Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 369 free, full-text research articles on human participants. First 3 results:

Outcomes of corneal crosslinking for central and paracentral keratoconus.
 

Author(s): Mingxia Tian, Ping Ma, Weiyan Zhou, Jie Feng, Guoying Mu

Journal: Medicine (Baltimore). 2017 Mar;96(10):e6247.

 

The aim of the study was to compare the therapy of corneal collagen crosslinking (CXL) for central and paracentral keratoconus.

Last Updated: 8 Mar 2017

Go To URL
Clinical application of TICL implantation for ametropia following deep anterior lamellar keratoplasty for keratoconus: A CONSORT-compliant article.
 

Author(s): Qin Qin, Liping Yang, Zifang He, Zhenping Huang

Journal: Medicine (Baltimore). 2017 Feb;96(8):e6118.

 

This study aimed to investigate the clinical application of phakic toric intraocular collamer lens (TICL) implantation in treating ametropia following deep anterior lamellar keratoplasty (DALK) for patients with keratoconus, especially the effectiveness and safety of high astigmatism ...

Last Updated: 22 Feb 2017

Go To URL
The Long-term Clinical Outcome after Corneal Collagen Cross-linking in Korean Patients with Progressive Keratoconus.
 

Author(s): Tae Gi Kim, Ki Young Kim, Jung Bin Han, Kyung Hyun Jin

Journal: Korean J Ophthalmol. 2016 Oct;30(5):326-334.

 

To evaluate the long-term clinical effectiveness and safety of corneal collagen cross-linking (CXL) in progressive keratoconus compared with untreated contralateral eyes.

Last Updated: 12 Oct 2016

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 43 free, full-text review articles on human participants. First 3 results:

Molecular and Histopathological Changes Associated with Keratoconus.
 

Author(s): Mariam Lotfy Khaled, Inas Helwa, Michelle Drewry, Mutsa Seremwe, Amy Estes, Yutao Liu

Journal: Biomed Res Int. 2017 ;2017():7803029.

 

Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal transplantation in the Western countries. KC usually starts at puberty and progresses until the ...

Last Updated: 2 Mar 2017

Go To URL
Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus.
 

Author(s): Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Christian Jonescu-Cuypers, Cristina Nicula, Dana Dascalescu, Miruna Cristea, Liliana-Mary Voinea

Journal: Dis. Markers. 2016 ;2016():1243819.

 

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains ...

Last Updated: 26 Aug 2016

Go To URL
Current techniques of lamellar keratoplasty for keratoconus.
 

Author(s): Leopoldo Spadea, Victoria De Rosa

Journal: Saudi Med J. 2016 Feb;37(2):127-36.

 

In recent years, there has been a considerable interest regarding the concept of lamellar keratoplasty (LK), which contributed in spreading the use of this procedure in the treatment of keratoconus. This is a new frontier in corneal surgery that minimizes trauma on the recipient patient ...

Last Updated: 3 Feb 2016

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Corneal Tissue Inlay for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 25 Jul 2016

Go to URL
Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 22 Apr 2016

Go to URL
Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

Go to URL