Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
Top

How do you compare to others with this condition?

Privately answer questions about your health. Let resources, you select, come to you.

Anonymously share and see how your answers compare with others with this condition while privately providing key pieces of information to medical researchers, disease advocacy groups, and others ONLY YOU select to help speed up cures and better alternatives.

 
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

View Details

 

General Support Organizations

Not finding the support you need? Show General Support Organizations

 
 
 
 
Top

General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

Go To URL
 
 
Top

Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 348 free, full-text research articles on human participants. First 3 results:

Corneal Biomechanical and Anterior Chamber Parameters Variations after 1-year of Transepithelial Corneal Collagen Cross-linking in Eyes of Children with Keratoconus.
 

Author(s): Abdelrahman Gaber Salman

Journal: Middle East Afr J Ophthalmol. ;23(1):129-34.

 

To assess the changes in corneal hysteresis (CH) and corneal resistance factor (CRF) 1-year following transepithelial corneal collagen cross-linking (CXL) treatment in eyes of children with keratoconus.

Last Updated: 9 Mar 2016

Go To URL
An Evaluation of Lysyl Oxidase-Derived Cross-Linking in Keratoconus by Liquid Chromatography/Mass Spectrometry.
 

Author(s): Anna Takaoka, Natasha Babar, Julia Hogan, MiJung Kim, Marianne O Price, Francis W Price, Stephen L Trokel, David C Paik

Journal: Invest. Ophthalmol. Vis. Sci.. 2016 Jan;57(1):126-36.

 

Current literature contains scant information regarding the extent of enzymatic collagen cross-linking in the keratoconus (KC) cornea. The aim of the present study was to examine levels of enzymatic lysyl oxidase-derived cross-links in stromal collagen in KC tissue, and to correlate ...

Last Updated: 19 Jan 2016

Go To URL
Association of Common Variants in LOX with Keratoconus: A Meta-Analysis.
 

Author(s): Jing Zhang, Lu Zhang, Jiaxu Hong, Dan Wu, Jianjiang Xu

Journal:

 

Several case-control studies have been performed to examine the association of genetic variants in lysyl oxidase (LOX) with keratoconus. However, the results remained inconclusive and great heterogeneity might exist across populations.

Last Updated: 30 Dec 2015

Go To URL

Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 36 free, full-text review articles on human participants. First 3 results:

An Update on the Safety and Efficacy of Corneal Collagen Cross-Linking in Pediatric Keratoconus.
 

Author(s): Hala El Rami, Elias Chelala, Ali Dirani, Ali Fadlallah, Henry Fakhoury, Carole Cherfan, George Cherfan, Elias Jarade

Journal: Biomed Res Int. 2015 ;2015():257927.

 

Keratoconus is a degenerative disease that affects adolescents and young adults and presents with variable thinning and conical deformation of the corneal apex. The resultant irregular astigmatism can progress to levels that can significantly affect everyday activities and overall ...

Last Updated: 22 Oct 2015

Go To URL
The genetic and environmental factors for keratoconus.
 

Author(s): Ariela Gordon-Shaag, Michel Millodot, Einat Shneor, Yutao Liu

Journal: Biomed Res Int. 2015 ;2015():795738.

 

Keratoconus (KC) is the most common cornea ectatic disorder. It is characterized by a cone-shaped thin cornea leading to myopia, irregular astigmatism, and vision impairment. It affects all ethnic groups and both genders. Both environmental and genetic factors may contribute to its ...

Last Updated: 15 Jun 2015

Go To URL
Keratoconus: an inflammatory disorder?
 

Author(s): V Galvis, T Sherwin, A Tello, J Merayo, R Barrera, A Acera

Journal: Eye (Lond). 2015 Jul;29(7):843-59.

 

Keratoconus has been classically defined as a progressive, non-inflammatory condition, which produces a thinning and steepening of the cornea. Its pathophysiological mechanisms have been investigated for a long time. Both genetic and environmental factors have been associated with ...

Last Updated: 9 Jul 2015

Go To URL
 
 
Top

Symptoms, Diagnosis, and Treatment

There are currently no related results available in Genetics Home Reference.

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
Top

Clinical Trial Information This information is provided by ClinicalTrials.gov

Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 3 Jul 2006

Go to URL
Orthokeratology for Keratoconus
 

Status: Not yet recruiting

Condition Summary: Orthokeratology; Keratoconus

 

Last Updated: 31 Dec 2008

Go to URL
Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 15 May 2014

Go to URL