Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

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General Support Organizations

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General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 428 free, full-text research articles on human participants. First 3 results:

Flattening effect of corneal cross-linking depends on the preoperative severity of keratoconus.
 

Author(s): Kozue Kasai, Naoko Kato, Kenji Konomi, Megumi Shinzawa, Jun Shimazaki

Journal: Medicine (Baltimore). 2017 Oct;96(40):e8160.

 

A retrospective observational study was conducted to validate the effect of corneal cross-linking (CXL) on eyes with progressing keratoconus, depending on severity.In total, 45 eyes of 33 patients (age: 23.9 ± 6.8 years, range: 14-42 years) with progressive keratoconus who underwent ...

Last Updated: 6 Oct 2017

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Multifocal Choroiditis with Retinal Vasculitis, Optic Neuropathy, and Keratoconus in a Young Saudi Male.
 

Author(s): Yousef Dhafiri, Khalid Al Rubaie, Omar Kirat, William N May, Quan D Nguyen, Igor Kozak

Journal: Middle East Afr J Ophthalmol. ;24(2):109-112.

 

The purpose of this study is to describe an association of unilateral multifocal choroiditis (MFC), retinal vasculitis, optic neuropathy, and bilateral keratoconus in a young Saudi male. A 27-year-old male patient with stable bilateral keratoconus presented with a painless vision ...

Last Updated: 22 Sep 2017

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Oxidative stress induces dysregulated autophagy in corneal epithelium of keratoconus patients.
 

Author(s): Rohit Shetty, Anupam Sharma, Natasha Pahuja, Priyanka Chevour, Neeraja Padmajan, Kamesh Dhamodaran, Chaitra Jayadev, Rudy M M A Nuijts, Arkasubhra Ghosh, Jeyabalan Nallathambi

Journal:

 

Oxidative stress is one of the key factors that contributes to the pathogenesis of keratoconus (KC). Macroautophagy is a vital cellular mechanism that is activated in response to oxidative stress. The aim of this study was to understand the role of the autophagic lysosomal pathway ...

Last Updated: 13 Sep 2017

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 47 free, full-text review articles on human participants. First 3 results:

Molecular and Histopathological Changes Associated with Keratoconus.
 

Author(s): Mariam Lotfy Khaled, Inas Helwa, Michelle Drewry, Mutsa Seremwe, Amy Estes, Yutao Liu

Journal: Biomed Res Int. 2017 ;2017():7803029.

 

Keratoconus (KC) is a corneal thinning disorder that leads to loss of visual acuity through ectasia, opacity, and irregular astigmatism. It is one of the leading indicators for corneal transplantation in the Western countries. KC usually starts at puberty and progresses until the ...

Last Updated: 2 Mar 2017

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Genomic strategies to understand causes of keratoconus.
 

Author(s): Justyna A Karolak, Marzena Gajecka

Journal: Mol. Genet. Genomics. 2017 Apr;292(2):251-269.

 

Keratoconus (KTCN) is a degenerative disorder of the eye characterized by the conical shape and thinning of the cornea. The abnormal structure of KTCN-affected cornea results in loss of visual acuity. While many studies examine how environmental factors influence disease development, ...

Last Updated: 29 Dec 2016

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Inflammatory Biomarkers Profile as Microenvironmental Expression in Keratoconus.
 

Author(s): Catalina Ionescu, Catalina Gabriela Corbu, Cristiana Tanase, Christian Jonescu-Cuypers, Cristina Nicula, Dana Dascalescu, Miruna Cristea, Liliana-Mary Voinea

Journal: Dis. Markers. 2016 ;2016():1243819.

 

Keratoconus is a degenerative disorder with progressive stromal thinning and transformation of the normal corneal architecture towards ectasia that results in decreased vision due to irregular astigmatism and irreversible tissue scarring. The pathogenesis of keratoconus still remains ...

Last Updated: 26 Aug 2016

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Clinical Trial Information This information is provided by ClinicalTrials.gov

Corneal Tissue Inlay for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 24 Aug 2017

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Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 22 Apr 2016

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Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

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