Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

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General Support Organizations

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General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 302 free, full-text research articles on human participants. First 3 results:

Prospective, randomized, double-blind trial to investigate the efficacy and safety of corneal cross-linking to halt the progression of keratoconus.
 

Author(s): Stefan J Lang, Elisabeth M Messmer, Gerd Geerling, Marc J Mackert, Tobias Brunner, Sylvia Dollak, Borislav Kutchoukov, Daniel Böhringer, Thomas Reinhard, Philip Maier

Journal:

 

Corneal cross-linking is widely used to treat keratoconus. However, to date, only limited data from randomized trials support its efficacy.

Last Updated: 21 Jul 2015

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Herpetic Keratitis after Corneal Collagen Cross-Linking with Riboflavin and Ultraviolet-A for Keratoconus.
 

Author(s): Awad Al-Qarni, Mosa AlHarbi

Journal: Middle East Afr J Ophthalmol. ;22(3):389-92.

 

To describe two cases of herpetic keratitis after corneal collagen cross-linking (CXL) for progressive keratoconus. An 18-year-old male and a 21-year-old male with rapidly progressive keratoconus were treated with CXL. Postoperatively, on the 6(th) and 9(th) days respectively, a dendritic ...

Last Updated: 16 Jul 2015

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Corneal Collagen Cross-Linking in the Treatment of Progressive Keratoconus: A Randomized Controlled Contralateral Eye Study.
 

Author(s): Mohammad A Seyedian, Soheil Aliakbari, Mohammad Miraftab, Hassan Hashemi, Soheila Asgari, Mehdi Khabazkhoob

Journal: Middle East Afr J Ophthalmol. ;22(3):340-5.

 

To assess the short-term efficacy and safety of corneal collagen cross-linking (CXL) in preventing the progression of keratoconus (KCN).

Last Updated: 16 Jul 2015

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 25 free, full-text review articles on human participants. First 3 results:

Safety and efficacy of epithelium removal and transepithelial corneal collagen crosslinking for keratoconus.
 

Author(s): Z Shalchi, X Wang, M A Nanavaty

Journal: Eye (Lond). 2015 Jan;29(1):15-29.

 

This review aims to assess the efficacy and safety of epithelial removal (ER) and transepithelial (TE) corneal collagen crosslinking (CXL) for the treatment of keratoconus. We used MEDLINE to identify all ER and TE CXL studies on keratoconic eyes (n≥20, follow-up ≥12 months). ...

Last Updated: 8 Jan 2015

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Intrastromal corneal ring segments: how successful is the surgical treatment of keratoconus?
 

Author(s): Jorge L Alio, Alfredo Vega-Estrada, Santiago Esperanza, Rafael I Barraquer, Miguel A Teus, Joaquim Murta

Journal: Middle East Afr J Ophthalmol. ;21(1):3-9.

 

This review evaluates the outcomes of intrastromal corneal ring segment (ICRS) implantation for the treatment of keratoconus considering a new grading system based on the preoperative visual impairment of the patient. Additionally, a five-year follow-up analysis of patients with stable ...

Last Updated: 26 Mar 2014

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The pathogenesis of keratoconus.
 

Author(s): A E Davidson, S Hayes, A J Hardcastle, S J Tuft

Journal: Eye (Lond). 2014 Feb;28(2):189-95.

 

Keratoconus (KC) is a common degenerative condition that frequently results in visual loss with an onset typically in early adulthood. It is the single most common reason for keratoplasty in the developed world. The cause and underlying pathological mechanism are unknown, but both ...

Last Updated: 13 Feb 2014

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 3 Jul 2006

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Orthokeratology for Keratoconus
 

Status: Not yet recruiting

Condition Summary: Orthokeratology; Keratoconus

 

Last Updated: 31 Dec 2008

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Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

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