Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

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General Support Organizations

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General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 360 free, full-text research articles on human participants. First 3 results:

Iridoschisis and keratoconus in a patient with severe allergic eye disease and compulsive eye rubbing: a case report.
 

Author(s): Imran H Yusuf, John F Salmon

Journal:

 

Iridoschisis is a rare disorder characterized by splitting of the anterior and posterior iris stroma, resulting in disintegrated iris fibrils which float freely in the anterior chamber. We report an exceptional case of bilateral iridoschisis occurring in conjunction with keratoconus ...

Last Updated: 26 May 2016

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Detection of the early keratoconus based on corneal biomechanical properties in the refractive surgery candidates.
 

Author(s): Zofia Pniakowska, Piotr Jurowski

Journal: Indian J Ophthalmol. 2016 Feb;64(2):109-13.

 

Subclinical keratoconus is contraindication to refractive surgery. The currently used methods of preoperative screening do not always allow differentiating between healthy eyes and those with subclinical keratoconus.

Last Updated: 7 Apr 2016

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Subclinical keratoconus detection by pattern analysis of corneal and epithelial thickness maps with optical coherence tomography.
 

Author(s): Yan Li, Winston Chamberlain, Ou Tan, Robert Brass, Jack L Weiss, David Huang

Journal: J Cataract Refract Surg. 2016 Feb;42(2):284-95.

 

To screen for subclinical keratoconus by analyzing corneal, epithelial, and stromal thickness map patterns with Fourier-domain optical coherence tomography (OCT).

Last Updated: 30 Mar 2016

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 41 free, full-text review articles on human participants. First 3 results:

Current techniques of lamellar keratoplasty for keratoconus.
 

Author(s): Leopoldo Spadea, Victoria De Rosa

Journal: Saudi Med J. 2016 Feb;37(2):127-36.

 

In recent years, there has been a considerable interest regarding the concept of lamellar keratoplasty (LK), which contributed in spreading the use of this procedure in the treatment of keratoconus. This is a new frontier in corneal surgery that minimizes trauma on the recipient patient ...

Last Updated: 3 Feb 2016

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An Update on the Safety and Efficacy of Corneal Collagen Cross-Linking in Pediatric Keratoconus.
 

Author(s): Hala El Rami, Elias Chelala, Ali Dirani, Ali Fadlallah, Henry Fakhoury, Carole Cherfan, George Cherfan, Elias Jarade

Journal: Biomed Res Int. 2015 ;2015():257927.

 

Keratoconus is a degenerative disease that affects adolescents and young adults and presents with variable thinning and conical deformation of the corneal apex. The resultant irregular astigmatism can progress to levels that can significantly affect everyday activities and overall ...

Last Updated: 22 Oct 2015

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The genetic and environmental factors for keratoconus.
 

Author(s): Ariela Gordon-Shaag, Michel Millodot, Einat Shneor, Yutao Liu

Journal: Biomed Res Int. 2015 ;2015():795738.

 

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its ...

Last Updated: 15 Jun 2015

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Corneal Tissue Inlay for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 25 Jul 2016

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Collagen Crosslinking for Keratoconus - a Randomized Controlled Clinical Trial
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 22 Apr 2016

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Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

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