Keratoconus

Common Name(s)

Keratoconus

Keratoconus is the degeneration of the structure of the cornea, which is the clear tissue covering the front of the eye. In this condition, the shape of the cornea slowly changes from the normal round shape to a cone shape. Most people who develop keratoconus start out nearsighted, which tends to become worse over time. The cause is unknown, but the tendency to develop keratoconus is probably present from birth. Keratoconus is thought to involve a defect in collagen, the tissue that makes up most of the cornea. Some researchers believe that allergy and eye rubbing may play a role.
 

Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

Last Updated: 15 Feb 2013

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General Support Organizations

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How do you compare to others with this condition?

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Advocacy and Support Organizations

 

Condition Specific Organizations

Following organizations serve the condition "Keratoconus" for support, advocacy or research.

National Keratoconus Foundation

The National Keratoconus Foundation (NKCF) is an outreach program of the Discovery Eye Foundation. The NKCF dedicated to the dissemination of information about keratoconus to patients, their families, and eye care professionals.

http://www.nkcf.org/

Last Updated: 15 Feb 2013

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General Support Organizations

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General Resources

KC-Link and NKCF Forum

Email and Web based Support groups

Updated 15 Feb 2013

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Scientific Literature

Articles from the PubMed Database

Research articles describe the outcome of a single study. They are the published results of original research.
The terms "Keratoconus" returned 282 free, full-text research articles on human participants. First 3 results:

Optical coherence tomography combined with videokeratography to differentiate mild keratoconus subtypes.
 

Author(s): Yaron S Rabinowitz, Xiaohui Li, Ana Laura Caiado Canedo, Renato Ambrósio, Yelena Bykhovskaya

Journal: J Refract Surg. 2014 Feb;30(2):80-7.

 

To develop parameters using a combination of optical coherence tomography (OCT) and videokeratography to detect early keratoconus.

Last Updated: 25 Apr 2014

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Modulatory effect of different riboflavin compositions on the central corneal thickness of African keratoconus corneas during collagen crosslinking.
 

Author(s): Timo Mark, Faustin Ngounou, James Tamon, Susanne Marx-Gross, Paul-Rolf Preussner

Journal: Middle East Afr J Ophthalmol. ;21(1):66-71.

 

A pilot investigation to transfer the established corneal collagen crosslinking (CXL) procedure in European eyes into clinically affected African eyes and to optimize the treatment by adapting the riboflavin composition.

Last Updated: 26 Mar 2014

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Rose-K versus Soper contact lens in keratoconus: a randomized comparative trial.
 

Author(s): Raghav Gupta, Rajesh Sinha, Pooja Singh, Namrata Sharma, Radhika Tandon, Jeewan S Titiyal

Journal: Middle East Afr J Ophthalmol. ;21(1):50-5.

 

To perform a comparative evaluation of the efficacy and acceptability of Rose-K and Soper contact lenses in Keratoconus.

Last Updated: 26 Mar 2014

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Reviews from the PubMed Database

Review articles summarize what is currently known about a disease. They discuss research previously published by others.
The terms "Keratoconus" returned 21 free, full-text review articles on human participants. First 3 results:

Intrastromal corneal ring segments: how successful is the surgical treatment of keratoconus?
 

Author(s): Jorge L Alio, Alfredo Vega-Estrada, Santiago Esperanza, Rafael I Barraquer, Miguel A Teus, Joaquim Murta

Journal: Middle East Afr J Ophthalmol. ;21(1):3-9.

 

This review evaluates the outcomes of intrastromal corneal ring segment (ICRS) implantation for the treatment of keratoconus considering a new grading system based on the preoperative visual impairment of the patient. Additionally, a five-year follow-up analysis of patients with stable ...

Last Updated: 26 Mar 2014

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Corneal sensitivity in keratoconus: a review of the literature.
 

Author(s): Leopoldo Spadea, Serena Salvatore, Enzo Maria Vingolo

Journal:

 

Corneal sensitivity has recently received much attention given the crucial role the corneal nerves play in maintaining normal corneal structure and function. An increased understanding of the corneal sensitivity and dry eye disease in keratoconus, including alterations of the conjunctival ...

Last Updated: 3 Dec 2013

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Oxidative stress in the pathogenesis of keratoconus and Fuchs endothelial corneal dystrophy.
 

Author(s): Katarzyna A Wojcik, Anna Kaminska, Janusz Blasiak, Jerzy Szaflik, Jacek P Szaflik

Journal:

 

Due to its localization and function, the cornea is regularly exposed to sunlight and atmospheric oxygen, mainly dioxygen, which produce reactive oxygen species (ROS). Therefore, corneal cells are particularly susceptible to oxidative stress. The accumulation of ROS in the cornea ...

Last Updated: 25 Sep 2013

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Symptoms, Diagnosis, and Treatment

There are currently no related results available in GeneReviews.

There are currently no related results available in Genetic Testing Registry.

 
 
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Clinical Trial Information This information is provided by ClinicalTrials.gov

Keratoconus Detection
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 21 Jun 2012

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Intacs for Keratoconus
 

Status: Recruiting

Condition Summary: Keratoconus

 

Last Updated: 3 Jul 2006

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Orthokeratology for Keratoconus
 

Status: Not yet recruiting

Condition Summary: Orthokeratology; Keratoconus

 

Last Updated: 31 Dec 2008

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