery bypass surgery (CABG) and percutaneous coronary intervention (PCI) in patients with chronic kidney disease (CKD) and patients on chronic dialysis. This study aimed ...

Last Updated: 12 Jul 2016

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Micro-Particle Curcumin for the Treatment of Chronic Kidney Disease
 

Status: Recruiting

Condition Summary: Chronic Kidney Disease

 

Last Updated: 25 Feb 2016

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Post-marketing Surveillance of Bixalomer in Patients With Pre-dialysis Chronic Kidney Disease
 

Status: Recruiting

Condition Summary: Chronic Kidney Disease

 

Last Updated: 28 Sep 2016

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Last Updated: 14 Dec 2016

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