Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

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General Support Organizations

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General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 343 free, full-text research articles on human participants. First 3 results:

An Evaluation of Lysyl Oxidase-Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry.
 

Author(s): Anna Takaoka, Natasha Babar, Julia Hogan, MiJung Kim, Marianne O Price, Francis W Price, Stephen L Trokel, David C Paik

Journal: Invest. Ophthalmol. Vis. Sci.. 2016 Jan;57(1):126-36.

 

Current literature contains scant information regarding the extent of enzymatic collagen cross-linking in the keratoconus (KC) cornea. The aim of the present study was to examine levels of enzymatic lysyl oxidase-derived cross-links in stromal collagen in KC tissue, and to correlate ...

Last Updated: 19 Jan 2016

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Association of Common Variants in LOX with Keratoconus: A Meta-Analysis.
 

Author(s): Jing Zhang, Lu Zhang, Jiaxu Hong, Dan Wu, Jianjiang Xu

Journal:

 

Several case-control studies have been performed to examine the association of genetic variants in lysyl oxidase (LOX) with keratoconus. However, the results remained inconclusive and great heterogeneity might exist across populations.

Last Updated: 30 Dec 2015

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A novel characterization of posterior keratoconus using anterior segment optical coherence tomography in an infant: a case report.
 

Author(s): Nisha Garg, Ta C Chang, Bibiana Jin Reiser, Kara M Cavuoto

Journal:

 

Posterior keratoconus is a rare cause of a corneal opacity in an infant. It is characterized by thinning of the posterior cornea without ectasia of the anterior cornea. Imaging of this condition with anterior segment optical coherence tomography (AS-OCT) has not been reported in the literature.

Last Updated: 5 Nov 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 35 free, full-text review articles on human participants. First 3 results:

The genetic and environmental factors for keratoconus.
 

Author(s): Ariela Gordon-Shaag, Michel Millodot, Einat Shneor, Yutao Liu

Journal: Biomed Res Int. 2015 ;2015():795738.

 

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its ...

Last Updated: 15 Jun 2015

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Keratoconus: an inflammatory disorder?
 

Author(s): V Galvis, T Sherwin, A Tello, J Merayo, R Barrera, A Acera

Journal: Eye (Lond). 2015 Jul;29(7):843-59.

 

Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with ...

Last Updated: 9 Jul 2015

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Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus.
 

Author(s): Z Shalchi, X Wang, M A Nanavaty

Journal: Eye (Lond). 2015 Jan;29(1):15-29.

 

This review aims to assess the efficacy and safety of epithelial removal (ER) and transepithelial (TE) corneal collagen crosslinking (CXL) for the treatment of keratoconus. We used MEDLINE to identify all ER and TE CXL studies on keratoconic eyes (n≥20, follow-up ≥12 months). ...

Last Updated: 8 Jan 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 3 Jul 2006

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Orthokeratology for Keratoconus
 

Status: Not yet recruiting

Condition Summary: Orthokeratology; Keratoconus

 

Last Updated: 31 Dec 2008

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Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

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